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© Copyright 2009 American Health Information Management Association. All rights reserved.
Coding for Hematology
Audio Seminar/Webinar April 2, 2009
Practical Tools for Seminar Learning
Disclaimer
AHIMA 2009 Audio Seminar Series • http://campus.ahima.org/audio American Health Information Management Association • 233 N. Michigan Ave., 21st Floor, Chicago, Illinois
i
The American Health Information Management Association makes no representation or guarantee with respect to the contents herein and specifically disclaims any implied guarantee of suitability for any specific purpose. AHIMA has no liability or responsibility to any person or entity with respect to any loss or damage caused by the use of this audio seminar, including but not limited to any loss of revenue, interruption of service, loss of business, or indirect damages resulting from the use of this program. AHIMA makes no guarantee that the use of this program will prevent differences of opinion or disputes with Medicare or other third party payers as to the amount that will be paid to providers of service.
CPT® five digit codes, nomenclature, and other data are copyright 2009 American Medical Association. All Rights Reserved. No fee schedules, basic units, relative values or related listings are included in CPT. The AMA assumes no liability for the data contained herein.
As a provider of continuing education the American Health Information Management Association (AHIMA) must assure balance, independence, objectivity and scientific rigor in all of its endeavors. AHIMA is solely responsible for control of program objectives and content and the selection of presenters. All speakers and planning committee members are expected to disclose to the audience: (1) any significant financial interest or other relationships with the manufacturer(s) or provider(s) of any commercial product(s) or services(s) discussed in an educational presentation; (2) any significant financial interest or other relationship with any companies providing commercial support for the activity; and (3) if the presentation will include discussion of investigational or unlabeled uses of a product. The intent of this requirement is not to prevent a speaker with commercial affiliations from presenting, but rather to provide the participants with information from which they may make their own judgments.
The faculty has reported no vested interests or disclosures regarding this presentation.
Faculty
AHIMA 2009 Audio Seminar Series ii
Robert S. Gold, MD
Dr. Gold is founder and CEO of DCBA, Inc., a consulting firm that provides physician-to-physician clinical documentation improvement programs (CDIP), as well as audit and education services to healthcare organizations. Dr. Gold has over 42 years of experience as a physician, medical director, and consultant. He is also a frequent speaker on clinical data quality, coding, and compliance issues for AHIMA and other organizations.
Table of Contents
AHIMA 2009 Audio Seminar Series
Disclaimer ..................................................................................................................... i Faculty ......................................................................................................................... ii Objectives ..................................................................................................................... 1 Agenda ........................................................................................................................ 1 Concepts and Definitions Clinically Speaking… Conundrum: Myel/Myelo- ...................................................... 2 Blood Cell Lines .................................................................................................. 2 Peripheral Blood and Bone Marrow Diagram ......................................................... 3 Peripheral Blood and Bone Marrow ...................................................................... 3 Get to Know Your Blood Cells .............................................................................. 4 Hematology Tests: Reference Value Examples ...................................................... 4 Get to Know Your Blood Cells .............................................................................. 5 WBC Differentials and “Shifts” ............................................................................. 5 Red Cells Common Anemia Codes ...................................................................................... 6 Subcategory 285.2x, Anemia in Chronic Illnesses .................................................. 6 Anemia Designations .......................................................................................... 7 Coding Clinic References ..................................................................................... 7 Myelodysplastic Conditions Myeloproliferative Disorders ................................................................................ 8 Coding Perspective and DRG Assignment ........................................................... 8-9 Blood Cell Lines .............................................................................................. 9-10 Coding Perspective and DRG Assignment ........................................................ 10-11 White Cells Blood Cell Lines ................................................................................................. 