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7/27/2019 Introduction Pharmaceutics
1/9
Dosage Fo
Formulation
m Design:
onsiderations
VJ
7/27/2019 Introduction Pharmaceutics
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Dosage F
Pharmaceutics
-study on the: formulation, manufactur
Pharmaceutical ingredients or excipi
-Selective use of these non medicinal agents
- Uses
solubilize thicken stabilize flavor
suspend dilute preserve efficacious
emulsify color appealing closure forms
orm Design
, stability,
nts
.
7/27/2019 Introduction Pharmaceutics
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Requirements of
formulation oConsideration of drug substances:
Ph sical chemical & biolo ical chara
*compatible with one another - stable,
& safe
*manufactured under appropriate meas
containers to make product stable
*labeled to promote correct use & store
life
proper design &
dosage form
teristics
fficacious, attractive, easy to administer
res of quality control & packaged in
d under conditions to maximize shell
7/27/2019 Introduction Pharmaceutics
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The Need for
To protect the drug substanceatmospheric oxygen or humidity.
To protect the drug substancegastric acid after oral administrat
osage Forms
from the destructive influences of(Coated tablets)
from the destructive influence ofion. (Enteric-coated)
7/27/2019 Introduction Pharmaceutics
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The Need for
To conceal the bitter, salty orsubstance. (Capsules, Flavored
To provide liquid preparationsinsoluble or unstable in the desir
osage Forms
ffensive taste or odor of a drug
syrups)
of substances that are eitherd vehicle. (Suspension
7/27/2019 Introduction Pharmaceutics
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The Need for
To provide clear liquid dosagSolutions)
To provide rate-controlled dtablets)
To provide optimal drug action(Ointments,Creams, Transder
osage Forms
forms of substances. (Syrups,
ug action. (Controlled-release
from topical administration sites.al patches)
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The Need for
To provide for insertion of a dr(Suppositories)
To provide placement of drugbody tissues (Injections)
To provide for optimal drug a
(Inhalants, Inhalation aeros
osage Forms
g into one of the bodys orifices
s directly in the bloodstream or
tion through inhalation therapy
ls)
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General Considerations
Determine desired product t
produ
develop and examine initial
product:
- desired features: drug releclinical
- pilot plant studies and pro
in Dosage Form Design
ype - framework for
t development.
ormulations of the
se profile bioavailabilityeffectiveness
duction scale-up.
7/27/2019 Introduction Pharmaceutics
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master formula
formulation that best meets the goals of
Factors to consider before formulation of
forms Therapeutic matters (nature of the
manner it is treated (locally or thr
age and anticipated condition of t
he product
a medicinal agent in one or more dosage
illness)
ugh systemic action)
e patient.