Courses Specificationsdeltauniv.edu.eg/.../2.-Pharmaceutics-Courses-Specs.pdfFaculty of Pharmacy Courses Specifications Fall and Spring (2016/2017) Delta University for Science and

Courses Specifications

Pharmaceutics Courses

2016-2017

Faculty of Pharmacy

Courses Specifications )2016/2017( Fall and Spring

Delta University

for Science and Technology

Faculty of Pharmacy, Delta University for Science and Technology

1

Dept. of Pharmaceutics

Orientation to Pharmacy ......................................................................................... 2

Pharmaceutical Calculations .................................................................................. 6

Pharmaceutics-1 ..................................................................................................... 10

Pharmaceutics-2 ..................................................................................................... 17

Physical Pharmacy ................................................................................................. 22

Biopharmaceutics and Pharmacokinetics ........................................................... 26

Drug Delivery Systems and Targeting ................................................................. 32

Pharmaceutical Technology-1 .............................................................................. 36

Pharmaceutical Technology-2 .............................................................................. 41

Radiopharmaceutics .............................................................................................. 48

Faculty of Pharmacy


Delta University



2

Orientation to Pharmacy

1. Basic Information:

Course title: Orientation to pharmacy

Course code: PH 101

Department: pharmaceutics

Program on which the course is given: B. Pharm.

Faculty: Pharmacy

University: Delta University for Science and Technology

Academic level: level 1 Spring semester 2016/ 2017

Specialization: Compulsory Pharmaceutical Courses

Prerequisite: None

Credit hours: Lecture: 1 Practical: 0 Total: 1

Approval date: 11/2/2017

2. Course Aims:

Identify the principles of basic and ethics of pharmacy practice; recognize the different types of

pharmaceutical dosage forms and drug delivery systems. Assess different types of prescriptions

and how to deal with each type. Identify the different pharmacy careers and the role of pharmacist

in each. To be able to recognize international and national pharmaceutical organizations. Know

simple idea about history and development of pharmacy profession.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A1 a1 Identify the principles of basic and ethics of pharmacy practice

A2 a2

Identify the different pharmacy careers and role of pharmacist as a member in health

care team in community, hospital, governmental and military pharmacies. Role of

pharmacist in pharmaceutical industries.

A6 a3 Describe properties of different pharmaceutical dosage forms and drug delivery

systems, routs of drug administration and different types of prescriptions.

A22 a4 Recognize international and national pharmaceutical organizations.

a5 Know simple idea about history and development of pharmacy profession.

b. Intellectual Skills:


B10 b1 Specify the role of pharmacist in different pharmaceutical organizations

B11 b2 Assess different types of prescriptions and how to deal with each type.

Faculty of Pharmacy


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c. Professional and Practical Skills:


C1 c1 Utilize the proper pharmaceutical and medical terminology, to communicate with

other health care professionals

d. General and Transferable Skills:


D 9 d1 Manage time effectively

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction for pharmacy ethics and pharmacy career 1

2. International and local pharmaceutical organizations 1

3. Role of pharmacist in different pharmaceutical work areas 1

4. Types properties of different dosage forms and drug delivery systems 1



7. Mid-Term exam --

8. Primary and secondary sources of pharmaceutical information 1

9. Types of prescriptions 1

10. Types of prescriptions 1

11. Routes of administrations 1

12. History of pharmacy profession 1

13. History of pharmacy profession 1

14. Final Exam

15. 12

4.2.Practical/Tutorial:

Week

No. Topics

No. of

hours

1. N/A

5. Teaching and Learning Methods:

5.1. Lectures using data show and white board

5.2. Discussion sessions

Faculty of Pharmacy


Delta University



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6. Student Assessment Methods:

6.1.Assessment methods:

1. Written quiz

exam to assess the ability of student to understand the course subjects

2. Written mid-

term exam to assess the ability of student to follow up the course subjects

3. Oral exam to assess the ability of student in expressing and presenting their knowledge

clearly in systemic approach

5. Written final

exam to assess the overall outcomes

6.2.Assessment schedule:

Assessment 1 Quiz 9th week

Assessment 2 Mid -term 7th week

Assessment 3 Oral 14th &15th weeks

Assessment 4 Written 14th &15th weeks

6.3.Weighing of Assessments:

course work 25

Final-Term Exam 65

Oral Exam 10

Total 100%

7. List of References:

No. Reference type

1.

Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design

and manufacture of medicines, 4th edition, Churchill

Livingstone, 2013.

textbook

2. H.C. Ansel; Pharmaceutical Dosage Forms and drug Delivery

Systems’ Lea & Febiger; Philadelphia; London. 9th ed. (2011). textbook

8. Matrix of course contents versus ILOs:

No. Course contents Study

week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Introduction for pharmacy

ethics and pharmacy career 1 a1,a4,a5 c1

2.

International and local

pharmaceutical

organizations

2 a1

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Delta University



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3.

Role of pharmacist in

different pharmaceutical

work areas

3 a1

4.

Types properties of

different dosage forms and

drug delivery systems

4,5,6 a2,a3 b1

5.

Primary and secondary

sources of pharmaceutical

information

8 a2,&a3

6. Types of prescriptions 9,10 a1,a2,a3 b1,b2 c1

7. Routes of administrations 11 a1,a2,a3 b1,b2 c1

8. History of pharmacy

profession 12,13 a1,a4,a5 b1,b2 d1

Name Signature

Course Coordinator: Dr. Enas Ibrahim El Zahaby

Head of Department: Prof. Dr. Ahmed Talaat Nouh

Approval Date 11/2/2017

Faculty of Pharmacy


Delta University



6

Pharmaceutical Calculations


Course title: Pharmaceutical calculation

Course code: PH 211

Department: pharmaceutics


Faculty: Pharmacy


Academic level: two Fall Semester 2016-2017


Prerequisite: Mathematics (PC 101)



2. Course Aims:

The aim of the course is to acquire students with the principles of pharmaceutical calculations. In

addition, managing proper and safe dispensing of medicine.




A17 a1 Distinguish the methods of pharmaceutical calculation

A22 a2 Recognize the proper medical terminology, abbreviations and symbols in health

reports and pharmacy practice



B19 b-1 Calculate the proper dose of drugs for adults and pediatrics

b-2 Apply simple mathematical conversions for weight, volume, temperatures ...



C1 c1 Utilize the proper medical terminology, to communicate with other health care

professionals

C3 c2 Employ proper calculations for preparation of different pharmaceutical

preparations

Faculty of Pharmacy


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D1 d1 Communicate effectively with patients and health care professionals

D3 d2 Work effectively as a part of a team to perform the required tasks

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Some fundamentals of measurement and calculation

Percent error 2

2.

