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CAT

(Critical Appraisal of the Topics)

OPUS 12 Scientist 2009 Vol. 3, No. 3

Submitted 09/2010; Revised 10/2010; Re-evised11/2010; Publis!ed 11/2010


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SCREEN FOR INITIAL VALIDITY ANDRELEVANCE

"!is #oun$l %$s $le$d& evie%ed b& OPUS 12Scientist US' ()ee-evie%ed electonic #oun$l*

"!e stud& %$s not s)onsoed b& $n& o+$ni$tiont!$t mi+!t inuence t!e stud& desi+n o esults

"!is inom$tion %ill !$ve $ diect im)$ct on t!e!e$lt! o ou )$tients

"!e )oblem $ddessed in t!is #oun$l is todetemine benets o e)idu$l (epid) vesus

int$venous/int$muscul$ (iv/im) $n$l+esi$ ot$um$tic ib $ctues (RFs) b& )eomin+ $ met$$n$l&sis stud&

"!is inom$tion, %ill euie us to c!$n+e ou

cuent )$ctice.


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DETERMINE THE INTENT OF THE ARTICLE

"!e investi+$tos %ee intended benets oe)idu$l (epid) vesus int$venous/int$muscul$(iv/im) $n$l+esi$ o t$um$tic ib $ctues (RFs)

b& )eomin+ $ met$ $n$l&sis stud&


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Cliicalcate!or"

Descriptio #referre$ St%$"Desi!

"!e$)& "ests t!e eectiveness o $

te$tment, suc! $s $ du+,su+ic$l )ocedue, o ot!eintevention

R$ndomied, double-

blinded, )l$cebo-contolled ti$l

i$+nosis e$sues t!e v$lidit& (is itde)end$ble4* $nd eli$bilit&(%ill t!e s$me esults be

obt$ined eve& time4* o $di$+nostic test, o ev$lu$test!e eectiveness o $ test indetectin+ dise$se $t $ )es&m)tom$tic st$+e %!en$))lied to $ l$+e )o)ul$tion

5oss-section$lsuve& (com)$in+t!e ne% test %it! $

eeence st$nd$d*

5$us$tion 'ssesses %!et!e $ subst$nceis el$ted to t!e develo)mento $n illness o condition

5o!ot o c$se-

contol

Po+nosis etemines t!e outcome o $

dise$se

6on+itudin$l co!ot

stud&


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7vidence

6evel

"!e$)&/Pevention,'etiolo+&/8$m

Po+nosis i$+nosis

1$ SR (%it!!omo+eneit&* o

R5"s

SR (%it!!omo+eneit&* oince)tion co!ot

studies; 5R:v$lid$ted in

dieent)o)ul$tions

SR (%it! !omo+eneit&*o 6evel 1 di$+nostic

studies; 5R: %it!1b studies omdieent clinic$l

centes

&' ndividu$l R5" (%it!n$o% 5ondence

ntev$l0? ollo%-u);

5R: v$lid$ted in$ sin+le

)o)ul$tion

V$lid$tin+ co!otstud& %it! +ood:::

eeence st$nd$ds;

o 5R: tested%it!in one clinic$l

cente

1c 'll o none 'll o none c$se-seies

'bsolute S)Pins $ndSnNouts


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6evel


Po+nosis i$+nosis


co!ot studies

SR (%it!!omo+eneit&* o

eit!e etos)ectiveco!ot studies ounte$ted contol

+ou)s in R5"s

SR (%it! !omo+eneit&*o 6evel =2 di$+nostic

studies

2b ndividu$l co!ot stud&(includin+ lo% u$lit&

R5"; e.+., @>0?ollo%-u)*

Retos)ectiveco!ot stud& o

ollo%-u) ounte$ted contol

)$tients in $n R5";eiv$tion o 5R:

o v$lid$ted ons)lit-s$m)leAAA onl&

7B)lo$to& co!otstud& %it! +ood:::

eeence st$nd$ds;5R: $te deiv$tion,

o v$lid$ted onl& ons)lit-s$m)leAAA o

d$t$b$ses

2c "OutcomesC Rese$c!;7colo+ic$l studies

"OutcomesCRese$c!

6evel 2 o7vidence


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6evel


Po+nosis i$+nosis


c$se-contol studies

SR (%it! !omo+eneit&*o 3b $nd bette studies

3b ndividu$l 5$se-

5ontol Stud&

Non-consecutive stud&;

o %it!out consistentl&$))lied eeence

st$nd$ds

4 5$se-seies ($nd )oou$lit& co!ot $nd

c$se-contol studiesA*

5$se-seies ($nd)oo u$lit&

)o+nostic co!ot

studies*

5$se-contol stud&,)oo o non-

inde)endent eeence

st$nd$d5 7B)et o)inion %it!out

eB)licit citic$l$))$is$l, o b$sed on

)!&siolo+&, benc!ese$c! o Cst

)inci)les"

7B)et o)inion%it!out eB)licit

citic$l $))$is$l, ob$sed on

)!&siolo+&, benc!

ese$c! o Cst)inci)les"

7B)et o)inion %it!outeB)licit citic$l

$))$is$l, o b$sed on)!&siolo+&, benc!

ese$c! o Cst

)inci)les"

6evel 3,D,E o7vidence


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ra$es ofRecoe$atio

' consistent level 1 studies

F consistent level 2 o 3 studies o

eBt$)ol$tions om level 1 studies5 level D studies o eBt$)ol$tions om

level 2 o 3 studies

level E evidence o toublin+l&inconsistent o inconclusive studies o$n& level


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HANK YOU

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