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Chronic Renal Failure. Pathophysiology and K-DOQI Guidelines Mahmoud El-Khatib, MD. Trends. Evaluation of CKD patients. Diagnosis Co morbid conditions Severity, assessed by level of kidney function Complications related to level of kidney function Risk of loss of kidney function - PowerPoint PPT Presentation
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Chronic Renal Failure
Pathophysiology and K-DOQI Guidelines
Mahmoud El-Khatib, MD
Trends
Evaluation of CKD patients
• Diagnosis• Co morbid conditions• Severity, assessed by level of kidney
function• Complications related to level of kidney
function• Risk of loss of kidney function• Risk for cardiovascular disease
Management of CKD patients
• Specific therapy based on diagnosis• Evaluation and management of co morbid conditions• Slowing the loss of kidney function• Prevention and treatment of cardiovascular disease• Prevention and treatment of complications of decreased
kidney function• Preparation for kidney failure and kidney replacement
therapy• Replacement of kidney function by dialysis and
transplantation, if signs and symptoms of uremia are present
Other management plan
• Dosage adjustment based on level of kidney function
• Detection of potentially adverse effects on kidney function or complications of CKD
• Detection of drug interaction• Therapeutic drug monitoring, if possible• Self management behaviors should be incorporated
to the plan• Referral to Nephrologist , when GFR < 30
ml/1.73m2
Individuals at increased risk of CKD
• They should be assessed as part of routine health encounters, to determine whether they are at increased risk of developing CKD, based on clinical and sociodemographic factors
• Individuals at increased risk of developing CKD should undergo testing for markers of kidney damage and to estimate GFR
• Individuals at increased risk, but found not to have CKD, should be advised to follow a program of risk factors reduction, and if appropriate undergo repeat periodic evaluation
Clinical evaluation of patients with increased risk for CKD
• All patients
-Measurement of blood pressure
-Serum creatinine to estimate GFR
-Prot/ Cr or Alb/ Cr ratio in first morning or random spot urine
-Examination of urine sediment
• Selected patients
-Ultrasound imaging
-Serum electrolytes
-Urinary concentration or dilution
-Urinary acidification
Laboratory evaluation of patients with CKD
• Serum creatinine to estimate GFR
• Prot/ Cr or Alb/ Cr ratio in a morning or random spot urine
• Examination of urine sediment
• Imaging of the kidney. Usually by ultrasound
• Serum electrolytes
Estimation of GFR
• GFR should be estimated from prediction equations which take into account : serum creatinine, age, gender,race, body size
• For adults: MDRD study, Cockcroft- Gault equations
• For children: Schwartz and Counahan- Barratt equations
• The serum creatinine alone should not be used to assess the level of kidney function
Estimation of GFR
*MDRD
GFR= 170x(sCr)-0.999x (age)-0.176x
(BUN)-0.170 x(Alb)+0.38x (0.762 if female)x (1.180 if black)
*Abbreviated MDRD
GFR= 186x (sCr)-0.58x (Age)-0.28x (0.742 if female)x (1.120 if black)
Estimation of GFR
*Cockcroft-Gault
Crc= (140- age)x weight/ 72x sCR( 0.85 if female
*Schwartz
Crc= 0.55x length/ sCr
*Counahan-Barratt
GFR= 0.43xlength/sCr
Creatinine Clearance
• Measurement of CrC using 24 hours urine collections does not improve the estimated GFR over that provided by prediction equations
• It is useful is certain situations: patients with exceptional dietary intake like vegetarian diet, creatine supplements, amputation, malnutrition,muscle wasting, extremes of age and body size, obesity, disease of skeletal muscles, paraplegia or quadriplegia
• Assessment of diet and nutritional status• Need to start dialysis
Assessment of proteinuria
• It is usually not necessary to obtain a timed urine collection( 24 hrs)
• First morning specimens are preferred, Random samples are acceptable
• Patients with a positive dipstick test should have quantitative protein measurement.