Interpretation of prescription or medication order

Metric system

Common system

2

3.

Continue: Interpretation of prescription or medication order

1) The apothecariesˋ

2) Avoirdupois measure

3) Household measures

Reducing and enlarging formulas

2

4.

Density

Specific gravity

Specific volume

2

5. Weight and volume of liquids and percentage preparation 2

6.

Continue: percentage preparation

Ratio strength

Simple conversion from percentage to ratio strength

2

7. Mid-term ---

8. Dilution and concentration

2

9. Stock solution

Dilution of alcohol 2

10. Allegation medial 2

11. Allegation alternate 2

12. Calculation of pediatric dose according to body weight, age and body

surface area 2

13. Calculation of chemotherapeutic dose according to body weight, age

and body surface area 2

14. Final Exam

15. 24

4.2.Practical/Tutorial: N/A

Faculty of Pharmacy


Delta University



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5.1. Lectures using data show

5.2. Discussion sessions



1. Written quiz exam to assess the ability of student to understand the course subjects

2. Written mid-term exam to assess the ability of student to follow up the course subjects

3. Written final exam to assess the overall outcomes


Assessment 1 Mid -term 7th week

Assessment 2 Class work 10th week



Class work 10

Mid-Term Exam 15

Final Term Exam 75

Total 100%


No. Reference type

1. Howard C. Ansel. Pharmaceutical Calculation, Lippincott,

Williams and Wilkins (14th edition), 2013. textbook



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1.

Some fundamentals of

measurements and

calculations

1 a2 c1

2.

Interpretation of

prescription or medication

order

2 b1 c2 d1

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3.

Continue: Interpretation of

prescription or medication

order.

Reducing and enlarging

formula.

3 b1 c3 d1

4.

Density

Specific gravity

Specific volume

4 a1

5.

Weight and volume of

liquids and percentage

preparation

5 a1

6.

Continue percentage

preparation

Ratio strength

Simple conversion from

percentage to Ratio

strength

6 a1

8 Dilution and concentration 8 a1

9 Stock solution

Dilution of alcohol 9 a1

10. Allegation medial 10 a1 c2

11 Allegation alternate 11 a1 c2

12. Calculation of pediatric

dose 12 a1,a2 b1 c2 d1,d2

13. Calculation of

chemotherapeutic dose 13 a1,a2 b1 c2 d1,d2

Name Signature

Course Coordinator: Prof. Ahmed Talaat Nouh

Head of Department: Prof. Ahmed Talaat Nouh


Faculty of Pharmacy


Delta University



10

Pharmaceutics-1


Course title: Pharmaceutics-1

Course code: PH 212

Department: Pharmaceutics


Faculty: Pharmacy


Academic level: 1stlevel Fall Semester 2016-2017


Prerequisite: PH 101 (Orientation to Pharmacy)

Credit hours: Lecture: 2 hrs Practical: 1hr Total: 3hrs

Approval date: 11 / 02 / 2017

1. Course Aims:

To provide students with a brief introduction to all pharmaceutical formulations such as; liquid

dosage forms, semisolid dosage forms and solid dosage forms. Understand concepts and theories

of the dispersed systems including; suspensions and emulsions. Definition and classification of

liquid dosage forms used via the different routes of administration. Methods of the preparation of

solution and various dispersed systems.


a. Knowledge and understanding: At the end of this course, student should be able to:

A2 a1 Define the properties of different types of pharmaceutical dosage forms

A6

a2 Describe and explain the different types of solutions, suspension, emulsion,

colloids and semisolids.

a3 Summarize the differences between suspensions and emulsions as an example for

dispersed system.

A22 a4 Recognize proper pharmaceutical terminology and abbreviations used in

pharmacy.

b. Intellectual Skills: At the end of this course, student should be able to:

B1

b1 Apply Stoke’s law and theory of sedimentation.

b2 Design appropriate formulations for solution; suspensions, emulsions and

semisolids.

b3 Interpret the theory of electrical properties of interfaces.

b4 Predict the stability of various dispersed systems.

Faculty of Pharmacy


Delta University



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c. Professional and Practical Skills: At the end of this course, student should be able to:

C3

c1 Utilize appropriate laboratory techniques in preparing solutions, suspensions and

emulsions.

c2 Perform experiments to enhance emulsion stability.

c3 Perform experiments to differentiate between different types of emulsion.

c4 Utilize appropriate laboratory techniques in preparing semisolid dosage forms.

d. General and Transferable Skills: At the end of this course, student should be able to:

D12 d1 Develop a rational thinking in formulation and production of medicines.

3. Contents

3.1.Lectures

No. of

week

Topic No. of hours

1

Advantages and disadvantages Of Solution As Oral

Dosage Form

Approaches To The Improvement Of Aqueous

Solubility

2

2

Non-aqueous solutions

Properties Of Non-aqueous Vehicles

Other Non-aqueous Solvents

2

3

Types Of Preparation

Stability of solutions

Manufacture of solutions

2

4

Pharmaceutical Applications Of Suspensions

Reconstitutable Suspensions

Solubility And Stability Considerations

Formulation Of Suspensions

Types of wetting agents

Electrical Properties Of Interfaces

2

5

Electrical Double Layer

Nernst And Zeta Potentials

Importance Of Zeta Potential

2

6

Effect Of Electrolytes

Promotion Of Flocculation

Flocculating Agents

2

7 Midterm Exam

8

Classification Of Suspending Agents

Problem Of Using Suspending Agents

Formulation additives

quiz

2

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Delta University



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9

Types of emulsion

Pharmaceutical Application of Emulsions

2

10

Tests for Identification of Emulsion type

Formulation of Emulsions

Choice of oil phase

Theories of Emulsification

1. Monomolecular adsorption

2. Multi-molecular adsorption

3. Solid particle adsorption


2

11

Stability of Emulsions

Methods of preparation of primary emulsion

Dry Gum Method

Wet Gum Method

2

12 13

Preparation of Emulsions containing more than one

oily liquid

Preparation of Emulsions containing Water soluble

substance

Preparation of Emulsions containing substances

insoluble in either oil or water

Preparation of Emulsions containing a small

proportion of oily substance.

Microemulsions.

