22
China Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION CPHI ( NYSE/Amex ) INVESTOR PRESENTATION www.chinapharmaholdings.com

China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Embed Size (px)

Citation preview

Page 1: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

China Pharma Holdings, Inc.

CPHI( NYSE/Amex )

INVESTORPRESENTATION

CPHI( NYSE/Amex )

INVESTORPRESENTATION

www.chinapharmaholdings.com

Page 2: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

2

Safe Harbor Statement

Safe Harbor Statement Under the Private Securities Litigation Reform Act of1995: Any statements set forth in this presentation that are not historicalfacts are forward-looking statements that involve risks and uncertainties thatcould cause actual results to differ materially from those in the forward-looking statements, which may include, but are not limited to, such factorsas unanticipated changes in product demand, increased competition, failureto obtain or maintain intellectual property protection, downturns in theChinese economy, uncompetitive levels of research and development,failure to obtain regulatory approvals, and other information detailed fromtime to time in China Pharma Holdings, Inc.’s filings and future filings withthe United States Securities and Exchange Commission.

The forward-looking statements contained in this presentation are madeonly of this date, and China Pharma Holdings, Inc. is under no obligation torevise or update these forward-looking statements.

Page 3: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

China Pharma - Helpson

Strong contender in new drugs as well as generics and First-to-Market generics. Highly profitable operation with robust new product pipeline.

Long History: wholly owned subsidiary Helpson was founded in 1993 with research focus

Production: 8 GMP-certified production lines with multiple formulation capabilities

Distribution: Strong track record of selling to public hospitals with national distribution network covering 30 municipalities and provinces

Diversified product portfolio composed of 20 branded and generic drugs

Future: New drugs and “Super” generic drugs in R&D Pipeline

China Pharma is a fully integrated pharmaceutical company with a focus on medicines for high incidence and high mortality diseases in China.

3

0

20

40

60

80

2005 2007 2009 2011

Revenue in USD Mln$ Mln

Page 4: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

China Market Place for Generics

Basic Generics: 1) Common drug2) Low demand on research and production capabilities3) Strong competition, often with hundreds of manufactures4) Lower gross margins5) Very large market, especially after Healthcare Reform

First-to-Market generics:1) Generics to the western world but new to China2) High demand on R&D and production capabilities3) Less competition4) High gross margins5) Selling mostly to hospitals in large cities6) Regulatory exclusivity 3yr- 5yrs (monitoring period)

4

The two “Generic” markets in China:

Page 5: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Company Overview – Product Focus

Main therapeutic areas: 1) CNS, Cardio-cerebral vascular2) Infectious and Respiratory Diseases 3) Digestive Diseases

Products:1) Newly Developed Drugs 2) Generics of Off-Patent Branded Drugs3) Modern Traditional Chinese Medicines

(TCMs)4) New formulations

5

Low-risk development based on market demand. Diverse portfolio of 20 products on the market.

Page 6: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Modern, Scalable Manufacturing Facilities

Eight Scalable, Modern, GMP-certified Production Lines

Located in Hainan, China; built in 2002

Approximately 8,000 m2 manufacturing facility

Ongoing Upgrades & Expansion to Meet Increasing Demand

$3 M investment in 2008 increased freeze dry powder injectable capacity

6

Production Line

1. Tablet 2. Capsule 3. Granule 4. Injectable 5. Dry Powder 6. Cefaclor Only 7. Biological API 8. Chemical API

Page 7: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

China’s Healthcare Reform

7

Chinese government are investing billions of RMB to implement a universal health-care system.

Medical insurance coverage massively expanded. Pharmaceutical industry will be realigned by new policies on quality and

pricing control (Essential Drug List, “EDL” & National Insurance Catalog, “NIC”).

Overall industry volume to expand strongly but margins will be under pressure for a period of time.

Opportunities for CPHI:1) Opportunity to expand distribution network into rural areas with very large

markets. Two (2) of the Company’s drugs are listed as on the National EDL and a few drugs are on provincial EDL.

