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7/22/2019 Biyani Conference - Oral Presentation
1/28
Dr. Xnbasf Tfngur
Nsscstnmt ZrleasslrDapnrt`amt le Hcl & Mnml Taofmlkliy,
Iuru Bn`hfasfwnr Qmcvarscty le _ocamoa &
Taofmlkliy, Fcssnr, Fnrynmn>81::>.
Cmdcn.
rtfngur33Jradcee`nck.ol`
Iamatco Amicmaarcmi le Hnotarclrfldlpscm
(Tfa Zurpka Zlwar Zrltacm)
elr c`prlvcmi cts nppkcontclms
7/22/2019 Biyani Conference - Oral Presentation
2/28
Hnotarclrfldlpscm (hX) cs n kcift-notcvntad
prltlm pu`p tfnt cs elr`ad wfam tfa 846
n`cml nocd prltacmHnotarcl-lpscmcs
olupkad tl tfa ofrl`lpflra nkk-trnms
ratcmnk.
7/22/2019 Biyani Conference - Oral Presentation
3/28
Hnotarclrfldlpscm cs n Dymn`co,
Trnms`a`hrnma Zrltacm
_avarnk trnms`a`hrnma spnmmcmi fakcoas
? Tyr rascduas flkd tfa HX cm pknoa
Xatcmnk scts nt tfa bumotclm sapnrntcmi tfa twl
fnke ofnmmaks
Mltcoa tfa Hnotarclrfldlpscm cs surrlumdad
hy Nsp nmd Nri
7/22/2019 Biyani Conference - Oral Presentation
4/28
Zfltlms elr Zrltlms
Hnotarclrfldlpscm tngas amariy erl` pfltlms
Tfcs amariy cs utckczad tl oranta n prltlm
irndcamt hy pu`pcmi prltlms lutscda tfa oakk.
Zrltlms nra nkklwad hnog cmtl tfa oakk hy nm NTZ
symtfnsa. Cm n mutsfakk2 Zfltlms nra usad tl plwar tfa oakk
E:E> NTZnsaF+
+ + + + + + +- - - - - - - - -
F+fv
NDZ NTZ
7/22/2019 Biyani Conference - Oral Presentation
5/28
_luroa le HX
HX cs prc`nrcky elumd
cm Nrofnahnotarcn
Fnklhnotarcn
snkcmnrcu`
Tfasa nra fnklpfckco
hnotarcn (c.a., tfay nra
elumd cm vary snktywntar a.i. Irant _nkt
Knga)
7/22/2019 Biyani Conference - Oral Presentation
6/28
Loourramoa le Fnklhnotarcn
Iamarn Fnklhnotarcn haklmicmi tl tfa fnklpfckco nrofnanirlup
nra tfa lmky iamarn tfnt olmtncm ratcmnk prltacms.
Fnklpfckco nrofnan irlup cm iamarnk irlw lm lrinmco suhstrntas nmd
raspcra cm n stnmdnrd ensfclm uscmi lxyiam. Flwavar, tfa fcif snkt
amvcrlm`amt cm wfcof tfa Fnklhnotarcn loour, nkklw lmky >/1tfnvncknhckcty le lxyiam.
Qmdar tfa nmnarlhco olmdctclms tfnt ol``lmky loour cm tfacr
fnhctnts, tfasa lrinmcs`s fnva noqucrad nktarmntcva `anms elr
amariy olmvarsclm.
Tfcs systa` dlas mlt usa ofklrlpfykk-hnsad ranotclm oamtars hut
rntfar rakcas lm ratcmnk ns n pfltlm nhslrhar nmd ratcmnk-olmtncmcmi
prltacms ns amariy trnmsduoars.
7/22/2019 Biyani Conference - Oral Presentation
7/28
Fnklhnotarcn fnva davaklpad n sat le elur ratcmnkprltacms,
Xfldlpscm - Hnotarclrfldlpscm
Fnklrfldlpscm - _amslry rfldlpscm
Twl le tfa` fnva samslry eumotclm,
Yfcka ltfar twl olmvart kcift amariy tl ofa`conk
amariy.
