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News from BGI
Spotlights in Genomics
Research Highlight
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April 2013Volume 3 Issue 4 Spotlights in Genomics / News from BGI / Research Highlight / Picks of BGI-Tech
www.genomics.cn
BGI Europe Collaborates with GENNET on Genetic Screening for Mendelian DisordersBGI Europe and GENNET, a center for genetics, fetal medicine and assisted reproduction, signed a Memorandum of Understanding (MOU) on genetic screening for Mendelian disorders. This partnership aims to encourage collaborative initiatives in the area of monogenic disease. More
BGI Tech Develops Novel "Ultra-Deep de novo" Assembly Solution for Heterozygous GenomesBGI Tech Solutions Co., Ltd., also referred to as "BGI Tech", introduced its novel assembly solution for facilitating heterozygous genomes research. This marks another technological breakthrough for BGI in heterozygous genome assembly after the completed genome sequencing of oyster, diamondback moth and pear. More
BGI and TGAC join efforts to tackle global challenges in food security, energy and healthThe Genome Analysis Centre (TGAC) and BGI will be working together aiming to strengthen research collaborations and build on the world-class genomics and bioinformatics capabilities of both institutions. This partnership will foster key research developments in the areas of food security, energy and health. More
Whole Genome Sequencing of Wild Rice Reveals the Mechanisms Underlying Oryza Genome EvolutionIn a collaborative study published online in Nature Communications, researchers from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, BGI-Shenzhen, and University of Arizona have completed the genome sequencing of wild rice Oryza brachyantha. This work provides new insights for researchers to understand the function and evolution of Oryza genomes. More
H3 Biomedicine and BGI Announce Collaboration to Develop and Share Crucial Cancer Genomic Sequencing DataH3 Biomedicine Inc., a biopharmaceutical company specializing in the discovery and development of oncology treatments, and BGI jointly announced that they have entered into a partnership to sequence and publish genomic data from pre-clinical cancer models. This research, which aims to identify and validate recurrent gene mutations that are potential targets for drug therapies, is crucial for the entire oncology drug discovery industry. Consistent with their respective ongoing commitments to open-access research, as well as BGI's distinguished history of published, collaborative research,
H3 and BGI will release the cancer genomic data to the global research community upon completion of data analysis. More
Genomic Sequences of Peregrine and Saker Falcons Throw New Lights on Evolution of a Predatory Lifestyle In a collaborative study published online in Nature Genetics, researchers from Cardiff University, BGI, International Wildlife Consultants, Ltd., and Abu Dhabi Falcon Hospital, have completed the genome sequencing and analysis of two iconic falcons, the peregrine (Falco peregrinus) and saker (Falco cherrug). The work provides an invaluable resource for the deep understanding of the adaptive evolution in raptors and the genetic basis of their wide distribution. More
Chinese Scientists Report the Latest Genomic Studies of Wheat, Shedding New Light on Crop Adaptation and DomesticationThe advanced online publication version of Nature today presents two manuscripts that provide an unprecedented glimpse into the adaptation and domestication of wheat. These achievements are the results of joint efforts led by the Institute of Genetics and Developmental Biology (IGDB), Chinese Academy of Sciences, Chinese Academy of Agricultural Sciences (CAAS), and BGI. The two projects sequenced and analyzed two ancestral wheat genomes of Triticum urartu and Aegilops tauschii, respectively, throwing light on the biology of the world’s primary staple crop and providing valuable new resource for thegenetic improvement of wheat. More
BGI Shenzhen Ranked 6th of NPI China Top 10 InstitutionsIn March of 2013, Nature Publishing Group published Nature Publishing Index (NPI) 2012 Asia Pacific. BGI Shenzhen is ranked 6th of China Top 10 Institutions and 18th of Asia Pacific Top 200 Institutions. More
BGI-Shenzhen Completes Acquisition of Complete GenomicsBGI-Shenzhen ("BGI"), a leading international genomics organization based in Shenzhen, China, today announced that through its wholly-owned subsidiary, Beta Acquisition Corporation, it has successfully completed the acquisition of Complete Genomics, Inc. (formerly NASDAQ: GNOM) ("Complete"), an innovative leader in accurate whole human genomic sequencing. More
China (Mainland) BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, ChinaTel: 400-706-6615 +86-755-2527-3620 Email: [email protected] www.genomics.cn
Asia Pacific（Hong Kong）BGI Hong Kong Co. Limited, 16th Dai Fu Street, Tai Po Industrial Estate, Tai Po, Hong KongTel: +852-3610-3510 Email: [email protected] bgitechsolutions.com
North America (Boston)BGI Americas Corporation, One Broadway, 14th Floor, Cambridge, MA 02142, USATel: +1-617-500-2741 Email: [email protected] www.bgiamericas.com bgitechsolutions.com
Europe (Copenhagen)BGI Europe, Copenhagen Bio Science Park, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark Tel: (+45) 70260806 Email: [email protected] bgitechsolutions.com
Japan(Kobe)BGI Japan, Kobe KIMEC Center BLDG. 8F, 1-5-2 Minatojima-minamimachi, Chuo-ku, KobeCity, Hyogo-pref. 650-0047, JAPANTel: +81-78-599-6108 Email: [email protected] www.bgisequence.com/jp/
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Meet BGI atHGM 2013 and 21st International Congress of GeneticsApril 13-18th, 2013, Singapore Learn More
www.genomics.cnSubscribe / Unsubscribe
A Novel Solution for Heterozygous Genomes—Ultra-Deep De novo Sequencing
Introduction
Aiming at the construction of the heterozygous genomes sequence map, BGI Tech has introduced a novel solution, which is based on the next high-throughput sequencing technology and ultra sequencing depth (>200X), to get high quality genome map by using the latest version of SOAPdenovo2, combining with the original algorithm on heterozygous sequence recognition.