Overall, reform is positive for CPHI and the Chinese Pharma industry.

Page 8: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Our Business Model: Commercialization

Secure, established networksSales infrastructure expansion

Distribution Increasing Market Share

We favor drugs with >$1 B global sales

High-incidence, high-mortality diseases

Drug Selection

New drugs

Reformulated drugs

Off-patent branded drugs

Experience with SFDA process

Development

8 GMP - Certified manufacturingproduction lines capable of multiple formulations

Expertise in new drug marketing and launching process

Commercialization

88

Page 9: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

9

Revenues by Therapeutic Category

2011 Revenue by Product Type

Other14% - $11 mil

CNS Cardio-Cerebrovascular32% - $25.8 mil

Respiratory, Anti-Viro/ Infection

39% - $32 milDigestive

15% - $12.4 mil

Page 10: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Diversified Product Portfolio

CNS & Cerebral-Cardiovascular

Diseases

Ograzel/Alginic Sodium Diester/Propylgallate:Stroke (cerebral thrombosis / embolism), coronary heart disease; hyperlipidemia. Propylgallate dry powder format more stable than other forms

Buflomedil: Peripheral blood vessel diseases, e.g. intermittent claudication; Raynaud’s disease. National Key New Product Award; 4 dosage forms on market.

Gastrodin: Brain trauma, neurasthenia, headache, anxiety, vertigo

Bumetanide: Diuretic used in edema caused by heart failure, hypertension, renal failure or acute poisoning

10

Anti-infection

Roxithromycin/Clarithromycin: Macrolide antibiotics: respiratory tract, urinary, soft-tissue infections. Clarithromycin: granules and capsule formats for easy administration to elderly and pediatric patients

Cefaclor/Cefalexin: Cephalosporin antibiotics: respiratory, urinary, soft tissue infections

Andrographolide: Anti-bacterial, anti-inflammatory, detoxifier: upper respiratory infection, bacilliary diarrhoea

Gall Wood Syrup Extract: Anti-bacterial, anti-inflammatory.

Page 11: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Cold - Flu

Digestive Disease

PuSenOK: Cold-flu symptoms: sinus and nasal congestion, pain, myalgia, fever, sore throat

Vitamin Supplements Vitamin B6: Vitamin B6 deficiency

Hepatocyte growth-promoting factor: Auxiliary treatment in acute and chronic hepatitis. Bioengineered medicine.Tiopronin: Treats acute Hepatitis B and drug-induced liver injury

Omeprazole Injections: is widely utilized to treat gastroesophageal reflux disease (GERD), and is highly effective in other conditions caused by excess acidic formulations in the stomach

Compound Ammonium Glycyrrhetate S for Injection: is used to treat abnormal functionality of the liver from liver disease.

Wound Recovery rhaFGF: Reparation of skin injuries

Diversified Product Portfolio (cont.)

11

Tumor DiseaseGranisetron: Cancer chemotherapy induced, and post operative nausea and vomiting

Page 12: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Research & Development (cont.)

Concentrating on therapies for key disease areas, among leading causes of death in PRC.

Expected Medical

Expenditures on key D

isease Categories

Sources: 1:Freedonia/Roth; 2: N E J M, 353(11):1124-1134, 2005 “Major Causes of Death Among Men and Women in China”

12

20 products commercialized prior to Jan 1, 2010;

1 (Tiopronin) Launched in May of 2009;

1 (Omeprazole ) Launched in 4th

quarter of 2009;

Strong Commercialization Track Record

Leveraging R&D efforts by

Collaborating

with Elite Academic

Institutions

Chinese Academy of Sciences

China University of Pharmaceuticals

Sichuan University

Chongqing Medical Industry Institute

Military Medical Academy Basic Medical Science Institute

China Pharma Holdings,

Inc.Joint R&D

China PharmaRetains

Ownership Rights from

resulting Intellectual Property

Page 13: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Compelling Product Pipeline

