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1997 oxirane derivatives
oxirane derivativesR 0030
51 - 119Studies on Triepoxide Analogues of Triptolide. — Triepoxideanalogues such as (IV) of the potent and antileukemic and immunosuppressivenatural product triptolide are prepared by oxidation of dienooxiranes suchas (I) with in situ generated dioxiranes and basic hydrogen peroxide. Theintermediate diepoxides (II) and (III) are found to be cytotoxic. — (YANG,D.; WONG, M.-K.; CHEUNG, K.-K.; CHAN, E. W. C.; XIE, Y.; TetrahedronLett. 38 (1997) 39, 6865-6868; Dep. Chem., Univ. Hong Kong, Hong Kong,Peop. Rep. China; EN)
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