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Cavendish Global Health Impact For

October 25-28, 2015

Ed Addison,

Chairman, Co-Founder and CEO

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ancreatic Cancer

People diagnosed50,000

Of all cancers in the!"

Of all cancer deaths US

#"

Will die frompancreaticcancer

$0,5%0

Key statistics for !"# from the American

Cancer Society$

Source$ American Cancer Society, %nc&

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 'argets pancreaticcancer

using real genomicsdata

Uses genome data aanalysis

to disco*er no*eltargets

(esigning drug leads for those targets

Findin& a Cure

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Central 'ervous ()stem *ise

+lheimers

5.! millionAmericans

ha*e it2/! are+omen

+m)otrophic a

(clerosisProgressi*edegenerationof motor ner*ecells in therain and

spinal cord

(oes notimpair yourintellect orsenses

%thleading causeof death

Onl) 

cause of

death in thetop "! inAmerica thatcant epre*ented,

slo+ed, orcured

%mpairs*oluntain*oluntmuscles

Often re

respiratfailure

Conside)%. as odisease

Source$ Al/heimer0s Association Source$ 'he 1ohns .op2ins Uni*ersity 

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A% technology identi3esno*el targets y souring

pulished research enalingas2et trials

(esigns drug leads fotargets and 3lters fo

properties such as rain arrier

Findin& a Cure

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Contains e*ery smmolecule to increa+ellness of peoplethe +orld, to pre*e

people from dyingrelie*e their pain asu5ering

he tric is to 3n

ri&ht ones

4irtual olecular (pace

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Our ission

re-6uali3ed candidates enable us treduce cost, accelerate developmen

and tar&et elusive indications

Improve health and+ell-eingthrough therapid and

e6cientdesign of ne+medicines

*esi&n smallmoleculesthat inhiitprotein

targetsproduced ypathologies

+ppl) cloucomputingandcomputatiochemistry t

design drug

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he ime is 'o7 or In (ilico

9h):• 7oores 8a+

• Accessiility of cloud-ased super computing

• Arti3cial intelligence

Ho7:• Store 9( model ofe*ery human protein inthe druggale genome

• Analy/e a proposeddrug for to:icity prior to

clinical trial

Emerging life sciencecenter

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Collaoration

de*eloping

" drugs, *alidation

data

;rant for

de*elopment of

disco*ery methods

and select drugs

7uscle gro+th

and in<ammation

research

Autism and cancer research

Paid

7alaria

Collaoration

de*eloping= drug

programs

4aluable ;elationships

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Ho7 do 7e *evelop edicinesChallen&in& *iseases:

%dentify the molecules+ith outstanding drug-li2e

properties that modulatethe acti*ity of proteintargets

• +ppl) the right technology• artner +ith *isionarycompanies

• Harness the trends of thedigital re*olution

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+ppendi<Cloud Pharmaceuticals %n*estor O*er*ie+

Fall !"#

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raditionaldiscover)has

Hi&h-throu&hputscreenin& is

imelinesand costso pastdevelopment e=orts

are

reviousin silicomethodsare

Low probabilityof success

Veryinecient 

Prohibitive

Unreliable

  RUG

ISCOVE

10,00

COMPOUN

PRE-CLINI

250

CLINICA

TRIALS

ACHIEVES F A

1

  RUG

10

he Opportunit)

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9hat 9e *o

•

Improve health and7ell-bein& through thecomputational designand rapid de*elopmentof ne+ therapies

•

(elect novel diseasetar&ets internally andthrough collaorations+ith uni*ersities,pharma, and iotechcompanies

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Ho7 9e *o It>uantum olecular *esi&nrocess

• (esign compounds that inhiit the acti*ity of protein targets,

+hich are produced y the genes responsile for certainpathologies

• Comine high-performance cloud computing, >uantummechanics?molecular mechanics, and molecular property

simulation

• Fundamentally transform and impro*e the design of ne+medicines

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9h) 9e +re ?etter

•

Computational chemistry po+ered ycloud computing helps streamline thedrug disco*ery process

• %t identi3es compounds that are ettersuited for de*elopment from the outset

• Pre-clinical de*elopment steps can then

e applied to a much more >uali3ed listof candidates

• 'his approach enales more rapidprogress at lo+er cost and a highersuccess rate, e*en +ith elusi*e targets

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*emonstrated on an) *iseaar&ets•

We are uilding an e:tensi*eproduct pipeline that spans a+ide range of indicationsincluding$

• 8ipid 7etaolism

• Oncology

• @iruses

• %n<ammation

• Central ner*ous systemC)SB diseases

• Acti*ity demonstrated in

iological assays

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Competitive +dvanta&es

•

Use of arti3cial intelligencesearches no*el molecular space toidentify the strongest matches toprotein targets, resulting in original%P and enormous di*ersity

• inding a6nity of molecules to

targets achie*es D! correlationusing >uantum chemistry, ma2ingour process *ery accurate

• iophysical models of chemicalproperties enales selection of*ery good drug candidates

harmacopia

'umate

@-herapeutics

4erseon

(chrodin&er

     +

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     ;

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     C     B

* I 4 @ ; ( B 

Competitive a

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?usiness odel

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9orld-Class ana&ement and?oard

@d +ddisonC@O

9 E:its: Entrepreneur

of the Gear

(hahar einan,h*C(O

ComputationalChemist,

(u2e Uni*ersity Post(oc

Well Pulished

a7rence Husic  CIO

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usiness 7odelE:pert

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)le ohme)er CFO

Former CFO H CEOAA% Pharma

Jaised o*er 9!!7

Pulic H Pri*ate

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ana&er 'o e hired

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>uestions:

@d +ddison, C@OCloud Pharmaceuticals %nc&L (a*is (ri*eJesearch 'riangle Par2, )C==!I

I"!B 9I-"!!ed&addisonMcloudpharmaceuticals&com