11 Rationale & Clinical Insight ................................................................................. 12 Coding Perspective and DRG Assignment ............................................................. 12 Blood Cell Lines ................................................................................................. 13 Rationale & Clinical Insight ................................................................................. 13 Coding Perspective and DRG Assignment ............................................................. 14 Neutropenias .................................................................................................... 14 Blood Cell Lines ................................................................................................. 15 Coding Perspective and DRG Assignment ............................................................. 15 Leukemoid Reaction – 288.62 ............................................................................. 16 Other –osis ....................................................................................................... 16 Blood Cell Lines ................................................................................................. 17 Clinical Insight .................................................................................................. 17 Platelets Primary Thrombocytopenia ................................................................................. 18 Thrombocytes (platelets) ................................................................................... 18 Rationale .......................................................................................................... 19
(CONTINUED)
Table of Contents
AHIMA 2009 Audio Seminar Series
Clinical Aspects Platelets and Platelet Deficiencies ................................................ 19 The Primary Thrombocytopenias ......................................................................... 20 Chapter 4 Diseases of the Blood and Blood-Forming Organs (280-289) .................. 21
Lymphomas Lymphoma Current Status .................................................................................. 22 Lymphatic Cell Lines .......................................................................................... 22 Clinical Perspective REAL .................................................................................... 23 Mature B-Cell Tumors (NHL) .......................................................................... 23-24 Mature T-Cell and Natural Killer Cell Tumors (NHL).......................................... 24-25 Hodgkin’s Lymphoma ......................................................................................... 25 Immunodeficiency-Associated Lymphoproliferative Disorders ................................. 26 Histiocytic and Dendritic Cell Neoplasms (CNS) .................................................... 26 Classification by Immunologic Subtype and Aggressiveness ................................... 27 Our Newer Subdivisions (2007) ........................................................................... 27 Leukemias Leukemias (204 – 208 series) ............................................................................. 28 Maturation in the Bone Marrow ........................................................................... 28 Leukemias ........................................................................................................ 29 Other Hematologic Conditions Code series 289.8x ............................................................................................ 29 Hypercoagulable States ...................................................................................... 30 Coding – Primary Hypercoagulable State (289.81) ................................................ 30 Coding – Secondary Hypercoagulable State (289.82) ............................................ 31 Coding – HIT – Heparin-Induced Thrombocytopenia (289.84) ............................... 31 Coding Clinic Reference ..................................................................................... 32 Bone Marrow Procedures Procedure Issues in Hematology ......................................................................... 32 CPT® Assistant Reference .................................................................................. 33 Bone Marrow Aspiration (38220) ......................................................................... 33 Procedure : Bone Marrow Aspiration ................................................................... 34 Bone Marrow Biopsy (38221) .............................................................................. 34 Procedure : Bone Marrow Biopsy ........................................................................ 35 Bone Marrow Aspiration (38220) vs. Biopsy (38221) ............................................. 35 Resource/Reference List ................................................................................................ 36 Audio Seminar Discussion .............................................................................................. 36 Become an AHIMA Member Today! ................................................................................. 37 Audio Seminar Information Online .................................................................................. 37 Upcoming Audio Seminars ............................................................................................ 38 Thank You/Evaluation Form and CE Certificate (Web Address) .......................................... 38 Appendix .................................................................................................................. 39 Resource/Reference List ....................................................................................... 40 CE Certificate Instructions
