Day 1: Monday ,18 November 2019

Chairs: Dr. Qamar Al Mutawa & Ms. Rawasi M Al Saadi

07:30 - 08:00 Registration

08:00 - 08:30 Opening Ceremony

08:30 - 09:00Objective of the workshop & Current status of the cyclotron in Kuwait

Dr. Shorouk Dannoon

09:00 - 10:00Introduction of Cyclotrons: Practical Information

Prof. Ibrahim Aljammaz

10:00 - 10:30 Break

10:30 - 11:30Production of PET Radioisotopes & 18F-FDG

Prof. Ibrahim Aljammaz

11:30 - 12:00 Break & Praying

12:00 - 01:00Production of Beyond FDG PET Radiopharmaceuticals

Prof. Vijay Kumar

01:00 - 02:00Facility, Design & Layout for Cyclotron According to GMP

Prof. Roberto La Forgia

Day 2: Tuesday, 19 November 2019

Chairs: Mrs. Lolwah Al Mutari & Ms. Zainab Al-Qallaf

08:30 - 09:30Automated Quality Control of PET Radiopharmaceuticals

Prof. Vijay Kumar

09:30 - 10:30Qualification & Validation according to GMP

Prof. Roberto La Forgia

10:30 - 11:30Radiopharmaceuticals Regulations: Pharmaceuticals Aspects & Radiation Protection

Prof. Ibrahim Aljammaz

11:30 - 12:00 Break & Praying

12:00 - 01:00Staff Requirements for PET Radiopharmaceuticals Production Facility

Prof. Vijay Kumar

01:00 - 01:30New PET radiopharmaceuticals: Research & Development

Prof. Ibrahim Aljammaz

01:30 - 02:00 Conclusions & Recommendations

RADIOPHARMACEUTICALS current status and future prospects

CYCLOTRON &

PET

OH

OH

OH

HO

F18

O

The Nuclear Medicine CouncilNuclear MedicineWorkshop

2019

18-19 November 2019

Jaber Al Ahmed Al-Sabah Hospital,Conference Hall

24618073cyclotronworkshop@hotmail.comwww.Kamp-Kw.com

For more Information :

pointsCME9

Under The Patronage of H.E. The Minister of Health

Dr. Basel H. Al Sabah

What is a Cyclotron?- It is a device that accelerates charged particles such as protons, deutrons,

particles to very high energies.

- Types of cyclotron:

- How does it work:- A charged particle can be accelerated to very high energies by making it

pass through a moderate electric field multiple times.

- Main internal components of cyclotron:

- Ion source, • Produces particles to be accelerated,- Magnet, • Keeps particles on a circular motion,- Radiofrequency system, • Accelerated beam,- Extraction system, • Guides particles out of the cyclotron,- Vacuum system,- Cooling system,- Diagnostics (beam probe)

- Main external components of cyclotron:• Quadrupoles, • Steering magnet,• Beam stop, • Beam viewers,

• Signals pickup elements, • Collimator,

- What is a hot cell?- It is a compartment made of lead that is thick enough to shield 511 kev pho-

tons. It is also used to house PET radiotracer synthesizers. In addition, there are class A dispensing unit in a hot cell.

1. Linear accelerators:Accelerate particles in a straight line.

2. Cyclotrons:Accelerate particles along an outward spi-ral path.

3. Synchrotrons:Cyclic accelerators that send the particles into a closed-loop path. PET

RadiopharmaceuticalsSynthesis

Ga-68 Dota Noc or PSMA synthesis

It is used to diagnose neuroblastoma or prostate.

Ga-68 generator elution

Labelling

Pure HCL

Purification

Peptide

Peptide recovery

Ethanol evaporation

Ethanol

Formulation NACL 0.9%

Ga-68 [Dota Noc] or

Ga-68 [PSMA]

Impurities waste

Waste

Quality control HPLC

ITLC

F-18 FDG synthesis

F-18 FDG (F-18 2-fluoro-2-deoxy-D-glucose) or fluorodeoxyglucose (glucose analogue).

It is used to diagnose cancer and infection in the tissues.

Cyclotron

F-18 Trapping

O-18 enriched water

Synthesis of F-18

Purification Impurities waste

Formulation

F-18 FDG

Quality control

Endotoxin

LAL test

HPLC

ITLC

PH

Dispensing

Release

Recovery O-18 K222

Evaporation