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Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Amie Eunah Hwang, PhD Kai-Ya Tsai, MSPH
James Huynh Lihua Liu, PhD
Heinz-Josef Lenz, MD Dennis Deapen, DrPH
Design By: Hinde Kast
Suggested Citation:
Hwang AE, Tsai KY, Huynh J, Liu L, Lenz H-J, Deapen D. Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017. Los Angeles Cancer Surveillance
Program, Norris Comprehensive Cancer Center, University of Southern California, 2020.
Copyright© 2020 by the University of Southern California.
All rights reserved.
This document, or parts thereof, may be reproduced in any form with citation.
CANCER IN LOS ANGELES COUNTY:
COLORECTAL CANCER
Los Angeles Cancer Surveillance Program USC/Norris Comprehensive Cancer Center
The Keck School of Medicine of the University of Southern California
CSP website: https://csp.usc.edu
Cancer data access portal for Los Angeles County + all California
https://explorer.ccrcal.org/
https://csp.usc.edu/https://urldefense.com/v3/__https:/explorer.ccrcal.org/__;!!LIr3w8kk_Xxm!61fQJrUNQ0af2iB4ntqMSy8Ro6aat5uKqhnRocB3GoVmR4zxagNQ3q5FKqSt70Cx-Xs$
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
PREFACE..................................................................................................................1
EXECUTIVE SUMMARY.......................................................................................2
HISTORICAL BACKGROUND OF THE CSP...................................................3
ACKNOWLEDGEMENT..................................................................................4
COLORECTAL CANCER STATISTICS..........................................................5
Incidence....................................................................................................................................5
Mortality...................................................................................................................................12
Survival.....................................................................................................................................16
SUMMARY OF COLORECTAL CANCER RISK FACTORS.......................22
Modifiable Risk Factors.........................................................................................................................22
Non-modifiable Risk Factors.................................................................................................................23
SUPPLEMENTAL MATERIAL ......................................................................25
The Diverse Population of Los Angeles County.....................................................................................25
How Cancer is Registered......................................................................................................................26
The Use of CSP Data for Research…………………………………………………………………...........26
The Importance of Investigating Time Trends and Survival……………………………………..........….27
Protection of Confidentiality………………………………………………………………………............28
Cancer Data………………………………………………………………………………………..….........28
Statistical Methods……………………………………………………………………………….…...........29
Cautions in Interpretations……………………………………………………………………….…....…..30
Table of Contents
As the most populous county in the United States with more than 10 million racially and ethnically
diverse residents, Los Angeles County is an ideal place for cancer research. The vast disparities in cancer
risk among different population groups provide excellent opportunities to gain better understanding
about the potential causes of each type of cancer in order to develop better cancer control and prevention
strategies. It was for this very reason a group of visionary faculty researchers in the University of
Southern California Medical School (now the Keck School of Medicine) established the Los Angeles
Cancer Surveillance Program (CSP).
For the past 50 years, the CSP has become a leader on the national and international stages for cancer
surveillance and cancer epidemiological research with multitudes of contributions to the field. The CSP
cancer data and its diverse demographics are a gold mine of information for not only scientific research,
teaching and training the next generation of public health professionals, but also for serving the
community needs and building academic and community partnerships.
The CSP is a valued member and strong partner of the Norris Comprehensive Cancer Center whose aim
is to make cancer a disease of the past, for which the CSP data plays a significant role. Likewise, the CSP
is able to leverage the expertise of Cancer Center scientists to ensure data are well used to achieve cancer
prevention and control. The CSP also partners with the Keck School of Medicine, the University of
Southern California, and the larger communities beyond. CSP informational reports like this one
underscore the CSP’s commitment to serving its local communities for the ultimate goal of improving cancer prevention, detection, treatment, and survival.
This report was prepared by the following researchers: Amie E. Hwang, PhD, cancer epidemiologist and
Assistant Professor; Kai-Ya Tsai, statistician; James Huynh, research assistant; Lihua Liu, PhD,
director and Associate Professor; Heinz-Josef Lenz, MD, clinical oncologist, Professor; Dennis
Deapen, DrPH, epidemiologist and Professor.
Preface 1
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Colorectal cancer is the third most commonly diagnosed cancer among men and the second most common among women in Los Angeles County. Over 3,800 people are newly diagnosed with colorectal cancer every year in Los Angeles County. Colorectal cancer occurs most commonly in the older population with an incidence rate of 71 per 100,000 for 50-64 year olds and 215 per 100,000 for 65+ year olds. Due to active screening for those 50 years of age or older, localized disease is more common in the older population, but younger patients are more frequently diagnosed with distant disease for whom screening recommendations are lacking. Non-Hispanic Blacks experience the worst burden of colorectal cancer as they have the highest incidence rate, higher proportion of distant disease and the highest rate of mortality. Compared to Non-Hispanic Whites, Non-Hispanic Blacks have 23% higher risk of being diagnosed with colorectal cancer and 56% higher risk of dying from colorectal cancer. Hispanics have lowest incidence and lower mortality than non-Hispanic Whites. Incidence rates of this cancer have steadily declined since 2000, most notably among Non-Hispanic Blacks and for localized diseases, but not in Hispanics. Mortality rates have also declined significantly for those over 65 years of age, but have remained unaffected for the other age groups. Risk for colorectal cancer is increased with an excess weight, sedentary lifestyle, red meat consumption, smoking, and alcohol intake. Those with family history of colon cancer or adenomatous polyps, Lynch syndrome and inflammatory bowel disease are also at elevated risk of colon cancer.
In order to provide the most comprehensive yet precisely focused information for the broader
community, we provide the colorectal cancer statistics in three publications independently focused on
colon cancer, rectal cancer and combined colorectal cancer. We recommend that the readers refer to the
other publications to serve their specific needs (“Cancer in Los Angeles County: Colon Cancer
Incidence, Mortality and Survival 2000-2017” and “Cancer in Los Angeles County: Rectal Cancer
Incidence, Mortality and Survival 2000-2017”).
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Executive Summary 2
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
The Los Angeles Cancer Surveillance Program (CSP) is the population-based cancer registry for Los
Angeles County. It identifies and obtains information on all new cancer diagnoses made in the County.