Coding for Hematology
AHIMA 2009 Audio Seminar Series 1
Notes/Comments/Questions
Objectives
Identify various hematological disorders and applicable ICD-9-CM diagnostic codesReview relevant AHA Coding Clinic references and clinical documentation practices to support accurate hematology codingReview bone marrow procedures and related code assignments
1
Agenda
Overview of blood cell linesAnemiaMyelodysplastic diseaseNeutropeniaLeukemoid reactionThrombocytopeniaHematologic neoplasmsHypercoagulable states
2
Coding for Hematology
AHIMA 2009 Audio Seminar Series 2
Notes/Comments/Questions
Clinically Speaking... Conundrum: Myel/Myelo-
Myel/Myelo-“Myel,” as in “myelitis” or
“myelopathy,” refers to the spinal cordmyelitis is inflammation of the spinal cord
myelopathy is disease of the spinal cord
Myel/Myelo-“Myel,” as in
“myelodysplasia” or “myelofibrosis,” refers to the bone marrowmyelofibrosis is fibrosis of the bone marrow
myelodysplasia exists when the bone marrow does not produce enough mature blood cells
3
Blood Cell Lines
238.71 Essential thrombocythemia238.72 Low grade myelodysplastic syndrome
lesions238.73 High grade myelodysplastic syndrome
lesions238.74 Myelodysplastic syndrome with 5q
deletion238.75 Myelodysplastic syndrome, unspecified238.76 Myelofibrosis with myeloid metaplasia238.79 Other lymphatic and hematopoietic
tissues 4
Coding for Hematology
AHIMA 2009 Audio Seminar Series 3
Notes/Comments/Questions
Peripheral Blood and Bone Marrow
5
Suffixes:-osis – too many of (thrombocytosis – too many
platelets, erythrocytosis too many red cells)
-emia – in the blood (thrombocythemia – too many platelets in the peripheral blood; anemia – not enough blood)
-ia – excess of (basophilia – too many basophils)
-penia – too few of (leukopenia – too few white cells, thrombocytopenia – too few platelets)
-plasia – production of (aplasia – no production of)
Peripheral Blood and Bone Marrow
6
Coding for Hematology
AHIMA 2009 Audio Seminar Series 4
Notes/Comments/Questions
Get to Know Your Blood Cells
Granulocytes
Platelets among erythrocytes
Segmented neutrophil Eosinophil
Basophil
LymphocyteMonocyte
Mononuclear white cells7
Hematology Tests: Reference Value Examples
Cell Type Too Few Range Too Many
Red Cells Anemia Hb 13(12) - 18(16) Erythrocytosis
Thrombocytopenia 150,000 - 400,000 Thrombocytosis
Leukocytopenia 4,300 - 10,800 Leukocytosis
Granulocytes Polymorphonuclears (PMNs)
Granulocytopenia Granulocytosis
- Neutrophils Neutropenia 50% - 70% Neutrophilia
- Eosinophils Eosinopenia 1% - 3% Eosinophilia
- Basophils Basophilopenia 0.4% - 1% BasophiliaAgranulocytesMononuclears- Lymphocytes Lymphocytopenia 25% - 35% Lymphocytosis
- Monocytes Monocytopenia 4% - 6% Monocytosis
Platelets
All White Cells
Agranulocytopenia Agranulocytosis
8
Coding for Hematology
AHIMA 2009 Audio Seminar Series 5
Notes/Comments/Questions
Get to Know Your Blood Cells
Lymphocyte
Mononuclears Polymorphonuclear leukocytes
9
WBC Differentials and “Shifts”
10
Mets
0%
Bands
0-5%
Lymphocytes
20-35%
SegmentedNeutrophils/PolymorphonuclearLeukocytes
60-75%
Eos
0-5%
Baso
0-3%
Monocytes
0-10%
"Normal" Differential
Mets Bands Segmented Neutrophils/Polymorphonuclear Leukocytes Lymphocytes MonosEos Bas
Left Shift
MetsBands LymphocytesSegmented
Neutrophils/PolymorphonuclearLeukocytes
Eos BasoMonocytes
Right Shift
Coding for Hematology
AHIMA 2009 Audio Seminar Series 6
Notes/Comments/Questions
Common Anemia Codes
285.1 – anemia due to acute blood loss FROM… name it
280.0 – anemia due to chronic blood loss FROM… name it
285.21 – anemia in chronic kidney disease –effect of chronic kidney disease
285.22 – anemia in neoplastic disease –effect of the tumor
285.29 – anemia in chronic illness – and name that illness (chronic hepatitis, lupus, osteomyelitis, etc.)
11
Subcategory 285.2x, Anemia in Chronic Illnesses
These codes can be used as the principal/first listed code if the reason for the encounter is to treat the anemia. They may also be used as secondary codes if treatment of the anemia is a component of an encounter, but not the primary reason for the encounter. When using a code from subcategory 285.2x, it is also necessary to use the code for the chronic condition causing the anemia.
12
Coding for Hematology
AHIMA 2009 Audio Seminar Series 7
Notes/Comments/Questions
Anemia Designations
284.89 – Acquired (secondary) aplastic anemia.Includes that due to antineoplasticchemotherapy.
285.0 – Refractory (primary) anemia due to drug, toxin or hereditary. Also includes congenital, drug-induced, hereditary, sex-linked hypochromic and vitamin B6-responsive refractory sideroblasticanemia.
238.72 – Idiopathic refractory (primary) anemia or that due to myelodysplasticsyndrome.
13
Coding Clinic References
Anemia of chronic disease• CC 4th Qtr 2008, volume 25, number 4, pages
195-201
• CC 4th Qtr 2000, pgs 39-40 – Diseases associated with anemia in chronic illness – if you don’t know the chronic disease and it’s not linked to the anemia, 285.29 is not the code!
