Author Index

A

Albertsson-Wikland, Kerstin, 21-29, 131-136

Alliger, Dana E., 38-52

B

Baker, Susan w., 200-208 Barnard, Martha U., 119-130 Bell, Jennifer J., 200-208 Berenbaum, Sheri A., 186-199 Bergada, Cesar, 53-{)0,

209-218 Bishop, Dorothy, 69-82

c

Campo, Stella Maris, 209-218 Carroll, Paul v., 9-20 Chemes, Hector Edgardo, 209-218 Christ, Emanuel R., 9-20 Clopper, Richard R., 38-52 Cuttler, Leona, 30-37

D

Dittmann, Ralf w., 200-208 Dolezal, Curtis, 200-208

Drotar, Dennis, 110-118

E

Elgar, Kate, 69-82 Erling, Ann E., 21-29

F

Fisher, Delbert A., 221- 234 Fung, Caroline, 38-52

G

Gidwani, Sonia, 200-208 Grunt, Jerome A., 119-130

H

Heinrich, Juan Jorge, 53-{)0 Howard, Campbell P., 119-130

J

Jacobson, Alan M., 139-150 Johnson, Suzanne Bennett,

165-173

255

256 Author Index

K R

Keselman, Ana Claudia, 53-60, 209-218

L

LeRoux, Linda, 38-52

M

MacGillivray, Margaret H., 38-52, 83-97

Malone, John I., 161-164 Martinez, Alicia Susana, 53-60 Mazur, Tom, 83-97 Meyer-Bahlburg, Heino F.L.,

200-208 Migeon, Claude J., 177-185 Moller, Anders, 131-136 Money, John, 1-6 Moore, Wayne v., 119-130 Morishima, Akira, 200-208 Morris, Elena, 69-82

N

New, Maria I., 200-208

P

Pantano, Liliana, 53-60

Roberts, Jessica C., 119-130

Roberts, Michael c., 119-130

Robinson, Jane R., 110-118 Ropelato, Maria Gabriela, 209-218 Rosenfeld, Ron G., 63-68 Rovet, Joanne F., 235-254

s

Sandberg, David E., 38-52 Schwartz, I. David, 119-130 Skuse, David, 69-82 Sonksen, Peter H., 9-20 Stabler, Brian, 101-109

u

Underwood, Louis E., 101-109

v

Vernberg, Eric M., 119-130

w

Wide Bowman, Ul1a, 131-136 Wiklund, Ingela K., 21-29 Wysocki, Tim, 151-160

Subject Index

Academic achievement in children with congenital

hypothyroidism, 244-245 relationship with growth hormone

treatment, 116 and short stature, 22-23 See also Cognitive functioning ;

