Cardiac Arrest Canabis

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    Cases Journal

    Open AccesCase Report

    Cardiac arrest following cannabis use: a case reportAbdo H Sattout* and Mark F Nicol

    Address: Department of Emergency Medicine, Macclesfield District General Hospital, Victoria Road, Macclesfield, Cheshire, SK10 3BL, UK

    Email: Abdo H Sattout* - [email protected]; Mark F Nicol - [email protected]

    * Corresponding author

    Abstract

    Background: Cannabis, orMarijuana, remains one of the most universally used recreational drugs.Over the last four decades, its popularity has risen considerably as it became easily accessible and

    relatively affordable. Peak use is amongst the young aged 18 to 25 years, although these figures are

    now shifting towards earlier teens. A strongly installed culture still regards cannabis a harmless

    drug, yet as more reports have shown there are considerable adverse cardiovascular events linked

    with its use.

    Case Presentation: In this paper, we present the case of a 15-year-old male who suffered a

    cardiac arrest following cannabis use and survived the episode.

    Conclusion: Cardiac arrest is a rare and possibly fatal consequence of cannabis use. Publicawareness should be raised by extensively promoting all potential complications associated with its

    use.

    IntroductionThe recreational use of cannabis, or marijuana, has beenon the rise since the 1960s. Its popularity has been cata-lysed by an easy accessibility and affordability. Peak use isgenerally amongst the young aged 18 to 25 years [1-3],although these figures are now shifting towards earlierteens [2]. Nevertheless, a strongly installed culture still

    regards cannabis harmless when compared to other exist-ing illicit drugs [1]. As more reports have shown, there areconsiderable adverse cardiovascular events linked with itsuse.

    Case ReportA 15-year-old English Caucasian male was brought to ouremergency department having suffered a witnessed car-diac arrest, following the use of alcohol and cannabis withfriends. Paramedics attended the scene within three min-utes of call being passed: cardiopulmonary resuscitation

    (CPR) was in progress by the patient's friends, and the firstrecorded rhythm was asystole. After two minutes of CPR,the rhythm changed into ventricular fibrillation (VF)

    which was successfully cardioverted into a sinus rhythmwith a single DC shock (200 J).

    On arrival to hospital, the patient was maintaining his air-

    way with respiratory arrhythmia. His vital signs showed ablood pressure (BP) of 115/86, a heart rate (HR) of 86bpm and a recorded GCS of 4 out of 15. In view of the res-piratory arrhythmia and impaired GCS, he was intubatedand ventilated.

    Investigations conducted in the emergency departmentshowed the initial 12-lead electrocardiogram (ECG) to bein a normal sinus rhythm without any acute ischaemia.No changes were identified on subsequent 12-lead ECGs.Urine drug screen (Princeton BioMeditech Corp., Accu-

    Published: 19 November 2009

    Cases Journal2009, 2:208 doi:10.1186/1757-1626-2-208

    Received: 12 October 2009Accepted: 19 November 2009

    This article is available from: http://www.casesjournal.com/content/2/1/208

    2009 Sattout and Nicol; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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    complications included ventricular tachy-arrhythmias [3]and atrial fibrillation [3,5,7,8].

    In our case, two facts need to be addressed. Firstly, the can-nabis causality was assumed on the result of the positive

    urine drug screen; hence, a full toxicology screen was notpursued. Secondly, an inpatient echocardiograph was alsonot documented and later not performed as the patientfailed to attend his outpatient's follow up. We feel theeffects of chronic cannabis abuse were most likely poten-tiated by the alcohol consumption. This could have led toa sudden over-parasympathetic activity along with a pos-sible tissue ischaemia, thus triggering the asystolic epi-sode.

    It is of interest to point out that there has been no reportyet in the literature stating an asystolic cardiac arrest fol-lowing cannabis use and survival at a young age.

    ConclusionRecreational use of cannabis will remain on the rise witha number of potentially serious, if not fatal, conse-quences. Availability and affordability has resulted in itbeing not only accessible to an adult population, but alsoteenagers. Since 2004, cannabis in the UK has been classi-fied as a 'class C' drug: a fact that is definitely carrying animmense health implication secondary to its consump-tion with calls already being raised to re-classify it as a'class B'. Public awareness should be extensively maderegarding all possible complications, and emergency phy-sicians should not assume asystolic arrest has an inevita-

    ble fatal outcome.

    AbbreviationsTHC: delta-9-tetrahydrocannabinol.

    ConsentWritten informed consent was obtained from the patient'sparents for publication of this case report. A copy of the

    written consent is available for review by the Editor-in-Chief of this journal.

    Competing interestsThe authors declare that they have no competing interests.

    Authors' contributionsAS, was responsible for the case review, literature reviewand final manuscript drafting.

    MN, was responsible for the manuscript critique andreview.

    All authors have read and approved the final manuscript.

    References1. Caldicott DG, Holmes J, Roberts-Thomson KC, Mahar L: Keep off

    the grass: marijuana use and acute cardiovascular events.Eur J Emerg Med2005, 12(5):236-44.

    2. Ashton CH: Pharmacology and effects of cannabis: a briefreview. Br J Psychiatry2005, 29(9):1184-93.

    3. Aryana A, Williams MA: Marijuana as a trigger of cardiovascular

    events: speculation or scientific certainty. Int J Cardiol2007,118(2):141-4.

    4. Vandhuick O, Pistorius MA, Jousse S, Ferreira-Maldent N, Guilmot JL,Guias B,et al.: Drug addiction and cardiovascular pathologies.

    J Mal Vasc2004, 29(5):243-8.5. Kosior DA, Filipiak KJ, Stolarz P, Opolski G: Paroxysmal atrial

    fibrillation in a young female patient following marijuanaintoxication - a case report of possible association. Med Sci

    Monit2000, 6(2):386-9.6. Ghuran A, Nolan J: Recreational drug misuse: issues for the

    cardiologist. Heart2000, 83(6):627-33.7. Lindsay AC, Foale RA, Warren O, Henry JA: Cannabis as a precip-

    itant of cardiovascular emergencies. Int J Cardiol 2005,104(2):230-2.

    8. Fisher BA, Ghuran A, Vadamalai V, Antonios TF: Cardiovascularcomplications induced by cannabis smoking: a case reportand review of the literature. Emerg Med J2005, 22(9):679-80.

    9. Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE: Trig-

    gering myocardial infarction by marijuana. Circulation 2001,103(23):2805-9.

    10. Bachs L, Morland H: Acute cardiovascular fatalities followingcannabis use. Forens Sci Int2001, 124(2-3):200-3.

    11. Daisley H, Jones-Le Cointe A, Hutchinson G, Simmons V: Fatal car-diac toxicity temporally related to poly-drug abuse. Vet HumToxicol1998, 40(1):21-2.

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