The CSP was organized in 1970 and operates within the administrative structure of the Keck School of
Medicine and the Norris Comprehensive Cancer Center of the University of Southern California. In
1987, it became the regional registry for Los Angeles County for the then new California Cancer
Registry. The CSP is one of 3 such regional registries collectively providing statewide cancer surveillance.
In 1992, the CSP joined the National Cancer Institute’s Surveillance, Epidemiology and End Results
(SEER) program. This consortium of 16 population-based SEER registries provides the federal
government with ongoing surveillance of cancer incidence and survival in the U.S. To date, the CSP
database contains more than 1.7 million records, and about 47,000 incident cancers are added annually.
The CSP is one of the most productive cancer registries in the world in terms of scientific contributions
toward understanding the demographic patterns and the causes of specific cancers. The CSP has a
bibliography of more than 10,000 publications in scientific journals. The registry supports a large
ongoing body of research funded mainly by the U.S. National Cancer Institute, other cancer research
organizations, and the State of California.
Historical Background of the CSP 3
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
The collection of cancer incidence data used in this study was supported by the California Department of
Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease
Control and Prevention’s (CDC) National Program of Cancer Registries, under cooperative agreement
5NU58DP006344; the National Cancer Institute’s Surveillance, Epidemiology and End Results
Program under contract HHSN261201800032I awarded to the University of California, San Francisco,
contract HHSN261201800015I awarded to the University of Southern California, and contract
HHSN261201800009I awarded to the Public Health Institute. The ideas and opinions expressed herein
are those of the authors and do not necessarily reflect the opinions of the State of California,
Department of Public Health, the National Cancer Institute, and the Centers for Disease Control and
Prevention or their Contractors and Subcontractors.
This work would not be possible without the work and dedication of CSP field technicians, other CSP
staff members, and cancer registrars across Los Angeles County and beyond.
Acknowledgement 4
Amie Hwang Kai-Ya Tsai James Huynh
Lihua Liu Heinz-Josef Lenz Dennis Deapen
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 1. Frequency and Distribution of Invasive Colorectal Cancer Cases by Sex, Age,
Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.
Male Female Male and Female N % N % N %
Age (years) 0-39 1,032 3 939 3 1,971 3 40-49 2,843 8 2,520 7 5,363 8 50-64 11,251 32 9,245 27 20,496 30 65+ 20,508 58 21,118 62 41,626 60
Race/Ethnicity Non-Hispanic White 16,721 47 15,831 47 32,552 47 Non-Hispanic Black 4,078 11 4,460 13 8,538 12 Hispanic 8,686 24 7,860 23 16,546 24 Asian/Pacific Islander 5,793 16 5,390 16 11,183 16 Other/Missing 356 1 281 1 637 1
Asian Pacific Islander Ethnicity Chinese 1,696 5 1,505 4 3,201 5 Japanese 902 3 877 3 1,779 3 Filipino 1,157 3 1,154 3 2,311 3 Korean 1,008 3 854 3 1,862 3 Vietnamese 372 1 376 1 748 1 South Asian 178 0 107 0 285 0 Thai/Hmong/Cambodian/Laotian 200 1 208 1 408 1 Hawaiian/Samoan 82 0 84 0 166 0
Socioeconomic Status High 7,017 20 6,529 19 13,546 20 Mid-High 7,380 21 7,253 21 14,633 21 Middle 6,856 19 6,763 20 13,619 20 Mid-Low 7,586 21 6,957 21 14,543 21 Low 6,795 19 6,320 19 13,115 19
Disease Stage Localized 13,586 38 12,690 38 26,276 38 Regional 12,593 35 11,894 35 24,487 35 Distant 7,061 20 6,643 20 13,704 20
Unknown 2,394 7 2,595 8 4,989 7
A total of 69,456 patients were diagnosed with colorectal cancer from 2000-2017 in Los Angeles County. 90% of
the patients were 50 years of age or older at diagnosis. 47% of the patients were Non-Hispanic Whites.
Colorectal Cancer Statistics 5
INCIDENCE
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
Age 0-39 Age 40-49 Age 50-64 Age 65+
Prop
ortio
n of
cas
es
Figure 1A. Distribution of Disease Stage by Age
Localized Regional Distant
Figure 1. Disease Stage Distribution of Invasive Colorectal Cancer by Age, Race/Ethnicity
and Socioeconomic Status, Los Angeles County, 2000-2017.
0%5%
10%15%20%25%30%35%40%45%50%
Prop
ortio
n of
cas
es
Figure 1B. Distribution of Disease Stage by Race/Ethnicity
Localized Regional Distant
Colorectal Cancer Statistics 6
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Figure 1. Disease Stage Distribution of Invasive Colorectal Cancer by Age, Race/Ethnicity
and Socioeconomic Status, Los Angeles County, 2000-2017.
Distant disease is more common among younger patients and localized disease is more
common among older patients.
Non-Hispanic Blacks have the highest proportion of distant disease. East Asians have the
lowest.
Patients of higher socioeconomic status are diagnosed with localized diseases more frequently.
0%5%
10%15%20%25%30%35%40%45%50%
Highest Upper-Middle Middle Lower-Middle Lowest
Prop
ortio
n of
cas
es
Figure 1C. Distribution of Stage by Socioeconomic Status
Localized Regional Distant
Colorectal Cancer Statistics 7
Table 2A. Age-Adjusted Incidence Rates of Invasive Colorectal Cancer by Sex, Age,
Race/Ethnicity and Disease Stage (per 100,000 population), Los Angeles County, 2000-2017.
The incidence of colorectal canc er is the highest in the older males. Hispanics have lower incidence than other race/ethnic groups. Patients are diagnosed with localized and regional diseases more frequently than
distant diseases.
