Upload
others
View
3
Download
0
Embed Size (px)
Citation preview
Center for Cancer Research Overview
Center to Reduce Cancer Health Disparities Workshop
Glenn Merlino, Ph.D.
Acting Scientific Director for Basic Research
May 2016
CCR is part of the Intramural Research Program (IRP) of NIH
EXTRAMURAL
Grants Programs Centers
INTRA MURAL
VISION Integrate basic, translational, and clinical
research to make cancer preventable, curable, or chronically manageable
Discovery-driven Basic Research
Clinical Trials & Patient Care
Translational Research
Clinical Research
225 PIs ~ $400M budget
Bethesda & Frederick
24 Basic
Science Laboratories
19 Clinical
Research Branches
3 Goal/Theme-
Oriented Programs
The CCR in numbers
190 postbaccalaureate/ predoctoral students 767 postdoctoral/ clinical fellows
335 summer students
226 staff scientists/staff clinicians 430 technical lab staff
A network of Labs/Branches • 46 Labs/Branches/Programs
• NIH Interest Groups - More than 80
• Centers of Excellence • Chromosome Biology • Immunology • Genomics • Genitourinary Malignancies • HIV
• Initiatives
• Rare Tumors • Advanced Preclinical Research • Comparative Oncology • Microbiome
The NCI CCR is a distinctive research environment
§ Bottom-up environment: Projects are investigator-driven
§ High-risk, high-impact research and technology development is encouraged
§ Secure resources
§ Highly interactive, interdisciplinary culture amongst basic and clinical scientists
§ Efficient bench-to-bedside-to-bench translation through access to the world’s largest clinical research hospital
§ Emphasis on underdeveloped research topics, emerging areas, rare cancers and underserved patient populations
What kind of research do we do?
Basic 49%
Clinical Translational
51%
§ Full spectrum from basic to clinical
§ High-risk, high-reward
§ Long time horizon
§ Creative, innovative, transformational, unique
§ Work that might not be possible in the extramural environment due to limitations in funding, infrastructure, patient populations
Interdisciplinary Strengths of CCR’s Research Portfolio
33%
14%
11%
11%
11%
8%
7% 5%
Cancer Biology
Immunology
Chromosome Biology/Epigenetics
Chemistry/Structural Biology/Biophysics
Cell and Developmental Biology
HIV/ Cancer Virology
Molecular Biology/Biochemistry/Microbiology
Genetics and Genomics
The NCI Intramural Clinical Research Program § The NIH is home to the largest clinical research center in the world
§ The NCI is one of its major users
§ The NIH clinical center is not a regular hospital § It is dedicated to patient-intensive clinical research and to develop new
approaches for prevention, diagnosis, and treatment of cancer
§ The NCI intramural clinical program is a resource for both basic and clinical scientists
§ Translate basic discoveries to the point of first-in-human use
Examples of groundbreaking CCR research
§ Human Papilloma Virus
§ Gene therapy
§ Immunotherapy
§ Imaging methods (basic and clinical)
§ Chromatin biology
CCR Training
Training programs exist for: High School students
College students
Post Baccalaureate students
Veterinary School students
Medical and Dental School students
Post Doctoral Training -- Ph.D. / D.V.M.
Post Doctoral Training -- M.D.
Clinical Fellowship Program
Professor, Scientist, Clinician, Tech, Admin, etc.
Student
Undergrad
Graduate
Postdoc
Junior PI
CCR offers training to young scientists at several levels of education:
• State-of-the-art laboratory facilities, technology, and equipment
• Scientific and professional skills workshops and training
• Lectures and courses by eminent scientists
• Mentoring in a collaborative, team-focused environment
• Competitive stipends, paid leave, and medical insurance
Why Train at the NIH?
