COLORECTAL CANCER BY THE NUMBERS - bms.com colorectal cancer by the numbers colorectal cancer, or crc,

COLORECTAL CANCER BY THE NUMBERS - bms.com colorectal cancer by the numbers colorectal cancer, or crc,

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  • COLORECTAL CANCER BY THE NUMBERS COLORECTAL CANCER, OR CRC, IS THE 3RD MOST COMMONLY DIAGNOSED CANCER IN THE WORLD. WORLDWIDE INCIDENCE IS EXPECTED TO INCREASE FROM 1.8 MILLION CASES DIAGNOSED IN 2018 TO 3.1 MILLION CASES BY 2040.

    1,026,000

    823,300

    CRC MORE COMMON

    IN MEN THAN WOMEN

    MEDIAN AGE

    67

    73

    AT DIAGNOSIS

    AT DEATH

    Source: American Cancer Society 2018

    STAGING & SURVIVAL RATES

    5-Year Relative Survival Rates

    THERE ARE FOUR STAGES OF CRC. PATIENTS WITH

    ADVANCED FORMS OF THE DISEASE HAVE FEWER

    TREATMENT OPTIONS & LOWER SURVIVAL RATES.

    RATES VARY GLOBALLY,

    DEPENDING ON THE STAGE AND

    TYPE OF COLORECTAL CANCER:

    COLON CANCER RECTAL CANCER

    92% 88%

    81% 83%

    13%

    87% 90%

    12%

    STAGE I

    STAGE I I

    STAGE I I I

    STAGE IV

    STAGE I

    STAGE I I

    STAGE I I I

    STAGE IV

    53%

    65%

    50%

    58%

    LOW HIGH

    COMMON RISK FACTORS

    HEAVY ALCOHOL USE

    SMOKINGOBESITY

    AGE OVER 50

    FAMILY HISTORY

    PHYSICAL INACTIVITY

    50+

    WEAKNESS AND FATIGUE

    UNINTENDED WEIGHT LOSS

    CHANGE IN BOWEL HABITS (SUCH AS DIARRHEA & CONSTIPATION)

    RECTAL BLEEDING

    BLOOD IN THE STOOL

    CRAMPING OR ABDOMINAL PAIN

    SIGNS & SYMPTOMSTREATMENT OPTIONS

    SURGERY RADIATION THERAPY

    TARGETED THERAPY

    © 2018 Bristol-Myers Squibb Company

    ESTIMATED NUMBERS OF ANNUAL NEW CRC CASES BY REGION (THOUSANDS)

    EUROPE 499.6

    CENTRAL AMERICA 19.5

    SOUTH AMERICA 97.6

    AFRICA 61.8

    AUSTRALIA & NEW ZEALAND 21.2

    COLORECTAL CANCER “HOT SPOTS”

    NORTH AMERICA 179.7

    ASIA 957.9

    Source: Globocan 2018

    CRC OFTEN BEGINS AS A GROWTH CALLED

    A POLYP, WHICH MAY FORM ON THE INNER

    WALL OF THE COLON OR RECTUM.

    MICROSATELLITE INSTABILITY HIGH (MSI-H) OR DNA MISMATCH REPAIR DEFICIENT (dMMR) CRC

    SOME CASES OF CRC ARE MSI-H OR dMMR, WHICH OCCURS WHEN THERE ARE

    DEFICIENCIES IN THE CELL'S ABILITY TO REPAIR DNA ERRORS DURING CELL DIVISION.

    5-YEAR SURVIVAL RATE RANGE:

    APPROXIMATELY 15% OF ALL PATIENTS

    WITH CRC HAVE MSI-H

    OR dMMR TUMORS.

    ABOUT 4-5% OF PATIENTS WITH METASTATIC CRC HAVE

    MSI-H OR dMMR TUMORS.

    PATIENTS WITH MSI-H OR dMMR METASTATIC CRC TYPICALLY HAVE A POOR PROGNOSIS WITH

    LOWER SURVIVAL RATES COMPARED TO PATIENTS WHOSE TUMORS ARE NOT MSI-H OR dMMR.

    A PATIENT’S TREATMENT OPTIONS

    ARE LARGELY DEPENDENT ON STAGE

    OF DISEASE, AND IN SOME CASES

    BIOMARKERS, AND MAY INCLUDE:

    CHEMOTHERAPY IMMUNOTHERAPY

    WHAT IS CRC?

    CRC IS A CANCER THAT FORMS IN THE TISSUES OF THE COLON OR RECTUM,

    WHICH ARE PART OF THE BODY’S DIGESTIVE OR GASTROINTESTINAL (GI) SYSTEM.