Colorectal Cancer Statistics 8
Male Female Male and Female Total 49.0 36.6 42.1 Age (years)
0-39 2.0 1.9 1.9 40-49 22.3 19.4 20.8 50-64 81.0 61.3 70.7 65+ 255.3 185.2 215.0
Race Non-Hispanic White 51.0 39.3 44.7 Non-Hispanic Black 62.8 49.3 54.9 Hispanic 40.6 28.4 33.5 Asian/Pacific Islander 48.2 34.5 40.4
Asian/Pacific Islander Ethnicity Chinese 43.1 31.4 36.7 Japanese 61.8 43.6 51.4 Filipino 45.1 29.8 35.7 Korean 54.4 34.6 42.9 Vietnamese 50.4 43.5 46.5 South Asian 26.1 15.9 21.0 Thai/Hmong/Cambodian/Laotian 46.7 36.0 40.3 Hawaiian/Samoan 86.5 64.9 71.5
Disease Stage Localized 18.7 13.8 16.0 Regional 17.4 12.9 14.9 Distant 9.5 7.2 8.2
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 2B. Incidence Rate Ratio for Invasive Colorectal Cancer by Sex and Race/Ethnicity,
Los Angeles County, 2000-2017.
Male Female Male and Female Race/Ethnicity
Non-Hispanic White (Reference) 1.00 1.00 1.00 Non-Hispanic Black 1.23 1.25 1.23 Hispanic 0.80 0.72 0.75 Asian/Pacific Islander 0.95 0.88 0.90
Asian/Pacific Islander Ethnicity Chinese 0.85 0.80 0.82 Japanese 1.21 1.11 1.15 Filipino 0.89 0.76 0.80 Korean 1.07 0.88 0.96 Vietnamese 0.99 1.11 1.04 South Asian 0.51 0.40 0.47 Thai/Hmong/Cambodian/Laotian 0.92 0.92 0.90 Hawaiian/Samoan 1.70 1.65 1.60
Non-Hispanic Blacks and Hawaiian/Samoan experience the highest incidence and excess risk of 23-70%,
and South Asians the lowest.
Colorectal Cancer Statistics 9
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Figure 2. Annual Age-Adjusted Incidence Rate Trends of Invasive Colorectal Cancer by
Disease Stage, Race/Ethnicity and Sex (per 100,000), Los Angeles County, 2000-2017.
0.0
5.0
10.0
15.0
20.0
25.0
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Age-
Adju
sted
Inci
denc
e Ra
te
Year of Diagnosis
Figure 2A. Annual Age-Adjusted Incidence Rate Trends by Disease Stage
Localized Regional Distant
Colorectal Cancer Statistics 10
0.0
10.0
20.0
30.0
40.0
50.0
60.0
70.0
80.0
90.0
Age-
Adju
sted
Inci
denc
e Ra
te
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Year of Diagnosis
Figure 2B. Annual Age-Adjusted Incidence Rate Trends by Race/Ethnicity among Males
Non-Hispanic White Non-Hispanic Black Hispanic Asian Pacific Islander
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
0.0
10.0
20.0
30.0
40.0
50.0
60.0
70.0
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Age-
Adju
sted
Inci
denc
e Ra
te
Year of Diagnosis
Non-Hispanic White Non Hispanic Black Hispanic Asian Pacific Islander
Figure 2. Annual Age-Adjusted Incidence Rate Trends of Invasive Colorectal Cancer by
Disease Stage, Race/Ethnicity and Sex (per 100,000), Los Angeles County, 2000-2017.
Figure 2C. An nual Age-Adjusted Incidence Rate Trend by Race/Ethnicity among Females
The downward trend of incidence is more prominent for localized and regional disease and for Non-
Hispanic Blacks. Incidence of regional colorectal disease increased slightly after 2014. The wide
racial/ethnic disparity in colorectal cancer has narrowed over time but the risks for Hispanics
remained unimproved.
Colorectal Cancer Statistics 11
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 3A. Age-Adjusted Mortality Rates of Colorectal Cancer by Sex, Age, and Race/Ethnicity
(per 100,000 population), Los Angeles County, 2000-2017.
Females have lower mortality than males in general but the difference is most notable for those over
age 50. The highest colorectal cancer mortality rate is among Non-Hispanic Black males followed by
Japanese and Thai/Hmong/Cambodian/Laotian males. Vietnamese females have the lowest colorectal
cancer mortality rate. Due to potential underestimation of rates in South Asians, South Asian data
should be interpreted cautiously (see Statistical Methods).
Colorectal Cancer Statistics 12
MORTALITY
Male Female Male and Female Total 18.0 12.9 15.1 Age (years)
0-39 0.5 0.4 0.4 40-49 6.1 4.8 5.5 50-64 23.2 16.4 19.7 65+ 105.4 74.8 87.6
Race/Ethnicity Non-Hispanic White 18.1 13.5 15.6 Non-Hispanic Black 28.3 20.4 23.6 Hispanic 15.7 10.2 12.4 Asian/Pacific Islander 16.0 10.7 13.0
Asian/Pacific Islander Ethnicity Chinese 16.2 11.5 13.6 Japanese 21.5 13.4 16.9 Filipino 14.6 8.4 10.8 Korean 17.3 11.5 13.9 Vietnamese 11.9 7.4 9.5 South Asian 5.5 5.2 5.4 Thai/Hmong/Cambodian/Laotian 21.3 10.1 14.0 Hawaiian/Samoan 16.5 10.4 13.4
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 3B. Mortality Rate Ratios for Colorectal Cancer by Sex and Race/Ethnicity,
Los Angeles County, 2000-2017.
Male Female Male and Female Race/Ethnicity
Non-Hispanic White (Reference) 1.00 1.00 1.00 Non-Hispanic Black 1.56 1.51 1.51 Hispanic 0.87 0.75 0.80 Asian/Pacific Islander 0.88 0.79 0.83
Asian/Pacific Islander Ethnicity Chinese 0.89 0.85 0.87 Japanese 1.19 0.99 1.08 Filipino 0.81 0.62 0.69 Korean 0.96 0.85 0.89 Vietnamese 0.66 0.55 0.61 South Asian 0.30 0.38 0.35 Thai/Hmong/Cambodian/Laotian 1.18 0.75 0.90 Hawaiian/Samoan 0.91 0.77 0.86
Non-Hispanic Black males are at 56% increased risk of dying from colorectal cancer compared to
Non-Hispanic White males. Hispanic females are at 25% lower risk of dying compared to Non-
Hispanic White females.
