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CELL THEORY
A Brief History
Robert Hooke named the cell [1665] based on observations of the cell walls of cork tissue
Anton van Leeuwenhoek documented unicellular organisms based on observations of protozoa [1673] and bacteria [1683]
Paramecium - Protocista
Amoeba - Protocista
Matthias Schleiden proposed that cells were the fundamental units of plants based on observations of plant tissue [1838]
Plant cells
Plant Cell
Theodor Schwann proposed that cells were the fundamental units of animals based on observations of animal tissue [1839]
Blood
Sperm
Schleiden and Schwann are credited as the founders of The Cell Theory [1839]
All living things are made of cells.
Cells exhibit the fundamental characteristics of life:
Obtain energy—photosynthesis, chemosynthesis, or digestion Use energy—respire Excrete Waste Show Order Homeostasis Evolve Reproduce Move Respond to changes in environment Grow and repair damage to self
The development of the Cell Theory involved the input of numerous individuals from various nationalities over many years
Rudolph Virchow stated “omnis cellula a cellula ” [all cells arise from pre-existing cells based on observations of dividing cells [1855]
Rudolph Virchow stated “omnis cellula a cellula ” [all cells arise from pre-existing cells based on observations of dividing cells [1855]
The Cell Theory was modified to incorporate Virchow’s work
All organisms are made of cells
Cells are the smallest structural and functional unit of an organism [that carries out the life processes]
All cells come from pre-existing cells
BUT, exceptions remain:
1. Single-celled organisms ARE cells, not composed of cells; that is, they are a-cellular
2. Many cells are unique in composition—muscle cells
and fungal hyphae are multi-nucleated (i.e., more than one nucleus)
And, what about viruses?
Are not composed of cells but consist of a nucleic acid (DNA or RNA) in a protein coat
Yet conduct all of the cell processes (although with help, not independently)
SO:
Could there be an organism that does not contain a single cell?
Might there be some other fundamental unit of life? At least, in some cases?
Are the life processes sufficient criteria to distinguish between the living and the non-living?
Microscopes
Max magnification – X1000
Max Resolution 0.2um
Max magnification X1000,000
Max Resolution 0.5nm
Microscopic measurements
mm – millimeters
μm – micrometer
nm - nanometers
1m = 1000mm = 1000,000μm= 1000,000,000nm
Comaparison of Light and Electron Microscopes
Light Microscope
Human Cheek Cell Nerve Cells
Transmission Electron Microscope
Plant Cell Mitochondrion
Scanning Electron Microscope
Human Sperm Insect Head
Sizes of Biological Structures
Thickness of leaf Paramecium Sharp end of pin Plant cell Animal cell Mitochondrion Bacterium Ribosome DNA molecule Hydrogen atom
O.5mm 200μm 100 μm 40μm 20μm 1μm 0.5-1μm 20nm 2nm 0.04nm
Red and White Blood Cells
S.E. M Light Microscope