13

Project Name Indication R&D Discovery

R&D Optimization

SFDA Tecnhical Analysis

SFDA Approved

Central Nervous System

CNS1 Alzheimer Disease

CNS2

Cardio Vascular

Rosuvastatin (Crestor Generic) Cholestero Control

Candesarten Hypertension

Heart Disease Drug Coronary Heart Disease

Infectious Diseases

Ceftriaxone and Tazobactam sodium Drug-Resistent AntiBiotic

Digestive

Hepatitis Drug Liver Protection

Pain & Wound Recover

PAIN-1 Pain Management

Clinical Trials (if Necessary)

Currently in Phase 2 Clinical Trial

Awatiting Final SFDA Production Approval

Awatiting Final SFDA Production Approval

Currently in Phase 3 Clinical Trial

Page 14: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Novel Antibiotic Combination in Clinical Trials

14

Antibiotic Blockbuster:

Third Generation Cephalosporin + Bacterial Enzyme Inhibitor 3rd generation Cephalosporin antibiotic Bacterial enzyme inhibitor Formulated to improve drug-resistance profile

3rd generation Cephalosporin alone encounters resistance 20%-70% of certain target pathogen strains may be resistant 2

Broad spectrum

$5.8 B Estimated Cephalosporin Antibiotic Market in China 3Company Expects Significant Revenue Contribution from drug after Launch.

Clinical Trials Addressing Antibiotic Resistance Clinical program initiated (November 2008) Phase II of the clinical trial commenced in early 2011 Potential approval in 2013 with a 3 to 5 year regulatory exclusivity (monitoring period)

Source: 1: Centers for Disease Control and Prevention, 2003; 2:Chinese Ministry of Health National Antimicrobial Resistance Investigation Net (MOHnarin); 3: SFDA Information Center

“Antibiotic resistance has been called one of the world’s most pressing public health concerns.”1

Page 15: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Cholesterol-lowering blockbuster statin product Worldwide sales for 2010 exceeded $5.5 billion The use of Crestor® has translated into a 60% decrease in the number of cardiac events (heart

attack, sudden cardiac death) and a 17% reduction in the risk of stroke. Has shown favorable results in international clinical comparisons with other leading statins, such

as Atorvastatin (Lipitor®), Pravastatin and Simvastatin.

Hyperlipidemia in China Prevalence rates estimated at 7% to 8%, which translates to approximately 100 million people

suffering from high cholesterol in China. With 30% penetration rate at 1/10 of US price for Crestor,

the Chinese market size would be $3.2 bln. A 2% market share would imply $64 mln per year in revenue for CPHI.

Clinical Trials Clinical Trials completed in December of 2010.

Currently awaiting SFDA production approval..

Pipeline Drug Highlight: RosuvastatinGeneric Form of Crestor®

15

1000

2500

4000

5500

2006 2007 2008 2009 2010

Global Crestor Sales$ Mln

Source: 2010 Astra Zeneca Annual Report

$ Mln$ Mln$ Mln

Page 16: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Generic form of Candesartan: 2007 worldwide sales over $2.5 billion1

Front-line therapy for Hypertension Well-tolerated, high safety record On China’s National Basic Medical Insurance Drug List

Sales of Sartan drugs in China2

2007 sales approached $190 million (RMB 1.3 billion) -- YoY increase of 56%

Hypertension in China3

60% of all urban adults aged 65+ years suffer hypertension Urban prevalence predicted to be 100 million by 2011

Clinical Trials Completed all review testing procedures Pending final SFDA production approval

Sources 1: Takeda Pharmaceutical Company Ltd., Annual Report 2008; 2: Medical Economic News 2008, Sept. 03; 3: Nature Reviews, Drug Discovery: 2008 May; 7 383-384.

Pipeline Drug Highlight: Candesartan.