Colorectal Cancer Statistics 13
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Figure 3. Annual Age-Adjusted Mortality Rate Trends of Colorectal Cancer by Age,
Race/Ethnicity and Sex (per 100,000), Los Angeles County, 2000- 2017.
0.0
20.0
40.0
60.0
80.0
100.0
120.0
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Age-
Adju
sted
Mor
talit
y Ra
te
Year of Death
Figure 3A. Annual Age-Adjusted Mortality Trends by Age
Age 0 to 39 Age 40 to 49 Age 50 to 64 Age 65+
Rate of dying from colorectal cancer has decreased significantly for older population, but for those under age
65, the mortality rates have not improved over time.
Colorectal Cancer Statistics 14
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
0.0
5.0
10.0
15.0
20.0
25.0
30.0
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Age-
Adju
sted
Mor
talit
y Ra
te
Year of Death
Figure 3C. Annual Age-Adjusted Mortality Rate Trends by Race/Ethnicity among Females
Non-Hispanic White Non-Hispanic Black Hispanic Asian Pacific Islander
0.0
5.0
10.0
15.0
20.0
25.0
30.0
35.0
40.0
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Age-
Adju
sted
Mor
talit
y Ra
te
Year of Death
Figure 3B. Annual Age-Adjusted Mortality Rate Trends by Race/Ethnicity among Males
Non-Hispanic White Non-Hispanic Black Hispanic Asian Pacific Islander
The significant disparity in mortality from colorectal cancer for Non-Hispanic Blacks has greatly been
reduced over time nonetheless, they still experience e the highest rate of colorectal cancer related death.
Colorectal Cancer Statistics 15
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 4. One- and Five-year Observed Survival from Invasive Colorectal Cancer by Sex, Age,
Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.
2000-2017.
The highest 5-year observed survival from colorectal cancer is found among South Asians and the
lowest among N on-Hispanic Blacks.
Colorectal Cancer Statistics 16
SURVIVAL
1 Year Survival (%) 95% CI
5 Year Survival (%) 95% CI
Sex Males 78.1 77.6-78.5 50.3 49.7-50.8 Females 77.4 76.9-77.8 51.2 49.7-50.8
Age (years) 0-39 87.1 85.5-88.6 60.2 57.7-62.6 40-49 87.5 86.6-88.4 63.0 61.6-64.4 50-64 86.1 85.6-86.6 62.5 61.8-63.2 65+ 71.9 71.5-72.4 43.1 42.6-43.7
Race/Ethnicity Non-Hispanic White 76.3 75.8-76.7 49.0 48.4-49.6 Non-Hispanic Black 72.8 71.8-73.7 44.3 43.2-45.4 Hispanic 80.2 79.5-80.8 53.3 52.5-54.2 Asian/Pacific Islander 81.6 80.9-82.3 55.7 54.7-56.7
Asian/Pacific Islander Ethnicity Chinese 81.5 80.0-82.8 56.6 54.7-58.4 Japanese 78.0 76.0-79.9 52.5 50.0-54.9 Filipino 82.5 80.9-84 56.2 53.9-58.3 Korean 84.0 82.2-85.6 57.7 55.2-60.1 Vietnamese 83.3 80.4-85.9 53.0 48.9-56.8 South Asian 84.7 79.8-88.5 64.4 57.8-70.2 Thai/Hmong/Cambodian/Laotian 76.8 72.2-80.7 49.3 43.8-54.7 Hawaiian/Samoan 78.6 71.4-84.1 47.1 38.8-54.9
Socioeconomic Status High 81.6 80.9-82.2 55.6 54.7-56.5 Mid-High 79.5 78.8-80.2 52.7 51.8-53.6 Middle 77.3 76.5-78.0 50.4 49.4-51.3 Mid-Low 77.2 76.5-77.9 49.0 48.1-49.9 Low 75.6 74.8-76.4 47.2 46.3-48.2
Disease Stage Localized 91.4 91.0-91.7 72.7 72.1-73.2 Regional 85.2 84.7-85.6 55.0 54.3-55.7 Distant 47.1 46.3-48.0 10.3 9.8-10.9 Unknown 50.9 49.4-52.4 22.5 21.1-23.8
CI: Confidence Interval
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 5. One- and Five-year Relative* Survival from Invasive Colorectal Cancer by Age,
Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.
Thai/Hmong/Cambodian/Laotian, and Hawaiian/Samoan colorectal patients have the worst 5-year
survival after accounting for expected survival from other causes of death. South Asians have the highest.
Colorectal Cancer Statistics 17
*Relative survival estimates the probability of survival from cancer considering the chances of dyingfrom other causes. It is calculated as a ratio of the observed survival among cancer patients to theexpected survival from all causes of death.
CI: Confidence Interval
1 Year Survival (%) 95% CI
5 Year Survival (%) 95% CI
Sex Males 83.5 83.0-83.9 63.9 63.2-64.7 Females 82.1 81.6-82.6 63.6 62.9-64.3
Age (years) 0-39 90.0 88.4-91.3 63.3 60.7-65.8 40-49 89.4 88.4-90.2 66.2 64.7-67.7 50-64 88.4 87.9-88.9 68.1 67.3-68.9 65+ 78.1 77.5-78.6 60.9 60.2-61.7
Race/Ethnicity Non-Hispanic White 81.9 81.4-82.5 64.9 64.1-65.7 Non-Hispanic Black 78.1 77.0-79.2 56.4 54.9-57.9 Hispanic 84.2 83.5-84.8 63.1 62.1-64.1 Asian/Pacific Islander 85.8 85.0-86.5 65.2 64.0-66.4
Asian Pacific Islander Ethnicity Chinese 86.0 84.5-87.3 68.0 65.8-70.2 Japanese 82.3 80.0-84.3 63.1 59.9-66.1 Filipino 86.9 85.2-88.4 64.9 62.3-67.4 Korean 87.8 85.9-89.4 66.7 63.8-69.5 Vietnamese 87.6 84.6-90.0 59.9 55.3-64.2 South Asian 89.1 83.9-92.8 70.7 62.8-77.2 Thai/Hmong/Cambodian/Laotian 77.9 73.0-82.0 53.6 47.3-59.5 Hawaiian/Samoan 80.8 73.0-86.6 54.6 44.5-63.6
Socioeconomic Status High 86.9 86.1-87.6 71.6 70.4-72.8 Mid-High 84.0 83.3-84.7 66.7 65.5-67.8 Middle 81.6 80.8-82.4 62.5 61.3-63.7 Mid-Low 81.7 80.9-82.4 60.7 59.6-61.8 Low 80.0 79.2-80.8 57.6 56.5-58.8
Disease Stage Localized 96.2 95.8-96.5 91.1 90.4-91.8 Regional 90.5 90.0-90.9 69.5 68.6-70.4 Distant 52.8 51.8-53.7 13.4 12.7-14.2 Unknown 57.4 55.6-59.2 32.0 30.0-34.0
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Figure 4. Annual 5-year Observed Survival Trends of Colorectal Cancer by
Age, Race/Ethnicity and Sex, Los Angeles County, 2000-2017.