7/22/2019 Biyani Conference - Oral Presentation
8/28
Hnotarclrfldlpscm cs nksl elumd cm sl`aumcoakkuknr pknmts nmd sl`a eumic.
Avlkutclm fns lptc`czad tfcs prltacm elrfcif pfltlofa`conk aeecocamoy, tfar`nkstnhckcty nmd oyokcocty, ns tfa lrinmcs`
`ust ha nhka tl eumotclm cm n flt, stnimnmtnmd rasluroa-kc`ctad amvcrlm`amt.
Ct nhslrhs kcift J 19: m` (vcschka iraam
kcift)
Xad nmd Hkua kcift cs raekaotad, icvcmi`a`hrnma cts purpka olklur
7/22/2019 Biyani Conference - Oral Presentation
9/28
7/22/2019 Biyani Conference - Oral Presentation
10/28
HX elr`s 8D orystnks cm vcvl, nmd tfasa onm hacslkntad ns purpka `a`hrnmas.
Tfa cslkntclm cs enockctntad hy tfa elkklwcmi2c. Fnklhnotarcnk oakks nra umstnhka cm wntar nmd oakk
kyscs loours.
cc. Tfa oakk a`hrnma cs erni`amtad, nmd tfaorystnkkcma pntofas le tfa purpka `a`hrnma nra sateraa ns erni`amts le knriast scza nmd fcifasthulynmt damscty.
Tfasa twl spaoceco eanturas nra usad cm tfa cslkntclmprloadura, actfar cm n ol`hcmntclm le sadc`amtntclmnmd cslpyomco irndcamt oamtrceuintclm kandcmi tl nprlduot le fcifast purcty, lr hy n ecktrntclmprloadura.
Hcltaofmlkliconk Zrlduotclm le HX
7/22/2019 Biyani Conference - Oral Presentation
11/28
Cm `lst le tfa nppkcontclms, hnotarclrfldlpscm
cs usad cm tfa Zurpka @a`hrnma (Z@) elr`,
haonusa cts kcharntclm erl` tfa orystnkkcma
pnognia raduoas hltf tfa ofa`conk nmd
tfar`ldymn`co stnhckcty.
Tfa tfraa hnsco `lkaouknr prlpartcas wfcof
`ny ha usad cm taofmconk nppkcontclms nra2
Zfltlakaotrco prlparty Zfltlofrl`co prlparty
Zrltlm trnmsplrt prlparty
Taofmconk Nppkcontclms le HX
7/22/2019 Biyani Conference - Oral Presentation
12/28
N scmika Z@ sfaat olmtncms savarnk tflusnmds le umcdcraotclmnkky
lrcamtad HX `lkaoukas.
Qplm ckku`cmntclm, n pfltlvlktnia up tl 81:`U par scmika
hnotarclrfldlpscm knyar cs iamarntad, nmd tfcs `ny ha usad actfar
ns nm cmdcontlr lr olmtrlk aka`amt elr vnrclus nppkcontclms.
Qplm nhslrptclm le n pfltlm, tfa hnotarclrfldlpscm `lkaoukaumdarilas n sarcas le vary rnpcd `lkaouknr ofnmias, lma le
wfcof cs tfa iamarntclm le n pfltlvlktnia.
Tfa pfltlvlktnia iamarntad onm ha anscky `ansurad hy
a`haddcmi tfa Z@ knyar hatwaam twl trnmspnramt akaotrldas.
N vlktnia cs cmduoad lmky durcmi tfa kcift cmtamscty ofnmia. Tfa
plknrcty le tfa scimnk cs dceearamt elr tfa LEELM nmd tfa LM
LEE trnmsctclm. Tfcs cs onkkad Dceearamtcnk Xasplmscvcty le Z@
knyars.
Zfltlakaotrco Zrlparty
7/22/2019 Biyani Conference - Oral Presentation
13/28
Cm n pcxakntad struotura wfcof
cs olntad wctf lrcamtad
hnotarclrfldlpscm,
pfltlvlktnias nra `ansuradlmky cm tflsa splts wfara n
ofnmia cm tfa kcift cmtamscty
loours.
Tfcs cs onkkad mlvakty ecktarcmi.
