July 2014Richard Bruce Buxton

Address

Department of RadiologyUCSD Center for Functional Magnetic Resonance Imaging9500 Gilman DriveLa Jolla, CA 92093-0677Telephone: (858) 822-0503Fax: (858) 822-0605email: rbuxton@ucsd.edu

Education

1976: B.S. in Physics, Massachusetts Institute of Technology1981: Ph.D. in Physics, Massachusetts Institute of Technology

Thesis: “Microwave observations of regions of small-scale star formation”.

Post Doctoral Training

6/81-6/83: Research Fellow in the Physics Research Laboratory, Department of Radiology, Massachusetts General Hospital; Development of positron emission tomography (PET) techniques.

6/83-7/84: Research Fellow in the Cerebral Blood Flow and Metabolism Laboratory, Department of Radiology, Massachusetts General Hospital; Applications of positron emission tomography.

Academic Appointments

6/81-7/84: Research Fellow, Department of Radiology, Harvard Medical School7/84-4/88: Instructor, Department of Radiology, Harvard Medical School4/88-5/90: Assistant Professor in Residence, Department of Radiological Sciences,

University of California, Irvine5/90-7/93: Assistant Professor, Department of Radiology, University of California,

San Diego7/93-7/00: Associate Professor, Department of Radiology, University of California,

San Diego7/00-present: Professor, Department of Radiology, University of California, San Diego

University Appointments

6/81-7/84: Research Fellow, Department of Radiology, Massachusetts General Hospital

7/84-4/88: Assistant in Physics, Department of Radiology, Massachusetts General Hospital

5/87-4/88: Director of NMR Physics Research, Department of Radiology, Massachusetts General Hospital

5/90- 7/01 Director of Magnetic Resonance Research, Department of Radiology, University of California, San Diego (UCSD)

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7/01-7/07 Director, Center for Functional Magnetic Resonance Imaging, UCSD2/06 – 6/2011 Co-Director, Magnetic Resonance Imaging, Radiology Imaging Lab,

UCSD

University Committee Activities

1986-1988: Magnetic Resonance Scientific Management Committee, Massachusetts General Hospital

1988-1990: Graduate Committee, Department of Radiological Sciences, University of California, Irvine

1989-1990: Admissions Committee (interviewer), College of Medicine, University of California, Irvine

1990-1994: Computing Advisory Committee, School of Medicine, University of California, San Diego

1990-present: Magnetic Resonance Research Committee, Department of Radiology, University of California, San Diego

1994-1995: UCSD/Salk Institute Planning Committee for a Functional Brain Imaging Research Center

1994-1995: UCSD Radiology Department, Research Ad Hoc Committee on Funding1995: UCSD School of Medicine, Liaison Committee on Medical Education

(LCME), Institutional Self-Study Evaluation (ISSE) Task Force Support Services Committee

1995: UCSD School of Medicine, Ad Hoc Promotion Committee1995-1996: UCSD Radiology Department, Alternate Representative to Academic

Senate1996-1998: Computing Advisory Committee2000-2002 Medical Scientist Training Program (MSTP) Admissions Committee2002-2005 Life Sciences Council2004-present Advisory Board member, Kavli Institute for Brain and Mind2006-present Radiology Academic Promotions Committee

Professional Societies

International Society for Magnetic Resonance in Medicine Organization for Human Brain MappingSociety for Neuroscience

Professional Service

1992 – 1994 Scientific Program Committee of the Society of Magnetic Resonance in Medicine, the primary group responsible for planning the yearly international meeting

1999 – 2003 Member of the National Institutes of Health Diagnostic Radiology Study Section (RNM)

2001 – 2004 Council member and Treasurer, Organization for Human Brain Mapping2001 - present Institutional Review Board (Human Subjects IRB), Salk Institute 2003 – 2005 Associate Editor, NeuroImage2004 Vice-Chair, Gordon Research Conference on “In Vivo Magnetic

Resonance”2006 Chair, Gordon Research Conference on “In Vivo Magnetic Resonance”2007 – 2011 Editorial Advisory Board, NMR in Biomedicine

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2010 External Advisory Committee for the Gulf War Illness Neuroimaging and Biomarker Studies Program, University of Texas, Southwestern, Dallas, Texas.

2010 Review Panel for the Danish National Research Foundation, evaluating the Center for Integrative Neuroscience, Aarhus University

2011 - present Advisory Board, UCLA Neuroimaging Training Program2011 - present Scientific Advisory Board for the Max Planck Institute for Biological

Cybernetics, Tuebingen, Germany

Additional National Review Panels:

June 1994 National Institutes of Health, Division of Research Grants, Diagnostic Radiology Study Section, Special Reviewer

February 1995 National Institutes of Health, Division of Research Grants, Diagnostic Radiology Study Section, Special Reviewer

April 1995 National Institutes of Health, National Institute on Aging, Scientific Review Office Site Meeting, Special Reviewer

June 1995 National Institutes of Health, National Institute on Aging, Scientific Review Office Committee Meeting, Special Reviewer

April 1996 National Institutes of Health on Aging, Scientific Review Office Site Visit, Special Reviewer

June 1996 National Science Foundation, Panel of the Biomedical Engineering & Research to Aid Persons with Disabilities Program, Special Reviewer

February 1998 National Institutes of Health, Division of Research Grants, Diagnostic Radiology Study Section, Special Reviewer

March 2007 National Institutes of Health, Center for Scientific Review, Neuroinformatics and Neuroimaging Special Emphasis Panel, Special Reviewer

June 2008 National Institutes of Health, Center for Scientific Review, Neuro-Technology Special Emphasis Panel, Special Reviewer

February 2009 National Institutes of Health, Center for Scientific Review, Neuro-Technology Study Section, Special Reviewer

July 2009 National Institutes of Health, Center for Scientific Review, Special Emphasis Panel (S10 applications), Chair.

October 2009 National Institutes of Health, Center for Scientific Review, P41 National Resource Review and site visit, Chair.

February 2010 National Institutes of Health, Center for Scientific Review, Academic and Industrial Partnerships Study Section, Chair

June 2010 National Institutes of Health, Center for Scientific Review, Neurotechnology B Study Section, Special Reviewer.

June 2011 National Institutes of Health, Center for Scientific Review, Translational/Clinical Study Section, 2nd-tier/Editorial Board Reviewer

June 2012 National Institutes of Health, Center for Scientific Review, Translational/Clinical Study Section, 2nd-tier/Editorial Board Reviewer

Oct 2012 National Institutes of Health, Center for Scientific Review, Translational/Clinical Study Section, mail reviewer

Jan 2013 National Institutes of Health, Center for Scientific Review, Translational/Clinical Study Section, mail reviewer

June 2013 National Institutes of Health, Center for Scientific Review, Translational/Clinical Study Section, mail reviewer

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Journal reviewer

Magnetic Resonance in Medicine, Neuron, Proceedings of the National Academy of Science (USA), NeuroImage, American Journal of Roentgenology, Journal of Cerebral Blood Flow and Metabolism, American Journal of Physiology, American Journal of NeuroRadiology, IEEE Transactions on Medical Imaging, International Journal of Imaging Systems and Technology, Neurobiology of Aging, Magnetic Resonance Imaging, Physics in Medicine and Biology, and Biorheology.

