Greta Krešić

Euro Weight Loss-2015Frankfurt, Germany

August 18 – 20, 2015

Azadeh Nadjarzadeh

Traditional herbal remedies: old things, new insights

Azadeh Nadjarzadeh, PhD in Nutrition, Shahid Sadoughi University of Medical

Sciences, Yazd, Iranazadehnajarzadeh@gmail.com

• Adding herbs and spices to food upgrade the taste of it.

• But they are more than it

Health benefits

• Antioxidant• Vitamin and minerals• Unique medicinal properties

• According to the National Center for Complementary Medicine Reports, nonvitamin, nonmineral products are the most popular complementary therapies in the US.

• Nearly, one out of five of the US population uses natural products.

• This population spend almost $15 billion on food supplements such as herbs.

• Did you encounter an overweight/obese person who wants to know which food can help weight loss?

• Overweight/obese people desire for a “magic bullet” for weight loss.

• Some of them may ask regarding their safety.• So the effectiveness and safety are important

issues for patients and practitioners.

• Herbs are not the cure-all, but they can increase the effectiveness of the weight loss diets.

Different forms of use

• Spices• Dietary supplements• Food• Herbal tea

• Obesity is the imbalance between energy intake and energy expenditure.

• So reducing energy intake with exercise are in the first line of fighting overweight.

• It is sometimes difficult and boring due to low speed.

Common plants claimed weight loss

• Psyllium• guarana• Dandelion• St. john’s worth• Bitter orange• Green tea• Licorice• Ginseng• Ephedra

• Cascara• Yerba mate• Country mallow• ...

• cinnamon

Affects blood sugar

Hunger feeling

Makes more energetic

Green tea

• It has long been debated as a weight loss aid.• More research is needed to confirm its

effectiveness.• Some studies showed nothing.• Others identified main components of it with

weight loss properties such as caffeine, catechins, and theanine.

• Boost the metabolismcaffeine

• Antioxidant flavonoid• Can lower lipid absorptioncatechins

• Increase dopamine release• May help reduction of stress eatingtheanine

• meta-analysis showed no significant (statistically and clinically) weight loss effect of green tea.

• Green tea has no effect on the maintenance of weight loss

• Adverse effects were rare.

• Jurgens GM et al. Cochrane Library. 2012

cumin

• Cuminum cyminum• Used in Iranian cuisine• Used as anti colic in Iranian traditional

medicine• There are some claims regarding its weight

loss effects• Some over the counter products of cumin

have been produced

• We need evidence

methodology

• RCT• Overweight/obese 20-60 yrs women(BMI>25

Kg/m2 )• Without serious disease or drug use• Without diabetes• No previous treatment regimens in the past

three months, • and lack of weight change by more than 2 kg in

the last month

• Computer randomization• Weight loss diet including yogurt (control

group)• Weight loss diet plus yogurt and

cumin( intervention group)• Single blind

• Energy deficit of 500 kcal.• Cumin dosage: 3 g( two divided dose) with

lunch and dinner plus 150 g low fat yogurt• Study duration: 3 months

• Dietary counselling• Food record for 3 days before and at the end

of the study• Counting the cumin packages• Reminding participants using phone calls

Data gathering

• FBS• Lipid profile• Anthropometry and Body composition

Energy and macronutrient intakes before and after the study

group Control (n=44) Intervention(n=44)

before after before after

Energy(Kcal) 2470.81±316 1920.41±278 2501.92±218 1900.85±220

CHO(%) 64 55 63 57

Pro(%) 12 15 10 13

Fat(%) 24 30 27 30

Baseline measurementsCumin (n = 44) Control (n=44) P value

Weight(Kg) 79.43±1.29 76.70±1.20 0.3

BMI(Kg/m2) 31.93±5.55 30.29±4.15 0.12

Waist circumference(Cm)

96.95±7.44 93.73±8.04 0.05

Fat free mass(Kg) 48.05±3.98 47.62±4.76 0.65

Fat mass(Kg) 31.40±9.93 29.60±8.01 0.34

Fat mass(%) 38.70±5.70 37.57±4.09 0.28

Change in anthropometric parameters

Cumin (n=44) Control (n=44) P-value

Weight(Kg) -6.20 (-7.92%) -4.19 (-5.55%) 0.005

BMI(Kg/m2) -2.35 (-7.14%) -1.31 (-5.54%) 0.005

Waist circumference(Cm)

-8.02 (-8.22%) -5.94 (-5.51%) 0.005

Fat free mass(Kg) -0.40 (-0.83%) -0.34 (-0.71%) 0.48

Fat mass(Kg) -5.51 (-18.12%) -3.75 (-10.66%) 0.005

Fat mass(%) -5.99 (-14.64%) -3.79 (-4.91%) 0.005

weight BMI Waist Circumference Fat Mass

-20

-18

-16

-14

-12

-10

-8

-6

-4

-2

0

-7.92-7.14

-8.22

-18.12

-5.54 -5.54 -5.51

-10.66

cumin control

Changes of anthropometric parameters in two groups(%)

CUMIN

TG Chol LDL HDL FBS0

20406080

100120140160180200

beforeafter

CONTROL

TG Chol LDL HDL FBS0

20406080

100120140160180200

beforeafter

Changes in biochemical parametersCumin (n=44) Control (n=44) P-value

TG (mg/dl) -23.06 (-12.8%) -5.04 (-0.88%) 0.02

Chol (mg/dl) -26.48 (-7.14%) -0.88 (-4.1%) 0.005

LDL-C (mg/dl) -9.62 (-7.19%) 0.44 (1.84) 0.001

HDL-C (mg/dl) 1.84 (3.4%) -0.82 (-0.31%) 0.049

FBS (mg/dl) -5.95 (-6.1%) -3.82 (-3.6%) 0.18

• Adding cumin to weight loss diet can improve body composition and lipid profile

Proposed mechanisms

• increase satiety• Decrease flatulence• Increase thermogenesis • Modulate lipid metabolism• Water elimination(causing sweat)

• Glycoside saponins prevent Chol absorptionand increase its fecal excretion by interfering with its enterohepatic circulation.

• Cumin seeds have some phytosterols such as beta sitosterol, delta 5 and delta 7 avenasterols, stigmasterol, campesterol, and lanosterol

• It may also have a role in upregulation of the LDL-C receptor and inhibition of 3-hydroxyl-3-methylglutaryl coenzyme A reductase.

conclusion

• In overweight/ obese women adding cumin to diet increase the beneficial effects of weight loss diet during 3 months.

• In men????• Longer period of time????• Other benefit????• Toxicity????

More information

THANK YOU SO MUCH FOR YOUR ATTENTION

Euro Weight Loss – 2016 Website:http://weightloss.global-summit.com/europe/

Meet the eminent gathering once again at

Euro Weight Loss-2016Vienna, Austria

September 19-21, 2016