35.0%
40.0%
45.0%
50.0%
55.0%
60.0%
65.0%
70.0%
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
5-ye
ar S
urvi
val p
roba
bilit
ies
Year of Diagnosis
Figure 4A. Annual Observed Survival Trends by Race/Ethnicity for Males
Non-Hispanic White Non-Hispanic Black Hispanic Asian Pacific Islander
35.0%
40.0%
45.0%
50.0%
55.0%
60.0%
65.0%
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
5-ye
ar S
urvi
val P
roba
bilit
ies
Year of Diagnosis
Figure 4B. Annual Observed Survival Trends by Race/Ethnicity for Females
Non-Hispanic White Non-Hispanic Black Hispanic Asian Pacific Islander
5-year survival probabilities for females have genera lly been improving since 2000. 5-year survival is higher for
Hispanic and Asian Pacific Islander females than Non-Hispanic White and Non-Hispanic Black females.
5-year survival probabilities for males improved since 2000 but slightly dropped after 2008 most notably
for Non-Hispanic Blacks. Non-Hispanic Black males have the lowest 5-year survival compared to the
other racial/ethnic groups.
Colorectal Cancer Statistics 18
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Figure 5. Kaplan-Meier Observed Survival Curves for Invasive Colorectal Cancer by
Age, Race/Ethnicity and Sex, Los Angeles County, 2000-2017.
Figure 5A. Kaplan-Meier Observed Survival Curves by Age
Colorec tal cancer patients aged 65 or older have significantly worse survival than those
under age 65. The survival patterns are similar for all age groups under 65.
Colorectal Cancer Statistics 19
Figure 5B. Kaplan-Meier Observed Survival Curve by Race/Ethnicity Among Males
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Survival disadvantage in Non-Hispanic Blacks with colorectal cancer is observed in both males and females. Asians Pacific Islanders and Hispanics have higher survival. The survival pattern
for Non-Hispanic white females is just as low as that for Non-Hispanic Black females
Figure 5C. Kaplan-Meier Observed Survival Curve by Race/Ethnicity Among Females
Colorectal Cancer Statistics 20
Figure 5. Kaplan-Meier Observed Survival Curves for Invasive Colorectal Cancer by
Age, Race/Ethnicity and Sex, Los Angeles County, 2000-2017.
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Table 6. Hazard Ratio* of Invasive Colorectal Cancer by Sex, Age, Race/Ethnicity,
Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.
Colorectal cancer patients aged 65 and older are more than twice as likely to die compared to those younger than
40. The excess risk of death is 2.5 fold for males and 3 fold for females. Lower socioeconomic status is associated
with higher risk of dying.
Colorectal Cancer Statistics 21
Male Female Male and Female HR 95% CI HR 95% CI HR 95% CI
Sex Males (Reference) 1.00 Females 0.93 0.91 - 0.95
Age 0-39 (Reference) 1.00 1.00 1.00 40-49 1.00 0.89-1.12 1.04 0.92-1.18 1.02 0.94 - 1.11 50-64 1.20 1.08-1.33 1.23 1.1-1.38 1.22 1.13 - 1.32 65+ 2.57 2.32-2.84 3.00 2.68-3.35 2.77 2.57 - 2.98
Race/Ethnicity Non-Hispanic White (Reference) 1.00 1.00 1.00 Non-Hispanic Black 1.09 1.04-1.13 1.00 0.96-1.05 1.04 1.01 - 1.08 Hispanic 0.87 0.84-0.91 0.83 0.79-0.86 0.85 0.83 - 0.87 Asian Pacific Islander 0.82 0.79-0.86 0.75 0.71-0.78 0.78 0.76 - 0.81
Socioeconomic Status High (Reference) 1.00 1.00 1.00 Mid-High 1.11 1.06-1.16 1.10 1.05-1.15 1.10 1.07 - 1.14 Middle 1.20 1.15-1.26 1.15 1.1-1.21 1.18 1.14 - 1.22 Mid-Low 1.26 1.2-1.32 1.26 1.2-1.32 1.26 1.22 - 1.3 Low 1.34 1.28-1.41 1.26 1.2-1.33 1.30 1.26 - 1.35
Disease Stage Localized (Reference) 1.00 1.00 1.00 Regional 1.57 1.51 - 1.62 1.62 1.57 - 1.69 1.59 1.55 - 1.64 Distant 6.61 6.37 - 6.87 6.92 6.65 - 7.2 6.75 6.57 - 6.93 Unknown 4.12 3.9 - 4.35 4.59 4.34 - 4.84 4.36 4.2 - 4.53
*Hazard ratios obtained from multivariate Cox regression models adjusting for all variables listed.HR: Hazard RatioCI: Confidence Interval
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Summary of Colorectal Cancer Risk Factors 22
MODIFIABLE RISK FACTORS
EXCESS WEIGHT
Excess weight, especially in men, is a known risk factor of colorectal cancer. This risk goes up with the increase in body weight. Obese individuals are at 40% increased risk than a person of normal weight.1 It is estimated that a quarter of the population in Los Angeles and nearly 40% of all adults in the US are obese.2
SEDENTARY BEHAVIORS
Physical inactivity throughout the day leads to a greater chance of developing colorectal cancer, independent of obesity. Prolonged sitting, such as while watching TV or working an office job, is associated with 60-90% excess risk of developing colorectal cancer.3,4
RED MEAT AND PROCESSED MEATS
The International Agency for Research on Cancer classifies processed meat as carcinogenic to humans and red meat as possibly carcinogenic. They concluded there was a strong positive association observed between the consumption of red meat or processed meat and colorectal cancer. Eating red meat and processed meat on a regular basis may increase the risk of colorectal cancer by 17-18%.5 Los Angeles ranked #1 in hot dog and sausage consumption in the US, consuming 31 million pounds in 2018. In the same year, 2.6 million Dodger dogs were consumed by Los Angeles County baseball fans.6