Invited presentations at scientific meetings

March 1995: American Society for Clinical Pharmacology and Therapeutics, San Diego. In a symposium on Neuroimaging as a Tool for the Clinical Pharmacologist: "Application of Functional Magnetic Resonance Imaging to Clinical Pharmacology"

March 1995: Cognitive Neuroscience Society, San Francisco. Organized a symposium on Imaging Human Cognition Using Functional MRI, and delivered the first lecture: "Principles of MRI and FMRI".

May 1996: International Society for Magnetic Resonance in Medicine, New York. Plenary talk on: "Quantitative Perfusion Imaging".

Aug 1996: International Workshop on Biomedical Imaging: MR and PET/SPECT, Fukui, Japan. Title: "Magnetic Resonance Imaging of Perfusion with Arterial Spin Labeling".

June 1997: Symposium on the Physiological Basis of Functional Neuroimaging, at the 3rd International Conference on Functional Mapping of the Human Brain, Copenhagen: "The coupling of blood flow and oxygen metabolism during brain activation".

June 1999: Symposium on the Coupling of Flow and Metabolism in the Brain, at the XIXth Meeting of the International Symposium on Cerebral Blood Flow, Metabolism and Function, Copenhagen: “Why coupling of flow and metabolism leads to mismatch”.

June 1999: 5th International Conference on Functional Mapping of the Human Brain, Dusseldorf: Key Note Lecture on “The physiological basis of fMRI”.

Sep 1999: Optical Society of America meeting, Santa Clara: “Tutorial on functional magnetic resonance imaging”.

April 2000: American Society of Neuroradiology meeting, Atlanta, Symposium on Advanced Imaging Techniques for the New Millenium: invited talk on “Cerebral Perfusion”.

Aug 2000: Gordon Research Conference on In Vivo Magnetic Resonance: invited talk on “The brain hemodynamic response to activation”.

Oct 2000: Society for Psychophysiological Research, Workshop on Functional MRI: Tutorial on “The hemodynamic response to activation”.

Nov 2000: International Symposium on Medical Imaging at the National Institute for Radiological Sciences, Chiba, Japan, - A New Horizon for Molecular Imaging. Invited talk on “Future directions for fMRI research”.

April 2001: International Society for Magnetic Resonance in Medicine, Glasgow, Scotland, Morning Categorical Course- fMRI: What can we measure? Invited talk on: “Modeling the hemodynamic response to brain activation”.

June 2001: Brain Activation and CBF Control, Tokyo, Japan. Invited talk on: “Coupling between CBF and CMRO2 during neural activity”.

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June 2002: Organization for Human Brain Mapping, Sendai, Japan. Educational symposium on fMRI: “Neurovascular Coupling”.

July 2003: International Society for Magnetic Resonance in Medicine, Toronto, Canada. Workshop on fMRI Experimental Methods: "Mechanisms of fMRI".

Sep 2003: New York University, Center for Neural Science, Biennial Symposium Imaging the Brain: Neurons, Networks and Behavior: invited talk on “Understanding the BOLD Effect”.

Nov 2003: The Institute for Complex Adaptive Matter, Santa Fe, New Mexico, Physics of Neural Tissue Workshop. Invited talk on: “A Thermodynamic Model for the Regulation of Brain Energy Metabolism and the Basis of fMRI”.

Feb 2004: The International Society for Optical Engineering, San Diego, invited talk on: "Investigating the physiology of brain activation with MRI".

March 2004: The International Society for Magnetic Resonance in Medicine Workshop on Quantitative cerebral perfusion imaging using MRI: A technical perspective, Venice, Italy, invited talk: “Quantifying Cerebral Blood Flow with Arterial Spin Labeling”.

March 2004: University of Michigan fMRI Speaker Series, "Investigating the physiology of brain activation with fMRI".

May 2004: International Society for Magnetic Resonance in Medicine, Kyoto, Japan. Workshop on Brain Function and fMRI: “Hemodynamic Responses to Neuronal Activity”.

May 2004: Kyoto University, Symposium on Cerebral Perfusion Imaging: invited talk on “The Cerebral Blood Flow Response to Brain Activation”.

July 2004: Vice Chair, Gordon Research Conference, Bates College, "In Vivo Magneetic Resonance"

July 2004: Institute for Pure & Applied Mathematics (IPAM) Summer School, University of California, Los Angeles, invited talk on: "Hemodynamic Models".

May 2005: International Society for Magnetic Resonance in Medicine, Miami, FL. Plenary Talk. “BOLD and its relationship to brain oxygenation”.

Sep 2005: 2005 Litchfield Lecturer, University of Oxford, UK. “The thermodynamics of thinking: what does fMRI tells us about the brain?” (Dr. Buxton also spent three weeks at Oxford as a visiting scholar.)

Oct 2005: Minnesota Workshops on High Field Imaging and Spectroscopy, & Magnetic Resonance Imaging of Brain Function, Univ of MN, invited talk: “Do we understand the physiologic basis of the signals we measure with fMRI?”

Feb 2006: Gatsby Workshop on Neural Activity and BOLD Functional MRI, University College London, England, invited lecture: “The thermodynamics of thinking: Is CBF regulation maintaining the ratio (02/C02) in cells?

April 2006: American Society for Neuroradiology (ASNR), Neuroradiology Education and Research (NER) Foundation Symposium 2006: Neuroimaging: State of the Art and Beyond, San Diego, CA: “Techniques – fMRI”.

Aug 2006: Gordon Research Conference, “Brain energy metabolism and blood flow”, Oxford University, invited talk on: “Models of the BOLD effect”.

June 2007: Symposium celebrating the opening of the High Field Magnetic Resonance Center at the Max Planck Institute, Tuebingen Germany, invited talk on: “Quantitative fMRI”.

Feb 2008: Riken Brain Science Institute, Tokyo, invited talk on: “The hemodynamic response in fMRI”.

Aug 2008: Gordon Research Conference “in vivo Magnetic resonance”, invited talk on: “Quantitative fMRI”.

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Aug 2009: Centre de Recherches Mathematiques, University of Montreal, workshop on “Brain activity modeling: from fine to coarse scale”, invited talk on: “Quantitative fMRI: modeling the physiological changes associated with brain activation”.

July 2010: International summer School on Multimodal Approaches in Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, invited keynote lecture on: “Brain oxygen metabolism: the importance of understanding it, and the challenge of measuring it”.