4

14 Written and oral exam 24 15


Week

No. Topics

No. of

hours

1. Preparation of aromatic water 1

2. Preparation of Strong Iodin Solution

And Black Draught (Senaa infusion)

1

3. Preparation of solution by decoction and infusion

1

4. Preparation of solution Mist alba and Black wash 1

5. Castor oil emulsion (wet method)

Castor oil emulsion (Dry Method)

1

6. Olive oil emulsion (Wet method)

Olive oil emulsion (Dry method)

1

7. Mid-Term exam --

8. Zinc oxide ointment (Oleaginous base) 1

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9. White field ointment (Absorption base) 1

10. Cold Cream 1

11. Vanishing Cream 1

12. Revision 1

13. Practical exam 1

14. Final Exam

15. 12


5.1 Lectures

5.2 Class discussions.

5.3 Lab Sessions.


6.1. Assessment methods:

1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Practical exam to assess professional and practical skills

3. Oral exam to assess knowledge, understanding, intellectual skills, general skills and

confidence

4. Quizzes to assess knowledge, understanding and intellectual skills

6.2. Assessment schedule:

Assessment 1 Mid-term 7th week

Assessment 2 Class work 5th week

Assessment 3 Practical 13th week



6.3. Weighing of Assessments:

Mid-Term Exam & course work 25

Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference type

1. H.C. Ansel; Pharmaceutical Dosage Forms and drug Delivery Systems’

Lea & Febiger; Philadelphia; London. 9th ed. (2011). textbook

2 Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design and

manufacture of medicines, 4th edition, Churchill Livingstone, 2013. textbook

Faculty of Pharmacy


Delta University



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7. Matrix of learning and skills:


week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1

Advantages and

disadvantages Of Solution

As Oral Dosage Form

Approaches To The

Improvement Of Aqueous

Solubility

1

a1-a4

Aromatic water

merchrochrom Solution c1, c2

2

Non-aqueous solutions

Properties Of Non-aqueous

Vehicles

Other Non-aqueous

Solvents 2

a1-a4 b1, b4 d1

Strong Iodin Solution

Black Draught (Senaa

infusion)

c1, c3

3

Types Of Preparation

Stability of solutions

Manufacture of solutions

3

a1-a4 d1

Antispasmodic oral

solution

( Docoction of

Ammivisnaga)

Calamine Lotion

c1, c3

4

Pharmaceutical

Applications Of

Suspensions

Reconstitutable

Suspensions

Solubility And Stability

Considerations

Formulation Of

Suspensions

Types of wetting agents

4 a1-a4 b1, b2 d1

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Electrical Properties Of

Interfaces

Mist alba

Black wash c1, c4

5

Electrical Double Layer

Nernst And Zeta Potentials

Importance Of Zeta

Potential

5

a1-a4

b1, b2

d1

Castor oil emulsion (wet

method)

Castor oil emulsion (Dry

Method)

c1, c4

6

Effect Of Electrolytes

Promotion Of Flocculation

Flocculating Agents

6

a1-a4 b1 - b4 d1

Olive oil emulsion (Wet

method)

Olive oil emulsion (Dry

method)

c1 , c2, c3

8

Classification Of

Suspending Agents

Problem Of Using

Suspending Agents


8

a1-a4 b1 - b4 d1

Zinc oxide ointment

(Oleaginous base) c1 , c2 , c3

9

Quiz 9

White field ointment

(Absorption base)

10

Types of emulsion

Pharmaceutical

Application of Emulsions 10 a1-a4 b1 - b4 d1

Cold Cream c1, c2, c3

11

Tests for Identification of

Emulsion type

Formulation of Emulsions

Choice of oil phase

Theories of Emulsification

4. Monomolecular adsorption

5. Multi-molecular adsorption

6. Solid particle adsorption

11 a1-a3 b1 – b3 d1

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Vanishing Cream c1 , c2 and c3

12

Stability of Emulsions

Methods of preparation of

primary emulsion

Dry Gum Method

Wet Gum Method

12 a1-a4 b1 - b4 c1 , c2 and c3 d1

revision

13

Preparation of Emulsions

containing more than one

oily liquid


containing Water soluble

substance


containing substances

insoluble in either oil or

water


Containing a small

proportion of oily

Substance

Microemulsions.

13 a1-a4 b1 - b4 c1 , c2 and c3 d1

Practical Exams

Name Signature

Course Coordinator: Prof. Ahmed Talat Ibrahim Nouh

Head of Department: Prof. Ahmed Talat Ibrahim Nouh


Faculty of Pharmacy


Delta University



17

Pharmaceutics-2


Course title: Pharmaceutics-2

Course code: PH 213



Faculty: Pharmacy


Academic level: 2nd level Spring Semester 2016-2017


Prerequisite: Pharmaceutics-1



2. Course aims: The course provides the students with the basic physicochemical principles in the

formulation, preparation and performance of rectal, vaginal suppositories, aerosols and sterile

parenteral and ophthalmic dosage forms. It also covers the different sterilization methods as

well as the quality control of the finished products. Studies of various formulations of

cosmetic preparations.



A2

a1 Recognize the physicochemical properties of drugs and various substances used in

preparation of medicines

a2 Recognize the physicochemical properties of different pharmaceutical dosage

form.

A6 a3 Describe the properties of different pharmaceutical dosage forms and drug

delivery systems.

A10 a4 Recognize the principles of sterilization.


B1 b1 Design process of formulation of safe effective medicines and dealing with new

drug delivery systems.


C3 c1 Employ proper and safe dispensing, labeling, storing and disposal of medicines and

pharmaceutical preparation.

Faculty of Pharmacy


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D4 d1 Write a report concerning topics of the course.

4. Contents

4.1.Lectures


Week

No. Topics

No. of

hours

1. Determination of the displacement value 1

2. Cocao butter suppositoires 1

3. Cocao butter suppositoires 1

4. Glycerogelatinsuppositeries 1

Week No. Topic No. of hours

1 Sterile Dosage Form: Parenterals 2

2 Sterile Dosage Forms:

Parenterals 2

3 Sterile Dosage Forms:

Ocular 2

4 Pharmaceutical Aerosol

Advantages& disadvantages, components of aerosols. 2

5 Pharmaceutical Aerosol 2

6 Cosmetics: Skin care 2

7 Midterm ---

8

Cosmetics

Body and hair care

Powders

Dentifrices

2

9 Sterilization 2

10 Sterilization 2

11 Suppositories 2

12 Suppositories 2

13 General revision 2

14 Final exams 24

15

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5. Zinc oxide pessaries 1

6. Soap glycerinsuppositeries 1

7. Mid-Term exam ---

8. Polyethylene glycol suppositeries 1

9. White field ointment (Absorption base) 1

10. Zinc oxide ointment (Oleaginous base) 1

11. Vanishing Cream and Cold Cream 1

12. Revision 1


14. Final Exam

15. 12


5.1 Lectures

5.2 Class discussions.

5.3 Lab classes.






confidence










Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%

Faculty of Pharmacy


Delta University



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No. Reference type

1. H.C. Ansel; Pharmaceutical Dosage Forms and drug Delivery

Systems’ Lea & Febiger; Philadelphia; London. 9th ed. (2011). textbook

2.

Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design

and manufacture of medicines, 4th edition, Churchill

Livingstone, 2013.

textbook



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1

Sterile Dosage Forms:

Parenterals

1

a1-a4

Determination of the

displacement value c1

2


Parenterals

2

a1-a4 b1 d1

Lowering of melting

point

Raising of melting

point

c1

3


Ocular 3 a1-a3 d1

Zinc oxide pessaries c1

4

Pharmaceutical

Aerosol

Advantages &

disadvantages,

components of

aerosols.

4

a1-a4 b1 d1

Medicated Soap

glycerin c1

Faculty of Pharmacy


Delta University



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5

Pharmaceutical

Aerosol

Formulation of

pharmaceutical

aerosols, Types of

Systems.

5

a1-a3 b1 d1

Beeswax- Borax Cold

Cream c1

6

Cosmetics: Skin care

7

a1-a4 b1 d1

Medicated creams

(Sunscreen Creams c1

8

Cosmetics

Body and hair care

Powders

Dentifrices

8 a1-a4 b1 d1

Acne Vulgaris Cream c1

9

Sterilization

9 a2-a4 b1 c1

Vanishing or Day

cream:

Cosmetic Sticks

10

Sterilization

10

Bees-wax – Borax

Cold Cream

11 Suppositories

11 a1-a4 b1 d1

Revision

12 Suppositories 12 a1-a4 b1 d1

13 Suppositories

13 a2-a4 b1 d1

Name Signature

Course Coordinator: Prof. Ahmed Talat Ibrahim Nouh

Head of Department: Prof. Ahmed Talat Ibrahim Nouh


Faculty of Pharmacy


Delta University



22

Physical Pharmacy


Course title: Physical pharmacy

Course code: PH314



Faculty: Pharmacy


Academic level: third level Fall Semester 2016- 2017

Specialization: Pharmaceutical science

Prerequisite: Physical chemistry

Credit hours: Lecture: 2 Practical:1 Total:3


2. Course Aims:

To recognize the physic-chemical properties of drugs and various substances used in preparation

of medicines, in addition to the properties of different pharmaceutical dosage forms, predicting the

incompatibilities that may occur during drug dispensing through conducting experiments and

interpretation of results. And finally improve the writing and presentation skills of the students




A2 a1

Recognize the physic-chemical properties of drugs and various substances used in

preparation of medicines, in addition to the properties of different pharmaceutical dosage

forms

A6 a2 Describe properties of different pharmaceutical dosage forms and drug delivery systems



B4 b1 Interpret the influence of physicochemical properties on formulation of drug products

Faculty of Pharmacy


Delta University



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C11

c1 Determine the rheological properties of different dosage forms

c2 Determine the surface tension, interfacial tension and critical micelle concentration

c3 Determine the solubility of pharmaceutical materials

c4 Prepare isotonic solutions and measure their tonicity

c5 Select the proper buffer system in pharmaceuticals preparation



D10 d1 Implement writing and presentation skills

d2 Work effectively in a team

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Surface and interfacial phenomena 2

2. Adsorption at liquid surfaces 2

3. Adsorption at solid interface 2

4. Adsorption at solid/liquid interface 2

5. Rheology 2

6. Flow characteristics of Newtonian fluids and viscosity 2

7. Mid-term

8. Non Newtonian materials 2

9. Rheology determination of rheological properties applications 2

10. Buffers and buffering agent 2

11. Buffers and buffering agent 2

12. Solubility and related phenomena 2

13. General revision 2

14. Final Exam

24 15


Week No. Topics No. of hours

1. Surface tension 1

2. Critical micelle concentration 1

3. Hydrophilic lipophilic balance 1

Faculty of Pharmacy


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4. Problems on HLB 1

5. adsorption 1

6. Rheology 1

7. Midterm

8. Concentration expression 1

9. Problems on isotonisty 1

10 buffers 1

11 Buffers problems 1

13 Practical exam 1

14 Final Exam 12

15


5.1. Lectures using data show and white board

5.2. Discussion sessions and problem solving

5.3. Experimental work and laboratories



1. Written quiz exam to assess the ability of student to understand the course subjects

2. Written midterm exam to assess the ability of student to follow up the course subjects

3. Oral exam to assess the ability of student in expressing and presenting their

knowledge clearly in systemic approach

4. Practical exam Professional and practical skills

5. Written final exam to assess the overall outcomes


Assessment 1 Course work 5th week

Assessment 2 Mid term 7th weeks

Assessment 3 Practical exam 13th weeks

Assessment 4 Final exam 14th &15th weeks



Practical exam 25

Final-Term Exam 40

Oral 10

Total 100%

Faculty of Pharmacy


Delta University



25


No. Reference type

1. A.N. Martin. Physical Pharmacy, Lippincott Williams & Wilkins, 2012. textbook

2. Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design and manufacture

of medicines, 4th edition, Churchill Livingstone, 2013. textbook



week

ILOs

Knowledge

and

understanding

Intellectual

skills

Professional

and

practical

skills

General and

transferable

skills

1. Surface and interfacial

phenomena 1 a1 c2

2. Adsorption at liquid

surfaces 2 a1, a2 b1 c2

3 Adsorption at solid interface 3 a1, a2 b1 c 2

4 Adsorption at solid/liquid

interface 4 a1, a2 b1 c2

5 Rheology 5 c1

6

Flow characteristics of

Newtonian fluids and

viscosity

6 a1 b1 c1

8 Non Newtonian materials 8 a1 b1 c1

9

Rheology determination of

rheological properties

applications

9 a1 b1 c1

10. Buffers and buffering agent 10 a1 b1 c5 d1

11. Buffers and buffering agent 11 a1 b1 c5 d1

12 Solubility and related

phenomena 12,13 a1 b1 c3 d1

Name Signature

Course Coordinator: Dr. Rashad kaod

Head of Department: Prof. Ahmed TalaatNouh


Faculty of Pharmacy


Delta University



26

Biopharmaceutics and Pharmacokinetics


Course title: Biopharmaceutics and Basic Pharmacokinetics

Course code: PH 321



Faculty: Pharmacy


Academic level: 3rd level Spring Semester 2016- 2017


Prerequisite: Physical Pharmacy

Credit hours: Lecture: 2 hrs Practical: 1hr Total: 3hrs


2. Course Objectives:

Provide students with the theoretical basis and basic principles of pharmacokinetics. Define various

aspects concerning drug absorption, distribution and elimination in the body. Explore and reflect

on various parameters affecting drug bio-availability of drugs to correlate the dosage form of the

drug to its bioavailability. Determine the pharmacokinetics of drugs administered by different

routes



A8

a1 Define the basics and distinguish the terms biopharmaceutics, pharmacokinetics and

pharmacodynamics.

a2

Summarize the effects of various physicochemical, biochemical, physiological and

pathological processes on the kinetics and extent of drug absorption, distribution,

and elimination.