Zfltlakaotrco Zrlpartcas
Akaotrlmcocmtarenoa nran
Kcift samsctcva
pcxakntad nran
@lva`amtle lhbaot
Dceearamtcnk rasplmsa le samslr nrrny(mlvakty dataotclm)
Akaotrlmco
cmtarenoanran
7/22/2019 Biyani Conference - Oral Presentation
14/28
N fyhrcd
sa`colmduotlrhnotarclrfldlpscm-
hnsad nrtcecocnk
ratcmn cs enst nmd
cmaxpamscva nmd
`c`cos tfa `ltclm
samsctcvcty le tfa
fu`nm ratcmn.
Nrtcecocnk Xatcmn
7/22/2019 Biyani Conference - Oral Presentation
15/28
Durcmi tfa pfltloyoka, hnotarclrfldlpscm oyokas
tfrluif n pncr le spaotrlsolpconkky dcstcmiucsfnhka
cmtar`adcntas, wfcof fnva nm nhslrptclm `nxc`u`
wfcof cs dceearamt erl` tfnt le tfa cmctcnk H stnta.
Cm `lst nppkcontclms tfa pfltlofrl`cs` le
hnotarclrfldlpscm cs usad cm olmmaotclm wctf tfapurpka tl yakklw nhslrptclm ofnmia wfcof cs rakntad tl
@ stnta elr`ntclm.
Qplm nocdcecontclm, n hkua `a`hrnma cs elr`ad wfcof
fns n scimceconmtky dceearamt pfltloyoka. Tfa elr`ntclmle n 3-ocs ratcmnk-olmtncmcmi stnta cs lhsarvad, nmd tfcs
cs tfar`nkky stnhka. Tfcs lpams tfa rluta tl klmi-tar`
stlrnia `ntarcnks hnsad lm hnotarclrfldlpscm.
Zfltlofrl`co Zrlpartcas
7/22/2019 Biyani Conference - Oral Presentation
16/28
Zfltloyoka
Tfa amariy trnppcmi
olmelr`ntclmnk trnmsctclm loours
wctfcm lma ps
Daprltlmntclm nmd raprltlmntclm
staps nra ofnrnotarczad hy
cmtar`adcntas wfcof olmtncmdcstcmot nhslrptclm spaotrn
Lma eukk turm le tfa oyoka loours
wctfcm n `s
Famoa anof stap fns n
ofnrnotarcstco olklur
Avary sao, 1: prltlms nra
axplrtad
Zurpka
Sakklw
7/22/2019 Biyani Conference - Oral Presentation
17/28
Zfltlofrl`co olklr oknsscecar
Zfltlofrl`co / Akaotrlofrl`co cmgs
Zfltlofrl`co pfltlirnpfco eck`
Nppkcontclms cm Hclsamslrs
Klmi-tar` pfltlrawrctanhka stlrnia le cmelr`ntclm
Maurnk matwlrgs
?-D cmelr`ntclm stlrnia
Mlmkcmanr lptconk ecktarcmi
Flklirnpfco pnttarm raolimctclm nmd cmtarearl`atry
Nppkcontclms hnsad lm tfa
pfltlofrl`cs`
7/22/2019 Biyani Conference - Oral Presentation
18/28
Ofanp, ansy wny le noou`ukntcmi
prltlms
Cmdustry
Euak oakk onrs
_wctofas
S-Ofnmmaks
Nrtcecocnk ratcmn
?-D @a`lrcas
Akaotrl-lptconkky olmtrlkkad spntcnk kcift
`ldukntlrs
_l`a Ltfar Nppkcontclms
7/22/2019 Biyani Conference - Oral Presentation
19/28
_uctnhckcty le Hnotarclrfldlpscm
Hnotarclrfldlpscm fns haam studcad lvar tfa pnst twl daondas ns n
`ntarcnk elr taofmconk nppkcontclms haonusa2
Cts stnhckcty cs ndaqunta
Ct fns savarnk taofmconkky cmtarastcmi eumotclms
Tllks elr hltf cts `ldcecontclm nmd prlduotclm cm taofmconk qunmtctcasfnva haam davaklpad
_tnhka nmd stnmdnrd strncms le hnotarcn nra nvncknhka elr cts
prlduotclm
Ct leears vnrclus cmtarenoa prcmocpkas, wfatfar lptconk, akaotrconk, lrofa`conk.