May 2012 International Society for Magnetic Resonance in Medicine, Melbourne, Australia, Weekend Course on Imaging Strategies: “Motion-sensitized MRI: Arterial Spin Labeling and Diffusion”

June 2012 Lecturer in the Cold Spring Harbor course Workshop on Cognitive Aging: “Controversies in fMRI, or How can we interpret the BOLD response?”

July 2012 Neuroimaging Statistics Workshop (in conjunction with the Joint Statistical Meeting of the American Statistical Association), San Diego, invited talk: “Physiological basis of the BOLD response”

Oct 2012 ISMRM Scientific Workshop, Amsterdam, on Perfusion MRI: Standardization, Beyond CBF, and Everyday Clinical Applications, invited talk: “CMRO2, OEF and brain activity quantification”

April 2013 International Society for Magnetic Resonance in Medicine, Salt Lake City, UT, Meet the Experts session (discussion with students and fellows about fMRI).

April 2013 International Society for Magnetic Resonance in Medicine, Salt Lake City, UT, Weekend Workshop on Single-Subject Neuroimaging: “The brain stress test”.

May 2014 International Society for Magnetic Resonance in Medicine, Milan, Italy Weekend Workshop on Perfusion: “What is perfusion, and how is it measured?”

June 2014 Organization for Human Brain Mapping, Hamburg Germany, Educational Symposium on A New Paradigm for studying Drug effects: “Future Directions”.

June 2014 Organization for Human Brain Mapping, Hamburg Germany, Morning Symposium on The Hemodynamic Response and Neurovascular Coupling: “Are blood flow and oxygen metabolism driven by different aspects of neural activity?”

June 2014 Neurofutures 2014, Seattle, WA, invited talk: “The potential and the challenge of assessing neural activity with functional MRI”

Honors

2005: Litchfield Lecturer, Oxford University2010: Fellow, International Society for Magnetic Resonance in Medicine

Teaching

1985-1988: Lectures in Instrumentation and Imaging Physics course for Residents (MGH).

1985-1988: Lectures in Magnetic Resonance Imaging course for visiting fellows (MGH).

1988-1990: Graduate courses for PhD students on the physics of magnetic resonance imaging and nuclear medicine (UCI).

1988-1990: Lectures in Physics of Radiological Science for Residents (UCI).1989: Lecturer at the 5th Annual Physics and Biology of Diagnostic and

Nuclear Radiology course, August 24-27, San Diego, CA.

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1990-present: Lectures in Physics of MRI for Residents and Fellows (UCSD).1990-1997: Associate Director and Lecturer at the annual UCSD Postgraduate

Course in Magnetic Resonance Imaging, San Diego CA.1994-present: Graduate courses in Neuroscience on Principles of Functional Magnetic

Resonance Imaging2001-2010 Residents' Core Physics Lectures, "Energy, Matter & Production of X-

Rays2004 UCSD Division of Physiology Seminar Series.2006-present fMRI in Cognitive Neuroscience courses at UCSD2007-2012 Annual UCLA Functional Neuroimaging Course (guest lectures)

Research Support as Principal Investigator

ACTIVE

1 R01 HL104118-01 (Buxton, Richard joint PI with Prisk, G. Kim) 04/01/2010-03/31/2014NIH/NHLBISpatial-Temporal Dynamics of Blood Flow in the Normal Human LungMajor Goals: To apply techniques originally developed for fMRI to investigations of the spatial and temporal variability of pulmonary blood flow.

5 R21 NS081405-02 (Buxton, Richard) 09/01/2012 – 08/31/2014

NIH/NINDSA New Approach for Quantitative fMRI

Major goals: Establish the basis for a new experimental paradigm for functional magnetic resonance imaging (fMRI) that makes possible the determination of fluctuating brain activity patterns during performance of complex tasks, at rest, or in response to a drug, in quantitative units of absolute cerebral blood flow (CBF).

2 R01 NS036722-14 (Buxton, Richard) 05/01/2014 – 04/30/2018NIH/NINDSThe Physiological Basis of Functional MRIMajor goals: Our overall goal is to develop a quantitative understanding of the coupling of blood flow and energy metabolism in the human brain, and to develop quantitative methods for assessing this coupling in health and disease.

1 R21 NS085478-01A1 (Buxton, Richard) 06/01/2014 – 05/31/2016NIH/NINDSDynamics of Oxygen Metabolism in the Human BrainMajor goals: Our overall goal is to establish the basis for a new experimental paradigm for functional magnetic resonance imaging (fMRI) that makes possible quantitative measurement of the dynamics of the cerebral metabolic rate of oxygen metabolism (CMRO2) noninvasively in the human brain.

COMPLETED

5 R01 NS42069-05 (Buxton, Richard) 09/30/2002 - 08/31/2007NIH/ NINDSThe Hemodynamic Response to Brain Activation

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Major goals: To use MRI techniques to investigate the coupling of cerebral blood flow and oxygen metabolism during activation in the human brain.

5 R01 NS36722-11 (Buxton, Richard) 02/28/1998 - 02/28/2014NIH/ NINDSPhysiological Basis of Functional MRIMajor goals: To develop a quantitative understanding of the coupling of neural activity, blood flow and energy metabolism in the human brain, and to develop quantitative methods for assessing this coupling in health and disease.

Bibliography

A. Research Articles

1. Buxton RB, Barrett AH, Ho PTP, Schneps MH. Search for methanol masers. Astronomical J 82:985-988, 1977.

2. Schneps MH, Ho PTP, Barrett AH, Buxton RB, Myers PC. Molecular hydrogen in globular clusters: a search for carbon monoxide. Astrophysical J 225:808-814, 1978.

3. Myers PC, Buxton RB. Observations of H2CO in the Orion Nebula at 1 centimeter wavelength. Astrophysical J 239:515-518, 1980.

4. Buxton RB. Microwave observations of regions of small scale star formation. Doctoral thesis, Department of Physics, Massachusetts Institute of Technology, 1981.

5. Brownell GL, Buxton RB, Burnham CB. Sequential sampling of blood activity using time-of-flight. In Proceedings of Time-of-Flight Workshop, ed. by LJ Thomas, IEEE Computer Society, pp 15-18, 1982.

6. Buxton RB, Wechsler LR, Alpert NM, Ackerman RH, Elmaleh DR, Correia JA. The measurement of brain pH using 11CO2 and positron emisson tomography. J Cereb Blood Flow and Metabol, 4:8-16, 1984.

7. Correia JA, Alpert NM, Buxton RB, Ackerman RH. Analysis of some errors in the measurement of oxygen extraction and oxygen consumption by the 15O equilibrium inhalation method. J. Cereb Blood Flow and Metabol 5:591-599, 1985.

8. Buxton RB, Alpert NM, Wechsler LR, Ackerman RH, Elmaleh DR, Correia JA. A kinetic model for the measurement of brain pH with 11CO2 and emission computed tomography. In Proceedings of the VII Nobel Conference on the Metabolism of the Human Brain Studied with Positron Emission Tomography, Raven Press, 1985.

