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Curriculum Vitae Last Updated: 04/18/2018

PERSONAL DATA Name: Michael E. Engel Birth Place: Franklin, IN Citizenship: United States

EDUCATION Years Degree Institution (Area of Study) 1983 - 1989 B.S. Purdue University, West Lafayette Campus (Biology)

West Lafayette, IN 1992 - 1994

Vanderbilt University School of Medicine (Medical Scientist Training Program) Nashville, TN

1994 - 1999 Ph.D. Vanderbilt University School of Medicine (Medical Scientist Training Program) Nashville, TN

1999 - 2001 M.D. Vanderbilt University School of Medicine (Medical Scientist Training Program) Nashville, TN

2001 - 2003 Resident Vanderbilt University Medical Center (Pediatrics – Special Alternative Pathway Trainee) Nashville, TN

2003 - 2006 Clinical Fellow Vanderbilt University Medical Center (Pediatric Hematology/Oncology) Nashville, TN

2004 - 2006 Research Fellow Vanderbilt University Medical Center (Department of Biochemistry) Nashville, TN

BOARD CERTIFICATIONS 10/27/2008 American Board of Pediatrics (Pediatrics), Certified 03/28/2011 American Board of Pediatrics (Sub: Ped Hematology-Oncology), Certified

CURRENT LICENSES/CERTIFICATIONS 2001 - Present American Heart Association: Basic Life Support - Physician (MD) 2001 - Present American Heart Association: Pediatric Advanced Life Support - Physician (MD) 2003 - Present CITI - Course in The Protection of Human Research Subjects - Physician (MD) 2006 - 2011 State of Tennessee: State License (TN) - Physician (MD) 2009 - Present United States Department of Justice: DEA Certificate (UT) - Physician (MD) 2011 - Present University of Utah-Department of Radiological Health: Certification (UT) 2011 - Present Institutional Animal Care and Use Committee-University of Utah: Certification (UT) 2012 - Present National Center for Biotechnology Information-Genomic Discovery: Certification 2012 David Eccles School of Business: Leadership Development for Healthcare Professionals (UT)

ACADEMIC HISTORY

Oncological Sciences 10/05/2010 02/01/2015

Hire, Adjunct Track, Adjunct Assistant Professor RPT action—Retention, Promotion to Adjunct Associate Professor and Award of Tenure

Pediatrics (Pediatric Hematology/Oncology) 10/05/2010 05/01/2014 02/01/2015

Hire, Tenure Track, - Scientist Scholar Assistant Professor RPT action—Tenure Track – Clinician Scholar Assistant Professor RPT action—Retention, Promotion to Associate Professor and Award of Tenure

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PROFESSIONAL EXPERIENCE Full Time Positions 1986 - 1989 Research Technician, Department of Analytical Chemistry, Great Lake Chemical Corporation, West

Lafayette, IN 1989 Research Associate, Department of Biochemistry, Purdue University, West Lafayette, IN 1989 - 1991 Research Associate, Salk Institute Biotechnology/Industrial Associates, San Diego, CA 1991 - 1992 Protein Chemist, Canji Inc, San Diego, CA 2006 - 2010 Hospital Appointment, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 2006 - 2010 2006 - 2010

Assistant Clinical Professor, Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN Research Instructor (Mentor—Scott Hiebert, PhD), Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN

2010 - 2015 Assistant Professor of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 2010 - 2014 Leukemia and Lymphoma Program Leader, Center for Children's Cancer Research, Salt Lake City,

UT 2010 - 2015 Adjunct Assistant Professor, Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT 2010 - Present 2015 - Present 2015 - Present

Hospital Appointment, Primary Children's Hospital, Salt Lake City, UT Associate Professor of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Adjunct Associate Professor, Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT

Editorial Experience 2011 - Present Editorial Board for Frontiers in Pediatric Oncology 2011 - Present Editorial Board for Advances in Bioscience and Biotechnology 2012 - 2014 Editorial Board for Conference Papers in Oncology Reviewer Experience Reviewer for Analytical Biochemistry Reviewer for Blood Reviewer for Nature Reviewer for Journal of Pediatric Hematology/Oncology Reviewer for Journal of Clinical Investigation Reviewer for Molecular and Cellular Biology Reviewer for Frontiers in Pediatric Oncology Reviewer for Pediatric Blood and Cancer Reviewer for Journal of Clinical Oncology-Personalized Medicine Reviewer for Biochimica et Biophysica Acta

SCHOLASTIC HONORS 1983 - 1989 Purdue University Dean’s List and President’s Convocation 1984 Phi Eta Sigma Honor Society 1992 National Research Services Award-Medical Scientist Training Program (MSTP) 1996 United States Army Breast Cancer Training Grant 2002 Boerth Award in Pediatrics (most outstanding intern), Vanderbilt University Medical Center 2002 American Board of Pediatrics Special Alternative Pathway Trainee 2003 Karzon Research Award in Pediatrics, Vanderbilt University Medical Center 2005 Newman Prize for Basic Science Research, Vanderbilt University Medical Center 2006 Dreyfus Foundation New Faculty Award Program, Vanderbilt University Medical Center Nominee 2006 Charles E. Culpepper Foundation Medical Scholars Program, Vanderbilt University Medical Center

Nominee 2006 Alex’s Lemonade Stand Foundation Young Investigator Award 2006 American Society of Pediatric Hematology/Oncology Young Investigator Award 2009 St. Baldrick’s Foundation Scholar 2009 Hyundai Scholar Award

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2009 2016 2017 2018

Top Performer Award-100th percentile Outstanding rating in patient satisfaction at Vanderbilt University (1 of only 3 faculty in the Department of Pediatrics awarded this distinction), Professional Research Consultants Faculty1000 Recognition for Outstanding Contribution to Biomedical Research Outstanding Educator Award of Health Scientist Graduate Students Nominee—University of Utah Leonard W. Jarcho Distinguished Teaching Award—University of Utah School of Medicine

ADMINISTRATIVE EXPERIENCE Administrative Duties 2007 - 2009 Assistant Pediatric Program Director, Vanderbilt University Medical Center, Monroe Carell Jr.

Children's Hospital at Vanderbilt, Nashville, TN 2010 - 2014 Leader, Leukemia & Lymphoma Research Program, Center for Children's Cancer Research,

University of Utah/Huntsman Cancer Institute, Salt Lake City, UT 2010 - 2014 Steering Committee, Center for Children's Cancer Research, University of Utah/Huntsman Cancer

Institute, Salt Lake City, UT 2011 - 2012 2011 - Present

Pediatric Hematology/Oncology Ambulatory Clinic Service and Organization Committee Huntsman Cancer Institute—Strategic Planning Committee

2011 - Present 2016 - Present 2017 - Present

Director-Pediatric Hematology/Oncology Fellowship Training Program Co-Director-MD/PhD Training Program, University of Utah School of Medicine Huntsman Cancer Institute Director’s Cabinet—Pediatric Oncology Representative

Professional Organization & Scientific Activities 2012 - Present 2014 - Present 2015 2015 - Present 2015 - Present 2016 - Present 2017 - Present 2017 - Present

Working Group Member, American Association for Cancer Research, Pediatric Cancer Working Group University of Utah School of Medicine Representative to the Association of American Medical Colleges (AAMC) Council of Faculty and Academic Societies (CFAS) Working Group Member, Future of Bioscience Graduate and Post-Doctoral Training, National Conference of Stakeholders, University of Michigan. Administrative Board Member, Council of Faculty and Academic Societies (CFAS), Association of American Medical Colleges (AAMC) Task Force Member, Joint Task Force for Strategic Planning, Council of Faculty and Academic Societies (CFAS)—Organization of Resident Representatives (ORR)—Group on Diversity and Inclusion (GDI), Association of American Medical Colleges (AAMC) Training Committee Member, American Society of Pediatric Hematology/Oncology (ASPHO) Principal Investigator, Pediatric Oncology Experimental Therapeutics Investigator Consortium (POETIC) MD/PhD Section Member, Group on Graduate Research, Education and Training (GREAT)

Grant Review Committee/Study Section 2010 - Present Georgia Cancer Coalition/Georgia Research Council 2010 - Present 2013 – 2015 2015 - Present 2014 - Present 2014 - 2016 2015 – Present 2016 - Present 2016 - Present

St. Baldrick's Pediatric Cancer Research Foundation American Cancer Society, Tumor Biology and Genomics Study Section, Ad hoc Member American Cancer Society, Tumor Biology and Genomics Study Section, Standing Member University of Utah-Office of the Vice President of Research Department of Defense—Congressionally Directed Medial Research Programs (CDMRP). Bone Marrow Failure Research Programs (BMFRP)—Idea Development Award-Molecular Biology and Biomarkers Panel (IDA-MBBM) Center for Clinical and Translational Sciences, Ad hoc reviewer, University of Utah School of Medicine National Cancer Institute, ZRG1-BMCT-C(01) Molecular Targets and Cancer Intervention, Ad hoc Member Primary Children’s Hospital Foundation, Ad hoc reviewer, University of Utah School of Medicine

