Delivering clinical research to make patients, and the NHS, better

Breast Cancer Research Report

Site Specific Group MeetingTuesday 13th January 2015

Maxine TaylorSenior Research Delivery Manager

Content of report

• Overview of network changes• Overview of research activity• New studies for the portfolio• Role research leads

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Introduction

• NIHR Clinical Research Network merged all cancer research networks with all other clinical research networks in England on 1st April 2014

• CRN - West of England is one of 15 new networks• This new geography does not map exactly to the site

specific group geography. It now includes Gloucestershire and Swindon but no longer includes Taunton and Yeovil

• Taunton and Yeovil are served by the CRN – South West Peninsula

• I will work closely with my counterpart in South West Peninsula to support this SSG in full

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West of England• Population 2.4 million• - Budget £13.2 million• - 7 Acute Trusts• - 2 Mental Health Trusts• - CCL Principal Treatment Centre• - Small core support team based at

host in Bristol• - Research will follow patient

pathways regardless of network geography

Map showing the 15 Clinical Research Networks in England

Purpose of the network

• Translation of national workstreams and objectives (generic and specialty specific) with strategic oversight of research activity within the geography of CRN - West of England in terms of:

– Portfolio• Balance, new studies, feasibility, industry trials

– Performance• Targets, support timely set up, support timely

recruitment– People

• Skill mix, workforce flexibility, training, resources

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Network Clinical Divisions• CancerDivision 1

• Diabetes Renal• Stroke Metabolic & endocrine• CardiovascularDivision 2• Children Reproductive health & childbirth• Genetics HaematologyDivision 3• Mental Health• Dementias & neurodegenerative diseases• NeurologyDivision 4• Primary care Ageing

Health services research• Oral & dental Dermatology• Musculoskeletal Public Health

Division 5• ENT Anaesthesia &

pain management• Surgery Critical care• Respiratory Opthalmology

• Critical care Infectious diseases

• Hepatology Gastroenterology

Division 6

CRN - West of England Management Model

• Division 1 • Division 5

• Divisions 2 & 6• Divisions 3 & 4

Maxine TaylorSenior RDM Workforce

Development

Martine CrossSenior RDM RM&G and

Industry Lead

Ruth AllenRDM

Business Intelligence

lead

Chantal SunterRDM

PCPIE and Comms Lead

Mary PerkinsChief Operating Officer

The Clinical Team

Dr Steve FalkClinical Director

6 Divisional Clinical LeadsProf Hugh Barr for Div 1

30 Specialty Leads

Sub Specialty Leads

Sue TaylorNetwork Consultant Nurse

Clinical Research Teams

NIHR CRN High Level Objectives• Set up as fast as you can• Recruit as many and as fast as you can• All organisations involved• Commercial and non commercial portfolio studies

Cancer specialty specific objectives• Recruitment overall at 20% of cancer incidence• Recruitment to interventional studies at 7.5% of cancer

incidence

How important is cancer on our patch?

58

23

172120

34

67

Research staff WTE per division

Div 1Div 2Div 3Div 4Div 5 Div 6Generic

• Cancer incidence 9544• 242 recruiting studies• £2 million (16%)• Funding per incident case approx

£220• Funding per recruit £800• Exceeded both recruitment

targets for last 2 years• Largest non commercial portfolio• Benefit from continued good

national and international links

West of England specialty portfolio compared to national

AgeingAnaesthesia, perioperative medicine and pain

CancerCardiovascular disease

ChildrenCritical care

Dementias and neurodegenerationDermatology

DiabetesEar, nose and throat

GastroenterologyGenetics

HaematologyHealth services and delivery research

HepatologyInfectious diseases and microbiology

Injuries and emergenciesMental Health

Metabolic and endocrine disordersMusculoskeletal disorders

Neurological disordersOphthalmology

Oral and dental healthPrimary CarePublic health

Renal disordersReproductive health and childbirth

Respiratory disordersStroke

Surgery

0 100 200 300 400 500 600 700 800

WE portfolio

National portfolio

Total studies 3827WE total 546=14%

0

500

1000

1500

2000

2500

3000

3500

4000

CRN: West of England Performance against Specialty goals 14/15 (Apr 2014 - Nov 2014)

Recruitment (Apr 2014 - Nov 2014) Recruitment goal (Apr 2014 - Nov 2014) Recruitment goal 2014/15

Gloucester

shire

Hospita

ls NHS F

oundation Tr

ust

Great W

estern

Hospita

ls NHS F

oundation Tr

ust

North Bris

tol NHS T

rust

Royal U

nited Hosp

ital B

ath NHS T

rust

Universi

ty Hosp

itals B

ristol N

HS Foundati

on Trust

West

on Area Hea

lth NHS T

rust

0

10

20

30

40

50

60

70

80

38

6 12 172

24

12 445

59

58

3 4

Recruitment to Breast cancer studies by study design type by CRN: West of England partner organisations (Apr 14 - Nov 14)

Both Interventional Observational

Recr

uits

Yeovil & Taunton recruitment by study design April – Nov 2014

Taunton Yeovil0

5

10

15

20

25

30

35

40

45

50

114

30

14

5

13ObservationalInterventionalBoth

Cancer Subspecialty Research Leads

• Within each network 13 subspecialty research lead roles are identified, mapping onto the national Clinical Studies Groups with the aim of:– Providing link between local network and CSGs – Promoting the research agenda to clinical colleagues

across the network and encouraging referrals– Advising on portfolio planning locally– Attendance at annual national meeting to discuss

portfolio planning and delivery and horizon scan for new studies – first meeting 9th March 2015

– Supporting the research delivery manager for the cancer specialty

• Role very similar to SSG Research Lead role 17

Imaging Adv. panel

Screening, Prevention &

Early Diagnosis

CTRad (Radiotherapy)

Psychosocial & Survivorship

Teenage &Young Adult

Palliative & Supportive Care

Biomarkers Adv. panel

Primary Care

Consumer Liaison Group

Breast CancerCSG

Lung CancerCSG Upper GI

CancerCSG

Colorectal CancerCSG

Kidney CancerCSG

Bladder CancerCSGTestis

CancerCSG

Gynae CancerCSG

PPI

Brain Tumours

CSGHead & Neck CSG

SarcomaCSG

MelanomaCSG

LymphomaCSG

Haematol.CSG Prostate

CancerCSG

Children’s Cancer &

Leukaemia

National Clinical Studies Groups

Division 1 Clinical Lead

•Brain cancer•H&N cancer •Lung cancer•Breast cancer•Sarcoma•Skin Cancer•Children/young people

•Upper GI cancer•Colorectal cancer•Urological cancer•Gynae cancer•Haem/lymphoma•Pall/Supportive & Psychosocial

13 LCRN Subspecialty Leads:

LCRN (x15)

Clinical Director

CRN WE Exec Board

COO

Division 1 RDM

Research Delivery Teams

Partnership Group Clin. Advisory Group

[ +/- other clinical roles]

CRN – West of England Sub specialtylead for breast cancer research

• Surgery – Mr Zen Rayter• Oncology – Dr Mark Beresford

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Contact & reference details

• Maxine.taylor@nihr.ac.uk

• Hugh.barr@glos.nhs.uk

• http://csg.ncri.org.uk/portfolio-maps/

• https://www.edge.nhs.uk/Account/Index?ReturnUrl=%2f

• http://www.crn.nihr.ac.uk/can-help/funders-academics/nihrcrn-portfolio/

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