9. Ackerman RH, Correia JAA, Alpert NM, D'Alton JG, Donnan GA, Davis SM, Kelley RE, Haley EC, Buxton RB, Taveras JT. Positron imaging in ischemic and hemorrhagic stroke disease. In Proceedings of the VII Nobel Conference on the Metabolism of the Human Brain Studied with Positron Emission Tomography, Raven Press, 1985.

10. Merrill EW, Ackerman RH, Buxton RB, Haley EC. Rapid clinical measurement of blood viscosity: relation of viscosity to hematocrit and plasma fibrinogen. Proceedings of the American Institute of Chemical Engineers Symposium on New Engineering Approaches to Artificial Organs, Chicago, November 1985.

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11. Greif WL, Buxton RB, Lauffer RB, Saini S, Stark DD, Wedeen VJ, Rosen BR, Brady TJ. Pulse sequence optimization for MR imaging using a paramagnetic hepatobiliary contrast agent. Radiology 157:461-466, 1985.

12. Wismer GL, Rosen BR, Buxton RB, Stark DD, Brady TJ. Chemical shift imaging of bone marrow: preliminary experience. AJR 145:1031-1037, 1985.

13. Wedeen VJ, Rosen BR, Buxton RB, Brady TJ. Projective MR angiography and quantitative flow-volume densitometry. Magn Reson Med 3:226-241, 1986.

14. Edelman RR, Johnson K, Buxton RB, Rosen BR, Shoukimas G, Davis KR, Brady TJ. Magnetic resonance imaging of hemorrhage: a new approach. AJNR 7:751-756, 1986.

15. Buxton RB, Wismer GL, Brady TJ, Rosen BR. Quantitative proton chemical shift imaging. Magn Reson Med 3:881-900, 1986.

16. Edelman RR, Hahn PF, Buxton RB, Wittenberg J, Ferruci, JT, Brady TJ. Rapid magnetic resonance imaging with suspended respiration: initial clinical application in the abdomen. Radiology 161:125-131, 1986.

17. Buxton RB, Edelman RR, Rosen BR, Wismer GL, Brady TJ. Contrast in rapid MRI: T1 and T2 weighted imaging. J Comput Assist Tomog 11:7-16, 1987.

18. Buxton RB, Alpert NA, Babikian V, Weise S, Correia JA, Ackerman RH. An evaluation of the 11CO2/PET method for measuring brain pH. 1. pH changes measured in states of altered PCO2. J. Cereb Blood Flow and Metabol 7:709-719, 1987.

19. Wismer GL, Buxton RB, Rosen BR, Fisel CR, Oot RF, Brady TJ, Davis KR. Susceptibility induced line broadening: applications to brain iron mapping. J Comput Assist Tomog 12:259-265, 1988.

20. Alpert NM, Buxton RB, Correia JA, Katz P, Ackerman RH. Measurement of end-capillary PO2 with positron emission tomography. J Cereb Blood Flow and Metabol 8:403-410, 1988.

21. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ. Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6:164-174, 1988.

22. Senda M, Buxton RB, Alpert NM, Correia JA, Mackay BC, Weise SB, Ackerman RH. The 15O steady-state method: correction for variation in arterial concentration. J Cereb Blood Flow and Metabol 8:681-690, 1988.

23. Rosen BR, Fleming DM, Kushner DC, Zaner KS, Buxton RB, Bennet WP, Wismer GL, Brady TJ. Hematologic bone marrow disorders: quantitative chemical shift imaging. Radiology 169:799-804, 1988.

24. Mikulis DJ, Chisin R, Wismer GL, Buxton RB, Weber AL, Davis KL, Rosen BR. Phase-contrast imaging of the parotid region. AJNR 10:157-164, 1989.

25. Buxton RB, Fisel CR, Chien D, Brady TJ. Signal intensity in fast NMR imaging with short repetition times. J Magn Reson 83:576-585, 1989.

26. Chisin R, Buxton RB, Ragozzino MW, Beaulieu PA, Fabian RL, Brady TJ. Preliminary clinical results with low flip angle spin-echo imaging: applications to the head and neck. AJNR 10:719-724, 1989.

27. Senda M, Alpert NM, Mackay BC, Buxton RB, Correia JA, Weise SB. Evaluation of the 11CO2 positron emission tomographic method for measuring brain pH. II. Quantitative pH mapping in patients with ischemic cerebrovascular diseases. J Cereb Blood Flow and Metabol 9:859-873, 1989.

28. Buxton RB, Wu EX. Measurement of diffusion and random motion effects with fast magnetic resonance (MR) imaging. Proceedings of the 1990 Annual SPIE meeting on Medical Imaging, Newport Beach CA.

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29. Nalcioglu O, Guo Q, Buxton RB. Measurement of eddy diffusivity by nuclear magnetic resonance imaging. Proceedings of the 1990 Annual SPIE meeting on Medical Imaging, Newport Beach CA.

30. Greensite FS, Buxton RB. Measure-theoretic aspects of contrast production in medical images. Proceedings of the 1990 Conference on Visualization in Biomedical Computing, Atlanta GA.

31. Wu EX, Buxton RB. Effect of diffusion on the steady-state magnetization with pulsed field gradients. J Magn Reson 90:243-253, 1990.

32. Chien D, Buxton RB, Kwong KK, Brady TJ, Rosen BR.MR diffusion imaging of the human brain. J Comput Assist Tomogr 14:514-520, 1990.

33. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ. MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med 17:336-347, 1991.

34. Buxton RB, Greensite F. Target-point combination of MR images. Magn Reson Med 18:102-115, 1991.

35. Lee HK, Nalcioglu O, Buxton RB. Correction for chemical shift artifacts in 19F imaging of PFOB: Simultaneous multislice imaging. Magn Reson Med 21:21-29, 1991.

36. Levenson H, Greensite F, Hoefs J, Friloux L, Silva E, Applegate G, Buxton RB. Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5 T vs. biopsy. AJR 156:307-312, 1991.

37. Tien RD, Buxton RB, Schwaighofer BW, Chu PK. Quantitation of structural distortion of the cervical neural foramina in gradient-echo MR imaging. J Magn Reson Imag 1: 683-687, 1991.

38. Mattrey RF, Schumacher DJ, Tran HT, Guo Q, Buxton RB. The Use of ImagentR BP in Diagnostic Imaging Research and 19F Magnetic Resonance for PO2 Measurements. Proceedings of the International Society of Artificial Organs and Symposium on Blood Substitutes, Canada, 1991.

39. Lee HK, Nalcioglu O, Buxton RB. Correction of chemical-shift artifacts in 19F imaging of PFOB: a robust signed magnitude method. Magn Reson Med 23:254-263, 1992.

40. Frank LR, Crawley AP, Buxton RB. Elimination of Oblique Flow Artifacts in Magnetic Resonance Imaging. Magn Reson Med 25:299-307, 1992.