AdvantagesLower cost: The sharp decline of cost in comparison with traditional heterozygous genome strategies.
Faster turnaround time: Only 6 months
Higher quality: The ultra depth, novel software, original algorithm and large fragment library guarantee the map with high quality.
Learn More
DNA Importance Continues....Maybe one day, everyone will have their own DNA profiles that like ID card.
Human Health & Medicine
1. Stem Cells Enable Personalized Treatment for Bleeding Disorder More
2. New Frontiers in Breast Cancer Screening More
3. Counting Copy Numbers Characterizes Prostate Cancer More
4. Antibody Evolution Could Guide HIV Vaccine Development More
5. Discovery in Neuroscience Could Help Re-Wire Appetite Control More
6. Shutting Down DNA Construction: How Senescence Halts Growth of Potential Cancers More
7. Cancer Growth Curtailed More
8. Cancer Checkpoint: Mitochondrial Metabolic Regulator SIRT4 Guards Against DNA Damage More
Pharma & Biotech
1. Breakthrough Cancer-killing Treatment has No Side-effects, Study Finds More
2. Cisplatin-Resistant Cancer Cells Sensitive to Experimental Anticancer Drugs Called PARP Inhibitors More
3. Resetting Addicted Brain: Laser Light Zaps Away Cocaine Addiction More
4. Phase 1 ALS Trial is First to Test Antisense Treatment of Neurodegenerative Disease: No Serious Adverse Effects Reported More
5. 3-D Scaffolds a New Tool to Fight Cancer More
6. Old Drug Offers New Hope Against Rare, Deadly Childhood Disease More
7. Medication Duloxetine Helps Reduce Pain from Chemotherapy More
8. Cancer Drugs an Unexpected Ally in the Battle Against Malaria More
Plants & Animals
1. An Ancient Biosonar Sheds New Light on the Evolution of Echolocation in Toothed Whales More
2. Let Me Introduce Myself -- Leafcutter Bee Megachile Chomskyi from Texas More
3. The Falsity of Living Fossils More
4. How Rats See Things More
5. An Inside Look at Carnivorous Plants More
6. Remaining Unnoticed For 100 Years, a Kyrgyz Onion Species Strikes With Its Beauty More
7. Genetic Study of House Dust Mites Demonstrates Reversible Evolution More
8. Team Provides New Insight into Photosynthesis More
60 years after the discovery of DNA structure - but what does that mean for us today?
This year marks the 60th anniversary of the historic discovery of DNA’s double helix structure- the basis of all life in the world. For their discovery, scientists Francis Crick, James Watson and Maurice Wilkins were awarded the 1962 Nobel Prize. Since then, DNA has launched a scientific revolution and forever changed human understanding of life.
We all know that DNA is what makes up human life, but what does that mean for us today?
Disease Diagnosis and TreatmentOne important area of DNA research is disease and medical research. The discovery of DNA has essentially led to breakthrough in drugs and treatments for patients with serious illnesses, especially for the hereditary diseases. Among them, adenosine deaminase (ADA) deficiency was the first disease approved for treatment with gene therapy.
Picks of breakthroughs:
Using Gene Therapy to Manipulate the Immune System Spurs Leukemia Hope
Gene May Help Predict Best Chemotherapy Treatment for Pancreatic Cancer Patients
Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome
The Hemophilias—From Royal Genes to Gene Therapy
Agriculture and DNAThe discovery of DNA has an important effect on agriculture because it has allowed breeders to facilitate the breeding of economic crops and animals that have a better resistance to against harsh environment and diseases. Major efforts are underway worldwide to help extricate vulnerable dryland communities out of poverty and hunger, particularly those in the under-developed countries and regions.
Picks of breakthroughs:
DNA Marker Technology to Improve Dairy Breeding Program
In Triplicate, Genes Make Maize Tolerant to Toxic Soil
Discovery of Genetic Mechanism Allowing Potato Cultivation in Northern Latitudes
A Promising Fruit: The Tree Tomato
Environment and DNAThreats to wildlife; loss of biodiversity; ecosystem deprivation; climate change/global warming and Ozone diminution have emerged as major environmental challenges for our planet today. Genomic technologies throw new lights on the environmental protection.
Picks of breakthroughs:
Preserving Nigeria's Biodiversity Through DNA Barcoding
Scientists Report First Sequencing Of Environmental Genome
Community Structure and Metabolism Through Reconstruction of Microbial Genomes From the Environment
Genomic and Functional Adaptation in Surface Ocean Planktonic Prokaryotes
Microbe
1. Study Unravel Mechanism Critical for Fungal Virulence More
2. Symbiotic Bacteria Program Daily Rhythms in Squid Using Light and Chemicals More
3. Microbe Swapping at the Roller Derby More
4. Head-On Collisions Between DNA-Code Reading Machineries Accelerate Gene Evolution More
5. How Microbes Survive at Bare Minimum: Archaea Eat Protein More
6. Scientists Develop Monkey Model to Study Novel Coronavirus Infection More
7. Declaring a Truce With Our Microbiological Frenemies More
Register Now
International Conference on Genomics in EuropeGhent, Belgium June 25-28, 2013
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