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Collaboration Opportunities
in 3D Printing
A/Prof Tim Sercombe
Head
School of Mechanical and Chemical Engineering,
The University of Western Australia
Faculty of Medicine, Dentistry and Health Sciences
UWA Research Week
Overview
• What is 3D Printing
• Real 3D Printing applications
• Some of our research
• The world of bio printing
• Get involved
Selection of 3D Printed parts produced at UWA
What is 3D Printing
• Correct term is additive manufacturing (AM)
• Generic term to cover a range of technologies.
• One common trait: all are layer-wise, additive manufacturing techniques that to build up parts in small material increments called voxels (i.e. volume elements).
• Geometric complexity far beyond conventional manufacturing – “complexity for free”
• Two parts can be built slight differently (i.e. customised) for almost no cost penalty
Load and resource optimized wheel bearing
manufactured using selective laser melting.
Source: fraunhofer.de
Topology optimised isotropic scaffold V.J. Challis, et al . Advanced Engineering Materials,
2010. 12(11): p. 1106-1110.
Custom acetabular cup
design that combines solid
and porous areas in one part. Source: fraunhofer.de
The Bad
Sydney Morning Herald
11/11/13
News.com.au
3/4/13
The Ugly
3D Printed Dress
http://www.irisvanherpen.com/ 3D Printed “hat"
http://sensoree.com/
Your very own 3D Printed Family from
3D scans
Source: own photo
3D Printing in the Body
• Collaborations between Engineering, Science
and Medicine has resulted in 3D printed parts
becoming more and more wide spread
• Mostly one-off customised orthopaedic
implant (“hard” devices)
• More recently, emerging area of producing
“soft” implants
Co-Cr dental crowns produced at UWA
Porous Ti mandible produced at UWA
CSIRO new blog, Oct 21, 2014
CSIRO produces replacement
heel for cancer patient
Oxford Performance
Materials uses 3DP to
produce cranial implant
Stryker 3DP standard implant
• Reduced cost
• Integration of porous
structures for biological
fixation
Conformis
Knee implants customised to
each patient – no two are alike • Improved alignment
• Less bone removed
• Reduced surgery times
• Improved recovery and outcomes.
3D Printed Ti acetabular cup
designed by RPH
Replacement hip produced
using 3D Printed Ti in China
3D Printing Equipment at UWA
Ultimaker 2
Realizer SLM100
Formlabs SLA
• Low cost printers
– Ultimaker 2 FDM
– Formlabs SLA
• Metal Printer
– Realizer SLM100
• Bioprinters
– Fab@Home 3: Dual Syringe
– Biobots Single Syringe
Fab@Home 3
Biobots
Research at UWA
• Current Ti implant materials are much stiffer than the bone it
replaces => stress shielding
0
20
40
60
80
100
120
Ti Ti 2448 Bone
Yo
un
g's
Mo
du
lus (
GP
a) Ti ~110 GPa
Cortical bone
10-30 GPa
Research at UWA
• Next generation of low modulus Ti alloys (eg Ti2448) are approx. half
conventional Ti.
0
20
40
60
80
100
120
Ti Ti 2448 Bone
Yo
un
g's
Mo
du
lus (
GP
a) Ti ~110 GPa
Cortical bone
10-30 GPa
Ti2448
50-60 GPa
0
20
40
60
80
100
120
0 20 40 60 80 100 120
Yo
un
g's
Mo
du
lus (
GP
a)
Density (%)
Conv. Ti
Low Modulus Ti
(Ti2448)
Research at UWA
• Still too high, but much closer
• Stiffness can be reduced by introducing porosity
• Ti2448 requires less porosity and therefore will have higher strength
Density for E = 10 – 30 GPa
• Conv. Ti = 25-50%
• Ti2448 = 40-70%
High Strength/Stiffness to
Weight Structures
0
1
2
3
4
5
6
7
8
9
10
0.00 0.50 1.00 1.50
Mo
du
lus
(G
Pa
)
Density (g/cm3)
Theoretical -
Optimised
SLM or EBM Ti Alporas
Ti foams
0
10
20
30
40
50
60
70
80
0 0.5 1
Co
mp
res
siv
e S
tre
ng
th (
MP
a)
Density (g/cm3)
Optimised
Gyroid
SLM or EBM Ti
Ti
foa
ms
Topology Optimised Gyroid
Next Steps/Collaboration
Opportunities
• Ti2448 is a relatively new alloy and some information is
known about its biological response
• But not in porous parts made using SLM.
• So we need to understand
– The difference in in vitro and in vivo response of Ti2448 against
conventional Ti alloys
– What is the effect of pore size and shape?
– How does the SLM processing (esp the rough surface) affects its
biological properties.
Bioprinting –the future of 3DP?
• What is bioprinting?
– The use of 3D Printing technologies to produce spatially-
controlled cell patterns where the cell function and viability is
preserved.
• What will it do?
– Provides a potential route to
produce replacement organs
– While the printing of large groups
of cells is possible, there is a
quantum leap from this to a fully
functioning organ.
New 3D Bioprinter with dual syringe delivery
3D Bioprinting Principle
• Harvest small amount of cells
• Cultivate/multiply them over a
period of days/weeks/months
while maintaining sterility
• Encapsulate cells into carrier
• Print scaffold while maintaining
optimum cell conditions and
minimal stress.
• Multiple syringes allows different
materials and/or cells to be
placed in very specific locations.
What’s being done in the area?
www.adafruit.com
Skin
US Army, Wakefield Forest
University, University of Toronto.
Aim is to print directly onto wounds
Organovo, Inc. (organovo.com)
First liver tissue printed (Jan ‘14)
Now commercially available (Nov ’14
www.3ders.org
Liver
Breast Cancer
TeVido BioDevices: Bioprints custom
grafts for breast cancer reconstructions
Bone
University of Sydney, Harvard-MIT,
University of Tokyo
University of Louisville: “A
whole heart within a decade!”
Cornell University
Heart Valves and Vessels
Initial Efforts at UWA
Need a really good seal
www.ciccenters.com
Two main problems with current devices: 1. Poor seal at top = device slippage and leaks 2. Leaks develop through the device = aneurysm
sac remains pressurised leaks
We previously created ECM aortic stent-graft scaffolds which remained patent in a porcine model
Davis et al. J Biomed Mater Res Part B 2014;102:89-97
Can we improve on this with bioprinting?
blo
od
flo
w
Aortic Aneurysm Stent-Grafts
Tympanoplasty – Replacement Eardrums
entkidsadults.com
real-i-d.net.com
ESIA and Deakin University are using silk to create a new typanic membranes
Silk is dissolved and cast into a thin membrane (30-90 μm)
http://www.deakin.edu.au/research/stories/2013/06/24/a-different-drum
Can we bioprint an alternative?