Cevac Chlamydia - ?· Cevac® Chlamydia Cevac® Chlamydia 1: EAE – stats and facts 2: What does disease…

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  • Cevac

    Chlamydia

    Cevac Chlamydia

    1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • MORE INFO

    Stats and factsCevac

    Chlamydia

    1. LONGBOTTOM, 2012 2. MEARNS, 2007

    The most frequently diagnosed cause of abortion in UK sheep is enzootic abortion (EAE), caused by the bacteria Chlamydophila abortus

    33.8%1increasing to 47.6% in flocks > 150 animals

    Prevalence of EAE in UK flocks:

    EAE is estimated to cost the sheep industry over

    per annum215 million

    Those who have experienced the losses associated with the condition are strongly motivated to prevent it happening again, proving the huge impact that it can have

    76.8%of flocks that have experienced EAE now vaccinate against infection only 15% of those farms without a history of infection vaccinate1

    MORE INFO

    1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • 2. MEARNS, 2007

    An abortion rate of over 2% is suggestive of an infectious cause and should be investigated

    Enzootic abortion causes foetal death in late pregnancy or birth of very weak lambs that rarely survive. Ewes are often well in themselves at the time of abortion

    If infection occurs more than 6 weeks from birth, it remains latent and remerges in the subsequent pregnancy (causing abortion or weak lambs)

    Abortion often occurs in storms, with typical abortion rates of 30%2

    What does the disease look like?

    MORE INFO

    MORE INFO

    MORE INFO

    MORE INFO

    Cevac

    Chlamydia1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • What does the disease look like?

    2. MEARNS, 2007

    An abortion rate of over 2% is suggestive of an infectious cause and should be investigated

    Having the odd abortion is often accepted by shepherds, but if 2-3% of the flock are aborting, or there is an abortion rate of greater than 1% over a couple of days, it is likely that the problem is infectious in origin and is likely to escalate

    Cevac

    Chlamydia1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • Bacteria enters sheep via the ingestion of infected afterbirth and vaginal dischargeBacterium is ingested by sheep as an elementary body (defined as extra-cellular, infectious, metabolically inactive and resistant to external media, such as antibiotics)

    The bacteria travels to the placenta, infecting the cells thereChlamydophila abortus has a tropism for ruminants placentas - the elementary body is taken into placental cells via endocytosis

    1

    6-10 hrs

    0 hrs

    10-24hrs 24-72hrs

    Bacteria multiply within the placental cellsThe elementary body converts to a reticulate body (defined as intra-cellular, metabolically active and sensitive to antimicrobials), allowing bacterial multiplication by binary division (the bacteria can only replicate within the cytoplasm of a eukaryote cell in this way)

    Escalating inflammation and cell damage interferes with placental function, shutting down the vital support that it offers the unborn lambExtensive cell lysis compromises foetal nutrient uptake, waste elimination, and gas exchange, leading to eventual foetal death or the birth of very weak lambs

    The multiplying bacteria cause the cell to burst, releasing more infective bacteria and causing inflammationReticulate bodies convert back to elementary bodies before cell lysis occurs, allowing further surrounding cell infection and eventual extensive tissue damage

    When initial infection occurs less than 6 weeks before a ewes due date, infection does not reach the placenta and cause damage. Instead, the bacteria remain hidden and seemingly harmless, until the ewe is next pregnant, when it travels to the placenta and causes abortion via the process explained aboveThe mechanism of this latency seems to include lymphoid tissue, but is currently poorly understood

    2 3 4

    5

    What does the disease look like?Enzootic abortion causes foetal death in late pregnancy or birth of very weak lambs that rarely survive. Ewes are often well in themselves at the time of abortion

    Enzootic abortion in ewes (EAE) is caused by the small, Gram-negative bacterium, Chlamydophila abortus.

    The Chlamydia bacteria infect the placenta, damaging it and so affecting (and often stopping) the development of the lamb

    Cevac

    Chlamydia1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • What does the disease look like?If infection occurs more than 6 weeks from birth, it remains latent and remerges in the subsequent pregnancy (causing abortion or weak lambs)

    YEAR 1

    Conception

    or

    Aborted lamb

    Infected lamb (rarely survives)

    6 weeks before due date

    Due date

    YEAR 2

    Conception

    Infected less than 6 weeks before due date

    Infected becomes latent - remains within sheep

    Infected more than 6 weeks before due date

    or

    Aborted lamb

    Infected lamb (rarely survives)

    or

    Cevac

    Chlamydia1: EAE stats and facts

    2: What does disease look like?

    How do I know its an infectious cause?

    How does Chlamydophila abortus cause abortion?

    Latent infections

    Abortion storms and unvaccinated flocks

    3: How disease is spread

    4: Impact of disease

    Zoonotic Risk

    5: Control of disease

    Reduction of infection following vaccination

    6: Why Cevac Chlamydia?

    Vaccine mode of action

    Pack sizes

    Cevac vaccination kit

    Sterimatic needle protector and cleaning system

    7: Vaccination points to consider

    8: FAQs

    9: In the face of an outbreak

    10: Relevant clinical paper titles and regulatory information

  • What does the disease look like?

    2. MEARNS, 2007

    Abortion often occurs in storms, with typical abortion rates of 30%2

    In unvaccinated flocks: Even though ewes have solid immunity post-abortion, in endemic flocks,

    an abortion rate of 5% a year can be seen. However, a typical feature of EAE is abortion storms that can involve 30% or more of ewes

    2-3 years after infection is introduced into the flock, abortion rates drop below 10%, then a new bout of abortions can occur in first time lambers and new replacement animals

    Naive, infection free flock 1st season 2nd season

    High abortion rate. Those infected less than

    6 weeks from delivery become latently infected