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Copyright © 2009 Pearson Education, Inc.
Genomics, Bioinformatics, and Proteomics
Chapter 21 Lecture
Concepts of GeneticsTenth Edition
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
Copyright © 2009 Pearson Education, Inc. Figure 21.1
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
21.1.1 High-Throughput Sequencing
Copyright © 2009 Pearson Education, Inc. Figure 21.2
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
21.1.2 The Clone-by-Clone Approach
21.1.3 Draft Sequences and Checking for Errors
Copyright © 2009 Pearson Education, Inc. Figure 21.3
Copyright © 2009 Pearson Education, Inc.
21.2 DNA Sequence Analysis Relies on Bioinformatics Applications and Genome Databases
21.2.1 Annotation to Identify Gene Sequences
21.2.2 Hallmark Characteristics of a Gene Sequence Can Be Recognized During Annotation
Copyright © 2009 Pearson Education, Inc. Figure 21.4
Copyright © 2009 Pearson Education, Inc. Figure 21.5
Copyright © 2009 Pearson Education, Inc. Figure 21.6a
Copyright © 2009 Pearson Education, Inc. Figure 21.6b
Copyright © 2009 Pearson Education, Inc. Figure 21.6c
Copyright © 2009 Pearson Education, Inc. Figure 21.7
Copyright © 2009 Pearson Education, Inc.
21.3 Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome
21.3.1 Predicting Gene and Protein Functions by Sequence Analysis
Copyright © 2009 Pearson Education, Inc. Figure 21.8
Copyright © 2009 Pearson Education, Inc. Figure 21.9
Copyright © 2009 Pearson Education, Inc.
21.3 Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome
21.3.2 Predicting Function from Structural Analysis of Protein Domains and Motifs
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21.4 The Human Genome Project Revealed Many Important Aspects of Genome Organization in Humans
21.4.1 Origins of the Project
21.4.2 Major Features of the Human Genome
Copyright © 2009 Pearson Education, Inc.
© 2012 Pearson Education, Inc. Table 21.1
© 2012 Pearson Education, Inc. Table 21.1
Copyright © 2009 Pearson Education, Inc.
Copyright © 2009 Pearson Education, Inc. Figure 21.11
Copyright © 2009 Pearson Education, Inc. Figure 21.12a
Copyright © 2009 Pearson Education, Inc. Figure 21.12b
Copyright © 2009 Pearson Education, Inc.
21.5 The “Omics” Revolution Has Created a New Era of Biological Research Methods
© 2012 Pearson Education, Inc. Figure 21.13
© 2012 Pearson Education, Inc.
Personal Genomics
The Human Microbiome Project
No Genome Left Behind—10K genomes in 5 years
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21.6 Comparative Genomics Analyzes and Compares Genomes from Different Organisms
Copyright © 2009 Pearson Education, Inc. Table 21.2
Copyright © 2009 Pearson Education, Inc. Table 21.3
Copyright © 2009 Pearson Education, Inc. Figure 21.12
© 2012 Pearson Education, Inc. Table 21.3
Copyright © 2009 Pearson Education, Inc.Figure 20-8 Copyright © 2006 Pearson Prentice Hall, Inc.
Copyright © 2009 Pearson Education, Inc. Figure 21.15
Copyright © 2009 Pearson Education, Inc. Table 21.4
Copyright © 2009 Pearson Education, Inc.
21.6 Comparative Genomics Analyzes and Compares Genomes from Different Organisms
The Rhesus Monkey Genome
The Sea Urchin Genome
The Neanderthal Genome
Evolution of Multigene Families
Copyright © 2009 Pearson Education, Inc. Figure 21.16
Copyright © 2009 Pearson Education, Inc. Figure 21.17
Copyright © 2009 Pearson Education, Inc. Figure 21.18
Copyright © 2009 Pearson Education, Inc.
21.8 Transcriptome Analysis Reveals Profiles of Expressed Genes in Cells and Tissues
Copyright © 2009 Pearson Education, Inc. Figure 21.21
Copyright © 2009 Pearson Education, Inc. Figure 21.22
Copyright © 2009 Pearson Education, Inc. Figure 21.22a
Copyright © 2009 Pearson Education, Inc. Figure 21.22b
Copyright © 2009 Pearson Education, Inc.
21.9 Proteomics Identifies and Analyzes the Protein Composition of Cells
Reconciling the Number of Genes and the Number of Proteins Expressed by a Cell or Tissue
Proteomics Technologies: Two-Dimensional Gel Electrophoresis for Separating Proteins
Copyright © 2009 Pearson Education, Inc. Figure 21.24
Copyright © 2009 Pearson Education, Inc. Figure 21.25
Copyright © 2009 Pearson Education, Inc.
21.9 Proteomics Identifies and Analyzes the Protein Composition of Cells
Proteomics Technologies: Mass Spectrometry for Protein Identification
Copyright © 2009 Pearson Education, Inc. Figure 21.26
Copyright © 2009 Pearson Education, Inc. Figure 21.27
Copyright © 2009 Pearson Education, Inc.
21.10 Systems Biology Is an Integrated Approach to Studying Interactions of All Components of an Organism’s Cells
© 2012 Pearson Education, Inc. Figure 21.29
