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DDRCC members Jack Gilbert and Vanessa Leone presented at this year’s science public outreach event “Pint of Science” under the theme “We Didn’t Choose the Bug Life, It Chose Us” Dr. Jack Gilbert presented his research entitled

“Invisible Influence: Exploring your microbial health” and Dr. Vanessa Leone presented “Diet, microbes, and circadian rhythm – Are they making you fat?" Dr. Corrie Moreau from the Field Museum also presented to round out a fun evening of Science education and cocktails at Beer Bistro North on May 18th, 2015. For more information on Pint of Science see their website at: https://pintofscience.us/

Kristina is a Postdoctoral Fellow in the laboratory of

DDRCC member and Director, Dr. Eugene B. Chang. She will be presenting her work entitled

“Diet, Gut Bacteria, and Metabolic Disease: Strategies to Promote Healthy Microbial

Communities" at Geek Bar Chicago's SCIENCE! Tuesday

August 18, 2015 7:00pm

Geek Bar Chicago 1941 W North Ave

Chicago, IL https://www.c2st.org/event/2015/06/c2st-speakeasy-dr-kristina-martinez

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DDRCC Digest

What’s new in the DDRCC? Members in the spotlight

P&F award announcement Transgenic mice available from Case Western Reserve

Volume 25, No. 3 August 2015 Upcoming

Community Outreach

C2ST Speakeasy with Dr. Kristina Martinez

DDRCC Members Participate in Pint of Science Community

Outreach

Chicago Council on

Science and Technology

Presents:

DDRCC Digest Volume 25, No. 3 Aug. 2015

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University*of*Chicago*Diges3ve*Disease*Research*Center**(DDRCC*)*Request*for*Applica3ons*Pilot*and*Feasibility*Awards*

Contact'Drs.'Cathy'Nagler,'Bana'Jabri,'or'Eugene'B.'Chang'prior'to'submi;ng'a'full'applica=on'by'July*17,*2015''Full'Applica=on'Due*Sept*4,*2015''

'

Please'see'our'website'www.uchicagoddrcc.org'

for'the'applica=on'format,'further'details'of'our'Research'Cores'and'examples'of'recently'funded'

projects.'

Interested*applicants*should*contact:*

Cathy'Nagler,'Ph.D.'cnagler@bsd.uchicago.edu''(2I6317)'[Director'of'P&F'Programs]''

Bana'Jabri,'M.D.,'Ph.D.'bjabri@bsd.uchicago.edu(4I8670)''

Eugene'Chang,'M.D.'echang@medicine.bsd.uchicago.edu''(2I6458)'

By*July*17th**before*submiNng*a*full*proposal**

!

Full!Proposals!are!due!Sept*4th,*2015*

*PLEASE'SEND'TOTAL'APPLICATION'IN'WORD'

FORMAT'(one'document)'TO'DDRCC'RESEARCH'MANAGER'JOELI'BRINKMAN'NO'LATER'THAN'5:00'

PM'ON*Friday,*Sept*4th*,*2015**

*Email:'jbrinkman@medicine.bsd.uchicago.edu'!

!Core'Facili=es/Services:''Integrated! Translational! Research! Core! Offers! the! IBD! patient! registry,! tissue!biobanking!facilities,!and!bioinformatic!support.!Host8Microbe! Core! Provides! unique! approaches! to! the! study! of! host@microbe!interactions,! including! cell/tissue! models,! gnotobiotic! mouse! technologies,! and!approaches! for! structural! and! functional! profiling! of! complex! microbial!communities.!Tissue! Engineering! and!Cell! Models! Core!Offers! unique! cell! and! tissue!models,!enteroids/organoids,! and! mouse! models! along! with! molecular! and! genetic!engineering!approaches!to!develop!new!model!systems.!Tissue!and!Cell!Imaging!Core!Access!to!surgical!pathology!specimens!and!archival!tissues! related! to! infectious,! neoplastic! and! inflammatory! bowel! diseases.! ! Also!offering!imaging!capabilities!for!tissue!and!cell!analysis.!Computational! Analysis! and! Modeling! Resource! Offers! Bioinformatics,!biostatistics,!high@throughput!microbial!analysis!and!modeling!&!simulation!to!aid!in!the!design,!execution!and!interpretation!of!research!projects.!!!

The' overarching' theme' of' the' DDRCC' is'research' in' Diges=ve' Health' and' Disease,'including' inflammatory' bowel' diseases' (IBD)'and' related' areas' of' intes=nal' inflamma=on,'immunology,' the' gut'microbiome,'metabolism,'and'epithelial'biology/cancer'of'the'GI'tract.''

DDRCC!Pilot!and!Feasibility!awards!are!offered!for!the!purposes!of:!