Anemia due to chemotherapy• CC 2nd Qtr 2008, pg 6 (284.89 + E933.1)
14
Coding for Hematology
AHIMA 2009 Audio Seminar Series 8
Notes/Comments/Questions
Myeloproliferative Disorders
Conditions resulting from variations in the bone marrow’s ability to proliferate (produce by reproduction) cell linesAcute disorders may be result of stimulants or poisoningsChronic disorders may be late effects of above or primary bone marrow disordersMay be too many or too few in peripheral blood
Essential thrombocythemia –bone marrow produces too many megakaryocytes – release too many platelets –spontaneous coagulation, blood clots, embolismMyelodysplastic syndromes of other cell lines – neoplasms with excessive production of blasts and release of few mature forms into peripheral blood• Too few red cells, inadequate
oxygenation and organ failures• Too few white cells, subject to
overwhelming infection15
Coding Perspective and DRG Assignment
Alpha: Syndrome, myelodysplastic; Thrombocytopenia
Tabular: Chapter 2, Neoplasms (140-239) IPPS MDC:• MDC 16, Diseases and Disorders of the Blood and
Blood-Forming Organs and Immunological Disorders
• MDC 17, Myeloproliferative Diseases and Disorders and Poorly Differentiated Neoplasms
As PrDx:• For 238.71-238.75
• DRG 811 Red blood cell disorders w MCC• DRG 812 Red blood cell disorders w/o MCC
16
Coding for Hematology
AHIMA 2009 Audio Seminar Series 9
Notes/Comments/Questions
Coding Perspective and DRG Assignment (cont’d)
As PrDx:• For 238.76-238.79
• DRG 823 Lymphoma & non-acute leukemia w other O.R. proc w MCC
• DRG 824 Lymphoma & non-acute leukemia w other O.R. proc w CC
• DRG 825 Lymphoma & non-acute leukemia w other O.R. proc w/o CC/MCC
• DRG 840 Lymphoma & non-acute leukemia w MCC
• DRG 841 Lymphoma & non-acute leukemia w CC
• DRG 842 Lymphoma & non-acute leukemia w/o CC/MCC
• DRG 820 Lymphoma & leukemia w major O.R. procedure w MCC
• DRG 821 Lymphoma & leukemia w major O.R. procedure w CC
• DRG 822 Lymphoma & leukemia w major O.R. procedure w/o CC/MCC
17
284.01 Constitutional red blood cell aplasia
284.09 Other constitutional aplasticanemia
Blood Cell Lines
reduction in all three cell lines – hereditary disorder (Fanconi’s anemia)
limitation of production of red cell line only due to in utero infection by Parvovirus or other viral infection
18
Coding for Hematology
AHIMA 2009 Audio Seminar Series 10
Notes/Comments/Questions
284.1 Pancytopenia
284.2 Myelophthisis
Blood Cell Lines
Invasion of bone marrow with cells or bacteria or fungi that replace and crowd out the cells that make blood or support the cells that make blood, leading to deficiency in all cell lines.
A “lab finding code” showing that all three cell lines are deficient – justifies studies – need conclusions as to etiology. Aplastic anemia's result in pancytopenia.
19
Coding Perspective and DRG Assignment
Alpha: Syndrome, Blackfan-Diamond; Anemia, Fanconi’s; Pancytopenia, Myelophthisis
Tabular: Chapter 4, Diseases of the Blood and Blood-Forming Organs (280-289)
IPPS MDC:• MDC 16, Diseases and Disorders of the Blood and
Blood-Forming Organs and Immunological Disorders • MDC 17, Myeloproliferative Diseases and Disorders
and Poorly Differentiated Neoplasms
As PrDx:• For 284.01-284.09
• DRG 811 Red blood cell disorders w MCC• DRG 812 Red blood cell disorders w/o MCC 20
Coding for Hematology
AHIMA 2009 Audio Seminar Series 11
Notes/Comments/Questions
Coding Perspective and DRG Assignment (cont’d)
As PrDx:• For 284.1-284.2
• DRG 823 Lymphoma & non-acute leukemia w other O.R. proc w MCC
• DRG 824 Lymphoma & non-acute leukemia w other O.R. proc w CC
• DRG 825 Lymphoma & non-acute leukemia w other O.R. proc w/o CC/MCC
• DRG 840 Lymphoma & non-acute leukemia w MCC
• DRG 841 Lymphoma & non-acute leukemia w CC
• DRG 842 Lymphoma & non-acute leukemia w/o CC/MCC
• DRG 820 Lymphoma & leukemia w major O.R. procedure w MCC
• DRG 821 Lymphoma & leukemia w major O.R. procedure w CC
• DRG 822 Lymphoma & leukemia w major O.R. procedure w/o CC/MCC
21
288.0 Neutropenia, unspecified
288.00 Neutropenia, unspecified
288.01 Congenital neutropenia
288.02 Cyclic neutropenia
288.03 Drug induced neutropenia
288.04 Neutropenia due to infection
288.09 Other neutropenia
Blood Cell Lines
22
Coding for Hematology
AHIMA 2009 Audio Seminar Series 12
Notes/Comments/Questions
Rationale & Clinical Insight
The understanding of hematological disorders has grown over the years. Not feasible to reclassify all of these conditions; decision to provide specific codes.It will be useful for better comparison to differentiate the various disorders and to consistently classify them between ICD-9-CM and ICD-10-CM.
Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophil granulocytes (a type of white blood cells).Neutrophils make up 50-70% of all circulating white blood cells.Neutrophils serve as the primary defense against infections by destroying bacteria in the blood.