Flwavar, tfa mntcva prltacm stckk knogs tfa lvarnkk aeecocamoy
maoassnry elr ol``arocnk vcnhckcty nmd vcrtunkky nkk suooasseuk
pfltlmco davcoas uscmi hnotarclrfldlpscm nra hnsad lm
ofa`conk lr iamatco vnrcnmts le tfa mntcva prltacm.
7/22/2019 Biyani Conference - Oral Presentation
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_flrt kceatc`a le lptconk prlduots
Lptconk eck`s cmolrplrntcmi HX cm n plky`arco `ntrcx fnva nkrandyhaam da`lmstrntad hy N`as rasanrofars nmd ltfars, tl nkklw tfa
raolrdcmi le axtra`aky fcif raslkutclm (=1::: kcmas/``) flklirn`s
wctf ranslmnhka dceernotclm aeecocamoy, tfnt nra lptconkky arnsnhka nmd
onm ha ra-wrcttam `ckkclms le tc`as wctflut eck` lr `ntarcnk
dairndntclm.
Flwavar, c`nias lr flklirn`s raolrdad nt rll` ta`parntura cm tfa
mnturnk elr` le HX (onkkad wckdtypa HX) fnva n sflrt kceatc`a(lm tfa
lrdar le `ckkcsaolmds tl n eaw saolmds) dua tl tfar`nk raknxntclm le
tfa axoctad `lkaouknr stnta hnog dlwm tl tfa irlumd `lkaouknr
stnta.
Yfcka npprlprcnta elr sl`a lptconk prloasscmi nppkcontclms, tfcs cs
umnooaptnhka elr dntn stlrnia nppkcontclms, wfara tfa dntn `ust
ra`ncm par`nmamtky raolrdad umtck notcvaky arnsad.
7/22/2019 Biyani Conference - Oral Presentation
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HX iama nmd plkypaptcda
965 muokaltcda struoturnk iama
>? NN praourslr saquamoa
+846 NN cm `ntura HX+> NN nt O-tar`cmnk saquamoa
Ml cmtarvamcmi saquamoas
Ct cs n 85 GD prltacm
7/22/2019 Biyani Conference - Oral Presentation
22/28
Nra Tfara Nmy Fcifky-olmsarvad
Xascduas
Xasukts le HKN_Tcmi tfa F. snkcmnrcu`HX sflwad vary
fcif fl`lkliy n`lmi nkk HX erl` n mu`har le dceearamt
Fnklhnotarcn.
Nrlumd tfa sofcee hnsa nt plsctclm 8>5, tfara cs ml
davcntclm cm NN ol`plsctclm elr n illd 4.1 Nmistrl`s.
Tfcs typa le nmnkyscs sflws tfnt tfa amtcra ratcmnk hcmdcmi
plogat cs fcifky olmsarvad. Tfaraelra, `nmy le tfa NNs
cm HX nra struoturnkky nmd/lr ontnkytconkky c`plrtnmt.
7/22/2019 Biyani Conference - Oral Presentation
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_cta dcraotad `utniamascs
HX randcky kamds ctsake tl iamatco amicmaarcmi, wfcof nkklws tfa iamarntclm le
iamatco vnrcnmts tfnt `ny plssass scimceconmtky dceearamt lptconk
ofnrnotarcstcos.
Cm lma axn`pka le iamatconkky amicmaarad HX, n vnrcnmt gmlwm ns D61M cs
orantad hy suhstctutcmi nm nspnrnicma rascdua elr nm nspnrtco nocd nt
plsctclm 61 cm tfa 846 n`cml nocd plkypaptcda ofncm manr tfa ratcmnk pnrt le
tfa `lkaouka.
Tfcs vnrcnmt sflws drn`ntconkky dceearamt hafnvclr cm tfa samsa tfnt tfa
axoctad `lkaouknr stnta elr`ad hy pfltlm nhslrptclm cm tfa rad pnrt le tfa
vcschka spaotru` cs tfar`nkky stnhka nmd dlas mlt daony hnog dlwm tl tfa
irlumd stnta.
