Harald Stenmark

Web page: http://www.ous-research.no/stenmark/ E-mail: stenmark@ulrik.uio.no Address: Dept. of Molecular Cell Biology, Inst. for Cancer Research, the Norwegian Radium Hospital, Montebello, N-0379 Oslo Born: 25. Oct. 1960, Honningsvåg, Norway Marital status: Married, one child (born 2011)

Education: Cand. Pharm. 1985, School of Pharmacy, University of Oslo Doctoral Degree: Dr. Philos. 1991, Faculty of Medicine, University of Oslo. Thesis title: “Entry of diphtheria toxin and related proteins into cells”. Supervised by Prof. Sjur Olsnes, the Norwegian Radium Hospital. Positions held:

1985-1991 Research assistant Department of Biochemistry, the Norwegian Radium Hospital

1991-1994 Postdoc Cell Biology Programme, EMBL, Heidelberg 1995-1997 Research fellow Department of Biochemistry, the Norwegian Radium

Hospital 1997-2009 Group leader Department of Biochemistry, the Norwegian Radium

Hospital 1999-2003 Adjunct professor Department of Pharmacy, University of Oslo 2004- Adjunct professor Inst. for Cancer Res. and Mol. Medicine, Univ. of Trondheim 2007-2017 Director Centre for Cancer Biomedicine, University of Oslo 2007- Professor Faculty of Medicine, University of Oslo 2009-2016 Head of Dept. Dept. of Molecular Cell Biology, Inst. for Cancer Research 2016-2017 Act. Institute Head Institute for Cancer Research 2018- Head of Dept. Dept. of Molecular Cell Biology, Inst. for Cancer Research 2018- Director Centre for Cancer Cell Reprogramming, University of Oslo

Scientific activity: Published 236 PubMed articles on cell biology and cancer in peer-reviewed international journals, including 7 papers in Nature (6 of these as senior author). Cited over 26,500 times (excluding self-citations). H-index: 81. (ISI Web of Science 02.04.2018) Papers published since 2008 cited over 10,000 times (excluding self-citations). H10-index: 40 Invitations: Invited speaker at 72 international research conferences (including 13 keynote lectures) and 41 international guest lectures. International networking: Partner in three EU research training networks (4th, 5th and 6th FP), one ESF network, one Poland-Norway network, two NordForsk networks, and two COST networks. PhD students trained as main supervisor: Camilla Raiborg (PhD 2005), Kristi G. Bache (PhD

2005, H.M the King’s Gold Medal). Karine Lindmo (PhD 2007), Ingrid Roxrud (PhD 2009), Lina M.W. Rodahl (PhD 2010), Antonia P. Sagona (PhD 2012), Viola H. Lobert (PhD 2012), Sigrid B. Thoresen (PhD 2014, H.M the King’s Gold Medal), Marina Vietri (PhD 2015, H.M the King’s Gold Medal), Tor Espen Thorvaldsen (PhD 2016), Liliane Christ (PhD 2017). Awards & honours:

1998 Investigator of the Top Research Programme of the Research Council of Norway 1999 Anders Jahre’s prize for younger medical scientists in the Nordic countries 2002 Elected member of the European Molecular Biology Organization (EMBO) 2002 Research prize of the Norwegian Radium Hospital 2004 Elected member of the Norwegian Academy of Science and Letters 2007 Centre of Excellence award, the Research Council of Norway 2008 Advanced Grant from the European Research Council 2010 Sir Hans Krebs medal (Federation of European Biochemical Societies, FEBS) 2011 Elected member of the European Academy of Cancer Sciences 2013 Research Prize of Oslo University Hospital 2014 King Olav V’s Prize for cancer research (the Norwegian Cancer Society) 2015 “Møbius” prize for outstanding research (Research Council of Norway) 2016 Elected member of the Royal Norwegian Academy of Science 2017 Centre of Excellence award, the Research Council of Norway 2018 Advanced Grant from the European Research Council

Editorial boards: EMBO Journal, Journal of Cell Biology, Current Biology, Developmental Cell, Experimental Cell Research, Traffic, Journal of Cell Science Commissions of trust (selected)

Duration Organization Assignment 1994-present

Universities of Oslo, Tromsø, Lund, Stockholm, Copenhagen, Odense, Helsinki, Geneva, Vienna, Liverpool, and Bangalore

Opponent at 28 doctoral disputations

2001-2004 The Research Council of Norway Chairman of evaluation panel 1 for basic biomedical research