23
Coding Perspective and DRG Assignment
Alpha: NeutropeniaTabular: Chapter 4, Diseases of the Blood and Blood-
Forming Organs (280-289) IPPS MDC:• MDC 16, Diseases and Disorders of the Blood and Blood-Forming
Organs and Immunological Disorders • MDC 25, Human Immunodeficiency Virus Infections
As PrDx:• DRG 814 Reticuloendothelial and immunity disorders w MCC • DRG 815 Reticuloendothelial and immunity disorders w CC• DRG 816 Reticuloendothelial & immunity disorders w/o CC/MCC• DRG 977 HIV w or w/o other related condition
24
Coding for Hematology
AHIMA 2009 Audio Seminar Series 13
Notes/Comments/Questions
288.4 Hemophagocytic syndromes
288.50 Leukocytopenia, unspecified –all white cell lines deficient
288.51 Lymphocytopenia –lymphocyte deficiency only
288.59 Other decreased white blood cell count
Blood Cell Lines
destruction of all three cell lines but not from lack of precursor cells – from destruction of maturing cells in bone marrow or in peripheral blood
25
Rationale & Clinical Insight
New code for macrophage disorders 288.4 was created due to the rare nature of these disorders.
Allow better statistical capture of this condition.
Macrophage disorders have an excessive and abnormal activation of macrophages, which are mature forms of the monocytes of the blood and blood marrow.These macrophages destroy blood cells, cause liver damage and promote bleeding problems.
26
Coding for Hematology
AHIMA 2009 Audio Seminar Series 14
Notes/Comments/Questions
Coding Perspective and DRG Assignment
Alpha: Syndrome, hemophagocytic; Hemophagocyticsyndrome
Tabular: Chapter 4, Diseases of the Blood and Blood-Forming Organs (280-289)
IPPS MDC: MDC 16, Diseases and Disorders of the Blood and Blood-Forming Organs and Immunological Disorders
As PrDx:• DRG 814 Reticuloendothelial and immunity disorders
w MCC• DRG 815 Reticuloendothelial and immunity disorders
w CC • DRG 816 Reticuloendothelial & immunity disorders w/o
CC/MCC27
Neutropenias
Terminology is importantNeutropenia only neutrophils are deficient (see leukocytopenia later, 288.50)
Agranulocytosis (granulocytopenia) implies deficiency of neutrophils, eosinophilsand basophils but functionally only impacts neutrophils – 288.0x series
Granulocytosis is excessive granulocytes (see later, 288.6x)
28
Coding for Hematology
AHIMA 2009 Audio Seminar Series 15
Notes/Comments/Questions
288.60 Leukocytosis, unspecified
288.61 Lymphocytosis (symptomatic)
288.62 Leukemoid reaction
288.63 Monocytosis (symptomatic)
288.64 Plasmacytosis
288.65 Basophilia
288.69 Other elevated white blood cell count
Blood Cell Lines
29
Coding Perspective and DRG Assignment
Alpha: Leukocytosis; Lymphocytosis; Monocytosis; Plasmacytosis; Basophilia
Tabular: Chapter 4, Diseases of the Blood and Blood-Forming Organs (280-289)
IPPS MDC: MDC 16, Diseases and Disorders of the Blood and Blood-Forming Organs and ImmunologicalDisorders
As PrDx:• DRG 814 Reticuloendothelial and immunity disorders
with MCC• DRG 815 Reticuloendothelial and immunity disorders
with CC • DRG 816 Reticuloendothelial & immunity disorders w/o
CC/MCC30
Coding for Hematology
AHIMA 2009 Audio Seminar Series 16
Notes/Comments/Questions
Leukemoid Reaction – 288.62
Excessive production or release of white cells in response to infectionNumber over 50,000 (normal 5,000 –10,000)Must rule out leukemia'sWe are used to seeing WBC increases in response to steroids and assigning 288.8 and E932.0 – NOT a leukemoidreaction
31
Other -osis
Leukocytosis – abundance of white cells –does not specify which line• Present in bacterial infections
• Must rule out myelogenous leukemia
Monocytosis – abundance of monocytes• Seen in mononucleosis
• Must rule out monocytic leukemia
Plasmacytosis – abundance of plasma cells• Must rule out plasmacytoma (multiple myeloma)
32
Coding for Hematology
AHIMA 2009 Audio Seminar Series 17
Notes/Comments/Questions
289.53 Neutropenic splenomegaly289.83 Myelofibrosis
Blood Cell Lines
33
Clinical Insight
Neutropenic splenomegaly – a group of conditions in which it is believed that the spleen traps neutrophils through some mechanism and causes a decrease in peripheral circulating neutrophils; synonyms:• Splenic neutropenia• Doan-Wiseman syndrome – 1938, Doan and
Wiseman described a condition in which neutropeniawas helped by splenectomy.
