Biomarkers and Drug Discovery• Angie Pannier• Mathias Schubert• Pat Dussault• Surinder Batra

Charge:• Your task is to develop core ideas/projects for an $8-10M

($1.25-1.5M per year for 5 years) NIH Center proposal.

• Specifically, you should consider the following questions

Briefly describe the core projects your group would design for the Center. Please dream big.• Cancer diagnostics

– Noninvasive• Imaging-based (small molecules)• Blood-borne (cellular or molecular targets)

– Detection with nanoparticles and then novel characterization techniques (to determine presence of ligand)

– Nanohybrid materials--Biomolecule capturing/filtering/microfluidics/readout techniques

– Detection for proteins, miRNAs, small molecules

• Diagnostics/Disease Screening Center (broader than cancer)—” Nanohybrid Biomaterials for Diagnostics”

– Screen for miRNAs– Sensitive RNA detection methods and probes– Sequencing– Profiles– Bioinformatics

• Personalized Medicine– Combine above with additional therapies

Identify the key faculty from both campuses to involve in these projects. Include their strengths. (UNMC on next slide)• UNL Faculty Strengths• Pat Dussualt• David Hage• Mathias Schubert• Angie Pannier• Eva Bachman-Schubert• Ravi Saraf• Yongfeng Lu• Rebecca Lai• Hendrik Viljoen• Yuris Dzenis• Ming Han• Srivatsan Kidambi• Dennis Alexander• Greg Bashford• Shadi Othman• Jung Yul Lim

Identify the key faculty from both campuses to involve in these projects. Include their strengths.• UNMC Faculty Strengths• Surinder Batra• Tony Hollingsworth• Aaron Sasson• Michelle Ouetllet• John Davis• Steve Remenga• Subodh Lele• Hamid Band• Vimla Band• Kay Wagner• Ken Cowan• CDDN (Sasha Kabanov and Tatiana Bronich)• Sanjay Singh• Howard Gendelman• Ken Bayles

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects.

• Better communication between campuses (and PIs)• Expand nanofabrication facilities (microelectronics,

prototyping)• Microfluidics faculty member• New graduate program

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested.

• J.A. Woollam Co.• LICOR• P & G• Abbott• PanCan • American Cancer Society• All disease specific….

Describe how you would link the Center to other campus resources.• Links to CDDN, NCMN, MR-SEC, Center for

Biotechnology, Nebraska Gateway for Nutrigenomics, UNMC Bioinformatics, Center for Neurosciences, Genetics Center

Increase communication between campuses (intracampus)• “Stanford BioDesign” analogy• Poster Sessions• Research talks• Biologists/clinicians: What are the problems?• Engineers: What are the tools?