2003-2005 Evaluation committee, Research Foundation of the Norwegian Radium Hospital

Member

2004-present

Universities of Oslo, Jyväskylä, Stockholm and Copenhagen

Member of 8 professorship committees

2006-2011 The Norwegian Cancer Society Member of evaluation panel B/2 for basic cancer research

2007-2014 European Research Council Member of evaluation panel LS3 for Starting Grants

2010

University of Gothenburg Member of RED10 evaluation panel for Biomedicine

2012 Cancer Research UK Member of Programme Review Panel

2012-present

Nordic committee for Anders Jahre’s medical prizes, University of Oslo

Chairman

2012 Nature Member of evaluation panel for the Nature Mentoring Award

2012-present

Committee for Dr. Ragnar Mørk’s cancer research prize, the Norwegian Radium Hospital

Chairman

2012-2015 The Norwegian Cancer Society Deputy chairman of the Research Committee

2014-present

ProLipids Centre of Excellence, Helsinki Member of Scientific Advisory Board

2014-present

PhD School of Pharmacy, University of Oslo Member of Scientific Advisory Board

2015-present

Norwegian Advanced Light Microscopy Imaging Network (NALMIN)

Coordinator

Major achievements The main research topic of HS has been to understand how alterations in cellular membrane dynamics promote cancer development. A central contribution was his discovery of a conserved protein domain called the FYVE domain, which binds to the membrane lipid PI3P, the catalytic product of the tumour suppressor PIK3C3 (Gaullier et al., Nature, 1998). By identifying and characterizing a number of FYVE domain-containing PI3P binding proteins, HS and his co-workers have uncovered how PI3P recruits cytosolic proteins to specific intracellular membranes to control lysosomal degradation of growth factor receptors (Simonsen et al., Nature, 1998; Raiborg et al., Nature Cell Biology, 2002). This is important in order to understand the tumour suppressor function of PIK3C3 because lysosomal degradation of growth factors is a key mechanism to prevent overstimulation of cells by growth factors, a mechanism that is often inactivated in cancer (Raiborg and Stenmark, Nature, 2009). A further breakthrough was the identification of two PI3P-binding proteins that cooperate to control lysosome positioning and protrusion outgrowth, a topic of high relevance to cell signalling and cancer metastasis (Raiborg et al., Nature, 2015). The group of HS has also shown how PI3P-binding proteins regulate the final stage of cell division, cytokinesis, and demonstrated how their dysfunction can cause an abnormal number of chromosomes, a condition that promotes cancer development (Sagona et al., Nature Cell Biology, 2010; Thoresen et al., Nature Cell Biology, 2014). The single discovery of the HS group that has gained most international attention (including commentary articles in both Nature and Science) was the identification of a cellular mechanism for sealing of the newly formed nuclear envelope during cell division, and the demonstration that failure of this mechanism causes DNA damage, which is a driver of cancer development (Vietri et al., Nature, 2015). Selected publications: Stenmark H, Vitale G, Ullrich O and Zerial M (1995) Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 83: 423-432 Simonsen A, Lippé R, Christoforidis S, Gaullier J-M, Brech A, Callaghan JM, Toh B-H, Murphy C, Zerial M and Stenmark H (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494-498. Gaullier J-M, Simonsen A, D’Arrigo A, Bremnes B, Aasland R and Stenmark H (1998) FYVE fingers bind PtdIns(3)P. Nature 394: 432-433. Raiborg C, Bache KG, Gillooly DJ, Madshus IH, Stang E and Stenmark H (2002) Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nature Cell Biol. 4: 394-398 Raiborg C and Stenmark H (2009). The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458: 445-452 Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C and Stenmark H (2010). PtdIns3P controls cytokinesis via KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nature Cell Biol. 12: 361-372. Thoresen SB, Campsteijn C, Vietri M, Schink KO, Liestøl K, Andersen JS, Raiborg C and Stenmark H (2014). ANCHR mediates Aurora B-dependent abscission checkpoint control through retention of VPS4. Nature Cell Biol. 16: 550-560 Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T and Stenmark H (2015). Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature 520: 234-238 Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A,

Raiborg C and Stenmark H (2015). Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Nature 522: 231-235 Katheder N, Khezri R, O’Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou T, Johansen T, Juhasz G, Bilder D, Brech A, Stenmark H and Rusten TE (2017). Microenvironmental autophagy promotes tumour growth. Nature 541: 417-420