A9

a3 Manage pharmacokinetic parameters used in clinical pharmacokinetics using plasma

and urine drug level data.

a4 Recognize empirical pharmacokinetic models used to devise and optimize dosage

regimens.


B9 b1 Investigate the ways of drug absorption, distribution and elimination of some selected drugs

B10 b2 Estimate dosage and dosage regimen based on pharmacokinetic principles

b3 Predict time of administration regarding time of eating.

B20 b4 Predict and calculate pharmacokinetic parameters regarding bioavailability and

bioequivalence according to different pharmacokinetic models.

Faculty of Pharmacy


Delta University



27


C11

c1 Monitoring patient` medical conditions with his medications based on basic

pharmacokinetics

c2 Manage patient` dose according to his pathological state

c3 Conduct effectively with the patient to find out his problem with the medication

adherence.


D3 d1 Work effectively as a part of a team.

D4 d2 Collect and evaluate data in accordance with standard mathematical methods

D11 d3 Use reasonable solutions for solving problems based on phamakokinetic data.

4. Contents 4.1. Lectures

No. of

week

Topic No. of hours

1 1. Introduction to Pharmacokinetics.

2 2. Order of reaction and reaction rate.

2 3. Drug Kinetics Following an Intravenous bolus

dose

2

3

4. Drug Kinetics following a Single Oral Dose.

2

4 5. Bioavailability and Bioequivalence.

2

5 6. Steady State Principle and Drug Kinetics during

Constant-Rate Infusion.

2

6

7. Multiple Dosing and Dosage Regimens.

8. Metabolite and Urinary Excretion Kinetics.

9. Measurement of kidney function

2

7 Midterm -

8

Introduction to Bio-pharmaceutics

Factors affecting drug absorption after oral

administration

2

9

Mechanism of drug absorption

Absorption window

2 Quiz

10 Physiological factors affecting drug absorption

Drug transporters

2

Faculty of Pharmacy


Delta University



28

11

Physico-chemical factors affecting drug absorption

Drug dissolution techniques

Dosage form factors affecting drug absorption

2

12

Partition coefficient

Factors affecting Distribution

Kinetics of plasma protein binding

Plasma protein binding

2


14 Final written exams 24

15

4.2. Practical/Tutorial:

Week

No. Topics

No. of

hours

1. Introduction to bio pharmaceutics and Pharmacokinetics 1

2. Order of elimination kinetics and elimination rate.

First order versus zero order kinetics

1

3. Problems using Cartesian and semilog papers 1

4. Drug Kinetics Following an Intravenous bolus dose 1

5. Drug Kinetics Following an Intravenous bolus dose (Problems one

compartment)

1

6. Drug Kinetics following a Single Oral Dose. 1

7. Mid-Term exam --

8. Absorption rate constant by residual method 1

9. Bioavailability and Bioequivalence. 1

10. Steady State Principle and Drug Kinetics during Constant-Rate

Infusion.

1

11. Trapizoidal method for determination of AUC 1

12. Revision 1

13. Practical Exam 1

14. Final Exam

15. 12


5.1 Lectures

5.2 Class discussions

5.3 Tutorials

Faculty of Pharmacy


Delta University



29






confidence










Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference Type

1. Shargel L, Wu-Pong S, Yu A B C. Applied Biopharmaceutics

and Pharmacokinetics New York: Appleton & Lange

Reviews/McGraw-Hill. (2005).

Textbook

2. Winter M E. Basic Clinical Pharmacokinetics, 4th Ed.

Philadelphia: Lippincott Williams and Wilkins. (2003) Textbook

3. Mohsen A. Hedaya. Basic Pharmacokinetics, Second Edition

(Pharmacy Education Series) (Feb 9, 2012) Textbook

4. Wolfgang A. Ritschel and Gregory L. Kearns. Handbook of

Basic Pharmacokinetics. Including Clinical Applications. (Sep

30, 2009)

Textbook

Faculty of Pharmacy


Delta University



30



Week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1

Introduction to

Pharmacokinetics. 1

a1, a2 b1,b2 c1,c3 d1,d3

Order of reaction and

reaction rate. a3,a4 b1, b4 c1,c2 d2

2 Drug Kinetics Following

an Intravenous 2 a1, a3 b3 c2 d1,d2,d3

3

Drug Kinetics following

a Single Oral Dose. 3 a1, a4 b1,b3 c1-c3 d1,d2,d3

4 Bioavailability and

Bioequivalence. 4 a1 b1,b2,b3 c1,c2 d2

5

Steady State Principle

and Drug Kinetics

during Constant-Rate

Infusion.

5 a1 b2,b3 c1,c3 d2,d3

6

Multiple Dosing and

Dosage Regimens.

Metabolite and Urinary

Excretion Kinetics.

Measurement of kidney

function

6 a1,a3 b2,b4 c1 d1,d2

8

Introduction to

biopharmaceutics 8

a1 b1,b2,b3 c1,c3 d1,d3

Introduction to

biopharmaceutics a1,a3 b1 c1,c2,c3 d1

9 Mechanism of drug

absorption 9 a3 b3 c1,c2 d1,d3

10 Absorption window

10 a2 b2 c3 d1,d2,d3

11

Physiological factors

affecting drug

absorption 11 a1,a2,a3 b1,b4 c3 d2,d3

Drug transporters

Faculty of Pharmacy


Delta University



31

12

Physico-chemical factors

affecting drug

absorption 12 a1,a2 b1,b2,b3 c2,c3 d1, d3

Drug dissolution

techniques

13

Dosage form factors

affecting drug

absorption 13 a2,a3 b1, b4 c2,c3 d1,d2

Factors affecting

Distribution Kinetics of

plasma protein bindin

Name Signature

Course Coordinator: Dr. Mahmoud Mokhtar Ahmed

Head of Department: Dr. Ahmed Talat Ibrahim Nouh


Faculty of Pharmacy


Delta University



32

Drug Delivery Systems and Targeting


Course title: Drug delivery systems and Targeting

Course code: PH422



Faculty: Pharmacy


Academic level: 4th level Fall semester 2016/2017

Specialization: Pharmaceutical science.

Prerequisite: Pharmaceutics-1

Credit hours: Lecture: 2 Practical: Total: 2


2. Course aims:

On completion of the course, the student will be able to:

Describe the characters and formulation of drug delivery dosage forms.