SMOKING
Smoking is a known cause of multiple cancers. Long-term smoking increases the risk of colorectal cancer by 26%.7 One-fifth of Black, Hispanic, and Asian males in Los Angeles are current smokers.2
ALCOHOL
Drinking any type of alcohol increases risk of colorectal cancer by 13% when compare d with non-drinkers. This risk increases with increased alcohol intake for both men and women.8 16% of adults in Los Angeles reported binge drinking (5 or more drinks for men, 4 or more for women) in the past month.2
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
FAMILY HISTORY AND INHERITED DISEASES
Those with an immediate family member who has experienced colorectal cancer or adenomatous polyps have 80% increased risk of developing colorectal cancer.9 Inherited diseases, such as familial adenomatous polyposis (FAP) and Lynch Syndrome, greatly increase colorectal cancer risk. Nearly 100% of people with FAP left untreated and 20-50% with Lynch syndrome will develop colorectal cancer in their lifetime.10
INFLAMMATORY BOWEL DISEASE (IBD)
IBD, such as Crohn’s disease or ulcerative colitis, elevates the risk for colorectal cancer. 1.3% of adults in the US have IBD.11 A study in northern California found that persons with Crohn's disease or ulcerative colitis had a 60% higher risk of developing colorectal cancer.12 A more recent summary of population studies from around the world concluded that those with IBD were almost 3-times as likely to develop colorectal cancer.13
RACE AND ETHNICITY
Non-Hispanic Blacks have the highest incidence rate of colorectal cancer in the US, 20% higher
than non-Hispanic Whites.14 Ashkenazi Jews are also at an increased risk.15 The population of
Los Angeles County is comprised of nearly 10% Non-Hispanic Blacks and has the second
largest Jewish population in the United States.16
REFERENCES
Summary of Colorectal Cancer Risk Factors 23
NON-MODIFIABLE RISK FACTORS
1. Renehan, Andrew G., et al. "Body-mass index and incidence of cancer: a systematic review andmeta-analysis of prospective observational studies." The Lancet 371.9612 (2008): 569-578.
2. Los Angeles County Department of Public Health, Office of Health Assessment andEpidemiology. Key Indicators of Health by Service Planning Area (2017).
3. Lynch, Brigid M. "Sedentary behavior and cancer: a systematic review of the literature andproposed biological mechanisms." Cancer Epidemiology and Prevention Biomarkers19.11 (2010): 2691-2709.
4. Boyle, Terry, et al. "Long-term sedentary work and the risk of subsite-specific colorectal cancer."American Journal of Epidemiology 173.10 (2011): 1183-1191.
5. Bouvard, Véronique, et al. "Carcinogenicity of consumption of red and processed meat." TheLancet Oncology 16.16 (2015): 1599-1600.
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Summary of Colorectal Cancer Risk Factors 24
6. The National Hot and Sausage Council. “Consumption Statistics from the National Hot Dog andSausage Council.” Consumption Stats, NHDSC www.hot- dog.org/media/consumption-stats.Accessed 29 November 2019
7. Coyle, Yvonne M. "Lifestyle, genes, and cancer." Cancer Epidemiology 472 (2009): 25-56.8. Cho E, Smith-Warner SA, Ritz J, et al. "Alcohol intake and colorectal cancer: a pooled analysis of
8 cohort studies." Annals of Internal Medicine. 140 (2004): 603–13.9. Calvert, Paula M. and Harold Frucht. "The genetics of colorectal cancer." Annals of Internal
Medicine 137.7 (2002): 603-612.10. Sampson, Julian R., et al. "Autosomal recessive colorectal adenomatous polyposis due to inherited
mutations of MYH." The Lancet 362.9377 (2003): 39-41.11. Dahlhamer, James M., et al. "Prevalence of inflammatory bowel disease among adults aged≥ 18
years—United States, 2015." Morbidity and Mortality Weekly Report 65.42 (2016): 1166-1169.12. Xie, Jianlin and Itzkowitz, Steven H. "Cancer in inflammatory bowel disease." World Journal of
Gastroenterology 14.3 (2008): 378.13. Ollberding, Nicholas J., et al. "Racial/ethnic differences in colorectal cancer risk: the multiethnic
cohort study." International Journal of Cancer 129.8 (2011): 1899-1906.14. Boursi, Ben, et al. "The APC p. I1307K polymorphism is a significant risk factor for CRC in
average risk Ashkenazi Jews." European Journal of Cancer 49.17 (2013): 3680- 3685.
15. Tighe, Elizabeth, et al. “Summary& Highlights- 2019”. The American Jewish Population Project(2019): 04-05
16. U.S. Census Bureau. American Community Survey, 2018 American Community Survey 5-YearEstimates, Table B02001. U.S. Census website. Retrieved May 02, 2020
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
THE DIVERSE POPULATION OF LOS ANGELES COUNTY
Los Angeles County is the most racially/ethnically diverse county in the U.S. The number of residents
living in Los Angeles County exceeds 10 million, according to the 2018 population estimates. Hispanic
or Latino individuals account for 48.5% of the County’s total population, in contrast to 38.9% in
California and 17.8% in the U.S.1 The proportion of non-Latino whites in Los Angeles County is 26.3%,
as compared to 37.5% in California and 61.1% in the U.S.1 About 8.5% of U.S. Latinos, 8.3% of U.S.