!1.''AOrac3ng*new*inves3gators'(Track*I),'including'senior'research'fellows'and'post'docs,'into'the'mission'areas'of'the'DDRCC.'This'is'intended'for'candidates'without'current'NIH'or'other'significant'extramural'support'to'ini=ate'research'into'diges=ve'diseases.'2.' Allowing' more* established* faculty*members' (Track* II),' who' are' not'currently' engaged' in' gastrointes=nal'research,' to' extend' their' inves=ga=ons'into'the'mission'areas'of'the'DDRCC.'3.' Permi;ng' faculty* members* already*engaged* in* research* of* Diges3ve*Diseases' (Track* III)' to' test' a' novel'hypothesis' that' is' significantly' different'from' the' inves=gator’s' mainstream'research.''''*Applica=ons' which' emphasize' DDRCC'core' use' and' strengthen' collabora=ve'interac=ons' amongst' DDRCC' scien=sts'are'par=cularly'encouraged.'''*It'is'an=cipated'that'these'pilot'projects'will'enhance'the'ability'of'inves=gators'to'compete' for' extramural' funding' in' IBD'and' related' areas' of' gastrointes=nal'research'!!!

Period*and*Amount*of*Funding:*'Funds' for' Pilot' &' Feasibility'projects' are' available' for' an'ini=al' period' of' one' year'beginning' December' 1,' 2015'a n d ' r a n g e ' b e t w e e n'$30,000I37,500'in'direct'costs.'''Successful' candidates' will' be'requi red' to' report' the i r'progress' 6' months' into' the'fiscal' year' for' con=nua=on' of'funding.'''Outcome'of'progress'during'the'first' year' will' determine' if'applicants' will' be' invited' to'reapply' for' a' second' year' of'funding.''''Funds' may' be' requested' for'personnel' (with' the' excep=on'of' PI' salary),' supplies,' services'and'other'costs'(not'equipment'or'travel).''

DDRCC Digest Volume 25, No. 3 2015

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Recently Published Manuscripts

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Constantinides MG, Gudjonson H, McDonald BD, Ishizuka IE, Verhoef PA, Dinner AR, Bendelac A. PLZF expression maps the early stages of ILC1 lineage development. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(16):5123-8. Devkota S, Chang EB. Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases. Digestive Diseases. 2015;33(3):351-6. Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR. gammadelta Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015;148(7):1417-26. Golan MA, Liu W, Shi Y, Chen L, Wang J, Liu T, Li YC. Transgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency. Digestive Diseases and Sciences. 2015;60(7): 1941-1947 Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Immunity. 2015;42(4):731-43. Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host & Microbe. 2015;17(5):681-9.

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Lu L, Yu Y, Guo Y, Wang Y, Chang EB, Claud EC. Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model. PloS One. 2015;10(4):e0124504. Pickard JM, Chervonsky AV. Intestinal Fucose as a Mediator of Host-Microbe Symbiosis. Journal of Immunology. 2015;194(12):5588-93. Setty M, Discepolo V, Abadie V, Kamhawi S, Mayassi T, Kent A, Ciszewski C, Maglio M, Kistner E, Bhagat G, Semrad C, Kupfer SS, Green PH, Guandalini S, Troncone R, Murray JA, Turner JR, Jabri B. Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015. Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Science Translational Medicine. 2015;7(286):286ra68. Yurkovetskiy LA, Pickard JM, Chervonsky AV. Microbiota and Autoimmunity: Exploring New Avenues. Cell Host & Microbe. 2015;17(5):548-52.

DDRCC Digest Volume 25, No. 3 Aug. 2015

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Erin Adams was promoted to full professor in the Department of Biochemistry and Molecular Biology at U of C

Yoav Gilad “broke the ‘social norms’ of science by using Twitter to question the results of a paper authored by Michael Snyder of Stanford University.

Sonia Kupfer Co-Directed, Best of the Annual Conferences in Digestive Diseases CME conference in Chicago, IL. June 13, 2015

Michael J. Rust will take part in the Award to Early-Career Scientists to Examine the Intersection of Biology and Physical Sciences through The Gordon and Betty Moore Foundation and Research Corporation for Science Advancement. Thirteen grants to five teams of investigators were awarded as part of 2015 Scialog: Molecules Come to Life. These grants, totaling $731k, enable awardees to pursue ambitious, high-risk, highly impactful discovery research on untested ideas in physical cell biology. Each investigator will receive $56,250 and work in teams of two or three.