41. Chien D, Kwong KK, Gress DR, Buonanno FS, Buxton RB, Rosen BR. MR Diffusion Imaging of Cerebral Infarction in Humans. AJNR 13:1097-1102, 1992.

42. Buxton RB. The diffusion sensitivity of fast steady-state free precession imaging. Magn Reson Med 29:235-243, 1993.

43. Frank LR, Buxton RB. Distortions from Curved Flow in Magnetic Resonance Imaging. Magn Reson Med 29:84-93, 1993.

44. Buxton RB, Kerber CW, Frank LR. Pulsatile Flow Artifacts in Two-dimensional Time-of-Flight MR Angiography: Initial Studies in Elastic Models of Human Carotid Arteries. JMRI 3:625-636, 1993.

45. Frank LR, Buxton RB, Kerber CW. Pulsatile Flow Artifacts in 3D Magnetic Resonance Imaging. Magn Reson Med 30:296-304, 1993.

46. Kantor HL, Rzedzian RR, Buxton R, Berliner E, Beaulieu P, Rosen B, Brady TJ, Pykett IL. Contrast induced myocardial signal reduction: effect of lanthanide chelates on ultra high speed MR images. Magn Reson Imag 12:51-59, 1994.

47. Elmaleh DR, Livni E, Alpert NM, Strauss HW, Buxton RB, Fischman AJ. Myocardial Extraction of 1-[11C] Betamethylheptadecanoic Acid. J Nucl Med 35:496-503, 1994.

48. Chong BW, Kerber CW, Buxton RB, Frank LR, Hesselink JR. Blood Flow Dynamics in the Vertebrobasilar System: Correlation of aTransparent Elastic Model and MR Angiography. AJNR 15:733-745, 1994.

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49. Guo Q, Mattrey RF, Guclu C, Buxton RB, Nalcioglu O. Monitoring of PO2 by spin-spin relaxation rate 1/T2 of 19F in a rabbit abscess model. Art Cells, Blood Subs, and Immob Biotech 22(4):1449-1454, 1994.

50. Prasad PV, Edelman RR, Buxton RB. Magnetic Resonance Perfusion Imaging. Intl J of Imaging Systems and Tech 6:230-237, 1995.

51. Tran HT, Guo Q,Schumacher DJ, Buxton RB, Mattrey RF. 19F chemical shift imaging technique to measure intracellular PO2 in vivo using perflubron. Acad Radiology 2:756-761, 1995.

52. Kerber CW, Hecht ST, Knox K, Buxton RB, Meltzer HS. Flow dynamics in a fatal aneurysm of the basilar artery. American Journal of Neuroradiology 17:1417-1421, 1996.

53. Buxton RB, Frank LR. A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow and Metab 17:64-72, 1997.

54. Frank LR, Brossmann J, Buxton RB, Resnick D. MR imaging truncation artifacts can create a false laminar appearance in cartilage. AJR 168(2):547-554, 1997.

55. Allen G, Buxton RB, Wong EC, Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science 275:1940-1943, 1997.

56. Hickok G, Love T, Swinney D, Wong EC, Buxton RB. Functional MR imaging during auditory word perception: a single-trial presentation paradigm. Brain and Language 58:197-201, 1997.

57. Martinez A, Moses P, Frank L, Buxton R, Wong E, Stiles J. Hemispheric asymmetries in global and local processing: evidence from fMRI. NeuroReport 8, 1685-1689, 1997.

58. Prasad PV, Kim D, Kaiser AM, Chavez D, Gladstone S, Li W, Buxton RB, Edelman RR. Noninvasive comprehensive characterization of renal artery stenosis by combination of STAR angiography and EPISTAR perfusion imaging. Magn Reson Med 38:776-787, 1997.

59. Wong EC, Buxton RB, Frank LR. Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR in Biomed 10:237-249, 1997.

60. Hickok G, Poeppel D, Clark K, Buxton R, Rowley H, Roberts TPL. Letter to the Editor: Sensory mapping in a congenitally deaf subject: MEG and fMRI studies of cross-modal non-plasticity. Human Brain Mapping 5:437-444, 1997.

61. Frank LR, Wong EC, Buxton RB. Slice profile effects in adiabatic inversion: application to multislice perfusion imaging. Magn Reson Med 38:558-564, 1997.

62. Frank LR, Buxton R, Wong EC. Probabilistic analysis of fMRI data. Magn Reson Med 39:132-148, 1998.

63. Reber PJ, Wong EC, Buxton RB, Frank LR. Correction of off resonance-related distortion in echo-planar imaging using EPI-based field maps. Magn Reson Med 39:328-330, 1998.

64. Wong EC, Buxton RB, Frank LR: Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 39:702-708, 1998.

65. Buxton RB, Wong EC, Frank LR. Dynamics of blood flow and oxygen metabolism during brain activation: the balloon model. Magn Reson Med 39:855-864, 1998.

66. Stefanacci L, Reber P, Costanza J, Wong E, Buxton R, Zola S, Squire L, Albright T. fMRI of monkey visual cortex. Neuron 20:1051-1057, 1998.

67. Wong EC, Buxton RB, Frank LR. A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging. Magn Reson Med 40:348-355, 1998.

68. Buxton RB, Frank LR, Wong EC, Siewert B, Warach S, Edelman RR. A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn Reson Med 40:383-396,1998.

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69. Martinez A, Anllo-Vento L, Sereno MI, Frank LR, Buxton RB, Dubowitz DJ, Wong EC, Heinze HJ, Hinrichs H and Hillyard SA. Involvement of striate and extrastriate visual cortical areas in spatial attention. Nature Neuroscience 4:364-369, 1999.

70. Frank LR, Wong EC, Haseler LJ, Buxton RB. Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling. Magn Reson Med 42: 258-267, 1999.

71. Brown GG, Kindermann SS, Siegle GJ, Granholm E, Wong EC, Buxton RB. Brain activation and pupil response during covert performance of the Stroop Color Word task. Journal of the International Neuropsychological Society 5:308-19, 1999.

72. Drummond SPA, Brown GG, Stricker JL, Buxton RB, Wong EC, Gillen JC. Sleep deprivation-induced reduction in cortical functional response to serial subtraction. NeuroReport 10:3745-3748, 1999.

73. Drummond SPA, Brown GG, Gillin JC, Stricker JL, Wong EC, Buxton RB. Altered brain response to verbal learning following sleep deprivation. Nature 403:655-657, 2000.

74. Hatabu H, Tadamura E, Prasad PV, Chen Q, Buxton R, Edelman RR. Noninvasive pulmonary perfusion imaging by STAR-HASTE sequence. Magn Reson Med 44:808-812, 2000.

75. Wong EC, Liu TT,Luh W-M, Frank LR, Buxton RB. T1 and T2 selective method for improved SNR in CSF attenuated imaging: T2-FLAIR. Magn Reson Med 45:529, 2001.