Educational attainment; Intelligence

Activities chosen by girls with congenital adrenal hyperplasia, 187- 188

Adenomas in congenital adrenal hyperplasia patients, 216

Adjustment of growth hormone deficiency

patients in adulthood, 56-57

psychosexual, in congenital adrenal hyperplasia, 195, 200--208

and resistance factors, in a study of short stature, 126

to short stature in adolescence, 119-130 and growth hormone deficiency,

in adolescence, 117 social

questionnaire developed in a Turner syndrome study, 73-74

relationship with stature, 112, 119-120

See also Psychological context

Adolescence, adjustment to short stature in, 119- 130

and growth hormone deficiency, 117

See also Puberty Adrenal cortex, steroid secretion by,

177-178 Adrenocorticotropic hormone

(ACTH), role in cortisol synthesis, 178

Adults male, status in congenital adrenal

hyperplasia, 183- 184 quality of life of, and growth

hormone deficiency, 24-25 Affective discrimination, in Turner

syndrome patients, 70 Age

and aggression in girls with congenital adrenal hyperplasia, 190

and growth hormone deficiency, 16

Aggression, in girls with congenital adrenal hyperplasia, 190

Aldosterone control of secretion of, 178 formation in adrenal cells lacking

17-hydroxylase, 177-178 American Diabetes Association, 151

on glycosylated hemoglobin assays, 166

257

258 Subject Index

American Pediatric Association, guidelines for thyroxine dosage, 239

Analysis, Bloom level, application to diabetes self-management, 157

Androgen-insensitivity syndrome, 46,XY pattern in, 3

Androgens effect on behaviors of females with

congenital adrenal hyperplasia, 190, 193-194

synthesis in the adrenal cortex, 177-178

Androstenedione, in congenital adrenal hyperplasia

secretion of, 178-179 suppressing plasma levels of, 180

Anthropometric variables and outcome variables, after

growth hormone therapy, 46 in a Turner syndrome study, 75-76

Antinatriuretic effect of growth hormone, 11

Apolipoprotein B, levels of, in growth hormone deficiency, 14

Application, Bloom level, in diabetes self-management, 157

Ateliotic dwarfism, 30 Atherosclerosis, premature, in growth

hormone deficiency, 12-13, 14 Athyrosis, and motor performance,

241 Attention deficit hyperactivity

disorder (ADHD) in children with congenital

hypothyroidism, 245-246 in children with thyroid hormone

resistance, 229 Attention disorder, in children with

treated congenital hypothy­roidism, 241-242

Auditory processing, role for thyroid hormone in, 237

Autoimmune disorders insulin dependent diabetes melli­

tus, 139 thyroiditis, in insulin dependent

diabetes mellitus, 162 in Turner syndrome, 89-90

Bayley-Pinneau height prediction method, 104

Beck Depression Inventory (BDI), 54 scores of hypopituitary patients, 57

Behavior/behavioral problems in congenital adrenal hyperplasia,

187-193 in congenital hypothyroidism, 227,

245-246 neuroendocrine hormone role in,

58 and ring chromosome, in Turner

syndrome, 91-92 relationship with growth hormone

treatment, 116 Behavioral inhibition task, in a

Turner syndrome study, 74 Benign intracranial hypertension

(BIH), in growth hormone replacement therapy, 16

Biographic study, planning of, I Birth defects, affecting the sex

organs, 3. See also Chromo-somal anomalies; Genes

Bloom's Taxonomy, application of diabetes self-management, 155-158

Bodily pain assessment, comparison of growth hormone deficiency patients and siblings, 44

Body composition, in growth hormone deficiency, 9-11, 30, 33

Body image and congenital adrenal hyperplasia,

195 and short stature, 113

Bone, formation of, in response to growth hormone, 11-12

Bone mineral density (BMD) in children with growth hormone

deficiency, 33 in growth hormone deficiency, 11-

12,30 in Turner syndrome, 85-86

Brain cerebral atrophy in late-treated

congenital hypothyroidism, 246

effects of prenatal and perinatal hormones on, 186

effects of thyroid hormone on development of, 227, 237

Brief Symptom Inventory (BSI), 43 Brown adipose tissue (BAT), thermo­

genesis involving, effect of thyroid hormones on, 224

Bulimia, in diabetes, 143

Calorie restriction, regulating blood glucose levels by. 163

Carbohydrate metabolism in growth hormone deficiency, 13

Cardiovascular system in growth hormone deficiency, 12-13 in Turner syndrome, 67, 88-89

Case studies congenital adrenal hyperplasia in

males age 4, 213-214 age 5,210-211,213 age 8,212 age 23, 211-212

publication restrictions on use of, 2 Castlemead Growth Program, 75 Child Behavior Checklist (CBCL)

scores of children with growth hormone deficiency, 119

in a Turner syndrome study, 72, 132 Child Growth Foundation, 71 Children

growth hormone deficiency therapy for, 30-37

quality of life of, in growth hormone deficiency, 22-24

Children's Depression Inventory, 123

Children's Growth Foundation, 93 Cholesterol, levels of

correlation with glycosylated hemoglobin levels, 167

response to growth hormone deficiency, 14

Chromosomal anomalies androgen-insensitivity syndrome,

46,XY,3 congenital virilizing adrenal

hyperplasia, 46,XX, 3

Subject Index 259

partial deletion of an X chromo­some, in Turner syndrome, 132

ring, in Turner syndrome, 70, 84, 91

in Turner syndrome, 63--67, 84 See also Genes; Karyotypes;

Mosaicism Chronic disorders

renal failure, effect of growth hormone on, 101

self-rating of psychological functioning in, 134-135

Cognitive functioning category of outcome research, I in congenital adrenal hyperplasia,

191-192 in congenital hypothyroidism,

specific deficits, 248-249 in early onset diabetes, 141 relationship with stature, 111-112 in Turner syndrome, 69-70 See also Academic achievement;

Educational attainment; Intelligence

Competence, relationship with stature, 112

Compliance with treatment in congenital adrenal hyperplasia,

182-183, 184 in congenital hypothyroidism, 248

Complications of diabetes, 168, 171 of salt-losing congenital adrenal

hyperplasia, 180-181 Comprehension, Bloom level of,

defined for diabetes self­management, 156-157

Congenital adrenal hyperplasia (CAR)

due to 21-hydroxylase deficiency, 177-185

and adult erotosexual status, 3 male fertility in, 209-218 psychological outcome in, 186-199 psychopathology outcomes

associated with, 2 psychosexual quality of life in,

200-208

260 Subject Index

Congenital hypothyroidism growth and development in, 221-234 neurobehavioral consequences of,