Symposium/Meeting Chair/Coordinator 2011 - 2014 2015

Annual Retreat-Center for Children's Cancer Research Graduate Student Research Retreat, Oncological Sciences, Snowbird Resort, Salt Lake City, UT

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2015 2017 - Present 2018

Council of Faculty and Academic Societies National Meeting Program Committee Annual MD/PhD—MSRP Combined Research Retreat, University of Utah School of Medicine, Deer Valley Resort, Park City, UT Frontiers in Pediatric Cancer Research, Prevention and Therapy, Huntsman Cancer Institute, Salt Lake City, UT

PROFESSIONAL COMMUNITY ACTIVITIES 1991 - 1992 Student Advisor, County of San Diego, Science Fair Official 2002 - 2006 Volunteer, Camp Horizon, Camp physician 2005 - 2009 Parent Volunteer, Scales Elementary, Cub Scout Pack 144 2009 - 2015 Parent Volunteer, Boy Scouts of America, Troup 86 (Nashville) and Troup 38 (Salt Lake City) 2010 - 2014 Grant Reviewer, Georgia Cancer Coalition, Extramural Research 2010 - Present Grant Reviewer, St. Baldrick's Foundation, Extramural Pediatric Cancer Research 2012 2014 2015 2016 2017

Volunteer Speaker, St. Baldrick's Foundation, Head shaving fundraiser participant and speaker Faculty Speaker, High School Health Science Teachers Conference, Huntsman Cancer Institute Speaker and Group Discussion Leader, Native American Student Mentoring Workshop, Huntsman Cancer Institute, Intercultural Cancer Council, Salt Lake City, UT Volunteer Speaker, Alex’s Lemonade Stand Foundation, Salt Lake City, UT Keynote Speaker, American Cancer Society Gala, Salt Lake City, UT

UNIVERSITY COMMUNITY ACTIVITIES College Level 2011 - Present 2011 - Present 2011 - Present 2013 - 2016 2016 - Present 2016 – Present HSC Level 2018

Applicant Interviewer, School of Medicine Admissions Committee Applicant Interviewer, Graduate Program in Molecular Biology/Biochemistry Admissions Committee Applicant Interviewer, MD/PhD Program Member, MD/PhD Program Steering Committee Member—ex officio, Medical School Admissions Committee, University of Utah School of Medicine Co-Director, MD/PhD Training Program, University of Utah School of Medicine Co-Chair, Physician-Scientist Development Task Force

Department Level 2013 - Present 2012 - Present 2014 - Present 2015 - Present

Faculty Leader, Oncological Sciences, Graduate Research Retreat. Planning and execution of the research retreat for trainees in Oncological Sciences Faculty Mentor, General Pediatrics Resident Advisory Group Member, General Pediatrics Residency—Clinical Competency Committee Member, Education in Pediatrics Across the Continuum (EPAC)—Clinical Competency Committee

Division Level 2011 - Present 2011 - Present 2014 - Present 2015 - Present

Fellowship Director, Pediatric Hematology/Oncology Chief Education Officer, Pediatric Hematology/Oncology Chair, Pediatric Hematology/Oncology Fellowship—Clinical Competency Committee Member, Pediatric Hematology/Oncology Fellowship—Program Evaluation Committee

Programs, Centers & Institutes 2011 - Present Applicant Interviewer, Program in Molecular Biology, Graduate Admissions Committee 2011 - 2015 Member, Huntsman Cancer Institute, Seminar Series Steering Committee 2011 2011 - 2014 2011 - Present 2014 - Present 2014 - 2016 2014 - Present 2014 - Present

Co-Facilitator, Huntsman Cancer Institute, Cancer Center Strategic Planning Group, Hematologic Malignancies Member, Center for Children’s Cancer Research (C3R) Steering Committee Member, Pediatric Oncology—Multidisciplinary Group (MDG) Member, Hematologic Malignancies—Disease Oriented Team (DOT) Co-Chair, Huntsman Cancer Institute, Working Group on Cancer Training Excellence. Grant Reviewer, University of Utah—Office of the Vice President of Research Grant Reviewer, University of Utah—Center for Clinical and Translational Science (CCTS)

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2014 - Present 2015 - Present 2015 - Present 2016 - Present 2017 - Present 2017 - Present

Member, Research Leadership Council—Huntsman Cancer Institute Member, Pediatric Cancer Working Group—Huntsman Cancer Institute Member, Physician-Scientist Recruitment Steering/Search Committee Grant Reviewer—ACS Institutional Research Grant Member, Huntsman Cancer Institute Director’s Cabinet Member, Cancer Education and Training Committee, Huntsman Cancer Institute

SERVICE AT PREVIOUS INSTITUTIONS 1993 - 1994 Member, Vanderbilt University School of Medicine, Curriculum Committee 1993 Member, Vanderbilt University School of Medicine, Microbes and Defense Academic Honor Society 1993 Member, Vanderbilt University School of Medicine, Admissions Committee 1993 Contributing Writer, Vanderbilt University School of Medicine, Paddle: Student generated guide to

Vanderbilt University School of Medicine and Nashville for incoming medical students 1995 President, Vanderbilt University School of Medicine, Microbes and Defense Academic Honor

Society 2001 - 2004 Member, Vanderbilt University Medical Center, Residency Curriculum Committee 2008 - 2010 Presenter, Vanderbilt University School of Medicine, Center for Scientific Outreach. "On being a

physician-scientist: getting to the starting line and running the race". Nashville, TN 2008 Advisor, Vanderbilt University Medical Center, Research Training Programs, Pediatric Residency

Program 2009 Panelist, Vanderbilt University School of Medicine, Career Development Workshop, Medical

Scientist Training Program 2009 - 2012 Research Mentor, Vanderbilt University School of Medicine, Emphasis Program 2009 - 2010 Program Representative, Vanderbilt University School of Medicine, Pediatric Hematology/Oncology,

Admissions and Recruitment 2009 - 2010 Presenter, Vanderbilt University School of Medicine, Medical Scientist Training Program. "Work-life

balance in academic medicine". Nashville, TN

CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES Association of American Medical Colleges (AAMC) – Council of Faculty and Academic Societies American Academy of Pediatrics (AAP) American Association for Cancer Research (AACR) American Society of Hematology (ASH) American Society of Pediatric Hematology-Oncology (ASPHO) Children's Oncology Group (COG) American Society for Microbiology (ASM) Federation of American Societies for Experimental Biology (FASEB)

FUNDING Active Grants 04/01/17 – 03/30/22 07/01/17 - 06/30/21 10/01/16 -09/30/18

R01 CA201235-01—Targeting the GFI1—LSD1 axis in T-cell acute lymphoblastic leukemia NIH-National Cancer Institute Principal Investigator(s): Michael E. Engel Role: Principal Investigator GFI1 post-translational modifications and control of gene expression American Cancer Society—Research Scholar Grant Principal Investigator(s): Michael E. Engel Role: Principal Investigator Hyundai Scholar Hope Grant—Targeting the GFI1—LSD1 axis to provoke oncogene-induced apoptosis in T-ALL Hyundai Hope on Wheels Foundation Principal Investigator(s): Michael E. Engel Role: Principal Investigator LSD1 inhibition for T-cell leukemia/lymphoma therapy

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02/01/17 - 01/31/19 11/01/17 - 10/30/20 10/04/17 - 10/03/19 10/04/16 - 10/03/18 07/01/17 - 06/30/19

Alex’s Lemonade Stand Foundation-REACH Grant Principal Investigator(s): Michael E. Engel Role: Principal Investigator A phase I clinical trial of the LSD1 inhibitor SP-2577 in relapsed/refractory leukemia V-Foundation-Innovation Award Role: Principal Investigator T32DK007115-41A1—A newly identified mutation, GFI1-T417M, and Aurora A Kinase signaling in severe congenital neutropenia pathogenesis Principal Investigators: Betty Leibold and Joseph Prchal National Institute for Diabetes and Digestive and Kidney Diseases Role: Mentor (Christopher Ours) T32DK007115-41A1—Determinants of GFI1B—LSD1 recruitment in erythroid and megakaryocyte differentiation Principal Investigators: Betty Leibold and Joseph Prchal National Institute for Diabetes and Digestive and Kidney Diseases Role: Mentor (Mattie Casey) CD11B/CD86 expression as a biomarker of LSD1 inhibition Hematologic Malignancies-DOT Special Projects Award—Huntsman Cancer Institute Principal Investigator(s): Michael E. Engel, Elizabeth Raetz and Sunil Sharma Role: Co-investigator and Scientific Lead

Pending Grants 11/01/17 Targeting GFI1/1B transcriptional control mechanisms in pediatric high-risk medulloblastoma

Hyundai Hope on Wheels Foundation Quantum Collaboration Award Finalist (1 of 8 nationally) Role: Principal Investigator

03/30/18 R01 CA201235-01—Diversity Supplement NIH-National Cancer Institute Principal Investigator(s): Michael E. Engel Trainee: Nathan Sweeney Role: Mentor for Supplemental Award/Principal Investigator of the Parent Grant