76. Miller KL, Luh W-M, Liu TT, Martinez A, Obata T, Wong EC, Frank LR, Buxton RB. Nonlinear temporal dynamics of the cerebral blood flow response. Human Brain Mapping 13:1-12, 2001.

77. Liu TT, Frank LR, Wong EC, Buxton RB. Detection power, estimation efficiency, and predictability in event-related fMRI. NeuroImage 13:759-773.

78. Martinez A, DiRussso F, Anllo-Vento L, Sereno MI, Buxton RB, Hillyard SA. Putting spatial attention on the map: timing and localization of stimulus selection processes in striate and extrastriate visual areas. Vision Research 41:1437-1457, 2001.

79. Buxton RB. Commentary: The elusive initial dip. NeuroImage13:953-958, 2001.80. Frank LR, Buxton RB, Wong EC. Estimation of respiration-induced noise fluctuations from

undersampled multislice fMRI data. Magn Reson Med 45:635-644, 2001.81. Liu TT, Wong EC, Frank LR, Buxton RB. Analysis and design of perfusion-based event-

related fMRI experiments. NeuroImage 16:269-282, 2002.94. Moses P, Roe K, Buxton RB, Wong EC, Frank LR, Stiles J. Functional MRI of global and

local processing in children. NeuroImage, 16(2):415-24. 2002. 95. Liu TT, Wong EC, Frank LR, Buxton RB. Analysis and design of perfusion-based event-

related fMRI experiments. NeuroImage, 16(1) 269-82. 2002. 96. Reber PJ, Wong EC, Buxton RB. Comparing the brain areas supporting nondeclarative

categorization and recognition memory. Brain Research, 14(2):245-57. 2002. 97. Reber PJ, Wong EC, Buxton RB. Encoding activity in the medial temporal lobe examined

with anatomically constrained fMRI analysis. Hippocampus, 12(3):363-76. 2002. 98. Love T, Swinney D, Wong E, Buxton R. Perfusion imaging and stroke: A more sensitive

measure of the brain bases of cognitive deficits. Aphasiology. 16:873-88, 200299. Buxton RB, Coupling between CBF and CMRO2 during neuronal activity. International

Congress Series 1235. 23-32, 2002. 100. Stiles J, Moses P, Roe K, Trauner D, Hesselink J, Wong E, Frank L, Buxton R. Alternative

brain organization after prenatal cerebral injury: Convergent fMRI and cognitive data. Journal of International Neuroscience Society. 9:604-622. 2003.

101. Passarotti AM, Paul BM, Bussiere JR, Buxton RB, Wong EC, Stiles J. The development of face and location processing: a fMRI study. Developmental Sciences, 6 (1), 100-117, 2003.

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102. Frank LR, Wong EC, Liu TT, Buxton RB. Increased diffusion sensitivity using hyperechoes. Magn. Reson. Med, 49(6):1098-105. 2003

103. Brown GG, Zorrilla LT, Georgy B, Kindermann, SS, Wong, EC, Buxton, RB. BOLD and perfusion response to finger-thumb apposition following acetazolamide administration: differential relationship to cortical perfusion. Journal of Cerebral Blood Flow and Metabolism. 23:829-837. 2003.

104. Obata T, Liu TT, Miller, KL, Luh WM, Wong EC, Frank LR, Buxton RB. Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients, NeuroImage, (21):144-153. 2004.

105. Buxton RB, Uludag K, Dubowitz, DJ, Liu, TT. Modeling the hemodynamic response to brain activation. NeuroImage, 23:S220-S233. 2004.

106. Uludag K, Dubowitz, DJ, Yoder EJ, Restom, Liu TT, Buxton RB. Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. Neuroimage 23:148-155, 2004.

107. Uludag K and Buxton RB. Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation. Magn Reson Med 51(5): 1088-9; author reply 1090, 2004.

108. Liu TT, Behzadi Y, Restom K, Uludag K, Lu K, Buracas GT, Dubowitz DJ, Buxton RB. Caffeine alters the temporal dynamics of the visual BOLD response. Neuroimage 23:1402-13, 2004.

109. Sirlin CB, Vera DR, Corbeil JA, Caballero MB, Buxton RB, Mattrey RF. Gadolinium-DPTA-Dextran: A macromolecular MR blood pool contrast Agent1 . Acad Radiol. 11:1361-1369. 2004.

110. Buxton, R. B. "Quantifying CBF with arterial spin labeling." J Magn Reson Imaging, 22(6): 723-6, 2005.

111. Bolar, DS, Levin, DL Hopkins, SR, Frank LR, Liu, TT, Wong, EC, Buxton RB, Quantification of Regional Pulmonary Blood Flow Using ASL-FAIRER. Magnetic Resonance in Medicine, . 55(6):1308-17.2006

113. Henderson AC, Levin DL, Hopkins SR, Olfert IM, Buxton RB, Prisk GK. Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow. J Appl Physiol. 101:583-589, 2006.

114. Leontiev O, Buxton RB. Reproducibility of BOLD, perfusion and CMRO2 measurements with calibrated-BOLD fMRI. Neuroimage. 35: 174-184, 2007.

115. Leontiev O, Dubowitz DJ, Buxton RB. CBF/CMRO2 coupling measured with calibrated-BOLD fMRI: sources of bias. Neuroimage 36:1110-1122, 2007.

116. Hopkins SR, Hendrson AC, Levin DL, Yamada K, Arai T, Buxton RB, Prisk GK. Vertical gradients in regional lung density and perfusion in the supine human lung: The slinky (R) effect. J Appl Physiol. 103:240-8, 2007.

117. Levin DL, Buxton RB, Spiess JP, Arai T, Balouch J, Hopkins SR. Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. J Appl Physiol. 102(5): 2064-70, 2007.

118. Prisk GK, Yamada K, Henderson AC, Arai TJ, Levin DL, Buxton RB, Hopkins SR. Pulmonary perfusion in the prone and supine postures in the normal human lung. J. Appl. Physiol 103:883-94, 2007.

119. Wu WC, Buxton RB, Wong EC. Vascular space occupancy weighted imaging with control of residual blood signal and higher contrast-to-noise ratio. IEEE Trans Med Imaging 26:1319-1327, 2007.

120. Ances BM, Leontiev O, Perthen JE, Liang C, Lansing AE, Buxton RB. Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI. Neuroimage 39:1510-1521, 2008.

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121. Buracas GT, Liu TT, Buxton RB, Frank LR, Wong EC. Imaging periodic currents using alternating balanced steady-state free precession. Magn Reson Med 59:140-148, 2008.

122. Dyer EA, Hopkins SR, Perthen JE, Buxton RB, Dubowitz DJ. Regional cerebral blood flow during acute hypoxia in individuals susceptible to acute mountain sickness. Respir Physiol Neurobiol 160:267-276, 2008.

123. Perthen JE, Lansing AE, Liau J, Liu TT, Buxton RB. Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study. Neuroimage 40:237-247, 2008.