235-254 Congenital malformations, in

children of Turner syndrome subjects, 87

Conners Parent Rating Scale, 243 Conners Teacher Rating Scale, 243 Correlational analyses, study of short

stature, 124-125 Corticoid therapy, effect on male

fertility in congenital adrenal hyperplasia, 209-210

Corticosterone formation in adrenal cells lacking 17-hydroxylase, 177-178

Corticotropin releasing hormone (CRH), role in secretion of cortisol, 178

Cortisol metabolism of, in congenital

hypothyroidism, 225 steps in the synthesis of, 177-178

Counseling, in idiopathic short stature, 107

Cretinism. See Congenital hypothy­roidism

Crohn's disease, in Turner syndrome, 89-90

Culture, and management of sexo­logical issues. 1-2. 4-5

Cytochrome P450. roles in steroid synthesis. 177-178

Depressive disorders Beck Depression Inventory (BDI),

54 scores of hypopituitary patients.

57 Children's Depression Inventory. in

a study of the effects of short stature. 123

and diabetes. 142 Development. in infants with

congenital hypothyroidism. 221-234

Diabetes non insulin dependent, 139

type 1 adherence to treatment regimen

in. 169 quality of life in, 169-170

type 2. quality of life in. 143-144 See also Insulin dependent diabetes

mellitus Diabetes Control and Complications

Trial (DCCT). 141. 151-152. 167

Diabetes-oriented quality of life measure (DQOL). 145-146

Diagnosis of growth hormone deficiency. 122 homogeneity of. for research

design. 2 in a study of the effects of short

stature. 124 of Turner syndrome. 83-84

Disability-stress-coping model of adaptation. application to children with short stature, 120-121

Dosage of growth hormone, 15

frequency of injection and outcome. 32

units. 16 of thyroxine. effect on IQ in

infants. 228

Educational attainment and diabetes. 142 of growth hormone deficient

patients. 54-55 versus siblings. 43

in Turner syndrome. 90-91 See also Academic achievement;

Cognitive functioning; Intelligence

Emotions distress of growth hormone

deficiency subjects. 45-46 neuroendocrine hormone role in

emotional and behavioral problems. 58

SF-36 comparison of siblings and growth hormone deficiency patients, 44

and short stature, 104-107, 112-113

Employment of diabetics, 142 of growth hormone deficient patients

in adulthood, 55-56 versus siblings, 43

Encephalocele, as a side effect of growth hormone replacement, 16

~-Endorphin, growth hormone effect on levels of, 14

Estrogen replacement at puberty, in Turner syndrome, 66, 86-87

Ethinylestradiol, for treating Turner syndrome, 132

Evaluation Bloom level, applied to diabetes self­

management, 158 of quality of life in diabetes, 139-

150 Executive functions

deficit of, in Turner syndrome, 70 measuring, in Turner syndrome, 74,

77-78 Exercise performance

and growth hormone deficiency, 12 and hypoglycemia, 165

Extracellular water, in growth hormone deficiency, 10

Eye ocular abnormality in Turner

syndrome patients, 88 retina, role for the thyroid hormone

in, 237 retinopathy, diabetic, effect of

bulimia on risk of, 143 visuomotor performance of children

treated for congenital hypothy­roidism, 241, 246

visuospatial abilities, in Turner syndrome patients, 76

Family Adaptability and Cohesion Scale III, 120

Family information form, 122-123 Fantasies, sexual, of females with

congenital adrenal hyperplasia, 192-193

Subject Index 261

Fat mass (FM), in growth hormone deficiency, 10-11

Fertility in congenital adrenal hyperplasia,

182 of males, 183,209-218

in point mutation of the follicle­stimulating hormone receptor gene, 216

Follicle-stimulating hormone receptor, point mutation, 216

Follow-up, to diagnosis of congenital hypothyroidism, 246

Friendship Interview, study of the effects of short stature, 123

Gender and cognitive abilities, in congeni­

tal adrenal hyperplasia, 191-192

and emotional distress, in growth hormone deficiency patients, 45-46

parental source of X chromosome in Turner syndrome, 70-71

and phenotype, 76, 78 and preferred play activity in

congenital adrenal hyperplasia, 188

and psychosocial effects of short stature, 23-24

Gender change by females, in congenital adrenal hyperplasia, 200-201

Gender identity, in congenital adrenal hyperplasia, 188-190

Genentech National Cooperative Growth Study, 107

General Health scale, SF-36, 42 difference between siblings and

growth hormone deficiency patients, 44

in evaluating quality of life in diabetes, 145

growth hormone deficiency patients' ratings, 48

262 Subject Index

Genes for the cholesterol side-chain

cleavage enzyme, 177 follicle-stimulating hormone

receptor, point mutation in, 216 SHOX, in Turner syndrome, 85 thyroid hormone receptor, mutation