Past Grants 07/01/06 - 06/30/08

MTG-16 in Normal and Malignant Hematopoiesis Vanderbilt Physician Scientist Development Program Principal Investigator(s): Michael E. Engel Vanderbilt University Role: Principal Investigator

07/01/07 - 06/30/08

Regulation of MTG16 function by signaling kinases Principal Investigator(s): Jennifer Pietenpol American Cancer Society—Institutional Research Grant Role: Project leader—Sub-Investigator

07/01/07 - 06/30/09

Regulation of Wnt Signaling by MTG-16 Principal Investigator(s): Michael E. Engel Alex's Lemonade Stand Foundation Role: Principal Investigator

12/01/07 - 06/30/10

Regulation of MTG16 Function by Phosphorylation Principal Investigator(s): Michael E. Engel National Institutes of Health Role: Principal Investigator

03/01/08 - 02/28/09

The relationship between Notch and GFI1 family proteins in transcriptional control Principal Investigator(s): Lawrence Swift, PhD National Heart, Lung, and Blood Institute Role: Research Mentor (Trainee: Michael Casner)

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10/01/10 - 09/30/15

K08DK080190 Regulation of MTG16 and Notch signaling in hematopoiesis Principal Investigator(s): Michael E. Engel National Institute of Diabetes and Digestive and Kidney Diseases Role: Principal Investigator

12/01/09 - 11/30/10

Runx1-MTG8 phosphorylation &Notch binding domains in cell growth and differentiation Principal Investigator(s): Michael E. Engel Hyundai Hope On Wheels Role: Principal Investigator

06/11/13 - 06/10/15 07/01/13 - 06/30/15

Notch--MTG16 interaction in hematopoiesis and leukemia Principal Investigator(s): Anthea Letsou Howard Hughes Medical Institute Role: Mentor (Trainee: Helena Lucente) T32DK007115—GFI1 and Notch signaling in neutrophil differentiation Principal Investigator(s): Gerald Spangrude and Betty Leibold National Heart, Lung, and Blood Institute Role: Mentor (Trainee: Luke Maese)

01/01/12 - 12/31/12 04/01/13 - 03/31/14 02/01/13 - 01/31/15 07/01/13 – 06/30/15

The role of Notch in GFI1B-dependent hematopoiesis Principal Investigator(s): Michael E. Engel University of Utah Vice President for Research Role: Principle Investigator Notch-mediated disruption of NKX2.2—MTG16 binding as a therapeutic strategy in EWS Principal Investigator(s): Michael E. Engel Sunbeam Foundation Role: Principal Investigator The role of NKX2.2--MTG16 binding in Ewing Sarcoma Nuclear Control Program—Huntsman Cancer Institute Principal Investigator(s): Michael E. Engel and Stephen Lessnick Role: Co-Principal Investigator GFI1—LSD1 interaction in T-ALL therapy Principal Investigator(s): Michael E. Engel St. Baldrick's Foundation Role: Principal Investigator

TEACHING RESPONSIBILITIES/ASSIGNMENTS Education Administration 2011 - Present 2013 - Present 2014 - 2016 2016 - Present

Fellowship Program Director, Division of Pediatric Hematology/Oncology Steering Committee, MD/PhD Program, University of Utah School of Medicine Co-chair, Cancer Training Excellence Initiatives, Huntsman Cancer Institute Co-Director, MD/PhD Training Program, University of Utah School of Medicine

Course and Curriculum Development 2006 - 2009 2009 - 2010 2015 - Present

Molecular Foundations of Medicine—problem-based learning course component: content development, faculty training and implementation for medical students Molecular Foundations of Medicine—Clinical Course Director Pediatric Leukemia Nano-Course Development, “TEAMED-UP” (Transdisciplinary Education and Medical Discovery—Unique Partnerships) Initiative

Courses Directed 2006 - 2009 Molecular Foundations of Medicine-Problem-based learning, Vanderbilt University School of

Medicine (104 students per year) 2011 - 2016

ONCSC 7700-003 Cancer Biology Journal Club, Oncological Sciences, University of Utah School of Medicine (15-25 students per year)

2011 - 2016 2017 - Present

ONCSC 6500-001 Clinical Cancer Biology, Oncological Sciences, University of Utah School of Medicine (20-25 students per year)

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ONCSC 7700-009 Cancer Training 360, Oncological Sciences, University of Utah School of Medicine (25-30 students per year)

Course Lectures 1993 - 1994 Student Instructor, Clinical Problem Solving, 16 students, Vanderbilt University School of Medicine.

(Supervisor: Dr. Thomas Oeltman) 1994 - 1998 Lecturer, Medical Histology, 104 students, Vanderbilt University School of Medicine. Developmental

Hematopoiesis 1994 - 1999 Lecturer, Biochemistry, 104 students, Vanderbilt University School of Medicine, VMSI Core

Curriculum. Molecular mechanisms of cell growth and differentiation 2003 Instructor, Neonatal Nurse Practitioner Program, 150 students, Vanderbilt University School of

Nursing. Pediatric Hematology/Oncology in the newborn 2003 - 2006 Lecturer, Pediatrics Clerkship Core Curriculum, 36 students, Meharry Medical College, Pediatrics.

Hematology Topics for the General Pediatrician 2004 Instructor, Pediatric Nurse Practitioner Program, 50 students, Vanderbilt University School of

Nursing. Presentation, diagnosis and management standards in Pediatric Hematology/Oncology 2004 - 2006 Lecturer, Pediatrics Clerkship Core Curriculum, 36 students, Meharry Medical College, Pediatrics.

Approach to the Pediatric Oncology Patient 2004 - 2010 Lecturer and Discussion Leader, Molecular Foundations of Medicine, 104 students, Vanderbilt

University School of Medicine. Principles of Chemotherapy-Molecular mechanisms and clinical applications

2004 - 2010 Lecturer and Discussion Leader, Molecular Foundations of Medicine, 104 students, Vanderbilt University School of Medicine. Sickle cell disease-Molecular determinants of clinical manifestations and treatment

2008 - 2010 Lecturer, Principles of Pediatric Hematology/Oncology, 24 students, Vanderbilt University School of Medicine. VMSIII Pediatric Clerkship

2012 - Present Primary Instructor, ONCSC7970 (23): Thesis Research-PhD, 12 SCH, 4 students, University of Utah, Oncological Sciences

2012 - Present Primary Instructor, ONCSC7720 (23): Lab Res Conferences, 3 SCH, 3 students, University of Utah, Oncological Sciences

2013 - Present Primary Instructor, ONCSC7720 (23): Lab Res Conferences, 2 SCH, 2 students, University of Utah, Oncological Sciences

2013 - Present Primary Instructor, ONCSC7970 (23): Thesis Research-PhD, 8 SCH, 2 students, University of Utah, Oncological Sciences

2013 - Present 2014 - Present 2015 - Present 2017 - Present

Instructor, MD ID 7310 (001): Cells, Molecules and Cancer, University of Utah School of Medicine, Undergraduate Medical Training (100 students per year) Instructor, ONCSC6520 (001): Medicine and Physiology for the Molecular Biologist, University of Utah School of Medicine, Undergraduate Medical Training (20 students per year) Instructor, ONCS6500 (001): Molecular Mechanisms of Cancer, University of Utah School of Medicine, Undergraduate Medical Training (20 students per year) Lecturer, ONCSC7700 (009): Molecular Pathogenesis of Acute Leukemia in Children, University of Utah School of Medicine, Undergraduate Medical Training (25-30 students per year)

Clinical Teaching 2006 - 2010 Supervising Attending, Pediatric Hematology/Oncology Inpatient and Outpatient Services, Monroe

Carell Jr. Children's Hospital at Vanderbilt 2009 - 2010 Clinical Director-Molecular Foundations of Medicine Course, Vanderbilt University School of

Medicine 2008 - 2010 Supervisor, Pediatric Residency Program Journal Club, Vanderbilt University Medical Center 2010 - Present Supervising Attending Physician, Division of Pediatric Hematology/Oncology, Primary Children's

Hospital, University of Utah School of Medicine 2012 Pediatric Board Review-Topics in Pediatric Hematology/Oncology, Primary Children's Medical

Center Trainee Supervision Fellow/Resident

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2006 – 2009 Pinki Prasad, MD. Monroe Carell Jr. Children’s Hospital at Vanderbilt. Clinical Fellow, Pediatric Hematology/Oncology. Role: Advisor/Mentor and Clinical Supervisor Trainee's Current Career Activities: Assistant Professor of Pediatrics, Division of Pediatric Hematology/Oncology, Louisiana State University Health Sciences Center, Children's Hospital of New Orleans, New Orleans, LA

2007 - 2010 Michael Eckrich, MD. Monroe Carell Jr. Children’s Hospital at Vanderbilt. Clinical Fellow, Pediatric Hematology/Oncology. Role: Advisor/Mentor and Clinical Supervisor Trainee's Current Career Activities: Assistant Professor of Pediatrics, Division of Pediatric Hematology/Oncology, Carolinas Medical Center.