16

Generic Form of Candesartan: anti-hypertension drug

Page 17: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

17

Sales & Marketing Network

17

Prescription-based sales and marketing network covering major hospitals across China

Well-experienced sales team: 16 sales offices, 30 provinces, ~1,250 distributors

Close relationship with hospitals and municipal pharma distributors allows rapid roll out of new products

Fewer intermediaries between end user (hospital pharmacies) and China Pharma enables CPHI to obtain higher profit margins

Extensive marketing network built over a decade represent a barrier-to-entry advantage for CPHI

Significant Market Share in Public Hospitals with National Distribution Network

Page 18: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

18

Extensive Distribution Network

Distribution System

18

Covering 30 provinces and municipalities

16 sales offices

Experienced Marketing Team

New Product Launch & Marketing Experience

Page 19: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Financial Highlights

Equity Snapshot Income Statement

Balance Sheet Cash Flow and Other

(In US$ millions) 12/31/2011Cash and equivalents $ 4.1 Accounts receivable 69.7Working capital 96.8Total assets 156.4Total long term debt 0.0Total shareholders’ equity 142.5

(in US $ millions, except EPS) FY’11 FY’10

Revenue $ 81.2 $ 74.4

Gross profit 29.0 30.3Gross margin % 36% 41%Op Income 22.0 24.7Net Income 19.3 23.4GAAP EPS $0.44 $0.54

(in US $ millions) FY’ 11 FY’ 10

Cash flow from operations $ 5.24 $ 7.79

Cash flow from investing -5.6 -10.5

Cash flow from financing 0.6 2.7

Ticker symbol (NYSE Amex): CPHI

Share price (3/31/12): $0.68

52-week price range: $0.62 - $2.75

Shares outstanding (3/31/12): 43.5 M

Market cap (3/31/12): $29.6 M

P/E (FY’11 EPS of $0.44): 1.55 X

Page 20: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

20

Investment Highlights

Proven record in commercializing new and generic drugs

Pipeline of new products with potential blockbuster drugs

Diversified product portfolio with 20 products

Highly profitable with >20% net income margin

Experienced nationwide distribution network mainly targeting hospitals;

Page 21: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

Management Team

Ms. Zhilin LiPresident and CEO

Helpson founder (wholly-owned China Pharma subsidiary) Chairman and CEO of Helpson since 1993 Former President of Haikou Bio-Engineering Institute, President of Sichuan Institute of Biology Biology degree from Sichuan University

Ms. Yao HuangCTO

Began career at Helpson in 1994 Certified Senior Engineer and Registered Pharmacist Graduated from Chengdu Chinese Medicine and Pharmaceutics University >25 years professional experience in pharmaceutical manufacturing.

Mr. Yingwen ZhangIndependent Director

Independent director since January 2008. Commercial Counselor of the China Embassy in Malaysia from 2000 through 2005. Member of the BOD at Chongqing Wanli Holdings (Group) LLC (SHA:600847)

Mr. Michael BennettIndependent Director

Independent director since February 2008. Serves as Independent Director for various Chinese companies listed in the US. Graduated from Michigan State University with an MBA in Finance and BA in Accounting.

Mr. Baowen DongIndependent Director

Independent director since March 2008. Engineering and Medical Science faculty at the Sichuan University from 2003 to 2008,

assessed and evaluated faculty teaching. Concentration in biomedical and medical information research. Graduated from Xi’an University of Science and Technology in 1966

21

Page 22: China Pharma Holdings, Inc. PPT 2012.pdfChina Pharma Holdings, Inc. CPHI ( NYSE/Amex ) INVESTOR PRESENTATION 2 Safe Harbor Statement SafeHarborStatementUnderthePrivateSecuritiesLitigationReformActof

22

Contact Information

China Pharma Holdings, Inc.Diana Huang & Sam HsingPhone: +86-898-6681-1730E-mail: [email protected] Site: www.chinapharmaholdings.com

Corporate Headquarters: Haikou City, Hainan, P.R.China