CiVentiChem India Presentation - 2012

8/3/2019 CiVentiChem India Presentation - 2012

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Global operations in the USA and India with project management,IP control and local solutions at our USA headquarters

CiVentiChem (India) Private Limited

(Formerly Known as Indus BioSciences Private Limited)

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History Business Overview

Services and Capabilities

Management Experience and Chemistry Expertise

Chemistry Specialties & Capabilities

Bulk Projects Performed in Plant

Chemistry Experience

Examples in Med. Chem & P R&D

Proprietary Building Blocks

Facilities

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Highlights of Presentation


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History

1994 - Founded in RTP, North Carolina

1999 Expanded to Larger Laboratory

2000 Reached12 Scientists at USA

2001 R&D Laboratories Opened in India with 5

Chemists

2009

Launch of our Plant inH

yderabad, India 2011 cGMP Synthesis lab in RTP, NC, USA

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Business Overview

HQ: RTP, North Carolina

Services: Chemistry Discovery & Synthetic Chemistry, Process Development, Manufacturing &

Analytical Services

People: 8

0 Experienced Scientists & Admin Facilities: USA and India

RTP, North Carolina and Hyderabad, India

50,000 Sq Ft Total Technical Facilities

Customers: Around 150 including10 of world Top 20 Pharma; 45 Biotechnology Companies.

Integrated Management Systems ISO-9001-2008 (QMS), 14001-2004 (EMS) and 18001-2007

(OSHA)

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Biological

TargetScreening Hits LaunchClinicalLeads

Drug

candidate

Pre -

clinical

Screening

Compounds

Custom

Synthesis

Parallel

Synthesis

Medicinal

ChemistryManufacturing

Pilot

Plant

Process

Scale -up

Associated

Chemistry

Peakdale Molecular Collaborators

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Biological

TargetScreening Hits LaunchClinicalLeads

Drug

candidate

Pre -

clinical

Screening

Compounds

Custom

Synthesis

Parallel

Synthesis

Medicinal

ChemistryManufacturing

Pilot

Plant

Process

Scale -up

Associated

Chemistry

CiVentiChem USA & India CiVentiChem India

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Our Role in Drug Development

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DEVELOPMENT

CHEMISTRY

Rapid Initial Scale-up to first KgProcess Research &

Development

Feasibility Studies

Pilot Development Manufacture

Manufacture Intermediatess &

APIs

cGMP & Non-GMP Protocols

RESEARCH CHEMISTRYMedicinal Chemistry

Focused Libraries

Reference Standards &

Metabolites

Lead Compounds & NCEs

Lead Optimization

Intermediates and Building

Blocks available and in-stock

PRODUCTION

CHEMISTRY

Pilot DevelopmentManufacture

Process Research &

Development

Contract Manufacturing

Manufacture Intermediates &

APIs


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Global Advantages

Flexibility of Choice USA or India or BOTH !!

Project Type

Deadline Output Scale or Volume

Research Requirements

Expertise Requirements

Communication and Project Control

Lowest Cost

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Business Overview - Clients

No. of clients 150

No. of Pharma Clients 10 (from world top 20

Pharma Companies) No. of Biotech Clients 10 +

No. of Catalogue Companies 5 +

No. of Fine Chemical Companies 10 +

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Services and Capabilities

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Research Chemistry Services

Medicinal Chemistry

Synthesis of Focused Libraries & Analogues

Synthesis of Reference Standards & Metabolites

Synthesis of Lead Compounds & NCEs

Lead Optimization & Parallel Synthesis

Novel Template Molecules Ready for Purchase

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Development/Manufacturing

Services

Rapid Initial Scale-up to 1stKilogram

Route Scouting

Process Development & Optimization

Manufacture of Intermediates API ready starting materials

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Management Experience

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Management Team

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Bhaskar Venepalli, Ph. DBhaskar Venepalli, Ph. D