2008 - 2010 2008 - 2010

Hong Nguyen, PhD, Vanderbilt University Medical Center. Laboratory Manager, Research Technician II, Vanderbilt University Medical Center, Nashville, TN. Role: Research Supervisor Trainee's Current Career Activities: Lab Manager, Research Technician III, Fred Lamb, MD, PhD (supervisor), Vanderbilt University Medical Center, Nashville, TN Clinton Carroll, MD, Vanderbilt University Medical Center, Department of Pediatrics. Resident, Monroe Carell Jr. Children’s Hospital at Vanderbilt. Role: Faculty Advisor Trainee’s Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Mississippi School of Medicine, Batson Children’s Hospital, Jackson, MS.

2009 - 2010 Jeremy Slone, MD. Monroe Carell Jr. Children’s Hospital at Vanderbilt. Clinical Fellow, Pediatric Hematology/Oncology. Role: Advisor/Mentor and Clinical Supervisor Trainee's Current Career Activities: Assistant Professor of Pediatrics, Division of Pediatric Hematology/Oncology, Baylor College of Medicine and the Texas Children's Hospital, Houston, TX, Adjunct Assistant Professor, Princess Marina Hospital, Gaborone, Botswana.

2011 - 2013 Daniel Andrade, PhD. University of Utah-Huntsman Cancer Institute. Notch-dependent regulation of GFI family members by ubiquitin family proteins in hematopoiesis. Role: Advisor/Research Mentor Trainee's Current Career Activities: Post-doctoral Fellow, University of Oklahoma, Oklahoma City, OK

2011 - 2014 Jasmin Jensen, MD. University of Utah. Scholarly Oversight Committee Member. Role: Advisor/Mentor Trainee's Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Hawaii, Kapi’Olani Medical Center for Women and Children, Honolulu, HI

2011 - 2014 Jack Staddon, MD, PhD. University of Utah. Scholarly Oversight Committee Member. Role: Advisor/Mentor Trainee's Current Career Activities: Staff Physician, Pediatric Hematology/Oncology, Billings Clinic, Billings, MT

2011 - 2012 Anupam Verma, MD. University of Utah. Scholarly Oversight Committee Member. Role: Advisor/Mentor Trainee's Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Utah, Primary Children's Hospital, Salt Lake City, UT

2011 - 2013 Mariko Sato, MD, PhD. University of Utah. Scholarly Oversight Committee Member. Role: Advisor/Mentor Trainee's Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Iowa—Carver College of Medicine, Iowa City, IA

2012 - 2015 Luke Maese, DO. University of Utah School of Medicine. Role: Advisor/Research Mentor Trainee's Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT

2012 - Present

Brenna Eldridge, MD. University of Utah School of Medicine.

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2013 - Present 2014 - Present 2014 – Present 2014 - Present 2017 - Present 2017 – Present 2018 - Present

Role: Advisor/Clinical Co-Mentor Trainee's Current Career Activities: Staff Physician-Pediatric Medicine, Kootenay Regional Boundary Hospital, Trail, British Columbia. Douglas Fair, MD. University of Utah School of Medicine. Role: Advisor/Mentor and Clinical Supervisor Trainee’s Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT Lorin Hall, MD, Resident, Department of Pediatrics, Primary Children’s Hospital. Role: Faculty Advisor Trainee’s Current Career Activities: Assistant Professor, Hospital Medicine, University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT Katherine Quayle, MD, Resident, Department of Pediatrics, Primary Children’s Hospital. Role: Faculty Advisor Trainee’s Current Career Activities: Community Pediatrician, Salt Lake City, UT Jessica Meznarich, MD. University of Utah School of Medicine. Role: Advisor/Research Mentor Trainee’s Current Career Activities: Assistant Professor, Pediatric Hematology/Oncology, University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT Christopher Ours, MD. University of Utah School of Medicine. Role: Advisor/Research Mentor Trainee’s Current Career Activities: Clinical Fellow, Pediatric Hematology/Oncology, University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT Wenxiang Sun, PhD. Huntsman Cancer Institute, University of Utah School of Medicine. Role: Advisor/Research mentor. Trainee’s Current Career Activities: Post-doctoral Fellow, Huntsman Cancer Institute, Salt Lake City, UT Mehraj U-Din Lone, PhD. Huntsman Cancer Institute, University of Utah School of Medicine. Role: Advisor/Research Mentor Trainee’s Current Career Activities: Post-doctoral Fellow, Huntsman Cancer Institute, Salt Lake City, UT

Medical Student 2008 - 2010 Jolene Mariotti-Jewell, Howard Hughes Medical Institute Research Fellowship, Ohio State University

School of Medicine. HHMI Medical Student Research Clerkship Role: Advisor/Research Mentor Trainee's Current Career Activities: Physician, Triangle Dermatology Associates, Durham, NC

2009 Zachary Yoneda, Vanderbilt University School of Medicine Emphasis Program Role: Advisor/Research Mentor Trainee's Current Career Activities: Assistant Professor, - General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN

2009 2014 2016 2016

Michael Casner, Vanderbilt University School of Medicine Emphasis Program Role: Advisor/Research Mentor Trainee's Current Career Activities: Resident Physician, - Emergency Medicine, UCLA Medical Center, Los Angeles, CA Ashley Lynn Miller-Trane, University of Utah School of Medicine-Medical Student Researh Program Role: Advisor/Research Mentor Trainee’s Current Career Activities: Fourth year medical student, University of Utah School of Medicine, Salt Lake City, UT Jordan Broadway, University of Utah School of Medicine-Medical Student Research Program Role: Advisor/Research Mentor Trainee’s Current Career Activities: Second year medical student, University of Utah School of Medicine, Salt Lake City, UT Christopher Lamb, University of Utah School of Medicine-Medical Student Research Program Role: Advisor/Research Mentor Trainee’s Current Career Activities: Second year medical student, University of Utah School of Medicine, Salt Lake City, UT

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2016 Trevor Annis, University of Utah School of Medicine-Medical Student Research Program Role: Advisor/Research Mentor Trainee’s Current Career Activities: Second year medical student, University of Utah School of Medicine, Salt Lake City, UT

Undergraduate 2011 - 2013 Ryan Quinton, University of Utah-Huntsman Cancer Institute. Undergraduate Research

Internship/BYU Honors Thesis Role: Advisor/Research Mentor Trainee's Current Career Activities: MD/PhD Student, Boston University, Boston, MA

2012 Colton Skaug, University of Utah-Huntsman Cancer Institute. Undergraduate Research Internship/McNair Scholar Role: Advisor/Research Mentor Trainee's Current Career Activities: Psych Associate, Fairview Health Services

2013 2014 2016

Brendan Innes, University of Utah, Summer HCI Internship Program Role: Advisor/Research Mentor Trainee's Current Career Activities: Medical Student, University of Massachusetts School of Medicine Maria Julia Bianca Corpuz, University of Utah, Undergraduate Research Access for Minorities Program (URAMP) Role: Advisor/Research Mentor Trainee’s Current Career Activities: City Year AmeriCorps Member, Philadelphia, PA Matthew McDermott, University of Utah Summer Research Internship Program Role: Advisor/Research Mentor Trainee’s Current Career Activities: PhD student, University of North Carolina-Chapel Hill

High School 2009 - 2010 2015

Naveen Chadalavada, Vanderbilt University SOM. Research Intern-Center for Scientific Outreach Role: Advisor/Research Mentor *First Prize for Excellence in Basic Research *Siemens Competition in Math, Science and Technology Semifinalist Trainee's Current Career Activities: Healthcare Consultant—Crowe Horwath LLP, Chicago, IL Quincy Parkes, University of Utah School of Medicine and the Huntsman Cancer Institute. Research Intern-Utah Academy for Math, Engineering and Science Role: Advisor/Research Mentor Trainee’s Current Career Activities: Undergraduate Student, University of Utah, Salt Lake City, UT

PhD/Doctorate 2012 - Present David McClellan, University of Utah. Role of the Notch—GFI1B axis in hematopoietic cell fate

specification Role: Advisor/Thesis Research Mentor Trainee's Current Career Activities: Graduate Program in Molecular Biology, Department of Oncological Sciences, University of Utah School of Medicine and the Huntsman Cancer Institute, Salt Lake City, UT

2012 - Present Helena Lucente, University of Utah. Role of MTG16 in the pathogenesis of T-cell phenotype acute lymphoblastic leukemia driven by the intracellular domain of Notch1 Role: Advisor/Thesis Research Mentor Trainee's Current Career Activities: Graduate Program in Molecular Biology, Department of Oncological Sciences, University of Utah School of Medicine and the Huntsman Cancer Institute, Salt Lake City, UT

2012 - 2016 2013 - 2016

John Fadul, University of Utah. Role of NKX2.2 in EWS-FLI1-mediated cell fate and transformation Role: Advisor/Thesis Research Co-Mentor Trainee's Current Career Activities: Post-doctoral Fellow, University of Utah School of Medicine and the Huntsman Cancer Institute, Salt Lake City, UT Matthew Velinder, University of Utah. Post-translational regulation of GFI1 as a determinant of epigenetic control of gene expression in hematopoiesis