Asian Americans, and 4.8% of U.S. Pacific Islanders live in Los Angeles County.1 People of multi-race
count for 3.9% of the County’s total population, much higher than the national average of 3.2%.1
The 1.4 million Asian Americans in Los Angeles County include 0.4 million Chinese, 0.3 million
Filipino, 0.2 million Korean, 0.1 million Japanese, 0.1 million Asian Indian and over 93,000
Vietnamese.1 Los Angeles County is also home to more than 28,000 Native Hawaiians and Other Pacific
Islanders.1
Among the 4.9 million self-reported Hispanics or Latinos in the County, 76% identify as Mexican, 8.4%
Salvadoran, 5.2% Guatemalan, 1.0% Puerto Rican, 0.8% Cuban, 1.0% Honduran, 0.9% Nicaraguan, and
2.8% South American.1
About 3.5 million Los Angeles County residents are foreign-born; 14.7% of them entered the country
since 2010.1 More than half (56.8%) of the total population five years of age or older speak a language
other than English.1
The 2.7 million non-Latino white population also has highly diverse origins. The population of
European origin includes large numbers of persons from Britain, Germany, Ireland, Italy, Russia,
France, and other parts of Europe. In the past 30 years the County experienced a substantial influx of
immigrants from Iran, Lebanon and the former Soviet Union. The Armenian community is estimated to
be nearly 200,000. Over 53,000 individuals of Arabic descent live in Los Angeles County.1
Every numerically important religious group in the U.S. is represented by sizable populations. There is
also a wide variation in socioeconomic and sociocultural characteristics of the County population.
Occupation and industry data reflect the diversity one would expect of a large urban metropolis. In
addition, Los Angeles County is characterized by geographic diversity, with regions of mountains,
valleys, deserts, and seashores.
With its large and diverse populations, Los Angeles County is an ideal place for monitoring cancer
occurrence and conducting epidemiological investigations.
Supplemental Material 25
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
HOW CANCER IS REGISTERED
Under the California model of reporting, a passive cancer surveillance system has been implemented
statewide, in which hospitals and other facilities where cancer is diagnosed or treated bear the
responsibility for identifying and reporting cancer cases to the local regional registry within six months
after the patient’s diagnosis or treatment. Pathologists diagnosing cancer are required to submit an
electronic copy of the pathology report within two weeks of diagnosis. Each hospital or other reporting
facility is required to complete a full report known as an abstract, including stage and treatment
information, on every cancer case seen at the facility. All completed abstracts are linked by to the
pathology reports to assure that one abstract is completed for each histologically-verified cancer
diagnosis. In addition, any previously unrecognized cancer diagnoses among Los Angeles County
residents, identified as a result of searching computerized death records, are traced back to patient
records in hospitals or other facilities so that data can be abstracted, when possible, in a similar way to
data found using pathology reports.
USE OF CSP DATA FOR RESEARCH
The CSP data serve as a descriptive epidemiological resource to generate new hypotheses regarding
specific cancer sites or histologic subtypes, monitor descriptive trends and patterns of cancer incidence,
and identify demographic subgroups at high risk of cancer. A high priority is always placed on
exploring demographic patterns and trends in cancer incidence among the racially and ethnically
diverse population of Los Angeles County.
Supplemental Material 26
THE IMPORTANCE OF INVESTIGATING CANCER TRENDS
To keep an eye on cancer ratesMonitoring cancer rates provides clues about what causes cancer. When we observe a change in the rate of
cancer that seems to follow a change in an environmental exposure, we consider the possibility of a link
between the exposure and cancer. For example, at the beginning of last century, increasing lung cancer
rates followed the introduction and increasing popularity of cigarettes and smoking.
To monitor improvements in cancer outcomesWhile cancer prevention is our ultimate goal, efforts are also focused on successful treatment. An ultimate
measure of treatment success is long-term survival, especially in the AYA age group with many more years
of life expectancy. We seek to identify the factors associated with long-term survival to benefit future
cancer patients.
To know whether cancer control efforts are workingWe also monitor cancer rates to provide a “report card” on how well cancer prevention programs work. We
generally expect that a successful intervention program, such as the introduction of the HPV (human
papillomavirus) vaccine should be followed by a decline in cervical and other HPV-related cancer rates.
To decide what resources are required to fight cancerBecause cancer is such an important health problem and is costly in terms of treatment and social costs,
such as loss of work time and quality of life, it is important to have a clear idea of the changing burden of
cancer on society. Government officials and policymakers use trends in cancer rates to determine funding
for screening, treatment and related social services, as well as to establish priorities for supporting effective
research into the causes and prevention of cancer and the development of treatments.
To see the effect of changes in cancer screening and detection methodsMany things can cause changes in cancer rates, including changes in the distribution of the factors that
cause the disease, changes in our ability to prevent or detect cancer early, changes in the population,
changes in diagnostic criteria to define a type of cancer, and even simple random variation.
To make cancer a disease of the past
Keeping an eye on cancer rates provides clues about the causes of cancer, how successful we are at
preventing cancer, and where we should focus our efforts in the future to make cancer a disease of the past.
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
Supplemental Material 27
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
PROTECTION OF CONFIDENTIALITY
Confidentiality procedures at the CSP are rigidly formulated and maintained. All employees of the
CSP sign a confidentiality pledge after being advised of the necessity for maintaining strict
confidentiality of patient information, and are shown methods to assure this. Confidentiality of
computerized data is assured by highly restricted access and protected by encryption. All reports and
summaries produced for distribution by the CSP, such as those presented here, are in statistical form
without any personal identifiers. All individual studies using confidential information obtained from
the registry are individually reviewed by the California Protection of Human Subjects Board. For
studies from outside investigators, review and approval by a federally approved institutional review
board is required.
CANCER DATA
Cancer data used in this report are based on new cancer cases diagnosed among the residents in Los
Angeles County from January 1, 2000 to December 31, 2017.