CCR Cores
Animal Resources
Imaging and
Microscopy
Nanotechnology
Clinical Research Support
Bioinformatics/ Computing
Flow Cytometry
Metabolomics
Drug Discovery
Chemistry/ Structural Biology
Cell Banking
and Aliquoting
Pharmacology
Genetics/ Genomics
Specialty CCR Programs
• Johns Hopkins University partnership in Drug Discovery Technologies • Associate Clinical Investigator Development Program • NCI/FDA Interagency Oncology Task Force (IOTF) Research and Regulatory Review
Fellowship • Summer Cancer Research Interns (CRI) Program for students from underrepresented
groups or disadvantaged backgrounds • Comparative Molecular Pathology Research Training Program • Sallie Rosen Kaplan fellowship program to retain women in independent science careers • Center for Cancer Training, Intramural Workforce Diversity Branch to increase scientific
workforce diversity
https://ccr.cancer.gov/training
Comparative Biomedical Scientists Training Program Trainees
Michigan(State(University(NCI(
Laboratory(of(Cancer(Biology((and(Gene:cs(
Metasta&c(Prostate((Cancer(
Ian&Moore,&D.V.M.( Anne&Sally&Davis,&D.V.M.(Heather&Tillman,&D.V.M.&Diplomate,&ACVP( Leah&Zadrozny,&D.V.M.(
Michigan(State(University(NIAID(
Laboratory(of(Infec:ous(Diseases(
Pandemic(Influenza(A(
NC(State(University(NIAID(
Laboratory(of(Infec:ous(Diseases(
Pandemic(Influenza(A(
NC(State(University(NHLBI(
Laboratory(of(Cardiac(Energe:cs(
Coronary(Atherosclerosis(
!
Sarah&Cramer,&D.V.M.&Diplomate,&ACVP(
Helen&Michael,&D.V.M.&Diplomate,&ACVP(
University(of(Maryland(NCI(
((((Laboratory(of(Cancer(Biology(and(Gene:cs(Melanoma(
University(of(Maryland(NCI(
Laboratory(of(Experimental(Immunology(
Effects(of(Microbiome(On(Cancer(
Purdue(University(NIAID(
Laboratory(of(Virology(Highly(Pathogenic(
Viruses(
Current Trainees - 2014
Michigan(State(University(NCI&
Pathology(Training/(Graduate(Studies(
Caroline&Andrews,&D.V.M.&Laura&Baseler,&D.V.M.&Diplomate,&ACVP(
Tiffany&Lyle,&D.V.M.&Diplomate,&ACVP(Purdue(University(
NCI(Laboratory(of(Molecular(
Pharmacology(Breast(Cancer((
Metastases(in(Brain(
Kara&Corps,&D.V.M.(NC(State(University(NINDS(
Neuroimmunology(Branch(Trauma&c(Brain(Injury(
Amy&McCalla,&D.V.M.(NC(State(University(
NCI(Pediatric(Oncology(Branch(Ewing’s(Sarcoma(((
Michigan(State(University(NCI&
Pathology(Training/(Graduate(Studies(
Jessica&Beck,&D.V.M.&Joy&Gary,&D.V.M.&Diplomate,&ACVP(
Michigan(State(University(NCI(
Laboratory(of(Cancer(Biology((and(Gene:cs(
Plasma(Cell(Tumors(
University(of(Maryland(NINDS&
Pathology(Training/(Graduate(Studies(
Ryan&Traslavina,&D.V.M.&Diplomate,&ACVP&
Trainees are graduate D.V.M. veterinarians aiming for a Ph.D. & specialty board certification!
Current and Former Trainees
Distinctive Alumni
CCR is consistently rated among the top ins4tu4ons in which to train*
*The Scien4st: Best Places for Postdocs Harold Varmus Former Director NIH, NCI
Kenneth Olden Former Director NIEHS
• 10 National Academy Members • 11 Institute of Medicine Members • 11 Academy of Arts & Sciences Members
How to start your career with us
https://ccr.cancer.gov/careers
@NCIResearchCtr
ccr.cancer.gov
www.cancer.gov