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2015 - Present

Role: Advisor/Thesis Research Mentor Trainee's Current Career Activities: Post-doctoral Fellow, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT Mattie Casey, University of Utah. The role of GFI1B post-translational regulation in high-risk medulloblastoma pathogenesis. Role: Advisor/Thesis Research Co-Mentor Trainee’s Current Career Activities: Graduate Program in Molecular Biology, Department of Oncological Sciences, University of Utah School of Medicine and the Huntsman Cancer Institute, Salt Lake City, UT

Faculty 2011 - 2013 2015 - Present 2016 - Present 2017 - Present 2017 - Present

Meghann McManus, University of Utah School of Medicine Role: Advisor/Faculty Mentor Current Career Activities: Affiliated Assistant Professor of Pediatrics, University of Tennessee College of Medicine-Chattanooga and Children’s Hospital at Erlanger. Andrew Harris, MD, University of Utah School of Medicine Role: Advisor/Faculty Mentor Current Career Activities: Assistant Professor of Pediatrics, University of Utah, Attending Physician, Pediatric Hematology/Oncology/Stem Cell Transplant, Primary Children’s Hospital. David Shyr, MD, University of Utah School of Medicine Role: Advisor/Faculty Mentor Current Career Activities: Assistant Professor of Pediatrics, University of Utah, Attending Physician, Pediatric Hematology/Oncology/Stem Cell Transplant, Primary Children’s Hospital Luke Maese, DO, University of Utah School of Medicine Role: Advisor/Faculty Mentor Current Career Activities: Assistant Professor of Pediatrics, University of Utah, Attending Physician, Pediatric Hematology/Oncology, Primary Children’s Hospital Nicholas Whipple, MD, University of Utah School of Medicine Role: Advisor/Faculty Mentor Current Career Activities: Assistant Professor of Pediatrics, University of Utah, Attending Physician, Pediatric Hematology/Oncology, Primary Children’s Hospital

Graduate Student Committees 2011 - 2014 Member, Brittni Bertola-Smith, University of Utah, PhD/Doctorate Committee 2011 - 2014 Member, Savita Sankar, University of Utah, PhD/Doctorate Committee 2011 Member, Daria Drobysheva, University of Utah, PhD/Doctorate Committee. Prelim Exam 2011 Chair, Matthew Velinder, University of Utah, PhD/Doctorate Committee. Prelim Exam 2012 - 2016 Co-Chair, John Fadul, University of Utah, PhD/Doctorate Committee 2012 - 2015 Member, Daria Drobysheva, University of Utah, PhD/Doctorate Committee 2012 - 2016 Chair, Matthew Velinder, University of Utah, PhD/Doctorate Committee 2012 Member, Daniel Appadurai, University of Utah, PhD/Doctorate Committee. Prelim Exam Committee 2012 Chair, Yixuan Guo, University of Utah, PhD/Doctorate Committee. Prelim Exam Committee 2013 - 2017 Chair, Helena Lucente, University of Utah, PhD/Doctorate Committee 2013 - Present Chair, David McClellan, University of Utah, PhD/Doctorate Committee 2013 - Present Member, Chongil Yi, University of Utah, PhD/Doctorate Committee 2013 - Present 2013 - 2017 2013 - Present 2014 - Present 2014 - 2015 2015 - 2015 2015 - Present 2015 2015 2015 - Present

Member, Blake Wilde, University of Utah, PhD/Doctorate Committee Member, Jason Tanner, University of Utah, MD/PhD/Doctorate Committee (MD, PhD) Member, Andrew Paquette, University of Utah, PhD/Doctorate Committee Member, Patricia Tiburcio, University of Utah, PhD/Doctorate Committee Member, Christa DeVette, University of Utah, PhD/Doctorate Committee (MD/PhD) Member, Kirsten Johnson, University of Utah, PhD/Doctorate Committee (MD/PhD) Co-Chair, Mattie Casey, University of Utah, PhD/Doctorate Committee Member, Russell Green, University of Utah, PhD/Doctorate Committee. Prelim Exam Committee Member, Adam Gardner, University of Utah, PhD/Doctorate Committee. Prelim Exam Committee Member, Milind Chalishazar, University of Utah, PhD/Doctorate Committee

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2015 - 2018 2015 - Present 2016 - Present 2016 - Present 2016 - Present 2017 - 2018 2017 - Present

Member, Jared Wallace, University of Utah, PhD/Doctorate Committee Member, Jillian Jafek, University of Utah, PhD/Doctorate Committee Member, Tian-Yeh Lim, University of Utah, PhD/Doctorate Committee Member, Timothy Mulvihil, University of Utah, PhD/Doctorate Committee (MD/PhD) Member, William Burnett, University of Utah, PhD/Doctorate Committee Member, Carissa Kim, University of Utah, PhD/Doctorate Committee Member, Bradley Weaver, Univeristy of Utah, PhD/Doctorate Committee (MD/PhD)

Educational Lectures

Didactic Lectures 2004 - 2010 2004 - 2010

Life threatening complications of sickle cell disease. Pediatric Hematology/Oncology Rotation for Pediatric House Officers (recurrent). Monroe Carell Jr. Children's Hospital at Vanderbilt. Nashville, TN Sickle Cell Disease—Clinical Correlation in Molecular Foundations of Medicine. Vanderbilt University School of Medicine, Nashville, TN

2004 - 2010 2004 - 2010

Chemotherapeutic agents, mechanisms of action, toxicities and management. Pediatric Hematology/Oncology Rotation for Pediatric Residents (recurrent). Monroe Carell Jr. Childen's Hospital at Vanderbilt. Nashville, TN Pediatric Oncology Patient/Family Encounter—Molecular Foundations of Medicine Clinical Correlation, Vanderbilt University School of Medicine, Nashville, TN

2004 - 2010 Tumor Lysis Syndrome and other metabolic abnormalities in Pediatric Oncology. Pediatric Hematology/Oncology Rotation for Pediatric House Officers (recurrent). Monroe Carell Jr. Children's Hospital at Vanderbilt. Nashville, TN

2004 - 2010 The opening salvo: Initial management of the pediatric oncology patient. Pediatric Hematology/Oncology Rotation for Pediatric House Officers (recurrent). Monroe Carell Jr. Children's Hospital at Vanderbilt. Nashville, TN

2005 - 2010 2013 - Present 2013 - Present 2013 - Present 2016 - Present 2017

Common pathogens in pediatric oncology patients. Pediatric Hematology/Oncology Rotation for Pediatric House Officers (recurrent). Monroe Carell Jr. Children's Hospital at Vanderbilt. Nashville, TN Pediatric Oncology Patient/Family Encounter—Cells, Molecules and Cancer Clinical Correlation, University of Utah School of Medicine, Salt Lake City, UT Introduction to Pediatric Oncology—Cells, Molecules and Cancer, University of Utah School of Medicine, Salt Lake City, UT Hematology for the Molecular Biologist—Medicine and Physiology for the Molecular Biologist, University of Utah School of Medicine, Salt Lake City, UT Rational Treatment of Cancer—Molecular Mechanisms of Cancer, University of Utah School of Medicine, Salt Lake City, UT Molecular Pathogenesis of Pediatric Leukemias—Nanocourse in Cancer Training-360, Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT

Department/Division Conferences 2003 SHOX gene dosage as a determinant of the short stature phenotype, Pediatric Endocrinology

Division Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt 2003 Pediatrics Morning Report--Sarcoidosis pathogenesis, presentation, diagnosis and treatment,

Monroe Carell Jr. Children's Hospital at Vanderbilt 2004 Mutational spectrum and molecular pathogenesis of Kallmann syndrome, Pediatric Endocrinology

Division Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt 2004 Pediatric Chief's Conference--Molecular mechanism of hypercalcemia in Non-Hodgkin

Lymphoma, Monroe Carell Jr. Children's Hospital at Vanderbilt 2005 Therapeutic options for recurrent/refractory alveolar rhabdomyosarcoma--Pediatric

Hematology/Oncology Division Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt 2005 - 2010 Pediatric Acute Lymphoblastic Leukemia, Molecular Pathogenesis, Clinical Manifestations and

Treatment, Pediatric Hematology/Oncology Fellows Educational Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt

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2005 Pediatric Chief's Conference--Acute lymphoblastic leukemia, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt

2006 - 2007 Pediatric Heme-Onc Emergencies, Pediatric Hematology/Oncology Division Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt

2007 Pediatric Chief's Conference--Transfusion Related Acute Lung Injury (TRALI), Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt

2007 Regulation of MTG proteins: Defining new targets for leukemia therapy, Department of Cancer Biology, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center

2008 Pediatrics Chief's Conference--Thrombosis in the Pediatric Patient, Monroe Carell Jr. Children's Hospital at Vanderbilt

2010 Notch-dependent regulation of gene expression--Beyond the canonical pathway, Pediatric Hematology/Oncology Division Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt

2011 MTG16 is required for T-cell fate specification, Research in Progress, Oncological Sciences, Huntsman Cancer Institute

2012 Histone H3K79me2 by DOT1L in MLL-altered leukemia pathogenesis, Pediatric Hematology/Oncology Division Conference, Primary Children's Medical Center, University of Utah