Myelofibrosis – primary form is unknown scarring of bone marrow, leading to decrease in all cell lines (another aplastic anemia results)
34
Coding for Hematology
AHIMA 2009 Audio Seminar Series 18
Notes/Comments/Questions
Primary Thrombocytopenia
287.30 Primary thrombocytopenia, unspecified
287.31 Immune thrombocytopenic purpura
287.32 Evan’s syndrome
287.33 Congenital and hereditary thrombocytopenic purpura
287.39 Other primary thrombocytopenia
35
Thrombocytes (platelets)
36
Coding for Hematology
AHIMA 2009 Audio Seminar Series 19
Notes/Comments/Questions
Rationale
287.3 has included non-essential modifiers for a variety of thrombocytopenic conditions, excluding thrombotic thrombocytopenic purpura 446.6 and transient thrombocytopenic purpura of the newborn 776.1. All are primary (not caused by another process) but have different primary etiologies.This breakdown permits better designation of the type of the primary etiologies.
37
Clinical AspectsPlatelets and Platelet Deficiencies
Platelets (or thrombocytes) are very small cellular components of blood that help the clotting process by sticking to the lining of blood vessels. Platelets are made in the bone marrow and survive in the circulatory system for an average of 9-10 days before being removed from the body by the spleen. Platelets are vital to life, because they help prevent massive blood loss resulting from trauma, as well as blood vessel leakage that would otherwise occur in the course of normal, day-to-day activity. Normal counts are about 150,000 to 350,000. With counts under 50,000, a patient is prone to have spontaneous bleeding.
38
Coding for Hematology
AHIMA 2009 Audio Seminar Series 20
Notes/Comments/Questions
The Primary Thrombocytopenias
Evans’ Syndrome is a combination of ITP and autoimmune hemolytic anemia (AIHA).
May be associated with neutropenia in 15% of patients.Cause is unknown.
Can have transient course or be recurrent and even fatal.
The immune thrombocytopenic purpura idiopathic thrombocytopenic purpura (ITP). Occurs in children after a viral infection and is often self-limited. In adults, lasts longer, again often following a viral infection or taking some medications or during a pregnancy. May involve the body’s immune system developing a tendency to destroy the body’s own platelets.
39
The Primary Thrombocytopenias
Congenital and hereditary thrombocytopenia (its title should be that way, not purpura) is a hereditary condition of decreased production of platelets, not of immune origin as is ITP. Where ITP responds to certain immunologic drugs, as steroids or immune globulins, congenital thrombocytopenia does not. It’s fortunately a rare variety of primary thrombocytopenia.
Normal platelet count
Thrombocythemia (-osis) 40
Coding for Hematology
AHIMA 2009 Audio Seminar Series 21
Notes/Comments/Questions
Chapter 4 DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (280-289)
287 Purpura and other hemorrhagic conditions
• Excludes: hemorrhagic thrombocythemia(238.7)
287.3 Primary thrombocytopenia• Evans' syndrome• Megakaryocytic hypoplasia• Purpura, thrombocytopenic
• Congenital• Hereditary• Idiopathic
41
Chapter 4 DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (280-289) (cont’d)
Thrombocytopenia:• Congenital• Hereditary• PrimaryTidal platelet dysgenesisExcludes:• Thrombotic thrombocytopenic purpura
(446.6)• Transient thrombocytopenia of newborn
(776.1)
42
Coding for Hematology
AHIMA 2009 Audio Seminar Series 22
Notes/Comments/Questions
Lymphoma Current Status
Lymphomas have been named by their discoverer or by some oddity of their activity, related to other diseases or manifestations
Recently divided into Hodgkins and high-grade, intermediate grade and low grade activity Non-Hodgkin’s lymphoma (NHL)
WHO (World Health Organization) has standardized the nomenclature proposed by the Revised European-American Lymphoma classification (REAL)
43
Lymphatic Cell Lines
44
• B-cell lymphocytes• T-cell lymphocytes• Natural killer cell
lymphocytes• And other minor groups
Coding for Hematology
AHIMA 2009 Audio Seminar Series 23
Notes/Comments/Questions