in, 229 Genitalia, virilized

effects on sexual life in congenital adrenal hyperplasia, 20 I

surgical reconstruction of, 186 Genomic imprinting, 71

and phenotypic variability in Turner syndrome, 76, 78-79

Gestational age (GA), and prevalence of transient primary hypothy­roidism, 231

Glucocorticoid replacement therapy, 179

Glucose intolerance, in Turner syndrome, 90

Glucose levels, self-monitored, utilization of data, 151-160

Gonadal dysgenesis, in Turner syndrome, 86-87

Gonadoblastoma, preventive surgery for, 87

Gonadotropin-releasing hormone agonists, effect in growth hormone deficiency and precocious puberty, 34

Gonadotropins negative feedback with sex

steroids, 214 suppression in males with congeni­

tal adrenal hyperplasia, 209 "Good baby syndrome", congenital

hypothyroidism as, 245 Growth

childhood, effect of diabetes type I on, 161-164

rate of, and therapy in children with Turner syndrome, 63--64

Growth hormone (GH) deficiency of, and quality of life

(QOL),21-29 effects of thyroid hormone on

secretion and action of, 221-222

pituitary and recombinant, com­parison of therapy with, 40-41

Growth hormone-releasing hormone (GHRH), and growth in children with growth hormone deficiency, 34

Growth hormone therapy change in growth velocity during,

31-32 in children

with congenital hypothyroidism, 222

without growth hormone deficiency, 10 1-109

and height in idiopathic short stature, 103-

104 in Turner syndrome, 84--85

impact in Turner syndrome, 63--68 replacement

in adults, 9-20, 24--25 in children, 30--37

Guidelines, for treating congenital hypothyroidism, 247

Harter Self-Perceptions Profile for Children, 123-124

Hashimoto's thyroiditis, in Turner syndrome, 89

Health-related quality of life (HRQOL), 140--141

Health status, and glycosylated hemoglobin values, 166-168

Health Survey SF-36. See General Health survey, SF-36

Hearing impairment in congenital hypothyroidism, 242 role for thyroid hormone in

auditory processing, 237 in Turner syndrome, 87-88

Heart disease association with diabetes, 166-167 atherosclerosis, in growth hormone

deficiency, 12-13, 14 Height in congenital adrenal hyper-

plasia of adults, 181 of males, 183 See also Short stature

Hemoglobin, glycosylated, 165-173 and growth, in childhood diabetes,

162 significance of assays for,

170-171 Hermaphroditism

in males assigned as boys, 4 assigned as girls, 3--4

psychopathology associated with, male and female, 2

Heterosexual activity, in women with congenital adrenal hyperplasia, 204

Hollingshead Four Factor Index, 123 Homovanillic acid, growth hormone

effect on levels of, 14 Hormones

effect on the female fetus, 178-179

levels of, in a 23-year-old man, 211-212

prenatal and perinatal levels of, effects on brain and behavior, 186

sex, replacement therapy for patients with hypopituitarism, 57-58

steroid in congenital adrenal hyperpla­

sia, 183-184 secretion by the adrenal cortex,

177-178 21-Hydroxylase deficiency, 177-185 17-Hydroxyprogesterone, secretion in

congenital adrenal hyperplasia, 178-179

Hyperactivity, in Turner syndrome, 131

Hyperglycemia, conditions leading to, 165-166

Hyperinsulinemia in growth hormone deficiency, 13 and stature, 161 in Turner syndrome, 90

Hyperlipidemia, risk of, in diabetes, 166--167

Hyperprolactinemia, in congenital hypothyroidism, 225

Subject Index 263

Hypoglycemia association with diabetes, 141

managing the risk of, 153 conditions leading to, 165-166 fear of, in diabetes, 140-141 in growth hormone deficiency, 30

