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(acetaminophen) for postoperative pain in adults (Review). The Cochrane

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parasetamol untuk nyeri pasca bedah operasi tangan rawat jalan: uji

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nyeri-pascabedah-operasi-tangan-rawat-jalan-uji-klinis-tersamar-ganda-

model-ganda-acak-paralel (accessed 9 february 2013).

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Paracetamol toxicity: epidemiology, prevention and cots to the health-

care system [internet]. 2002 [cited 2012 dec 20]: 95 (9): 609-619.

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53

Lampiran 1

Ethical Clearance

54

Lampiran 2

Surat Ijin Penelitian

55

Lampiran 3

Dokumentasi Penelitian

1.Penimbangan sampel tikus wistar jantan

2.Sistem pengandangan tiap kelompok

3.Pakan dan minum standart

56

4.Pemberian parasetamol lewat sonde lambung

5.Pengambilan darah melalui vena periorbita

6.Proses pemeriksaan kadar SGOT

57

Lampiran 4

Hasil Uji Laboratorium

Kelompok Kadar SGOT (U/l)

Kontrol

Kontrol

Kontrol

Kontrol

Kontrol

P1

P1

P1

P1

P1

P2

P2

P2

P2

P2

8,1

14,7

13,1

15,1

10,9

27,1

51,0

48,8

60,7

16,6

67,7

38,1

55,1

43,5

31,0

Keterangan

Kontrol : Tidak diberi perlakuan

P1 : Diberi parasetamol 18mg 4x sehari selama 2 hari

P2 : Diberi parasetamol 18mg 4x sehari selama 4 hari

58

Lampiran 5

Output Uji Statistik

1.Uji normalitas data

Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent

Kadar SGOT 15 100.0% 0 .0% 15 100.0%

Descriptives

Statistic Std. Error

Kadar SGOT Mean 33.433 5.1798

95% Confidence Interval for

Mean

Lower Bound 22.324

Upper Bound 44.543

5% Trimmed Mean 32.937

Median 31.000

Variance 402.455

Std. Deviation 20.0613

Minimum 8.1

Maximum 67.7

Range 59.6

Interquartile Range 36.3

Skewness .275 .580

Kurtosis -1.413 1.121

Tests of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Kadar SGOT .199 15 .112 .917 15 .171

a. Lilliefors Significance Correction

59

2. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 1)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 2

hari 5 40.840 18.2850 8.1773

Independent Samples Test

Levene's Test

for Equality of

Variances t-test for Equality of Means

F Sig. t df

Sig.

(2-

tailed)

Mean

Difference

Std. Error

Difference

95% Confidence

Interval of the

Difference

Lower Upper

Kadar

SGOT

Equal

variances

assumed

17.424 .003 -

3.437 8 .009 -28.4600 8.2800 -47.5538 -9.3662

Equal

variances

not

assumed

-

3.437 4.202 .024 -28.4600 8.2800 -51.0195 -5.9005

3. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 2)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 4

hari 5 47.080 14.5046 6.4866

60

Independent Samples Test

Levene's

Test for

Equality of

Variances t-test for Equality of Means

F Sig. t df

Sig.

(2-

tailed)

Mean

Difference

Std. Error

Difference

95% Confidence

Interval of the

Difference

Lower Upper

Kadar

SGOT

Equal

variances

assumed

8.698 .018 -

5.245 8 .001 -34.7000 6.6156 -49.9557 -19.4443

Equal

variances

not

assumed

-

5.245 4.321 .005 -34.7000 6.6156 -52.5423 -16.8577

4.Uji Statistik ANOVA

ANOVA

Kadar SGOT

Sum of Squares df Mean Square F Sig.

Between Groups 3421.665 2 1710.833 9.278 .004

Within Groups 2212.708 12 184.392

Total 5634.373 14

61

Multiple Comparisons

Kadar SGOT

LSD

(I) Pemberian

Parasetamol

(J) Pemberian

Parasetamol

Mean

Difference (I-J)

Std.

Error Sig.

95% Confidence

Interval

Lower

Bound

Upper

Bound

kontrol 18mg 4x sehari

selama 2 hari -28.4600

* 8.5882 .006 -47.172 -9.748

18mg 4x sehari

selama 4 hari -34.7000

* 8.5882 .002 -53.412 -15.988

18mg 4x sehari

selama 2 hari

kontrol 28.4600* 8.5882 .006 9.748 47.172

18mg 4x sehari

selama 4 hari -6.2400 8.5882 .481 -24.952 12.472

18mg 4x sehari

selama 4 hari

kontrol 34.7000* 8.5882 .002 15.988 53.412

18mg 4x sehari

selama 2 hari 6.2400 8.5882 .481 -12.472 24.952

*. The mean difference is significant at the 0.05 level.

62

Lampiran 6

Daftar Riwayat Hidup

Identitas

Nama : Alif Adlan Zulizar

NIM : G2A009134

Tempat/tanggal lahir : Kebumen, 15 September 1990

Jenis kelamin : Lak-laki

Alamat : Jalan Tirto Mukti VIII/1, Semarang

Nomor Telpon : (024) 6715109

Nomor HP : 08560221885

e-mail : chakiizul@yahoo.co,

Riwayat Pendidikan Formal

1. SD : SD SUPRIYADI Lulus tahun : 2003

2. SMP : SMPN 2 Semarang Lulus tahun : 2006

3. SMA : SMA SEMESTA Semarang Lulus tahun : 2009

4. FK UNDIP : Masuk tahun : 2009

Keanggotaan Organisasi

1. Staf Bidang Hubungan Luar Negri BEM KU UNDIP Tahun 2009 s/d 2010

2. Anggota Medical Creative Art FK UNDIP Tahun 2009 s/d 2011

3. Ketua Medical Creative Art FK UNDIP Tahun 2011 s/d 2012

4. Anggota Komisi Disiplin Pemilihan Raya FK UNDIP Tahun 2010

5. Ketua Komisi Disiplin Pemilihan Raya FK UNDIP Tahun 2011

6. Sie Acara PMB FK UNDIP Tahun 2010

7. Sie Publikasi Dokumentasi Sientific Fair 2011 Tahun 2011

8. Sie Acara Pekan Olahraga Seni 2011 FK UNDIP Tahun 2011

9. Sie Acara Kemah Bakti 2012 FK UNDIP Tahun 2012

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