First classified by cell type – the cell which, if normal, most closely looks like the tumor cell• B-cell tumors• T-cell tumors• Natural killer cell
tumors• And other minor
groups
http://dir.niehs.nih.gov/dirlep/liverpath/hyperplastic/lymph5.htm 45
Clinical Perspective REALRevised European-American Lymphoma Classification
Mature B-Cell Tumors (NHL)
Chronic lymphocytic leukemia/small lymphocytic lymphomaB-cell prolymphocytic leukemia Lymphoplasmacytic lymphoma/WaldenströmmacroglobulinemiaSplenic marginal zone lymphomaPlasma cell neoplasms – plasma cell myeloma, plasmacytoma, monoclonal deposit disease, heavy chain diseasesExtranodal marginal zone B cell lymphoma (mucosa-associated lymphoid tissue, MALT lymphoma)
46
Coding for Hematology
AHIMA 2009 Audio Seminar Series 24
Notes/Comments/Questions
Mature B-Cell Tumors (NHL) (cont’d)
Nodal marginal zone B cell lymphoma Follicular lymphomaMantle cell lymphoma Diffuse large B cell lymphoma Mediastinal (thymic) large B cell lymphoma Intravascular large B cell lymphoma Primary effusion lymphoma Burkitt lymphoma/leukemiaLymphomatoid granulomatosis
47
Mature T-Cell and Natural Killer Cell Tumors (NHL)
T cell prolymphocytic leukemia T cell large granular lymphocytic leukemia Aggressive NK cell leukemia Adult T cell leukemia/lymphoma Extranodal NK/T cell lymphoma, nasal type Enteropathy-type T cell lymphoma Hepatosplenic T cell lymphoma Blastic NK cell lymphoma
48
Coding for Hematology
AHIMA 2009 Audio Seminar Series 25
Notes/Comments/Questions
Mature T-Cell and Natural Killer Cell Tumors (NHL) (cont’d)
Mycosis fungoides/Sezary syndrome Primary cutaneous CD30-positive T cell lymphoproliferative disorders• Primary cutaneous anaplastic large cell
lymphoma • Lymphomatoid papulosis
Angioimmunoblastic T cell lymphoma Peripheral T cell lymphoma, unspecified Anaplastic large cell lymphoma
49
Hodgkin’s Lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma Classical Hodgkin lymphoma • Nodular sclerosis • Mixed cellularity• Lymphocyte-rich • Lymphocyte depleted or
not depleted
50
Coding for Hematology
AHIMA 2009 Audio Seminar Series 26
Notes/Comments/Questions
Immunodeficiency-Associated Lymphoproliferative Disorders
Associated with a primary immune disorder Associated with the Human Immunodeficiency Virus (HIV) Post-transplant Associated with Methotrexate therapy
51
Histiocytic and Dendritic Cell Neoplasms (CNS)
Histiocytic sarcoma Langerhans cell histiocytosisLangerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell sarcoma/tumor Dendritic cell sarcoma, unspecified
52
Coding for Hematology
AHIMA 2009 Audio Seminar Series 27
Notes/Comments/Questions
Classification by ImmunologicSubtype and Aggressiveness
B cell• small lymphocytic• lymphoplasmacytic• follicular• marginal zone, MALT• marginal zone, nodal• mantle cell• diffuse large B cell• primary mediastinal
large B cell• Burkitt's-like
T cell• peripheral T-cell• anaplastic large
T/null cell• lymphoblastic
53
Our Newer Subdivisions (2007)
200.3x Marginal zone
200.4x Mantle zone
200.5x Primary CNS
200.6x Anaplastic large cell
200.7x Large cell lymphoma
202.70 Peripheral T-cell
.x0 Unspecified site
.x1 Head, face, neck nodes
.x2 Intrathoracic nodes
.x3 Intraabdominal nodes
.x4 Nodes axilla, upper limb
.x5 Inguinal, lower limb
.x6 Pelvic nodes
.x7 Spleen
.x8 Multiple sites54
Coding for Hematology
AHIMA 2009 Audio Seminar Series 28
Notes/Comments/Questions
Leukemias (204 – 208 series)
Acute varieties (208.0)Chronic varieties (208.1)• Myelogenous – all bone marrow – mostly
granulocytes• Granulocytic – neutrophilic, basophilic,
eosinophilic precursors – blasts• Histiocytic• Lymphocytic (lymphoid – synonyms)• Monocytic (monocytoid – synonyms)• Megakaryocytic (platelet precursors)• Plasmacytic (plasma cell)
55
Maturation in the Bone Marrow
56
Coding for Hematology
AHIMA 2009 Audio Seminar Series 29
Notes/Comments/Questions
Leukemias
Chemotherapeutic regimens depend on stageInitial acute – remission induction – to induce remissionIn remission – consolidation chemoIn relapse (recurrence) – may need reinduction to induce remission againBeware of chronic lymphoma with TRANSFORMATION! May become acute leukemia! Ask the physician!