from absence of cortisol secre­tion, 178-179

in insulin dependent diabetes mellitus, 167-168

Hypoglycemia Fear Survey, 147 Hypopituitarism, life expectancy

associated with, 12-13 Hypothalamic-pituitary hypothyroid­

ism, 228-229 Hypothalamic-pituitary lesions,

precocious puberty associated with, 31

Hypotheses, study of the effects of short stature, 121

Hypothyroidism, 221-234 changes in IQ and specific cogni­

tional functions in, 2 transient, 230-231

identifying and treating in a screening program, 239

Hypothyroxinemia of prematurity, 230-231

Idiopathic short stature (ISS), effect of growth hormone in, 101-109

Inflammatory disorders, in Turner syndrome, 89-90

In-person interview, comparison with telephone interview, 39

Institute of Child Health, London, 74 Insulin dependent diabetes mellitus

(IDDM), 139 effect on childhood growth and

development, 161-164 incidence of, 165

Insulinlike growth factor-I for children with growth hormone

receptor defects, 34 levels of, in diabetes type 1, 162

Intelligence in congenital hypothyroidism, 227-

228 treated from infancy, 240

264 Subject Index

Intelligence (continued) effect of growth hormone on, 116 relationship with stature, 111 verbal IQ, in Turner syndrome, 77-

78 See also Cognitive functioning

Intersex Society of North America, 194-195

Intersexuality, in congenital adrenal hyperplasia, 200-208

Interviewing techniques, in-person versus telephone, 39

Iodine deficiency as a cause of congenital hypothy­

roidism, 221 as a cause of transient hypothyroid­

ism, 230 Isolated growth hormone deficiency,

versus multiple pituitary hormone deficiency, 44

and emotional distress, 45-46 and health-related QOL, 45

Kabi Pharmacia International Growth Study (KIGS), 102-103

Karyotypes in Turner syndrome, 75,84

and heart malformation prevalence, 89

mosaic, 132 relationship of phenotype with,

69-82 Keloid scars, in Turner syndrome, 90 Kidney, malformation of, in Turner

syndrome, 89 Knowledge

Bloom classification of, 156 about diabetes, and glycosylated

hemoglobin values, 168

Labelling, and stigmatization, 135 Language development, in treated

congenital hypothyroidism, 241

Lean body mass (LBM), in growth hormone deficiency, 10-11

Learned helplessness, 142-143 Learning disabilities, in Turner

syndrome, 134

Levothyroxine (L-T4), for treating congenital hypothyroidism, 238

Lifespan, and childhood growth hormone deficiency, 31

Lipid metabolism in diabetes, 166--167 in growth hormone deficiency, 14

Lipoprotein(a) levels, response to growth hormone deficiency, 14

Longitudinal studies of short stature, and growth hormone therapy, 26-27

Long-term studies, planning of, 2 Lymphedema, in Turner syndrome, 90

Marriage rates for congenital adrenal hyperplasia

patients, 182 for growth hormone deficiency

patients, 48, 55 Maryland Parent Attitude Survey, 120 Maternal interest display, in congeni­

tal adrenal hyperplasia, 190-191

Measurements behavioral and cognitive, Turner

syndrome study, 72-75 of the effects of short stature, 122-

124 of emotional status related to short

stature, 104-107 of outcomes for children with short

stature, 115 of quality of life, 21-22

for diabetics, 145 in growth hormone deficiency,

25-27 Memory, of children with treated

congenital hypothyroidism, 241

Menses, in congenital adrenal hyperplasia, 182

Metabolism in congenital hypothyroidism, 224 in growth hormone deficiency, 13-

14 Micropenis, case studies, 3 Mineralocorticoid replacement, 179

Monitoring, of treatment for congeni­tal adrenal hyperplasia, 179-180

Mortality in growth hormone deficiency, 31 in Turner syndrome, 67

Mosaicism in Turner syndrome, 84 and functioning, 70 and heart malformation, 89 incidence of, 132 and parental source of the X

chromosome, 76 Motor ability, effects of congenital

hypothyroidism in, 241 Motor skills, in congenital hypothy­

roidism, 227 Multiple pituitary hormone defi­

ciency (MPHD) versus isolated growth hormone deficiency, 44

Muscle strength, and growth hormone deficiency, 12

Mutation point, in the FSH receptor gene,

216 in the thyroid hormone receptor

gene, 229 See also Genes; Mosaicism

National Cooperative Growth Study (NCGS), 106, 112

National Health Examination Survey, 105

National Institute of Child Health and Human Development, 2

Nervous system in congenital hypothyroidism

dysfunction of, 227 maturation of, 22~228 neurocognitive functions, selective,

in children with, 240-241 neuroimaging in, 246

Neuroendocrine hormones, role in emotional and behavioral problems, 58

Neuropsychological assessment in diabetes, 141 in Turner syndrome, 74

Neurotransmitter systems, develop­ment and regulation of, 237

Subject Index 265

Nevi, pigmented, in Turner syndrome, 90

Noninsulin dependent diabetes (NIDDM), 139

Obesity, and noninsulin dependent diabetes, 139

Ocular abnormality, in Turner syndrome, 88

Ossification, delayed, in congenital hypothyroidism, 238

Osteoporosis, in growth hormone deficiency, 11-12

Otitis media, in Turner syndrome, 87-88

Outcome variables, and anthropomet­ric variables, after growth hormone therapy, 46