• Protein/ creatinine ratio, Albumin/ creatinine ratio are acceptable methods
• Patients with +ve two tests spaced by 1 to 2 weeks are diagnosed to have persistent proteinuria
Assessment of proteinuria 2
• Albumin/creatinine ratio rather than protein/ creatinine ratio should be used if albumin excretion less than 500mg/ g of creatinine
• Orthostatic proteinuria must be excluded by repeat measurement on a first morning specimen
False results in measurement of proteinuria
• False +ve
-dehydration
-hematuria
-infection
-urine pH> 8
• False –ve
-excessive hydration
-Para proteins
Proteinuria as a risk factor
• Proteinuria as a risk factor for cardiovascular disease
• Proteinuria as a mediator and a marker of progressive kidney disease
• Persistent massive proteinuria as the inciting factor that leads to nephritic syndrome
Markers for CKD other than protein
• Abnormalities in the urine sediment
• Abnormalities in the imaging studies
• Tubular low-molecular weight proteins, specific mononuclear cells.
Level of GFR and Hypertension
• High Bp is both a cause and complication of CKD• May develop early during the course of CKD and
is associated with adverse outcomes• Faster loss of kidney function• Development of cardiovascular disease• Optimal Bp of <130/85• Multi drug therapy is the rule
Level of GFR and Anemia
• Patients with GFR < 60 should be evaluated for anemia
• Anemia of CKD should be evaluated and treated
• The main cause is Erythropoietin deficiency
• Other causes of anemia should be evaluated
Level of GFR and nutritional status
• Malnutrition develops during the course of CKD and associated with adverse outcomes
• Low protein and calorie intake is an important cause of malnutrition in CKD
• Patients with GFR of <60 should undergo assessment of dietary protein and energy intake and nutritional status
• Patients with GFR <20 should be evaluated by serial measurements of albumin, edema-free body weight, nPNA
• BMI < 23.6 is indicative of malnutrition
Level of GFR and bone disease
• Bone disease and disorders of calcium and phosphorus metabolism develop during the course of CKD
• Patients with GFR <60 should be evaluated
• Elevated PTH seems to be an early marker of abnormal bone mineral metabolism
Neuropathy
• Neuropathy develops during the course of CKD and may become symptomatic
• May be manifested as encephalopathy, peripheral polyneuropathy, autonomic dysfunction, sleep disorders, peripheral mononeuropathy
• There is insufficient evidence to define a specific threshold level of GFR that is associated with an increased prevalence or severity of neuropathy
Level of GFR and indices of functioning and well-being
• Impairments in domains of functioning and well-being develop during the course of CKD
• May be related to socio-demographic factors, conditions causing CKD, complication of kidney disease or possibly directly related to reduced GFR
• Patients with GFR<60 should undergo regular assessment for impairment of functioning and well-being
• Establish a baseline and monitor changes• Assess the effect of interventions
Factors affecting functioning and well-being of CKD patients
• Late referral and inadequate pre-dialysis care• Effect of illness on physical,psychological and
social functioning• Satisfaction with health and care• Complications of CKD: anemia, malnutrition,bone
disease, neuropathy• Co morbid conditions: diabetes, cardiovascular
disease
Treatment intervention to slow the progression of CKD
• With proven effectiveness: strict glucose control in diabetes, strict Bp control, ACEI, ARB
• Inconclusive: dietary protein restriction, lipid lowering therapy, partial correction of anemia
Prevention of acute GFR decline in CKD patients
• Volume depletion
• Intravenous radiographic contrast
• Nephrotoxic agents like aminoglycosides, amphotericin B,NSAID’s, cyclosporine, tacrolimus
• Obstruction of urinary tract
Follow up1
• Measurements of serum creatinine for estimation of GFR, at least once a year.
• More often measurements: if GFR <60, fast GFR decline>4ml/ year, risk factors for faster progression, ongoing treatment to slow progression, exposure to risk factors for acute GFR decline
• Risk factors for faster decline of GFR related to the type of kidney disease, African-American race,lower baseline kidney function, male gender, older age
Follow up 2
• Higher levels of proteinuria, lower serum albumin, higher Bp level, poor glycemic control, smoking.
• Anemia, dyslipidemia are inconclusive risk factors for faster decline
CKD as a risk factor for CVD
• Patients with CKD irrespective of the diagnosis are at increased risk for CVD
• Increase in CAD, cerebro vascular disease, peripheral vascular disease, heart failure
• Both traditional and CKD related risk factors may contribute to this increased risk
• All patients with CKD should be considered highest risk group irrespective of levels of traditional CVD risk factors