57
Code Series 289.8x
This code series has been expanded toinclude:
289.81 Primary hypercoagulable state
289.82 Secondary hypercoagulable state
289.84 Heparin-induced thrombocytopenia (HIT)
289.89 Other specified diseases of blood and blood-forming organs
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Notes/Comments/Questions
Hypercoagulable States
This has become more and more identified in the last two years in patients with DVT and embolic phenomenaIt has led to the use of Coumadin for anticoagulation in addition to the usual DVT patient or the Atrial fibrillation or the patient with MI or occlusive stroke –and the problems that arise from long-term Coumadin use
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Coding – Primary HypercoagulableState (289.81)
Conditions due to inborn errors and lack ofcertain chemicals that influence the prevention of clot formation under normalconditions
Antithrombin deficiencyProtein C deficiencyProtein S deficiencyActivated Protein C ResistanceDysfibrinogenemiasInherited abnormalities of fibrinolysis
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Coding – Secondary Hypercoagulable State (289.82)
Derived conditions leading to tendencyto make clots at undesirable times
Lupus anticoagulant syndromeMalignancies, especially pancreasMyeloproliferative disordersParoxysmal nocturnal hemoglobinuriaPregnancyNephrotic syndromeInflammatory bowel disease (Crohn’s)Drug-related
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Coding – HIT - Heparin-Induced Thrombocytopenia (289.84)
Distinct, relatively common life-threatening clinical condition occurring in 3-5% of all patients receiving unfractionated heparin for at least 5 days. Totally different clinical picture from other drug-induced thrombocytopenias. • Presents with arterial or venous thrombosis
(DVT, PE, stroke, MI)• Transfusion of platelets generally
contraindicated• Patients require therapeutic doses of alternative
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Notes/Comments/Questions
Coding Clinic Reference
Heparin-Induced Thrombocytopenia (HIT) CC 4th Qtr 2008, pg 100-101
Remember there can be documented Heparin Induced Thrombocytopenia with Thrombosis! (HITT) – same code
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Procedure Issues in Hematology
Bone marrow biopsy/aspiration• ICD-9-CM: 41.31 - same code for both biopsy
and aspiration of bone marrow
• CPT: • 38220 – bone marrow aspiration only
• 38221 – bone marrow biopsy, needle or trocar
• HCPCS: G0364 (temporary) - Bone marrow aspiration performed with bone marrow biopsy through the same incision on the same date of service
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Notes/Comments/Questions
CPT® Assistant Reference
Bone Marrow Biopsy, Bone Marrow Aspiration, and Bone Biopsy, July 1998, Volume 08, Issue 7, pages 4-7
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Bone Marrow Aspiration (38220)
May be performed independent of bone marrow biopsy or may immediately follow a biopsyEvaluates cellular population not the alteration of cells due to diseaseFollowing penetration of bone cortex, syringe is attached to the needle and fluid aspirated
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Notes/Comments/Questions
Procedure: Bone Marrow Aspiration
Close-up of technique used to obtain bone marrow sample by
aspiration through a needle.
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Bone Marrow Biopsy (38221)
Evaluates • Presence and relative quantification of
abnormal cells (lymphoma, leukemia, etc.)• Relative abundance of normal marrow cells• Presence of tumor metastasis • Presence of myelofibrosis
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Notes/Comments/Questions
Procedure: Bone Marrow Biopsy
Posterior view of pelvic region with target area for bone marrow biopsy highlighted.
After penetration of bone, needle/trocar is rotated several times, withdrawn several millimeters, then reinserted to the original depth at a slightly different angle. Rotated again, then withdrawn using the same twisting motion used during insertion.
Posterior view of pelvis with hypodermic needle penetrating skin at an angle to reach the ilium just below the iliac crest. Needle slowly advanced with twisting motion.
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Bone Marrow Aspiration (38220) vs. Biopsy (38221)
AspirationRetrieving fluid from bone marrowObtained via needle (University of Illinois)Does not produce intact tissue
BiopsyRetrieving cancellous boneObtained via needle (e.g. Jamshidi) or trocarProduces core of intact marrow
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Resource/Reference List
National Center for Health Statistics; ICD-9-CM Coordination and Maintenance Committee:http://www.cdc.gov/nchs/about/otheract/icd9/maint/maint.htm
ASHhttp://www.hematology.org
ICD-9-CM Official Coding Guidelines for Coding and Reportinghttp://www.cdc.gov/nchs/datawh/ftpserv/ftpicd9/icdguide08.pdf
AHA Coding ClinicsCoder’s Desk Reference
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Appendix
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Resource/Reference List ....................................................................................... 40 CE Certificate Instructions
Appendix
AHIMA 2009 Audio Seminar Series 40
Resource/Reference List http://www.cdc.gov/nchs/datawh/ftpserv/ftpicd9/icdguide08.pdf
http://www.cdc.gov/nchs/about/otheract/icd9/maint/maint.htm
http://www.hematology.org
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