Ovarian failure, in Turner syndrome, 8~87

Oxandrolone effect on growth rate, in combina­

tion with growth hormone, 63-64

effect on hyperinsulinemia, 90 effect in Turner syndrome, 132

Panhypopituitarism, and puberty, 30-31

Parents, rating of psychological functioning of Turner syn­drome children, 131-136

Pediatric endocrinology, outcome research in, 1-6

Peers, relationships with, in Turner syndrome, 131

Perceived Social Support from Family, in a study of the effects of short stature, 123

Peripheral insulin resistance, in Turner syndrome, 90

Personality traits development of, in diabetes type I,

163 in Turner syndrome, 133, 134

Phenotype, in Turner syndrome, 85

relationships with karyotype, 69-82

266 Subject Index

Phobic anxiety scores, in pituitary growth hormone treatment, 47

Physical appearance, in congenital adrenal hyperplasia, 186

Pituitary effects of congenital hypothyroid­

ism on, 221 inhibition of, due to androgens,

209-218 Pituitary thyrotropin (TSH), levels of,

in screening for congenital hypothyroidism, 238

Port Stevens Manifesto, on growth hormone replacement, 16

Prediction, conceptual frameworks for guiding, 115-116

Premature infants, hypothyroxinemia in, 230-231

Prenatal environment hormone levels in

effects on brain and behavior, 186

testosterone effect on the female fetus, 178-179

identification of conditions associated with Turner syndrome in, 63

treatment of congenital adrenal hyperplasia in, 186, 194-195

Problem areas in diabetes (PAID), 146-147

Problem-solving, in self-management of blood glucose levels by diabetics, 155

Protein metabolism, in growth hormone deficiency, 13

Protocol comparison with siblings, growth

hormone deficiency patients, 41-43

effects of short stature study, 121-124

growth hormone deficiency study, 54

intersexuality study in congenital adrenal hyperplasia, 202

psychological functioning in Turner syndrome, 132-133

stature and quality of life study, 110-111

Psychoendocrinology, pediatric, 1-6 Psychological context

adjustment of females with congenital

adrenal hyperplasia, 194-195 mediators of, in individual with

short stature, 119-130 in self-monitoring of blood

glucose, 154-155 well-being

in congenital adrenal hyperpla­sia, 186-199

in growth hormone deficiency, 14-15

See also Adjustment; Behavior/ behavioral problems; Emotions

Psychopathology category of outcome research, I in Turner syndrome, 2

Psychosexual adjustment, in congeni­tal adrenal hyperplasia, 195, 200-208

Psychosocial function effect of height on, in growth

hormone deficiency, 49-50 effect of therapy on, in growth

hormone deficiency, 33, 38-40 in hypothalamic-pituitary lesions, 31 in Turner syndrome, 66-67, 69, 91-

93 Puberty

abnormal in growth hormone deficiency,

30-31 in Turner syndrome, 63

in congenital adrenal hyperplasia patients, 181-182

male, 183 onset of, in Turner syndrome, 87 precocious

in congenital hypothyroidism, 225

treating, 34

Quality of life (QOL) in congenital adrenal hyperplasia,

200-208

defining, 140-141 in diabetes, 139-150, 169-170 effect of stature on, 110-118 in growth hormone deficiency,

14-15,21-29 childhood onset, 38-52, 53-60

Health Survey SF-36 scores, 44 Quality of studies, evaluating,

113-116

Receptors, nuclear, for thyroid hormone, 237

Rejection experiences, study of the effects of short stature, 125-126

Rejection Experiences Questionnaire, 123

Renal anomalies, in Turner syndrome, 89

Renin-angiotensin system, effects of growth hormone on, II

Reproductive outcome, in women with congenital adrenal hyperplasia, 20 I, 206. See also Fertility