2011 - present Acquired and Inherited Bone Marrow Failure Syndromes, Pediatric Hematology/Oncology Fellows Educational Conference, Primary Children's Medical Center, University of Utah School of Medicine (recurrent)

2013 2013 2014 2015 2015 2017

The role of GFI1 in the pathogenesis of lymphoblastic leukemias and lymphomas, Pediatric Hematology/Oncology Division Conference, Primary Children’s Hospital, University of Utah School of Medicine Leveraging the GFI1—LSD1 relationship to treat acute lymphoblastic leukemias and lymphomas. Research conference of the Center for Investigational Therapeutics, Huntsman Cancer Institute, University of Utah School of Medicine. The GFI1—LSD1 axis as a therapeutic target in Notch-driven cancers, Oncological Sciences Research Retreat, University of Utah School of Medicine. Notch-driven hematopoietic cell fate decisions via the MTG16—GFI1—LSD1 axis, Fellow Research Conference, Division of Hematology and Hematologic Malignancy, University of Utah School of Medicine and the Huntsman Cancer Institute. Epigenetic therapy for T-cell acute lymphoblastic leukemia/lymphoma, Pediatric Cancer Working Group Research Conference, University of Utah School of Medicine and the Huntsman Cancer Institute. Targeting the epigenome in pediatric malignancies—mitigating the impact of conventional chemotherapy. Department of Pediatrics—RIP, University of Utah School of Medicine.

Continuing Education

CE Courses Taught 2006 Lecturer, Pediatric Heme/Onc Nursing Continuing Education

Other Educational Activities 1984 Teaching Assistant, Developmental Biology and Physiology, Purdue University (Supervisor: Dr.

Mary Stiller) 1985 Teaching Assistant, Cell Biology and Genetics, Purdue University (Supervisor: Dr. Anna Berkowitz) 1993 - 1994 Immunology tutor for first year medical students via Microbes and Defense Academic Society 2007 Step Master and Case Author-Molecular Foundations of Medicine Course, Vanderbilt University

School of Medicine 2007 - 2008 Problem-based learning facilitator-Molecular Foundations of Medicine Course, Vanderbilt University

School of Medicine 2009 - 2010 Howard Hughes Medical Institute Medical Student Research Fellowship--Awarded to Jolene

Mariotti, a medical student under my supervision.

PEER-REVIEWED JOURNAL ARTICLES

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1. Vedvick T, Buckholz RG, Engel M, Urcan M, Kinney J, Provow S, Siegel RS, Thill GP. (1991). High-level secretion of biologically active aprotinin from the yeast Pichia pastoris. J Ind Microbiol, 7(3), 197-201. PMID 1373002.

2. Darnay BG, Engel M. (1992). An efficient method for pouring sequencing gels. Biotechniques, 13(6), 859. PMID 1476736.

3. Kawabata M, Imamura T, Miyazono K, Engel ME, Moses HL. (1995). Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha. J Biol Chem, 270(50), 29628-31. PMID 8530343.

4. Engel ME, Datta PK, Moses HL. (1998). Signal Transduction by Transforming Growth Factor-β: A Cooperative Paradigm with Extensive Negative Regulation. J Cell Biochem, 30/31, 111-112. PMID 9893262.

5. Engel ME, Datta PK, Moses HL. (1998). RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. J Biol Chem, 273(16), 9921-6. PMID 9545335.

6. Sarkar DK, Pastorcic M, De A, Engel M, Moses H, Ghasemzadeh MB. (1998). Role of transforming growth factor (TGF)-beta Type I and TGF-beta type II receptors in the TGF-beta1-regulated gene expression in pituitary prolactin-secreting lactotropes. Endocrinology, 139(8), 3620-8. PMID 9681516.

7. Engel ME, McDonnell MA, Law BK, Moses HL. (1999). Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem, 274(52), 37413-20. PMID 10601313.

8. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL. (2001). Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell, 12(1), 27-36. PMID 11160820.

9. Engel ME, Hickstein DD, Bauer TR Jr, Calder C, Manes B, Frangoul H. (2006). Matched unrelated bone marrow transplantation with reduced-intensity conditioning for leukocyte adhesion deficiency. Bone Marrow Transplant, 37(7), 717-8. PMID 16489359.

10. Frangoul H, Wills M, Crossno C, Engel M, Domm J. (2007). Acyclovir-resistant herpes simplex virus pneumonia post-unrelated stem cell transplantation: a word of caution. Pediatr Transplant, 11(8), 942-4. PMID 17976133.

11. Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW. (2008). Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol, 28(20), 6234-47. PMID 18710942.

12. Engel ME, Hiebert SW. (2010). The enemy within: Awakening endogenous retroviruses. Nat Med, 16, 517-518. PMID 20448571.

13. Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert SW. (2010). Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification. Mol Cell Biol, 30(7), 1852-63. PMID 20123979.

14. Hunt A, Fischer M, Engel ME, Hiebert SW. (2011). Mtg16/Eto2 contributes to murine T-cell development. Mol Cell Biol, 31(13), 2544-51. PMID 21536648.

15. Fagan E, Slone J, Shoemaker A, Black J, Berlin J, Engel ME. (2012). Neuroendocrine carcinoma in an adolescent with hypercortisolemia. J Pediatr Hematol Oncol, 34(3), 117-119. PMID 22441712.

16. Mixon BA, Eckrich M, Lowas S, and Engel ME. (2013). Vincristine, Irinotecan and Temozolomide for treatment of relapsed alveolar rhabdomyosarcoma. J Pediatr Hematol Oncol, 35(4), 163-166. PMID 22735885.

17. 18. 19. 20. 21. 22.

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. (2012). Kaiso directs the transcriptional co-repressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE, 7(12), 1205-1218. PMID 23251453. Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, and Williams CS. (2015). The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 29(3), 786-795. PMID 25398765. Nguyen H, Mariotti J, Bareyan D, Carnahan R, Cooper T, Williams CS and Engel ME. (2015). Anti-MTG16 antibodies reveal MTG16 subcellular distribution and nucleocytoplasmic transport in erythroleukemia cells. Antibody Tech J. 2015(5), 27-41. Fadul J, Bell R, Hoffman LM, Lawlor ER, Beckerle MC, Engel ME and Lessnick SL. (2015) EWS/FLI1 utilizes NKX2-2 to repress mesenchymal features of Ewing Sarcoma. Genes & Cancer, 6(3-4), 129-143. PMID 26000096. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS and Campbell R. (2015). Pegasparaginase treatment alters thrombin generation by modulating the protein C and S system in acute lymphoblastic leukemia. Blood Coagulation and Fibrinolysis. (Epub ahead of print). PMID 26196196.

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23.

Andrade D, Velinder M, Singer J, , Maese L, Bareyan D, Nguyen H, Chandrasekharan M, Lucente H, McClellan D, Jones D, Sharma S, Liu F, and Engel ME. (2016) Sumoylation regulates Growth Factor Independence (GFI) 1 in transcriptional control and hematopoiesis. Mol Cell Biol, 36(10) 1438-1450. PMID 26951200. Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, and Engel ME. (2016) GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Biochem J. 473 3355-3369. PMID 27480105.

BOOK CHAPTERS 1. Engel ME, and Hiebert SW. (2010). Pro-leukemic RUNX1 and CBF mutations in the pathogenesis of acute myeloid

leukemia. In Lalitha Nagarajan, PhD (Eds.), Cancer Treatment and Research (Acute Myelogenous Leukemia-Genetics, Biology and Therapy, 125, pp. 127-147). New York: Springer. PMID 20306249

OTHER (Commentary/Letters/Editorials/Case Reports/Video/Film)

Other 1. Engel ME. (1999). Rho GTP-Binding Proteins and the C-Jun N-Terminal Kinase Cascade. Ph.D. Thesis. Vanderbilt

University.

Patents 1. Engel ME, Vedvick T, Urcan M, Buckholz R, and Kinney J. (1993). Expression System for Bovine Pancreatic

Trypsin Inhibitor (BPTI/Aprotinin) Peptides. U.S. Patent No. US5258302. Washington, D.C. U.S. Patent and Trademark Office.

PENDING PUBLICATIONS

Journal Articles 1. 2. 3. 4.

Engel ME, Hunt A, and Hiebert SW. (In preparation). Phosphorylation of Myeloid Translocation Gene (MTG)-16 by A-kinase regulates NCoR recruitment and transcriptional repression. Frontiers Peds Oncol. Lucente H, Bareyan D, McClellan D, Velinder M, Casey M, and Engel ME. (submitted) MTG16 directs lymphoid versus bilineal phenotype in Notch-driven leukemia. Disease Models and Mechisms. McClellan D, Casey M, Bareyan D, Mason C, Chandrasekharan M, Singer J, Velinder M and Engel ME. (In preparation) LSD1-dependent recruitment of HMG20B by GFI1B is required for erythroid lineage allocation from biopotent hematopoietic progenitors. Exp Hematol. McClellan D, Singer J, Bareyan D, Chandrasekharan M and Engel ME. (In preparation) Differential SUMOylation of GFI1B splice variants alters recruitment of an LSD1-dependent complex required for erythroid lineage allocation. Mol Cell Biol.