Analyze the best method for preparation and determine the ideal character of each.



A6

a1 Illustrate the prosperities of active and inactive ingredients on the design of

different dosage forms

a2 Describe the characters and formulation of drug delivery dosage forms



B1 b1 Estimate the differences between methods of formulations for various controlled

and colloidal drug new delivery systems in a safe and effective way


C15 c1 Illustrate the basic concepts of controlled drug delivery and targeting

c2 Monitor the methods of development of colloidal carriers for targeting of drugs


D1 d1 Communicate effectively with patients and health care professionals

D3 d2 Work effectively as a part of a team

D4 d3 Collect and present data clearly in oral or written reports

Faculty of Pharmacy


Delta University



33

4. Contents:

No. Topic No. of hours

1. Controlled and modulated release drug delivery systems

(definition, advantages, disadvantages, theory, methods ) 2

2. -Colloidal drug delivery systems( Liposomes ) 2

3. -Therapeutic applications of liposomes. 2

4. -Advantages of proliposomes as a controlled release drug

delivery systems. 2

5. -Colloidal drug delivery systems( Niosomes )

Quiz 2

6. -Therapeutic applications of niosomes. 2

7. -Midterm exam. -

8. -Advantages of niosomes as controlled drug delivery systems. 2

9. -Different controlled release drug delivery systems. 2

10. -Nanoparticles as controlled drug delivery systems. 2

11. -Microemulsions. 2

12. -Controlled drug delivery systems" coated beads,

microencapsulation, complex formation, resonated drugs,.etc" 2

13. -Microspheres and microcapsules.

-Different types of microspheres. 2

14. Final exam -

15. Final exam 24


5.1. Lectures

5.2. Scientific report (Oral and written)





confidence




Assessment 2 Course work 5th week



Faculty of Pharmacy


Delta University



34


Mid-Term Exam and course work 25

Final-Term Exam 65

Oral Exam 10

Practical Exam -

Total 100%


No. Reference type

1.

Clive G. Wilson, Patrick J. Crowley. Controlled Release in

Oral Drug Delivery (Advances in Delivery Science and

Technology) , 425, 2011

textbook

2. Xiaoling Li. Design of Controlled Release Drug Delivery

Systems (McGraw-Hill Chemical Engineering) ,435, 2005 textbook

4. www.Pubmed.Com

www.sciencedirect.com Periodicals and website



week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1.

Controlled and modulated

release drug delivery systems

(definition, advantages,

disadvantages, theory, methods)

1 a1 b1 c1 d1,d2

2. -Colloidal drug delivery

systems( Liposomes ) 2 a1,a2 b1 c1-c2 d1,d2

3. -Therapeutic applications of

liposomes. 3 a1,a2 b1 c2 d3

4.

-Advantages of proliposomes as

a controlled release drug

delivery systems.

4 a2 b1 c1,c2 d1-d3

5. -Colloidal drug delivery

systems( Niosomes ) 5 a2 b1 c2 d2

http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&field-author=Clive%20G.%20Wilson&ie=UTF8&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_2?_encoding=UTF8&field-author=Patrick%20J.%20Crowley&ie=UTF8&search-alias=books&sort=relevancerank

http://www.pubmed.com/

http://www.sciencedirect.com/

Faculty of Pharmacy


Delta University



35

6.

-Therapeutic applications of

niosomes.

-Advantages of proniosomes as

controlled drug delivery

systems.

6 a2 b1 c1 d3

8. -Different controlled release

drug delivery systems. 8 a1 b1 c1,c2 d1

9. -Nanoparticles as controlled

drug delivery systems. 9 a2 c1,c2 d1-d3

10. -Microemulsions. 10 a1 b1 c1,c2 d1

11.

-Controlled drug delivery

systems" coated beads,

microencapsulation, complex

formation, resonated drugs,

.etc"

11 a2 b1 c1,c2 d1,d2

12. -Microspheres and

microcapsules. 12 a2 b1 c1,c2 d1-d3

13. -Different types of

microspheres. 13 a1, a2 b1 c1,c2 d2

Name Signature

Course Coordinator: Dr. Mahmoud Mokhtar

Head of Department: Prof. Ahmed Talat Nouh


Faculty of Pharmacy


Delta University



36

Pharmaceutical Technology-1

1. Basic Information

Course title: Pharmaceutical Technology-1

Course code: PH 431



Faculty: Pharmacy


Academic level: 4th level Spring Semester 2016-2017

Specialization: Pharmaceutical science

Prerequisite: None


Approval date: 11/ 02 / 2017


The course provides the students with the basic principles, concepts, and theories of various

unit operations related to pharmaceutical technology and energy consumption. The course

covers most of the equipment utilized in heat transfer, evaporation, drying and crystallization

to achieve the maximum outcomes and proper manufacturing. The course also covers how to

select the most suitable equipment for manufacturing certain drugs.




A7

a1 Describe the equipment design and operation.

a2 Identify the differences between various instruments to show the suitable one for

certain pharmaceutical operation.

a3 Enumerate factors affecting the unit operation process in manufacture of medicines.

a4 Describe the importance of each part of the instrument stressing on its significance

and the way of improving its function.


B2

b1 Justify good manufacturing practice (GMP) and good safety practice guidelines in

pharmaceutical technology.

b2 Apply the validation techniques for the manufacturing equipment, starting materials,

methods of manufacturing including semi-finished and finished products.

b3 Integrate the equipment to suit certain operations.

b4 Design the appropriate validation protocol for the equipment covered in the course.

Faculty of Pharmacy


Delta University



37


C4 c1 Utilize the studied equipment for different unit operations.

C8 c2

Analyze and perform experiments for certain unit operations to find out the proper

technique for pharmaceutically accepted production.

c3 Manage the different instruments of each unit operation.


D5

d1 Develop information technology skills dealing with different instruments.

d2 Use the animation programs of the computer to show the operational pattern of the

equipment.

4. Contents: 4.1. Lectures

Week Topic No. of Hours

1 -Introduction and definitions.

-Layouts for manufacture of pharmaceutical products.