Resistance factors, and adjustment, in a study of short stature, 126

Resting energy expenditure (REE), in growth hormone deficiency, 13

Retina, role for the thyroid hormone in, 237

Retinopathy, diabetic, effect of bulimia on risk of, 143

Risk factors to adjustment, and short stature,

125-126 for diabetic retinopathy, 143

Rokitansky syndrome (MRKS), and adult erotosexual status, 3

Salt-losing congenital adrenal hyperplasia, 178-179

and gender-role behavior of females, 200

and sexual responses of adult women, 202-205

Sample, and quality of studies, 113-114

Subject Index 267

Screening, for congenital hypothy­roidism, 235-254

Self-concept, and short stature, 113, 120 Self-esteem

in diabetes, 142 in Turner syndrome, 93, 131

Self-management of diabetes, 152 patients' use of glucose level data,

153 Self-perception, in Turner syndrome,

132, 133 Sensorineural hearing loss, in Turner

syndrome, 88 Sex hormones

negative feedback between steroids and gonadotropins, 214

replacement therapy, for patients with hypopituitarism, 57-58

Sexology folk, attributes of, 4-5 pediatric, outcome research in,

1-6 Sexual Behavior Assessment Sched­

ule (SEBAS-A), 202 Sexuality, in congenital adrenal

hyperplasia, 192-193 Sexual orientation, in women with

congenital adrenal hyperplasia, 204-206

Short stature adult height in Turner syndrome,

64-65, 84-85 effects of

on children, 22-23, 25-26, 119-130

on children, in Turner syndrome, 69

in growth hormone deficiency, 30-33

on quality of life (QOL), 110-118 on social adjustment, 58

Siblings, quality of life in childhood onset growth hormone

deficiency, 55 comparison with growth hormone

deficiency patients, 38-52 Side effects, of growth hormone

replacement, 15-16, 33 psychosocial, 23

268 Subject Index

Simple virilizing congenital adrenal hyperplasia, 178-179. See also Salt-losing congenital adrenal hyperplasia

Social adjustment phobia, in adults with growth

hormone deficiency, 24-25 questionnaire developed in a Turner

syndrome study, 73-74 relationship with stature, 112,

119-120 skills training, for children with

short stature, 126 Social Adjustment Scale-Self Report

(SAS-SR), 42-43 comparison of siblings in growth

hormone deficiency, 45 Social Anxiety Scale-Revised, 123 Social cognition, in Turner syndrome

subjects, 76-77 Social life, of growth hormone

deficiency patients, 55 Social psychology, in Turner syn­

drome, 135 Social Relationship Scale (SRS), 42 Somatization scale, BSI, comparison

of growth hormone deficiency with MPHD, 48-49

Spatial tasks, performance of children with treated congenital hypothyroidism, 241

Standards of care, for optimizing outcomes in Turner syndrome, 83-97

Statistical study, planning of, 1 Steroid hormones

in congenital adrenal hyperplasia, male patients, 183-184

secretion, by the adrenal cortex, 177-178

Stigmatization, in Turner syndrome, 135

Stochastic model, relating hypoglyce­mic episode detection and self­treatment behaviors, 154

Stress, and cortisol replacement therapy, 180

Stroop task, performance by Turner syndrome patients, 70

Study design evaluating, 114-115 for growth hormone deficiency

evaluations, 26-27 Subjective integration, and adult

height, growth hormone deficiency study, 47

Subjects congenital adrenal hyperplasia

study of women, 202 growth hormone deficiency study

comparison with siblings, 40-41 in idiopathic hypopituitarism,

53-54 study of the effects of short stature,

121 Turner syndrome studies

of phenotype-karyotype relation­ships, 71-72

rating of psychological function­ing, 133

Suicide, in Turner syndrome, 67 Surgery, to correct external genitalia

in CAH, 180, 182 Synthesis, Bloom level, applied to

diabetes self-management, 158

Tanner stage, in a study of short stature, 122-123

Teacher Report Form (TRF), for a Turner syndrome study, 72

Technetium scanning, for evaluation of congenital hypothyroidism, 238

Telephone interview, comparison with in-person interview, 39

Testes, size of, in adolescents with congenital adrenal hyperplasia, 209

Testosterone effect on adult spermatogenesis,

215-216 effect on the female fetus,

178-179 Therapy alternatives, in growth

hormone deficiency, 34 Thyroglobulin (TBG), serum levels

confirming athyrosis, 238

Thyroid, dysgenesis of, 221 Thyroid hormone, resistance to, 229 Thyroid-stimulating hormone (TSH)

in hypothalamic-pituitary hypothy­roidism, 228-229

in treated and untreated congenital hypothyroidism, 225-226

Thyrotropin releasing hormone (TRH), deficiency of, 228-229

Thyroxine (T4)