124. Fleisher AS, Podraza KM, Bangen KJ, Taylor C, Sherzai A, Sidhar K, Liu TT, Dale AM, Buxton RB. Cerebral perfusion and oxygenation differences in Alzheimer's disease risk. Neurobiol Aging 30:1737-48, 2009.

125. Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB. Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp 30:1120-32, 2009.

126. Arai TJ, Henderson AC, Dubowitz DJ, Levin DL, Friedman PJ, Buxton RB, Prisk GK, Hopkins SR. Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans. J Appl Physiol 106:1057-64.

127. Dubowitz DJ, Dyer EA, Theilmann RJ, Buxton RB, Hopkins SR. Early brain swelling in acute hypoxia. J Appl Physiol 107:244-52, 2009.

128. Henderson AC, Prisk GK, Levin DL, Hopkins SR, Buxton RB. Characterizing pulmonary blood flow distribution measured using arterial spin labeling. NMR Biomed 22:1025-35, 2009.

129. Fleisher AS, Sherzai A, Taylor C, Langbaum JB, Chen K, Buxton RB. Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer’s disease risk groups. Neuroimage 47:1678-90, 2009.

130. Theilmann RJ, Arai TJ, Samiee A, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Quantitative MRI measurement of lung density must account for the change in T2* with lung inflation. J Magn Reson Imag 30:527-34, 2009.

131. Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, Buxton RB, Benson D, Smith DM, Little SJ, Richman DD, Moore DJ, Ellis RJ; HNRC group. Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain. Neurology 73:702-8, 2009.

132. Burnham KJ, Arai TJ, Dubowitz DJ, Henderson AC, Holverda S, Buxton RB, Prisk GK, Hopkins SR. Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans. J Appl Physiol 107:1559-68, 2009.

133. Ances BM, Vaida F, Yeh MJ, Liang CL, Buxton RB, Letendre S, McCutchan JA, Ellis RJ. HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging. J Infect Dis 201:336-40, 2010.

134. Buxton RB. Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism. Front Neuroenergetics 2:8.

135. Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level dependent functional MRI. Proc Natl Acad Sci USA 107:15246-51, 2010.

136. Hopkins SR, Arai TJ, Henderson AC, Levin DL, Buxton RB, Kim Prisk G. Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans. J Physiol 588:4759-68, 2010.

137. Sá RC, Cronin MV, Henderson AC, Holverda S, Theilmann RJ, Arai TJ, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI. J Appl Physiol 109:1950-9.

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138. Ances B, Vaida F, Ellis R, Buxton R. Test-retest stability of calibrated-fMRI in HIV- and HIV+ subjects. Neuroimage 54:2156-62, 2011.

139. Ances BM,Vaida F, Cherner M, Yeh MJ, Liang CL, Gardner C, Grant I, Ellis RJ, Buxton RB; the HIV Neurobehavioral Research Center (HNRC) Group. HIV and chronic methamphetamine dependence affect cerebral blood flow. J Neuroimmune Pharmacol. (Epub ahead of print) 2011.

140. Thesen T, Leontiev O, Song T, Dehgani N, Hagler DJ Jr, Huang M, Buxton R, Halgren E. Depression of cortical activity in humans by mild hypercapnia. Hum Brain Mapp (epub ahead of print) 2011.

141. Griffeth VEM, Perthen JE, Buxton RB. Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans. Neuroimage 57:809-816, 2011.

142. Griffeth VEM, Buxton RB. A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal. Neuroimage 58:198-212, 2011.

143. Arai TJ, Prisk GK, Holverda S, Sá RC, Theilmann RJ, Henderson AC, Cronin MV, Buxton RB, Hopkins SR. Magnetic resonance imaging quantification of pulmonary perfusion using calibrated arterial spin labeling. J Vis Exp. 2011 May 30;(51).

144. Buračas GT, Jung Y, Lee J, Buxton RB, Wong EC, Liu TT. On multiple alternating steady states induced by periodic spin phase perturbation waveforms. Magn Reson Med. 67:1412-1418, 2012.

145. Moradi F, Buracas GT, Buxton RB. Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex. Neuroimage 59:601-607, 2012.

146. Small SA, Schobel SA, Buxton RB, Witter MP, Barnes CA. A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nat Rev Neurosci. 12:585-601, 2011.

147. Devor A, Sakadzic S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. “Overshoot” of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci 31:13676-81, 2011.

148. Blockley NP, Griffeth VE, Buxton RB. A general analysis of calibrated BOLD methodology for measuring CMRO2 responses: Comparison of a new approach with existing methods. Neuroimage 60:279-289, 2012.

149. Henderson AC, Sá RC, Barash IA, Holverda S, Buxton RB, Hopkins SR, Prisk GK. Rapid intravenous perfusion of 20 ml/kg saline alters the distribution of perfusion in healthy supine humans. Respir Physiol Neurobiol. 180:331-41, 2012.

150. Burrowes KS, Buxton RB, Prisk GK. Assessing potential errors of MRI-based measurements of pulmonary blood flow using a detailed network flow model. J Appl Physiol 113:130-41, 2012.

151. Robertson HT, Buxton RB. Imaging for lung physiology: what do we wish we could measure? J Appl Physiol 113:317-27, 2012.

152. Liang CL, Ances BM, Perthen JE, Moradi F, Liau J, Buracas GT, Hopkins SR, Buxton RB. Luminance contrast of a visual stimulus modulates the BOLD response more than the cerebral blood flow response in the human brain. Neuroimage 64:104-11, 2013.

153. Asadi AK, Cronin MV, Sa RC, Theilmann RJ, Holverda S, Hopkins SR, Buxton RB, Prisk GK. Spatial-temporal dynamics of pulmonary blood flow in the healthy human lung in response to altered FIO2. J Appl Physiol 114:107-18, 2013.

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154. Blockley NP, Griffeth VEM, Gemuska MA, Bulte DP, Buxton RB. An analysis of the use of hyperoxia for measuring venous cerebral blood volume: comparison of the existing method with a new analysis approach. Neuroimage 72:33-44, 2013.

155. Simon AB, Griffeth VEM, Wong EC, Buxton RB. A novel method for measuring cerebral blood flow and oxygen metabolism dynamics in response to an unknown neural stimulus. PLoS One 8:e54816, 2013.

156. Henderson AC, Sa RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR. The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung. J Appl Physiol 115:313-24, 2013.

157. Leontiev O,Buracas GT, Liang C, Ances BM, Perthen JE, Shmuel A, Buxton RB. Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex. Neuroimage 68:221-8, 2013.

158. Moradi F, Buxton RB. Adaptation of cerebral oxygen metabolism and blood flow and modulation of neurovascular coupling with prolonged stimulation in human visual cortex. Neuroimage 2013 82:182-9, 2013.