Cancer patients are grouped by sex (male, female), age (0-39, 40-49, 50-64, 65+ years old), race/
ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic, Asian/Pacific Islander),
socioeconomic status (SES) (high, mid-high, middle, mid-low, low), and stage of disease at diagnosis
(localized, regional, distant). Asian/Pacific Islanders are further categorized as Chinese, Japanese,
Filipino, Korean, Vietnamese, South Asian that includes Indian, Pakistani, Sri Lankan, Nepalese,
Bhutanese, and Sikkimese, and Thai/Hmong/Cambodian/Laotian. Localized stage refers to cancer
that has not spread from original location. Regional stage refers to cancer that has spread beyond
original location to either nearby organs/lymph nodes, and distant stage refers to cancer that has spread
to other parts of the body.
The follow-up of cancer patients is conducted by the CSP through a combination of methods including
information sharing from the reporting hospitals, record linkage with vital statistics, Social Security
Administration, driver license information, and credit records. The follow-up information helps to
determine the vital status of a cancer patient, calculate the survival time, and estimate the survival rate of
the specific cancer.
Supplemental Material 28
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
STATISTICAL METHODS
We provide case count and percentage distribution of cancer cases by patient demographics and tumor
stage at diagnosis. In order to compare cancer risk levels among different groups, we calculate and
present the age-adjusted incidence rates and age-adjusted mortality rates by considering the number of
cancer occurrences and cancer related deaths, respectively, in relation to the size of the group’s at-risk
population. In order to preserve statistical stability of rate estimation and comply with the suppression
rules set by the California Cancer Registry (CCR), minimum case count of less than event threshold for
numerator is set at 11 is not shown in tables and not used for calculating rates. Annual population
estimates for 2000-2017 in Los Angeles County by aggregated racial/ethnic groups were provided by
the CCR based on the county level estimates by the National Center for Health Statistics. We
estimated the annual populations for Asian and Pacific Islander ethnic groups as identified in the 2000
and 2010 population censuses as well as the 2011-2015 American Community Survey 5-year Estimates
using linear interpolation and extrapolation. South Asian population included Asian Indians,
Pakistanis, Sri Lankans, Bangladeshis, and Nepalese. Because Bhutanese and Sikkimese, two small
population groups, are included in the incidence data but not in the population data, rate estimates for
South Asians may be overestimated slightly.
Observed survival is the actual percentage of patients still alive at some specified time after the diagnosis
of cancer. It considers deaths from all causes, cancer or otherwise. Relative survival estimates the
probability of survival from cancer after considering the chances of dying from other causes. It is
calculated as a ratio of the observed survival among cancer patients to the expected survival from all
causes of death using survival probabilities in the general population of same age group. Using non-
parametric Kaplan-Meier survival function, we calculated the observed survival at 5-years after
diagnosis by cancer type and stratified by sex, age, race/ethnicity, SES, and tumor stage. Graphs of the
estimates of the survival rate allow us to see how the survival probability changes over time and differs
by patient and tumor characteristics. We also estimated hazard ratio by comparing the probability of
deaths between age groups, race/ethnicity groups, SES and stage using multivariate Cox regression
model.
As with all population-based cancer registries, the CSP does not directly contact patients for follow-up.
The quality of follow-up information is critical to the survival evaluation. The accuracy of a patient’s
racial/ ethnic classification depends on the patient’s racial/ethnic identification recorded in the medical charts.
Supplemental Material 29
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
CAUTIONS IN INTERPRETATION
This information may be based on self-identification by the patient, on assumptions made by an
admission clerk or other medical personnel, or on an inference made using race/ethnicity of parents,
birthplace, maiden name or last name. Efforts that evaluate the data quality of population-based cancer
registries have concluded that misclassification of race/ethnicity may exist for a very small portion of the
registry records. The reliability of estimates for at-risk population may affect the cancer risk estimates.
Finally, special caution should be used when interpreting the meaning of the analyses that are based on
only a few cases. Calculations based on small numbers are statistically unstable.
REFERENCE
1. U.S. Census Bureau, 2014-2018 American Community Survey 5-Year Estimates.
Supplemental Material 30
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
Cancer in Los Angeles County: Colorectal Cancer Incidence, Mortality and Survival 2000-2017.
Los Angeles Cancer Surveillance Program USC/Norris Comprehensive Cancer Center
The Keck School of Medicine of the University of Southern California
Table 1. Frequency of Invasive Colorectal Cancer Cases by Age, Race, Socioeconomic Status, Disease Stage and Subtype, Los Angeles County, 2000-2017.Figure 1. Disease Stage Distribution of Invasive Colorectal Cancer by Age, Race/Ethnicity and Socioeconomic Status Cases, Los Angeles County, 2000-2017.Figure 1. Disease Stage Distribution of Invasive Colorectal Cancer by Age, Race/Ethnicity and Socioeconomic Status Cases, Los Angeles County, 2000-2017.Table 2A. Age-Adjusted Incidence Rates of Invasive Colorectal Cancer by Sex, Age, Race/Ethnicity and Disease Stage (per 100,000 population), Los Angeles County, 2000-2017.Table 2B. Incidence Rate Ratio for Invasive Colorectal Cancer by Sex and Race/Ethnicity, Los Angeles County, 2000-2017.Table 3A. Age-Adjusted Mortality Rates of Colorectal Cancer by Sex, Age, and Race/Ethnicity (per 100,000 population), Los Angeles County, 2000-2017.Table 3B. Mortality Rate Ratios for Colorectal Cancer by Sex and Race/Ethnicity, Los Angeles County, 2000-2017.Figure 3. Annual Mortality Rate Trends of Colorectal Cancer by Age, Race/Ethnicity and Sex (per 100,000), Los Angeles County, 2000- 2017.Table 4. One- and Five-year Observed Survival from Invasive Colorectal Cancer by Age, Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.Table 5. One- and Five-year Relative* Survival from Invasive Colorectal Cancer by Age, Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.Figure 4. Annual 5-year Observed Survival Trends of Colorectal Cancer by Age, Race/Ethnicity and Sex, Los Angeles County, 2000-2012.Figure 5. Kaplan-Meier Survival Curves for Invasive Colorectal Cancer by Age, Race/Ethnicity and Sex, Los Angeles County, 2000-2017.Table 6. Hazard Ratio* (HR) of Invasive Colorectal Cancer by Age, Race/Ethnicity, Socioeconomic Status and Disease Stage, Los Angeles County, 2000-2017.