dosage of, American Pediatric Association guidelines, 239

levels of, screening for congenital hypothyroidism, 238

therapy in children catchup growth from, 223-224 in congenital hypothyroidism,

222-223 Total body water (TBW), in growth

hormone deficiency, 10 Tower of Hanoi task, in a Turner

syndrome study, 74--75 Treatment, cost versus benefit of

in diabetes, 140--141 prenatal, in congenital adrenal

hyperplasia, 186 Turner's Syndrome Society, 93 Turner's Syndrome Society of the

United States, 93 Turner syndrome

impact of growth hormone therapy on, 63-68

nature of IQ deficit in, 2 phenotype-karyotype relationships

in, 69-82

Subject Index 269

psychological functioning in, 131-136

psychopathology outcomes in, 2 standards of care for optimizing

outcomes in, 83-97 treatment with growth hormone,

101

Ultrasonography, for evaluating congenital hypothyroidism, 238

Vagina reconstruction, in congenital adrenal hyperplasia, 182

Vasoactive intestinal polypeptide, growth hormone effect on levels of, 14

Visuomotor performance, of children with treated congenital hypothyroidism, 241, 246

Visuospatial abilities, in Turner syndrome patients, 76

Wechsler Adult Intelligence Scales­Revised (WAIS-R), 74

Wechsler Intelligence Scales for Children (WICS), 74

Weinberger Adjustment Inventory, 119 Wessex Growth Study, 113 Wessex Regional Genetics Labora­

tory, 75 Wilm's tumor, association with

horseshoe kidney, 89

Youth Self Report (YSR), Turner syndrome study, 72

PROCEEDINGS IN THE SERONO SYMPOSIA USA SERIES

Continued from page ii

MOLECULAR AND CELLULAR ASPECTS OF PERIIMPLANTATION PROCESSES Edited by S.K. Dey

THE SOMATOTROPHIC AXIS AND THE REPRODUCTIVE PROCESS IN HEALTH AND DISEASE

Edited by Eli Y. Adashi and Michael O. Thorner

GHRH. GH. AND IGF-I: Basic and Clinical Advances Edited by Marc R. Blackman, S. Mitchell Harman, Jesse Roth, and Jay R. Shapiro

IMMUNOBIOLOGY OF REPRODUCTION Edited by Joan S. Hunt

FUNCTION OF SOMATIC CELLS IN THE TESTIS Edited by Andrzej Bartke

GLYCOPROTEIN HORMONES: Structure. Function. and Clinical Implications Edited by Joyce W. Lustbader, David Puett, and Raymond W. Ruddon

GROWTH HORMONE II: Basic and Clinical Aspects Edited by Barry B. Bercu and Richard F. Walker

TROPHOBLAST CELLS: Pathways for Maternal-Embryonic Communication Edited by Michael 1. Soares, Stuart Handwerger, and Frank Talamantes

IN VITRO FERTILIZATION AND EMBRYO TRANSFER IN PRIMATES Edited by Don P. Wolf, Richard L. Stouffer, and Robert M. Brenner

OVARIAN CELL INTERACTIONS: Genes to Physiology Edited by Aaron J. W. Hsueh and David W. Schomberg

CELL BIOLOGY AND BIOTECHNOLOGY; Novel Approaches to Increased Cellular Productivity

Edited by Melvin S. Oka and Randall G. Rupp

PREIMPLANTATION EMBRYO DEVELOPMENT Edited by Barry D. Bavister

MOLECULAR BASIS OF REPRODUCTIVE ENDOCRINOLOGY Edited by Peter C.K. Leung, Aaron J.W. Hsueh, and Henry G. Friesen

MODES OF ACTION OF GnRH AND GnRH ANALOGS Edited by Wi1liam F. Crowley, Jr., and P. Michael Conn

FOLLICLE STIMULATING HORMONE: Regulation of Secretion and Molecular Mechanisms of Action

Edited by Mary Hunzicker-Dunn and Neena B. Schwartz

SIGNALING MECHANISMS AND GENE EXPRESSION IN THE OVARY Edited by Geula Gibori

GROWTH FACTORS IN REPRODUCTION Edited by David W. Schomberg

PROCEEDINGS IN THE SERONO SYMPOSIA USA SERIES

UTERINE CONTRACTILITY: Mechanisms o/Control Edited by Robert E. Garfield

NEUROENDOCRINE REGULATION OF REPRODUCTION Edited by Samuel S.C. Yen and Wylie W. Vale

FERTILIZATION IN MAMMALS

(Continued)

Edited by Barry D. Bavister, Jim Cummins, and Eduardo R.S. Roldan

GAMETE PHYSIOLOGY Edited by Ricardo H. Asch, Jose P. Balmaceda, and Ian Johnston

GLYCOPROTEIN HORMONES: Structure. Synthesis. and Biologic Function Edited by William W. Chin and Irving Boime

THE MENOPAUSE: Biological and Clinical Consequences o/Ovarian Failure: Evaluation and Management

Edited by Stanley G. Korenman