Flwavar, ct cs stckk lptconkky arnsnhka vcn tfa nhslrptclm le n hkua pfltlm, nmd
cs tfus n illd prakc`cmnry onmdcdnta elr usa cm flklirnpfco dntn stlrnia
7/22/2019 Biyani Conference - Oral Presentation
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_a`c rnmdl` `utniamascs nmd
dcraotad avlkutclm
_a`c-rnmdl` `utniamascs nmd dcraotad
avlkutclm wckk pkny n prl`cmamt rlka cm eutura
aeelrts cm hclakaotrlmco lptc`czntclm.
Unrclus strntaicas umdar study nra elousad uplm
`ldukntcmi tfa pfltlakaotrco hafnvclr le hX.
_uooasseuk nktarntclms onm kand tl `ldcecad hXtfnt rasplmd dceearamtky tl ofnmias cm pF, famoa
nkklwcmi olmtrlk lm cts pfltlakaotrco hafnvclr.
7/22/2019 Biyani Conference - Oral Presentation
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^unmtu` @aofnmcos studcas
^unmtu` `aofnmcos-`lkaouknr `ldakcmi study le tfa
HX `lkaouka c`pnrts n daapar umdarstnmdcmi le ofnmias
ct umdarilas durcmi tfa pfltloyoka.
Tfcs wckk amnhka avnkuntclm le tfa aeeaots le spaocecoiamatco `utntclms lm tfa pfltloyoka nmd tl cdamtcey
iamatco `utntclms tfnt wckk `ldcey tfa pfltloyoka cm n
olmtrlkkad ensfclm.
Hacmi nhka tl sc`uknta tfa `lkaouknr hafnvclr le HX cmdceearamt iamatco olmeciurntclms wckk nkklw us tl iucda tfa
iamatco amicmaarcmi ofnmias tl ha parelr`ad
axparc`amtnkky cm tfa knhlrntlry.
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Olmokusclm
Iamatco amicmaarcmi npprlnofas fnva nkrandy
haam nppkcad tl HX ns n `anms tl nktar tfa
`lkaouka's lptconk prlpartcas, prc`nrcky tfrluif
tfa taofmcqua le scta-spaoceco `utniamascs.
Ct cs flpad tfnt tfa tfar`nk raknxntclm wckk ha
hklogad cm tfa iamatconkky amicmaarad HX wctflut
ol`prl`cscmi tfa nttrnotcva pfltlofa`conkprlpartcas tfnt amnhka vnrclus prl`cscmi
nppkcontclms.
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Xaearamoas
E. T. Flmi nmd E. F. Flmi (>338) NCZ Olme. Zrlo. / Ulku`a 858 / Cssua >.
858, pp. 8:4-8>9
Ycsa GB, Ickkaspca MH, _tunrt BN, Grahs @Z, Hcria XX. (8::8) Tramds
Hcltaofmlk. 8::8 _ap78:(3)2?69-34.
Fn`pp MN. (8:::) Nppk @corlhclk Hcltaofmlk. 8::: Bum71?(5)25??-3.
Ialria B. Turmar, _fcrcsfn Ofcttchlycmn, Knuram Zlfram, Gcrg I. Fcmas, Blfm
B. Olrracn, nmd Drnga O. @ctofakk (8::6) Hclofa`cstry 8::6.
Lastarfakt, D. (>336) Tfa struotura nmd `aofnmcs` le tfa en`cky le ratcmnk
prltacms erl` fnklpfckco nrofnan. Ourr. Lpcm. _truot. Hclk. 6, 4631::. Knmyc, B. G. (>336) Qmdarstnmdcmi struotura nmd eumotclm cm tfa kcift-drcvam
prltlm pu`p hnotarclrfldlpscm. B. _truot. Hclk. >84, >54>96.
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Tfnmgselrylur
NttamtclmDr Xnbasf Tfngur rtfngur33Jradcee`nck ol`Nsscstnmt Zrleasslr
Dapnrt`amt le Hcl & Mnml Taofmlkliy,
Iuru Bn`hfasfwnr Qmcvarscty le _ocamoa & Taofmlkliy,
Fcssnr, Fnrynmn>81::>. Cmdcn.