DDRCC Member Awards and Achievements

As part of the Midwest DDRCC Alliance, Case Western Reserve is offering SAMP1 and TNFDARE mice at a discount to DDRCC members through their mouse models core. The overall goal of this core is to provide centralized mouse modeling services that will enhance the pace of in vivo digestive disease-related research and provide communal access to unique mouse models. The SAMP1 and TNFDARE mice are great chronic Crohn’s Disease-like ileitis models that are not commercially available. (Pizarro TT, Pastorelli L, Bamias G, Garg RR, Reuter BK, Mercado JR, Chieppa M, Arseneau KO, Ley K, Cominelli F. SAMP1/YitFc mouse strain: A spontaneous model of Crohn's disease-like ileitis. Inflamm Bowel Dis. 2011 May 6.) and Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med. 2002 Dec 16;196 (12):1563-74., Case Western can provide DDRCC members up to 24 experimental mice age and sex matched for $1,800-2,000. For more information, contact U of C DDRCC Research Manager, Joeli Brinkman jbrinkman@medicine.bsd.uchicago.edu

SAMP1 and TNFDARE mice

New Resources

Did you know?

DDRCC

members:

DDRCC Digest Volume 25, No. 3 2015

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Media Mentions

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John Alverdy Featured in "Ambivalence over plus-size and proud" Chicago Tribune 6/1/15 http://www.chicagotribune.com/news/ct-plus-size-model-health-0602-20150601-story.html Eugene B. Chang Featured on the Microbiome podcast Episode 7: "Gut Bacteria and Circadian Clocks" 5/18/15 http://directory.libsyn.com/episode/index/id/3559445 Fredric L. Coe Research featured in Medill Reports Chicago "Kale sheds bum rap on kidney stones" by Angeles Barnes 5/21/15 http://news.medill.northwestern.edu/chicago/kale-sheds-bum-rap-on-kidney-stones/ Jack Gilbert Featured in "Urban microbes come out of the shadows" by Rachel Ehrenberg in Nature News 6/22/15 http://www.nature.com/news/urban-microbes-come-out-of-the-shadows-1.17818 David Gozal Research featured in "Americans, their physicians should take sleep seriously: chest doctors" by Kathryn Doyle in Reuters Health 6/15/15 http://www.reuters.com/article/2015/06/15/us-health-sleep-thoracic-statement-idUSKBN0OV24J20150615?feedType=RSS&feedName=healthNews Bana Jabri Research featured in "The Myth of Big, Bad Gluten" By Moises Velasquez-Manoff in the New York Times 7/4/15 Chuan He Research featured in "Modified DNA Base 5-Formylcytosine Has A Specific Biological Role" Chemical & Engineering News 6/22/15 http://cen.acs.org/articles/93/web/2015/06/Modified-DNA-Base-5-Formylcytosine.html Cathryn Nagler Research featured in the The Salisbury Post "Your Microbiome becomes you" by Chris Magryta 6/4/15 http://www.salisburypost.com/2015/05/26/your-microbiome-becomes-you/ David T. Rubin Featured in "How newest class of drugs could save billions of dollars" By Ellen Jean Hirst in The Chicago Tribune 6/22/15 http://www.chicagotribune.com/business/ct-biosimilars-future-of-pharma-0322-biz-20150320-story.html#page=1 Sushila Dalal Featured in "Around the World With Crohn's Disease" University of Chicago Medicine 6/2/15 http://www.uchospitals.edu/specialties/gi/ibd/stories/robinson.html

Carole Ober Featured in "Study seeks to determine environmental factors that protect against asthma, allergies" in The Medical News 6/11/15 http://www.news-medical.net/news/20150612/Study-seeks-to-determine-environmental-factors-that-protect-against-asthma-allergies.aspx

Future of Research Chicago (FORChicago) is coming in October of 2015. FORChicago is one in a series of national symposia on the future of the scientific endeavor. The symposium will deal with specific issues and challenges affecting early career scientists and postdocs and propose educational and policy changes in order to enhance the productivity and effectiveness of the postdoc experience overall and in career development. Organized as collaboration amongst postdocs in the Chicago area, several postdocs affiliated with the DDRCC are participating. The FORChicago symposium will take place October 29th, 2015 for more information and to register visit the website at: futureofresearch.org/chicago/

Future of Research Chicago

DDRCC Digest Volume 25, No. 3 Aug. 2015

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Upcoming Conferences

Farewell to DDRCC member and ITR Core Co-Director, John Kwon. Dr. Kwon and his laboratory are joining the faculty at UT Southwestern. Dr. Joel Pekow will be the new Co-Director of the ITR Core. The DDRCC would like to thank Dr. Kwon for his service and wish him the best of luck on his new adventure.

Got News or want to see your name in print? Contact the DDRCC Program Manager,

Joeli Brinkman, jbrinkman@medicine.bsd.uchicago.edu

Visit us on the web http://www.uchicagoddrcc.org

Or follow us on twitter @UChicago_DDRCC

Other News