RECENTLY PUBLISHED ABSTRACTS 1. Mariotti J, Nguyen HN and Engel ME. (2010). Structure—function relationships between RUNX1-MTG fusion

proteins and core components of the Notch transcription complex [Abstract]. American Association for Cancer Research National Meeting. Washington, DC.

2. Mangrum DS, Shams S, Downie J, von Schwelder U, Rodic V, Engel ME, Barnette P, Frazer JK, Trede N, Pei D, Cheng C, Mullighan C, Yang J, Miles R, Schiffman JD. (2011). Focal 22q11.22 loss combined with IKZF1 alterations predict very poor outcome in childhood acute lymphoblastic leukemia [Abstract]. American Society of Hematology National Meeting, San Diego, CA.

3. Andrade DL, Bareyan D, Singer J, Quinton R, Engel ME. (2012). Regulation of GFI1 proteins by Notch intracellular domains [Abstract]. American Association for Cancer Research National Meeting.

4. Andrade D, Singer J, Bareyan D, McClellan D, Lucente H, Chandrasekharan M, and Engel ME. (2013). Notch and PIAS3 differentially regulate sumoylation of GFI1 to modulate transcriptional repression [Abstract]. AACR National Meeting, Washington, DC.

Engel, Page 17

5. 6. 7. 8. 9. 10. 11. 12.

Andrade D, Maese L, Singer J, Bareyan D, McClellan D, Lucente H, Quinton R, Chandrasekharan M, Liu F, and Engel ME. (2013). Sumoylation regulates the half-life of Growth Factor Independence (GFI)-1 to modulate transcriptional repression [Abstract]. ASPHO National Meeting, Miami, FL. Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Maese L, Chandrasekharan M, Theisen E, Liu F, Sharma S and Engel ME. (2013). Lysine Specific Demethylase-1 inhibition as a therapeutic strategy that leverages the requirement for Growth Factor Independence-1 in Notch-driven T-ALL [Abstract]. AACR Pediatric Oncology Working Group-Pediatric Cancer at the Crossroads-Translating Discovery into Improved Outcomes, San Diego, CA. Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Chandrasekharan M, Theisen E, Liu F, Sharma S, Maese L, and Engel ME. (2013). Notch alters SUMOylation to govern GFI1 protein stability and support its transcriptional repression function [Abstract]. American Society of Hematology National Meeting, New Orleans, LA. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS, and Campbell RA. (2014). Pegasparaginase treatment in acute lymphoblastic malignancy alters thrombin generation through modulation of the protein C and S system. [Abstract]. ASPHO National Meeting, Chicago, IL. Velinder M, Singer J, Meznarich J, Thiesen E, Fulcher J, Tracy CM, Franklin S, Sharma S, and Engel ME. (2015). GFI1 SNAG domain methylation directs LSD1 recruitment to control transcription and cell fate determination in hematopoiesis. [Abstract]. American Society of Hematology National Meeting, Orlando, FL. Meznarich J, Bareyan D, Velinder M, Theisen E, Maese L, McClellan D, Lucente H, Singer J, Sharma S and Engel ME. (2016) P21WAF expression antagonizes LSD1 inhibitor efficacy in T-ALL cells. [Abstract] ASPHO National Meeting, Minneapolis, MN. Lucente H, Bareyan D, McClellan D and Engel ME. (2017) MTG16 variants provide context to Notch signaling to direct leukemic phenotype. [Abstract] American Society of Hematology National Meeting, Atlanta, GA. McClellan D, Singer J, Velinder M, Bareyan D, Lucente H, Casey M and Engel ME. (2017) GFI1B splice variants differentially regulate transcription and megakaryocyte/erythrocyte fate in hematopoiesis. [Abstract] American Society of Hematolgy National Meeting, Atlanta, GA.

UNPUBLISHED POSTER PRESENTATIONS 1. 2. 3. 4. 5. 6. 7. 8.

Quinton R, Bareyan D, Andrade DL, Singer J, McLellan D, Engel ME. (2011). Myeloid Translocation Gene (MTG) 16 and the Notch pathway in in vitro erythropoiesis. HCI Summer Internship Program Research Symposium, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT. Skaug C, Bareyan D, Singer J, Engel ME. (2012). MTG16 nucleocytoplasmic transport correlates with altered hemoglobinization of murine erythroleukemia cells. HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah, Salt Lake City, UT. Fadul J, Engel ME, Lessnick S. (2013). Novel interactions of NKX2.2: A partnership with MTG16 in Ewing Sarcoma pathogenesis. Society for Developmental Biology—Southwest Regional Meeting, University Guest House and Conference Center, University of Utah, Salt Lake City, UT. Innes B, Bareyan D, Singer J, Lucente H, McClellan D, Velinder M, Engel ME. (2013). Enforced nuclear localization of MTG16 suppresses terminal erythropoiesis in murine erythroleukemia cells. HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Corpuz MJB, McClellan D, Singer J, Velinder M, Bareyan D, Lucente H, Maese L and Engel ME. (2014). Effect of LSD1 in hematopoiesis depends upon enzymatic and non-enzymatic functions of LSD1. HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Trane AL, Singer J, Bareyan D, Velinder M, McClellan D, Lucente H, Maese L, and Engel ME (2014). Regulation of Myeloid Translocation Gene (MTG)-16 in erythropoiesis by inducible nuclear translocation. Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Corpuz MJB, McClellan D, Singer J, Velinder M, Bareyan D, Lucente H, Maese L and Engel ME. (2014). Effect of LSD1 in hematopoiesis depends upon enzymatic and non-enzymatic functions of LSD1. University of Maryland—Undergraduate Research Symposium in Chemical and Biological Sciences, University of Maryland, Baltimore, MD. McDermott M, McClellan D, Velinder M, Bareyan D, Lucente H and Engel ME. (2014). LSD1 inhibitor SP-2509 effects on T-ALL cell growth reflect structural and enzymatic contributions by LSD1. HCI Summer Internship

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9. 10. 11. 12.

Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Broadway J, Casey M, Bareyan D, and Engel ME. (2017). HDAC recruitment by GFI1 as a determinant of neutrophil differentiation. Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Lamb C, McClellan D, Bareyan D, Sharma S, and Engel ME. (2017). Mechanism of action of the LSD1 inhibitor, SP-2577. Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Casey M, Modzelewska K, Sorrels S, Engel ME and Stewart R. (2017). Modeling malignant pediatric brain tumors in zebrafish to assess therapeutic approaches. Zebrafish Disease Models, San Diego, CA. Casey M, McClellan D, Stewart R and Engel ME. (2018). Understanding the GFI1B—LSD1 axis in zebrafish hematopoiesis. International Zebrafish Conference, Madison, WI.

ORAL PRESENTATIONS Keynote/Plenary Lectures National 2006 Phosphorylation-mediated control of gene expression by the myeloid translocation gene protein,

MTG16: Implications for hematopoietic stem cell self-renewal and leukemogenesis. American Society of Pediatric Hematology/Oncology. San Francisco, CA

Meeting Presentations (Not Published Abstracts and Not Unpublished Posters) International 1995 The Immunophilin FKBP12 Interacts with the TGF- β Type I receptor. International Symposium on

Second Messengers. Nashville, TN. 2007 MTG16-mediated transcriptional repression and NCoR interaction are regulated by A-kinase.

American Association for Cancer Research National Meeting, Los Angeles, CA. 2009 2014 2015 2017

Myeloid translocation gene (MTG)-16 binds intracellular domains of Notch receptors to coordinate Notch-dependent cell fate specification. American Society of Hematology National Meeting, New Orleans, LA. Growth Factor Independence (GFI)-1 post-translational modification in hematopoietic differentiation. American Society for Pediatric Hematology/Oncology National Meeting, Chicago, IL. GFI1 SNAG domain methylation directs LSD1 recruitment to control transcription and cell fate determination in hematopoiesis. American Society of Hematology National Meeting, Orlando, FL. The GFI1—LSD1 axis as a therapeutic target in Notch-driven T-ALL. T-ALL Workshop of the International T-ALL Consortium, Leuven, Belgium.

National 1994 Secretion and Purification of Recombinant Aprotinin Analogs from the Methylotropic Yeast Pichia

pastoris. International Symposium of the Protein Society-San Diego, CA. 1998 The role of Rho proteins in TGF-beta signaling. FASEB Summer Research Conference-Receptors

and Signal Transduction. Copper Mountain, Colorado 2012 - Present Myeloid translocation gene (MTG)-16 nucleocytoplasmic transport contributes to erythroid

differentiation in murine erythroleukemia cells. National Institutes of Diabetes and Digestive and Kidney Diseases-Conference on non-malignant hematology, Bethesda, Maryland, USA

2013 2014 2015 2016 2017

Mtgr1 is required for GSI-induced paneth cell differentiation, American Gastroenterological Society National Meeting, Orlando FL. Growth factor independence (GFI)-1 post-translational modifications in hematopoietic differentiation. American Society of Pediatric Hematology/Oncology National Meeting. Chicago, IL. Optimizing the environment for Faculty engaged in Graduate Medical Education. Association of American Medical Colleges National Meeting. Baltimore, MD. Effective Scientific Communication—Moderator for opening plenary session. CFAS/ORR/GDI National Meeting, Salt Lake City, UT Focus on the Physician-Scientist Workforce. Association of American Medical Colleges (AAMC) Learn-Serve-Lead National Meeting, Boston, MA

Local/Regional

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2005 Post-translational modifications of MTG16. Vanderbilt Medical Center Research Forum. 2005. Vanderbilt University Medical Center. Nashville, TN

2007 Phosphorylation of the MTG16 NHR4 domain by A-kinase regulates NCoR binding and transcriptional repression, Newman Society Scientific Retreat, Nashville, TN.