159. Wegener S, Artmann J, Luft AR, Buxton RB, Weller M, Wong EC. The time of maximum post-ischemic hyperperfusion indicates infarct growth following transient experimental ischemia. PLoS One. 8(5):e65322, 2013.

160. Griffeth VEM, Blockley NP, Simon AB, Buxton RB. A new functional MRI approach for investigating modulations of brain oxygen metabolism. PLoS One 8:e68122, 2013.

161. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. Connecting the dots in the B.R.A.I.N., Neuron 80:270-4, 2013.

162. Bracko O, Di Pietro V, Lazzarino G, Amorini AM, Tavazzi B, Artmann J, Wong EC, Buxton RB, Weller M, Luft AR, Wegener S. 3-Nitroproprionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow. J Cereb Blood Flow Metab. 2014 [Epub ahead of print].

163. Buxton RB, Griffeth VE, Simon AB, Moradi F. Variability of the coupling of blood flow and oxygen responses in the brain: a problem for interpreting BOLD studies but potentially a new window on the underlying neural activity. Front Neurosci. 8:139-44, 2014.

B. Books

1. Buxton, RB. Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques, Cambridge University Press (first edition 2002, second revised edition 2009).

C. Reviews and Book Chapters

1. Buxton RB, Alpert NM, Ackerman RH, Wechsler LR, Elmaleh DR, Correia JA. Measurement of brain pH with positron emission tomography. In Positron Emission Tomography, ed. by M Reivich, Alan R. Liss, Inc., New York, 1985.

2. Ackerman RH, Correia JA, Alpert NM, Haley EC, Buxton RB, Elmaleh DR, Taveras JT. PET studies of stroke. In Positron Emission Tomography, ed. by M Reivich, Alan R. Liss, Inc., New York, 1985.

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3. Ackerman RH, Burbank KM, Buxton RB, Haley EC, Babikian BL, Correia JA, Alpert NM, Davis SM, Katz PM, Rosner B, Dorsey FC. Relationships between viscosity factors and CBF and porous bed viscometry in normals and stroke prone subjects. In Cerebral Ischemia and Hemorheology, ed. by A. Hartmann and W. Kuschinsky, Springer-Verlag, Berlin, 1986.

4. Brady TJ, Wismer GL, Buxton RB, Stark DD, Rosen BR. Magnetic resonance chemical shift imaging. In Magnetic Resonance Annual 1986, ed. by HY Kressel, Raven Press, New York, NY, 1986.

5. Edelman RR, Buxton RB, Brady TJ. Rapid MR Imaging. In Magnetic Resonance Annual (1987) ed. by HY Kressel, Raven Press, New York, NY 1987.

6. Buxton RB, Brady TJ, Wismer GL, Rosen BR. Chemical shift imaging. In Magnetic Resonance Imaging (MRI), 2nd edition, ed. by CL Partain, WB Saunders Co., Philadelphia, PA, pg.1564-1583, 1989.

7. Edelman RR, Rubin JB, Buxton RB. Flow. In Clinical Magnetic Resonance Imaging, ed. by RR Edelman and JR Hesselink, W.B. Saunders Co., Orlando FL, 1990.

8. Buxton RB. Fast Diffusion Sensitive Imaging with Steady-State Free Precession (SSFP). In Diffusion and Perfusion Magnetic Resonance Imaging, ed. by Denis LeBihan, Raven Press, New York, pg. 41-49, 1995.

9. Buxton RB. Magnetic Resonance Imaging: Technical Considerations. In Diagnosis of Bone and Joint Disorders, third edition, ed. by D. Resnick, W. B. Saunders Co., Philadelphia, PA, pg. 170-190, 1995.

10. Buxton RB, Frank LR, Prasad PV. Principles of Diffusion and Perfusion MR Imaging. In Clinical Magnetic Resonance Imaging, edition 2, ed. by R. Edelman, J. Hesselink, M. Zlatkin, W. B. Saunders Co., Philadelphia, PA, pg. 233-270, 1996.

11. Buxton RB, Wong EC, Frank LR. Magnetic resonance imaging of perfusion with arterial spin labeling. In Recent Advances in Biomedical Imaging, Proceedings of the International Workshop on Biomedical Imaging: MR and PET/SPECT, Fukui , Japan, ed. by Y. Ishii, Y. Yonekura, Y. Fujibayashi, and N. Sadato. Elsevier, 1997.

12. Buxton RB, Wong EC, LR Frank. Chapter 23: The post-stimulus undershoot of the functional MRI signal, in Functional MRI, ed. by C. Moonen and P. Bandettini, Springer-Verlag, Berlin, pg. 253-262, 1999.

13. Wong EC, Buxton RB, Frank LR. Quantitative perfusion imaging using arterial spin labeling. Neuroimaging Clinics of North America Vol. 9, Number 2, pp.333-342, May 1999.

14. Frank LR, Wong EC, Buxton RB, Resnick D. Mapping the physiologic parameters of articular cartilage with magnetic resonance imaging. Topics in Magnetic Resonance Imaging. 10:152-179 (1999).

15. Buxton RB, Coupling between CBF and CMRO2 during neuronal activity. International Congress Series 1235. 23-32, 2002.

16. Buxton RB, Uludag K, Dubowitz, DJ. Investigating the physiology of brain activation with MRI. In: Proc. SPIE Vol. 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images. (AA Amini, A Manduca, Eds). The International Society for Optical Engineering, Los Angeles, 2004.

17. Uludag K, Dubowitz DJ, Buxton RB. Chapter 9: Principles of functional imaging of the brain. In: Clinical Magnetic Resonance Imaging (3rd Ed). (RR Edelman, JR Heselink and MB Zlatkin, Eds). Naughton Project Management: England. 2005.

18. Jezzard P, Buxton RB. The clinical potential of functional magnetic resonance imaging. J Mag Reson Imaging, 23:787-793. 2006. (Invited Review; Drs Jezzard and Buxton were co-editors for this issue of the journal).

19. Brown GG, Perthen JE, Liu TT, Buxton RB. A primer on Functional Magnetic Resonance Imaging. Neuropsychol Rev. 17:107-125, 2007.

20. Buxton RB. Dynamic models of BOLD contrast. Neuroimage 62:953-61, 2012.

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21. Blockley NP, Griffeth VE, Simon AB, Buxton RB. A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism. NMR Biomed 26:987-1003, 2013.

22. Buxton RB. The physics of functional magnetic resonance imaging. Rep Prog Phys 76(9):096601 2013.

23. Buxton RB. Perfusion confusion: What is perfusion and what do we measure? Chapter 44 in MR and CT Perfusion Imaging: Clinical Applications and Theoretical Principles, edited by Roland Bammer, Lippincott (in press).

24. Buxton RB. Models of fMRI signal changes. In Brain Mapping: An Encyclopedic Reference, edited by Arthur Toga, Paul Thompson and Karl Friston, Elsevier (in press).

D. Abstracts

(>200 published abstracts from scientific meetings)

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