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Decision presented by the committee board members: Nicholas Mann & Katelyn Strasser
FUTURE FUNDING FOR ALZHEIMER’S
DISEASE
October 14, 2014MPH 543 Leadership and Organizational Management in HealthcareConcordia University Nebraska
Most common form of dementia
Alters memory, thinking, and behavior
Affects over 5 million Americans
6th leading cause of death in the United States
(Alzheimer’s Association, n.d.)
WHAT IS ALZHEIMER’S?
Unknown how disease process begins
Damage to the brain involves amyloid plaques and tau tangles
Neurons lose function
Brain tissue shrinks
WHAT IS ALZHEIMER’S?
(National Institute on Aging, 2014)
AgeOver 65
GeneticsFamily history
Other causesLinks to cardiovascular disease and diabetes
(CDC, 2014).
RISK FACTORS
Alzheimer’s has seven stagesStage 1: No impairmentStage 2: Very mild cognitive declineStage 3: Mild cognitive declineStage 4: Moderate cognitive declineStage 5: Moderately severe cognitive
declineStage 6: Severe cognitive declineStage 7: Very severe cognitive decline(Alzheimer’s Association, n.d.)
STAGES AND SIGNS
Most expensive disease in the country
Medicare and Medicaid spending
Out-of-pocket costs
(Alzheimer’s Association, n.d.)
COSTS
Burden to caregiversPhysical and emotional strain
DepressionLoss of jobs
Projected future costs to increase Baby Boomer generation ages
(Alzheimer’s Association, n.d.)
COSTS
Acetylcholinesterase inhibitorsApproved to treat early to moderate stagesSupport communication among nerve cellsDelay the progression of symptoms for 6 to 12 months in 50% of cases (Alzheimer’s Association, n.d.)
CURRENT TREATMENTS
Donepezil (Aricept)
Rivastigmine (Exelon) Galantamine (Razadyne)
Donepezil (Aricept): Approved to treat all stages of Alzheimer’s
Rivastigmine (Exelon): Approved to treat mild to moderate Alzheimer’s
Galantamine (Razadyne): Approved to treat mild to moderate Alzheimer’s
Benefits: Each has the same mechanism of action-to increase communication among nerve cells.
Side effects: nausea, vomiting, loss of appetite, and increased frequency of bowel movements.
(Alzheimer’s Association, n.d.)
CURRENT TREATMENTS
We support funding for the three cholinesterase inhibitors.
Our decision is in accordance with the National Institute for Health and Clinical Excellence (NICE) guidelines.
Funding is granted on the basis of other NICE principles
(Alzheimer’s Society, 2014)
FUNDING DECISION
Funding for new drugs other than acetylcholinesterase inhibitorsThese drugs will affect the disease process, not just the symptoms.
“Investing in research now will cost our nation far less than the cost of care for the rising number of Americans who will be affected by Alzheimer’s in coming decades.” –Bill Thies, Ph.D., Senior Scientist in Residence, Alzheimer’s Association.
(Alzheimer’s Associat ion, n.d.)
FUNDING DECISION
Alzheimer’s Associat ion. (n.d.) . Facts and fi gures. Retr ieved from http:/ /www.alz.org/ alzheimers_disease_facts_and_fi gures.asp Alzheimer’s Associat ion. (n.d.) . Seven stages of Alzheimer’s. Retr ieved from http:/ / www.alz.org/alzheimers_disease_stages_of_alzheimers.aspAlzheimer’s Associat ion. (n.d.) . Treatments for Alzheimer’s disease. Retr ieved from http:/ /www.alz.org/alzheimers_disease_treatments.aspAlzheimer’s Associat ion. (n.d.) . What is Alzheimer’s? Retr ieved from http:/ /www.alz.org/alzheimers_disease_what_is_alzheimers.aspAlzheimer’s Society. (2014). Drug treatments for Alzheimer’s disease. Retr ieved from http:/ /www.alzheimers.org.uk/si te/scripts/documents_info.php?
documentID=147Centers for Disease Control and Prevention. (2014). Alzheimer’s disease. Retr ieved from http:/ /www.cdc.gov/aging/aginginfo/alzheimers.htmKing’s Col lege London. (2014). World Alzheimer Report 2014 reveals persuasive evidence for dementia r isk reduction. Retr ieved from http:/ /
www.sciencedai ly.com/releases/2014/09/140917073258.htmNational Inst i tute on Aging. (n.d.) . Alzheimer’s disease fact sheet. Retr ieved from http:/ /www.nia.nih.gov/alzheimers/publ icat ion/alzheimers-disease-fact-
sheet
REFERENCES