Chief Executive OfficerChief Executive Officer

ProfessionalProfessional ExperienceExperience

25 + Years experience in fine chemicals including13

Yrs experience in R&D, new product development &

Business Management at Eastman Kodak-Eastman

Chemical Company

Expertise in CRAMS & Fine Chemicals

Founder of Civentichem in 1994 in USA

EducationEducation

Ph.D. from Osmania University, H yderabad (IND)

Post Doctoral Research at University of

Southampton (England) & Rockefeller

University, New York, (USA)

Vasu (Srinivas) Chittineni, Ph. DVasu (Srinivas) Chittineni, Ph. D

Chief Technical OfficerChief Technical Officer


20 + Years experience in synthetic organic

chemistry

Expertise in Complex Organic Syntheses,

Chiral & Carbohydrate Chemistry

Co founder of Civentichem in 1994

EducationEducation

Ph.D. from Kakatiya University (IICT,

Hyderabad, INDIA)

Post Doctoral Research at Duke University ,

NC, USA


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Management Team

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Venkataiah Sunku, Ph. DVenkataiah Sunku, Ph. D

Managing DirectorManaging Director


30 + Years experience in pharma including8

Yrs experience as Director R&D at Aurobindo

Pharma (India)

Expertise in Process Development & Plant Scale

operations

Developed processes for 22 bulk drugs &

Transferred to Mfg Plants

EducationEducation

Ph.D. in Chemistry from Osmania University,

Hyderabad (INDIA).

6 Publications & Patents

Venu (Venugopal) Veeramaneni, Ph. DVenu (Venugopal) Veeramaneni, Ph. D

Head R&D and BD&PMHead R&D and BD&PM


18 Years experience in Drug Discovery

(Medicinal &Synthetic Organic Chemistry. Including

11 yrs at Dr. Reddys Discovery Research.

Expertise in Synthesis of NMEs & Complex

Organic Syntheses

EducationEducation

Ph.D. in Chemistry from JNTUniversity (DRF,

Hyderabad, INDIA)

25 Publications, Patents & Presentations


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Research Team @ Civentichem India

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Hari Prasad Chittineni, Ph.D.Hari Prasad Chittineni, Ph.D.

Section Head, Process DevelopmentSection Head, Process Development

14 Yrs Experience in Carbohydrate, Heterocyclic

Chemistry including4 Yrs in AVRA Synthesis

Expertise in Process Development

M.Sc. From Osmania University

Ph.D. from JNT University


Venkat Laxman Rao Cilamkoti, Ph.D.Venkat Laxman Rao Cilamkoti, Ph.D.

Section Head, Medicinal ChemistrySection Head, Medicinal Chemistry

16 Yrs experience in Multi Step Organic

Synthesis including8 Yrs in Dr Reddys Discovery

Research

Expertise in Medicinal & Small scale Chemistry

M.Sc. From Osmania University

Ph.D. from Osaka University, Japan


VineelVineel,, Ph.DPh.D

Group Leader

5 Yrs Exp in

Sugar & ChiralChemistry.

Ph.D. from

JUNTU

MamathaMamatha

Group Leader

8 Yrs Exp in

Azaindole &Indazole

Chemistry

M.Sc. from

Osmania

University

GopalGopal

Group Leader

8 Yrs Exp in

Process & ScaleUp Chemistry

M.Sc. from

Osmania

University

ShyamShyam

Group Leader

8 Yrs Exp in

Med. Chem. &Small Scale

M.Sc. from

Osmania

University

RCRC SekarSekar

Group Leader

8 Yrs Exp in

Med. Chem. &Small Scale

M.Sc. from

Osmania

University

RajithaRajitha

Group Leader

8 Yrs Exp in

New BuildingBlocks

M.Sc. from

Osmania

University


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Research Team @ Civentichem India

Venkataiah, Ph.D.Venkataiah, Ph.D.

MDMD

Documents

CiVentiChem India Presentation - 2012