2011 Myeloid Translocation Gene (MTG) 16 and Notch Signaling in erythropoiesis 2011 2014

Being all things to all people: An expanding role for MTG16 in hematologic malignancy LSD1 as a surrogate target for GFI1 inhibition in T-ALL, Aspen Pediatric Hematology/Oncology Research Conference—In conjunction with University of Colorado-Denver. Aspen, CO.

Invited/Visiting Professor Presentations National 2009 Targeting the Notch transcription complex in acute myeloid leukemia pathogenesis. Medical

University of South Carolina and the Hollings Cancer Institute, Charleston, SC. 2009 MTG16 regulates Notch-dependent lineage allocation in hematopoiesis. University of Utah and the

Huntsman Cancer Institute-Research Conference, Salt Lake City, UT. 2010 MTG16 and the Notch transcription complex: New partners in hematopoietic cell fate specification.

Indiana University School of Medicine and the Herman B. Wells Center for Pediatric Research, Indianapolis, IN.

2010 2013 2015 2015 2017 2018 2017

A patnership between MTG16 and Notch in cell fate specification: Implications for normal and malignant hematopoiesis. Oklahoma University Health Sciences Center. Oklahoma City, OK. Overcoming pathologic co-dependency between Notch and GFI1 reveals a new therapeutic opportunity in T-ALL. University of Alabama-Birmingham and Children’s Hospital of Alabama, Birmingham, AL. Rational Cancer Treatment. University of Mississippi School of Medicine and Batson Children’s Hospital, Jackson, MS. GFI1 SUMOylation and LSD1 recruitment in transcriptional control and granulocyte differentiation. Rutgers University and the Cancer Institute of New Jersey, New Brunswick, NJ. NICD—GFI1—LSD1 axis inhibition by the LSD1 inhibitor, SP-2577, as a therapeutic strategy for relapsed/refractory T-ALL. POETIC Summer Research Conference, Canmore, Alberta, CA. Breaking Bad: the GFI1 transcriptional repressor complex as a therapeutic target in acute leukemia. University of Virginia School of Medicine, Charlottsville, VA. MD/PhD, is it right for me? Society for Advancing Chicanos/Hispanics and Native Americans in Science (SACNAS) National Meeting. Salt Lake City, UT.

Local/Regional 2010 An unexpected role for MTG16 in Notch Signaling? New insights from new tools. Huntsman Cancer

Institute-Multidisciplinary Cancer Research Retreat. Salt Lake City, UT 2011 Notch signaling in hematopoiesis: It gets by with a little help from a friend. Center for Children's

Cancer Research "Supergroup" presentation. University of Utah/Huntsman Cancer Institute, 2011. 2011 2013 2014 2014 2017

A role for MTG proteins in Notch signaling. Research in Progress, Huntsman Cancer Institute, Salt Lake City, UT. SUMOylation governs recruitment of epigenetic effectors to GFI1-regulated genes to control survival in T-ALL, Molecular Medicine Research Training Program Symposium, Park City, UT. Notch disrupts GFI1 SUMOylation to support its anti-apoptotic role in T-ALL. Center for Children’s Cancer Research “Supergroup” presentation. University of Utah and Huntsman Cancer Institute, 2013. The Notch—GFI1—LSD1 axis as a therapeutic opportunity in T-ALL. University of Utah and Huntsman Cancer Institute, Hematology/Oncology Fellow Research Conference, Salt Lake City, UT Targeting LSD1 in relapsed leukemia—Molecular foundations and phase I clinical trial. Huntsman Cancer Institute-Hematologic Malignancies Disease Oriented Team Symposium, Salt Lake City, UT

Grand Rounds Presentations 2005 Epigenetic gene regulation in acute leukemia. Vanderbilt University Medical Center. Grand Rounds

in Hematology, Nashville, TN. (Invited)

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2008 MTG proteins at the nexus of hematopoietic cell fate determination. Children’s Mercy Hospital and Clinic-Grand Rounds, Kansas City, MO. (Invited)

2009 2013 2015

MTG proteins and Notch signaling in the pathogenesis of acute leukemia. MD Anderson Cancer Center, Children’s Cancer Hospital-Pediatric Grand Rounds, Houston, TX. (Invited) Forks in the Road: Notch, GFI1, MTG16 and the SUMOylation machinery in hematopoietic cell fate specification, University of Utah School of Medicine, Grand Rounds—Hematology and Hematologic Malignancy, Salt Lake City, UT. (Invited) Targeting an adaptive response to Notch activation in T-ALL. University of Mississippi School of Medicine and Batson Children’s Hospital, Jackson, MS. (Invited)

Outreach Presentations 2000 Presenter, Vanderbilt University Medical Alumni Association, Medical Research, as student’s

perspective 2007 Speaker, Leukemia and Lymphoma Society, Man and Woman of the year celebration. Nashville, TN 2008 2009

Speaker, Leukemia and Lymphoma Society, Man and Woman of the year kick-off dinner "A Tale of 3 Friends". Nashville, TN Speaker, Hyundai Hope On Wheels, Handprint Ceremony Speaker, Nashville, TN

2011 2014 2015 2016 2017 2017 2017

Speaker, Hyundai Hope On Wheels, Handprint Ceremony Speaker, Salt Lake City, UT Speaker, Utah High School Science Educators, Cancer Research Programs at the Huntsman Cancer Institute, Salt Lake City, UT Speaker, “On being a physician-scientist: valuable lessons learned along the way”. Native American Student Mentoring Workshop, Huntsman Cancer Institute, Intercultural Cancer Council Speaker, “We must go faster”, the story of a boy we might have helped”. Alex’s Lemonade Stand Foundation fund raising event for Pediatric Cancer Research. Speaker, “MD/PhD, is it right for me?”. SACNAS National Meeting. Salt Lake City, UT Speaker, “Preparing for a career as an MD/PhD trained physician-scientist”, NIH Graduate Student Career Fair. Bethesda, MD. Speaker, “Knowledge, Skill and Passion are not enough...mobilizing the public to support pediatric cancer research”. American Cancer Society Gala. Salt Lake City, UT.

OTHER SCHOLARLY ACTIVITY

Other Scholarly Activities 1989 The kinetics of HMG-CoA reductase, the rate limiting enzyme in polyisoprenoid biosynthesis, via

characterization of site-directed mutants, Preceptor: Victor Rodwell, Ph.D., Purdue University 1992 Expression, purification and characterization of N-terminally truncated Liver-enhanced activator

Protein, a naturally occurring splice variant with dominant negative behavior, Preceptor: Linda Sealy, Ph.D., Vanderbilt University School of Medicine

1993 Purification and characterization of rat Retinyl-ester-hydrolase, Preceptor: David Ong, Ph.D., Vanderbilt University School of Medicine

1993 Cell cycle dynamics of AKR-2B mouse fibroblasts constitutively expressing the c-myc oncogene, Preceptor: Harold L. Moses, M.D., Vanderbilt University School of Medicine

1994 - 1995 Farnesyl Protein Transferase-α, the shared subunit of protein isoprenylprenyltransferases in TGF- β signaling, Preceptor: Harold L. Moses, M.D., Vanderbilt University School of Medicine

1994 - 1999 Rho GTP-binding proteins and the c-jun N-terminal kinase cascade in transforming growth factor-β signal transduction, Thesis Research, Advisor: Harold L. Moses, M.D., Vanderbilt University School of Medicine

2004 - 2007 Post-translational modifications and regulation of myeloid translocation gene proteins. Advisor: Scott W. Hiebert, PhD., Department of Biochemistry and the Vanderbilt-Ingram Cancer Center

2006 - 2010 Role of MTG family proteins in Notch-dependent signal transduction. Department of Pediatrics and Cancer Biology. Monroe Carell Jr. Children’s Hospital and the Vanderbilt-Ingram Cancer Center

2010 - Present 2011 - Present

Notch signaling in normal and malignant hematopoiesis. Department of Pediatrics, University of Utah School of Medicine, Department of Oncological Sciences, Huntsman Cancer Institute-Center for Children’s Cancer Research

Engel, Page 21

Epigenetic effectors of Growth Factor Independence-1 as therapeutic targets in T-cell acute lymphoblastic leukemia. Department of Pediatrics, University of Utah School of Medicine, Department of Oncological Sciences, Huntsman Cancer Institute