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Brain Mechanisms in Memory Engram: physical representation of memory in brain Karl Lashley (1929)- earliest psychologists to study Believed memory stored in association cortex Performed series of lesion Deficit related to size of lesion, not location His conclusion: equipotentiality
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Copyright © 2009 Allyn & Bacon
How Your Brain Stores Information
Chapter 11Learning, Memory, and Amnesia
Studying Memory Neuroscientists
Psychophysiologists Behavioral Paradigms
Morris Water Maze
Copyright © 2009 Allyn & Bacon
Copyright © 2009 Allyn & Bacon
Brain Mechanisms in Memory Engram: physical representation of
memory in brain Karl Lashley (1929)- earliest
psychologists to study Believed memory stored in association
cortex Performed series of lesion Deficit related to size of lesion, not location His conclusion: equipotentiality
Generally accepted
Copyright © 2009 Allyn & Bacon
Copyright © 2009 Allyn & Bacon
Localization of Memory Penfield (1958)-stimulation in parts of
temporal lobe produced specific memories in human patients; flawed because could’ve been related to seizures
Sparked interest in Temporal lobes in role of formation and retention of long-term memories
Copyright © 2009 Allyn & Bacon
Temporal lobe and Memory Patients w/ anterograde amnesia (deficit
in ability to form NEW memories) Case Study: HM
Accident led to seizures bilaterial removal of temp lobes (hippo, amygdala, & some assoc cortex)
Seizures improved; IQ, personality, skills unchanged, earlier memories intact
Suffered anterograde amnesia
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Amnesic Effects of Bilateral Medial Temporal Lobectomy H.M. – an epileptic who had his
temporal lobes removed in 1953 His seizures were dramatically reduced
– but so was his long-term memory Mild retrograde amnesia and severe
anterograde amnesia
Copyright © 2009 Allyn & Bacon
Tissues typically
excised in medial
temporal lobectomy
Copyright © 2009 Allyn & Bacon
Copyright © 2009 Allyn & Bacon
Conclusions from HM studies Aspects of memory managed by diff
parts of brain Damage to medial temp lobesaffects
explicit NOT implicit memories Not affect LTM, but does affect transfer
of STM to LTM
Copyright © 2009 Allyn & Bacon
Amnesia Retrograde (backward-acting) – unable
to remember the past Anterograde (forward-acting) – unable
to form new memories While H.M. is unable to form most types
of new long-term memories (LTM), his short-term memory (STM) is intact
Copyright © 2009 Allyn & Bacon
Where Are Memories Stored?Each memory is stored diffusely throughout
the brain structures that were involved in its formation
Hippocampus – spatial location Perirhinal cortex – object recognition Mediodorsal nucleus – Korsakoff’s Basal forebrain – Alzheimer’s disease
Copyright © 2009 Allyn & Bacon
Where Are Memories Stored? (continued)
Damage to a variety of structures results in memory deficits
Inferotemporal cortex – visual perception of objects – changes in activity seen with visual recall
Amygdala – processes emotional memories
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Where Are Memories Stored? (continued)
Damage to a variety of structures results in memory deficits (continued)
Prefrontal cortex Temporal order of events and working
memory Different part of prefrontal cortex may mediate
different types of working memory – some evidence from functional brain imaging studies
Copyright © 2009 Allyn & Bacon
Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability.... When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased.
Copyright © 2009 Allyn & Bacon
Synaptic Mechanisms of Learning and Memory
What is happening within the brain structures involved in memory? Hebb – changes in synaptic efficiency are the
basis of LTM Repeated stimulation of neural circuits
Long-term potentiation (LTP) – synapses are effectively made stronger by repeated stimulation
Copyright © 2009 Allyn & Bacon
Long-term Potentiation (LTP) Rapid series of electrical shocks to hippo
pathway increases PSPs in target cells. Experience makes these synapses more
efficient Change in responsiveness in target cells
called LTP Memories are thought to be encoded by
modification of synaptic strength
Enhancement in signal transmission between two neurons that results from stimulating them synchroniously
Enhanced communication between pre- and post synaptic neuronsimprovement in postsyn. To receive signals from pre Increasing activity of receptors and number of
receptors
Copyright © 2009 Allyn & Bacon
Copyright © 2009 Allyn & Bacon
Long-Term Potentiation (LTP) LTP is consistent with the synaptic
changes hypothesized by Hebb LTP can last for many weeks LTP only occurs if presynaptic firing is
followed by postsynaptic firing Hebb’s postulate for learning
Co-occurrence of firings in pre- and postsynaptic neurons necessary for learning and memory
Copyright © 2009 Allyn & Bacon
LTP as a Neural Mechanism of Learning and Memory
Elicited by high frequency electrical stimulation of presynaptic neuron; mimics normal neural activity
LTP effects are greatest in brain areas involved in learning and memory
Copyright © 2009 Allyn & Bacon
Structural Changes from LTP Increase in number and size of
synapses Increase in number and size of
postsynaptic spines Changes in the pre-and post-synaptic
membranes
Durbach (2000) Two changes in brain 1) Internal structure of neurons around
area of synapse 2)Increase in number of synapses
between neurons
Copyright © 2009 Allyn & Bacon
Next Class
Copyright © 2009 Allyn & Bacon
Stress and the Brain