10

2 Heat Transfer

1. Concept

2. Heat transfer equipment

3 A. Single pass heater

B. Multiple pass heater

C. Liquid-Liquid Heat Exchanger

4 Evaporation

1. Concept

2. Evaporation Equipment

A. Standard type

B. Long tube

C. Basket

5

6 Evaporation (cont.)

D. Forced Circulation

E. Film evaporators

3. Accessories

2

7 Midterm

8

Drying

1. Concept

2. Pscychometry

3. Equilibrium Moisture Contents

4. Drying behavior for materials

5. Equipment

2

Faculty of Pharmacy


Delta University



38

A. Drying of Solids

B. Drying of Suspension

Lyophilization

9 Crystallization

Concept -

Equipment-

2

10 - Fundamentals and concepts,

Crystallization (Theories)

- Factors affecting crystallization process

- Fractional Crystallization

2

11 Equipment-

1. Cooler Crystallizers

2. Evaporative Crystallizers

3. Vacuum Crystallizers

4. Cooler Crystallizers

5. Evaporative Crystallizers

Vacuum Crystallizers

2

12 Extraction

2


14 Written exam 24

15


Week

No. Topics

No. of

hours

1. Fundamentals to pharmaceutical technology parti 1

2. Fundamentals to pharmaceutical technology part ii 1

3. Heat transfer problems 1

4. Heat transfer problems 1

5 Evaporation problems 1

6 Evaporation problems 1

7 Mid-Term exam ---

8. Drying problems 1

9 Capsules 1

10 Capsules 1

11 Tablets 1

12. Tablets 1


14. Final Exam

15. 12

Faculty of Pharmacy


Delta University



39







confidence










Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference Type

1.

1. Lachman/Lieberman's. Theory and practice of industrial pharmacy. 4th ed.

(2013.(

2. Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design and

manufacture of medicines, 4th edition, Churchill Livingstone, 2013.

Textbook

5.1 Lectures

5.2 Class discussion, Drawing sketches

5.3 Lab Sessions

Faculty of Pharmacy


Delta University



40


No.

Course contents Study

week

ILOs

Lecture Practical knowledge and

Understanding

Intellectual

Skills

Professional and

Practical skills

General and

Transferable

skills

1. Heat Transfer Heat Transfer

Problems

1 a1 b1 , b2 c1 , c2 d1 , d2

2. Heat Transfer 2 a2 b1 , b2 d2

3. Heat Transfer 3 a2 b1 , b2 c1 , c3 d2

4. Evaporation

Evaporation

problems

4 a1, a2 b1 , b2 c1 , c3 d2

5. Evaporation

Quiz 5 a1, a2 b1,b4 c1 , c3 d2

6. Evaporation 6 a2 b1, b4 c1 , c3 d2

8. Drying Equipment 8 a2 b1 , b2 c1 , c2 , c3 d1 , d2

9. Crystallization Crystallization 9 a1, a2 b1 , b2 c1 d1 , d2

10. Crystallization

Crystallization

Equipment

10 a1, a2 b1 , b2 c1,c2 d1 , d2

11. Crystallization 11 a3, a4 b1 , b2 c2,c3 d1 , d2

12. Extraction Extraction

Equipment 12 a3, a4 b1 , b3 c3 d1 , d2

13. Extraction Practical exam 13 a1, a2 b1 , b3 c3 d1 , d2

Name Signature

Course Coordinator: Dr. Yasser Abd El Aleem

Head of Department: Prof. Ahmed Nouh


Faculty of Pharmacy


Delta University



41

Pharmaceutical Technology-2


Course title: Pharmaceutical Technology-2

Course code: PH 532



Faculty: Pharmacy


Academic level: 5th level Fall semester 2016/2017


Prerequisite: Pharmaceutical Technology-1




The course provides the students with the basic principles, concepts, and theories of various unit

operations related to particle size reduction, particle size enlargement, solid mixing, liquid

mixing, semisolid mixing, filtration and centrifugation. The course covers most of the equipment

utilized in particle size reduction, particle size enlargement, solid mixing, liquid mixing and

semisolid mixing, filtration, centrifugation to achieve the maximum outcomes and proper

manufacturing.




A7

a1 Describe the equipment design and operation.

a2 Identify the differences between various instruments to show the suitable one for

certain pharmaceutical operation.

a3 Enumerate factors affecting the unit operation process in manufacture of medicines.

a4 Describe the importance of each part of the instrument stressing on its significance

and the way of improving its function.



B2

b1 Interpret the concept and theory of different unit operations

b2 Select the most suitable equipment for certain operations.

b3 Design the appropriate protocol for manufacturing different dosage forms

Faculty of Pharmacy


Delta University



42



C4 c1 Utilize the studied equipment for different unit operations.

C8 c2

Analyze and perform experiments for certain unit operations to find out the proper

technique for pharmaceutically accepted production.

c3 Manage the different instruments of each unit operation.



D5

d1 Develop information technology skills dealing with different instruments.

d2 Use the animation programs of the computer to show the operational pattern of the

equipment.

4. Contents:

4.1. Lectures

Week Topic No. of Hours

1 Particle size reduction

Objectives of size reduction

Influence of material products on size reduction

Influence of size reduction on size distribution

Size reduction methods

12

2 Compression method (Roller mill)

Attrition methods (Roller mill)

Combined Attrition and Impaction methods (Pin mill &

Fluid energy mill)

Colloid mill

Selection of particle size reduction methods

3 Theory, concept, reasons and importance of size

enlargement

4 Equipment for dry and wet granulation

5 Size separation, importance and equipment

6 Theory, concept and importance of mixing

Mixing of liquids (Equipment)

7 Midterm exam ---

8 Mixing of solids and semisolids (Equipment)

2

9 Theory, concept and importance of filtration

2

Faculty of Pharmacy


Delta University



43

10 Equipment of filtration

2

11 Theory, concept and importance of centrifugation 2

12

equipment of centrifugation 2

13 Revision

2

14 & 15 Oral and Written Exam 24


Week

No. Topics

No. of

hours

1. Equipment

Powder angle of repose 1

2. Equipment


3. Equipment


4. Car`s Index, Equipment 1



7. Mid-Term exam --

8. Mixing Equipment 1

9.

Size Enlargement Equipment 1

10. Extraction Equipment 1

11. Extraction Equipment 1

12. Particle size Separation 1

13. Practical Exam 1

14. Final Exam

15. 12


5.1 Lectures

5.2 Class discussion, Drawing sketches

5.3 Practical Classes

Faculty of Pharmacy


Delta University



44






confidence









Assessment 1 Mid-term 15%

Assessment 2 Quiz 10%

Assessment 3 Practical 25%

Assessment 4 Oral 10%

Assessment 5 Written 40%


No. Reference Type

1. Lachman/Lieberman's. Theory and practice of industrial pharmacy. 4th ed.

(2013). Textbook

2. Michael E. Aulton, Kevin G Taylor. Pharmaceutics, the design and

manufacture of medicines, 4th edition, Churchill Livingstone (2013). Textbook

Faculty of Pharmacy


Delta University



45



Week

ILOs

Lecture Practical knowledge and

Understanding

Intellectual

Skills

Professional and

Practical skills

General and

Transferable skills

1.

