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DANIEL RĂDUȚĂ
ROMANIAN ASSOCIATION AGAINST LEUKEMIA
Center of Excellence for treatment of hematologic
diseases
Briefly
Center of Excellence at Bucharest University Hospital Treatment of hematological diseases
One of the most renowned European centers offers the know-how San Raffaele Hospital, Milano, Italy
ARIL (Romanian Association against Leukemia) supports the project
Summary
Hematological diseases and their treatment in Romania Through the story of a leukemia patient: me
The need for improving Romanian conditions Expressed in facts and numbers
Our proposal
The project
People and expertise
What is a hematological disease
Hematological diseases affect the bone marrow and blood There are chronic and acute forms Leukemia and lymphoma account for 90%
I was diagnosed with Acute Leukemia in 2009 Left untreated, acute forms kill you in a few weeks
Some say is a death sentence I’m the living proof of the contrary
The treatment
Two major therapies Chemotherapy (full cycle) Bone marrow transplantation (BMT), preceded by initial
chemotherapy
Acute forms are the most difficult to treat Aggressive chemotherapy that weakens the patients immunity and
organism One needs proper sterile facilities to avoid (often fatal) complication BMT is required in many of such cases
I was treated in one of the best facilities in Romania However, the sterile conditions are still lower than the standards As a result, many patient suffer fatal complications Lucky me …
Bone marrow transplantation
BMT is increasingly preferred as the best solution My form of leukemia required a BMT
Only two types of transplant are performed in Romania Autologous (using one self's healthy cells) Matched Related Donor (MRD): uses stem cells from a fully
compatible brother or sister
I needed one of the others Partially Matched Related Donor Matched Unrelated Donor (MUD) With stem cells from Cord Blood
BMT in this cases
In another EU country at a cost of at least 120.000€
As a Romanian, you have two choices Pay the money from your own pocket Access special government funds
A fund raising campaign got me the money in 2 monthsThe government procedure can take as long as 12
months While waiting, a patient receives further aggressive chemotherapy
Again I was lucky!
A few other patients who did not find cure in Romania
People you see here are some that appeared in mass-media and some we had time to request their explicit agreement
Situation in Romania
European Cancer Observatory estimated
3265 people
were diagnosed with leukemia or lymphoma in 2008
At most 140 BMT
were performed in 2009, according to the Romanian official press releases
15601705
LeukemiaLymphoma
Sources: European Cancer Observatory ( http://eu-cancer.iarc.fr ) , Romanian Newspapers and Journals
4%
96%
Therapy
BMTOnly chemotherapy
Situation in Europe
A study of EBMT shows that most European countries perform at least 200 BMT per 10 million inhabitants
with many of them performing at least 400 BMTper 10 million inhabitants
EBMT (European Group for Blood and Marrow Transplantation) study can be found here
HSCT stands for Hematopoietic Stem Cell Transplantation which is just another name for BMT
Comparison
Incidence of leukemia and lymphoma does not vary significantly from year to year
BMT procedures in Europe increased each year
So we may perform a fairly accurate comparison between Romania and EU for 2009
BMT per 10 million0
50
100
150
200
250
300
350
400
RomaniaWestern EUCentral EU
How many would have a better chance
If Romania reaches at least Central Europe’s minimum BMT rate,
260 more patients
would be transplanted each year, thus having a much better chance for long-term survival
4%
96%
Actual
BMT Full chemotherapy
12%
88%
Desired
BMT Full Chemotherapy
Our proposal
Center of Excellence at Bucharest University Hospital (SUUB)
People involved The team from San Raffaele Hospital in Milan, lead by dr. Fabio Ciceri The team from SUUB lead by dr. Horia Bumbea and dr. Ana Vlădăreanu
Competencies Italian team agreed to transfer the expertise and competencies the
Romanian team does not yet poses
Facility Equipping a brand-new transplant facility Improving the existing hematological facility Updating the diagnostic laboratory with the latest technology
HSR, the key partner
Who is HSR Bone Marrow Transplantation Unit at San Raffale Hospital,
Milano, Italy Participants in this project include dr. Fabio Ciceri, dr. Jacopo
Peccatori, dr. Andrea Assanelli, cs. Vincenzo Matozzo
They will offer intensive training and supervision to professionals at SUUB They evaluated three potential partners in Romania They chose SUUB team as the most promising one
The collaboration is ready to take off Training plan is made, resources and costs estimated
More about HSR on their website: http://www.fondazionesanraffaele.it/EN_home/index.html
More about HSR
BMT Unit is considered one of the best in Europe
Recognized by the community as having very good research activity
One of the few centers in Europe who successfully perform PMRD transplants on a large scale
Comparison to Romanian centers HSR performed more transplants than all our centers HSR performs all 5 types of transplant, compared to
only 2
Project goal & objectives
The Goal Improve the treatment conditions in Romania and
consequently save more patients Perform PMRD transplants in Romania
Main Objectives 30 transplants in the 2nd year of functioning The first PMRD transplant in Romania in the 2nd year
Secondary Objectives Build up transplant expertise at SUUB and also in the
Romanian medical community Expand the transplant center in the following years
Project activities
Management
Communication plan
Monitoring & controlling
Planning & estimations
People & Responsibilitie
s
Medical training
Facility costs
Other costs
Project documentation
Obtaining funds
Applying for Swiss funds
Applying for EU programs
Donations and sponsors
Medical training
Training at HSR
Interventions at HSR
Supervised activity at
SUUB
Assisted activity at
SUUB
Facility equipment
Acquisition process
Implementation
Communication & PR
Project Website &
Blog
Online Media
Traditional Media
Presentations and
networking
Project estimated costs
Facility costsStaff training Interventions costsOther costs
Interventions costs would be supported by the Romanian Public Assurance
For the rest, we must find solutions
Facility50%
Train-ing4%
In-ter-ven-tions40%
Other6%
5.000.000 €
Project team
The backbone consists of the two great medical teams A very promising medical team at SUUB One of Europe’s most renowned medical teams as mentors
Supporting team Full-time involvement of ARIL’s president, Monica Bunaciu,
formerly diagnosed with leukemia Daniel Răduță, formerly diagnosed with leukemia, Project
Manager at BitDefender Adina Ovedenie, ARIL volunteer, expert in European funds Diana Stoleru, ARIL volunteer, Chanel Manager at BitDefender Ruxandra Predescu, ARIL volunteer, PR specialist