Concepts of

Industrial

Plarmacy

Concepts and

definitions

Pharmacists in

industry (role and

activities).

Particle size

reduction

Objectives of size

reduction

Influence of

material products

on size reduction

Influence of size

reduction on size

distribution

Size reduction

methods

Equipment

Powder angle of

repose

1 a1 b1 , b2 c1 , c2 d1 , d2

2.

Compression

method (Roller

mill)

Attrition methods

(Roller mill)

Combined

Attrition and

Impaction

methods (Pin mill

& Fluid energy

mill)

Colloid mill

Selection of

particle size

reduction

methods

2 a2 b1 , b2,b3 d2

Faculty of Pharmacy


Delta University



46

3.

Concepts of

Industrial

Plarmacy

Concepts and

definitions

Pharmacists in

industry (role and

activities).

Particle size

reduction

Objectives of size

reduction

Influence of

material products

on size reduction

Influence of size

reduction on size

distribution

Size reduction

methods

3 a2 b1 , b2 c1 , c3 d2

4.

Particle size

separation

Size separation

methods (sieving

– fluid

classifications)

Car`s Index,

Equipment

4 a1 , a2 b1 , b2 ,b3 c1 , c3 d2

5.

Elutriation

methods

Cyclon method

Selection of size

separation

process

Quiz

5 a1 , a2 b1 c1 , c3 d2

6.

Mixing

The importance

of mixing

The mixing

process

Tumbling

mixers-blenders

Agitator mixer

6 a1, a3 b1 , b3 c1 , c3 d2

Faculty of Pharmacy


Delta University



47

7. Midterm Exam

8.

Mixing of

miscible liquids

and suspensions

Mixing of

semisolids

Equipment 8 a1 , a2 b1 , b2 ,b3 c1 , c2 , c3 d1 , d2

9. Size Enlargement

Reasons of

granulations

Methods of

granulations

Granulation

mechanisms

Pharmaceutical

granulation

Equipment

9 a1 , a2 b1 , b2 c1 , c2 , c3 d1 , d2

10. 10 a1 , a2 b1 , b2,b3 d1 , d2

11.

Dry granulation Equipment

11

a1, a2, a3,

a4 b1, b3 c3 d1, d2

12. 12

13. revision

Practical Exam

Name Signature

Course Coordinator: Dr: YaserAbd El aleem

Head of Department: Prof. Ahmed Nouh


Faculty of Pharmacy


Delta University



48

Radiopharmaceutics 1. Basic Information:

Course title: Radiopharmaceutics

Course code: PH 521



Faculty: Pharmacy


Academic level: 5th level Spring semester 2016/2017


Prerequisite: N/A

Credit hours: 2 Practical: n/a Total:2


2. Course Aims:

Understanding definition, uses and danger of radiopharmaceuticals. In addition to increasing the

skills of nuclear pharmacists.




A2

a1 Describe the radioisotopes and radiopharmaceuticals

a2 Define the characteristics of ideal isotopes in medical field and how they are

produced

A6 a3 Describe the different aseptic manufacturing processes for radiopharmaceuticals.



B1 b1 Design and plan for quality control in Nuclear Medicine Department.

b2 Formulate guidelines for nuclear pharmacy practice.

B4 b3 Share in designing guidelines for proper sewage disposal in a Nuclear Medicine

Departments.



C2 c1 Validate and conduct quality control tests of sterile dosage forms.

c2 Perform experiments to differentiate between different types preparations.

C13 c3 Utilize different methods for preparation of sterile radiopharmaceuticals

Faculty of Pharmacy


Delta University



49



D10 d1 Write a report concerning topics of the course

d2 Discuss and present reports in the class related to the course topics.

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction to radioisotopes 2

2. Production of isotopes 2

3. Introduction to radiopharmaceuticals 2

4. Production of and types of official radiopharmaceuticals 2

5. Hazards and quality control 2

6. Sterilization 2

7. Mid-Term exam ---

8. Applications in disease treatment (Part I) 2

9. Applications in disease treatment (Part I) continue 2

10. Applications in diagnosis PartII) 2

11. Applications in diagnosis (PartIII) 2

12. Applications in pharmaceutical research 2

13. Revision 2

14. Final Exam

15. 24


Week No. Topics No. of

hours

1. N/A


5.1. Lectures with data show

5.2. Class discussion





Faculty of Pharmacy


Delta University



50

3. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence


confidence


5. Case study to assess the skills of problem-solving and data presentation






Mid-Term Exam & course work 25%

Final-Term Exam 65%

Oral Exam 10%

Total 100%


No. Reference type

1. G.S. Banker, C.T. Rohdes. Modern Pharmaceutics, 4th Edition,

Marcel Dekker, Inc textbook

2. Howard C. Ansel. Pharmaceutical Calculation, Lippincott,

Williams and Wilkins (14th edition), 2013. textbook

3

Mark Shumate, kooby DA, Alazrak NP. A clinician’s Guide to

nuclear oncology: Practical molecular imaging and

Radionuclide therapies. Society of nuclear medicine, 2007,

ISBN 978-0- 972647-8-5

textbook

4

Taylor A, Schuster DM, Naomi Alazrak NP : A clinician’s

Guide to nuclear medicine, 2nd edition, Society of nuclear

medicine, 2000, ISBN 978-0-932004-72-7

textbook



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Introduction to

radioisotopes 1 a1, a2 b1 c1 d1

2. Production of isotopes 2 a3 b2 c2 d1

Faculty of Pharmacy


Delta University



51

3. Introduction to

radiopharmaceuticals 3 a1, a2 b1 c2 d1

4.

Production of and types of

official

radiopharmaceuticals

4 a3 b3 c3 d1

5. Hazards and quality control 5 a1 b3 c3 d1

6 Sterilization 6 a2 b2 c1, c3

7.

Applications in medicine,

agriculture ,and

industry(part 1)

8 a2 b2 c3 d1

8


agriculture ,and

industry(part 1) continue

9 a2 b2 c3 d1

9.


agriculture ,and

industry(part I1)

10 a2 b2 c3 d2

10.


agriculture ,and

industry(part I1I)

11 a2 b2 c3 d2

11.


agriculture ,and

industry(part I1I) continue

12 a2 b2 c3 d2

12. Revision 13

Name Signature

Course Coordinator: Dr. Amal Ahmed Fouad Halim

Head of Department: Prof Dr Ahmed Nouh

Approval Date 11-2-2017

Documents

Courses Specificationsdeltauniv.edu.eg/.../2.-Pharmaceutics-Courses-Specs.pdfFaculty of Pharmacy Courses Specifications Fall and Spring (2016/2017) Delta University for Science and