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Skin microbiomeMedical Hydrology Implications
Dra Lara Rei
Prof. Doutor Pedro Cantista
90% of cells in a human belong to microbiome1
Bacterias
Fungi
Vírus
Microbiome
skin
oral mucosagastrointestinal
tract
vagina
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2012 Ottman, Smidt, de Vos and Belzer
Caesareanvaginal delivery
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Skin functions
▪ Protection
▪ Barrier
▪ Habitat
▪ Regulation
▪ Hormones
▪ Temperature
▪ Sensation
▪ Pain
▪ Tact
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'' a healthy skin microbiome ''
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•Actinobacteria
•Proteobacteria
•Firmicutes
•Bacteroides
4 dominant filos onskin2
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3
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Acne Eczema pitiríase capilis
Propionibacterium acnesPityrosporum ovale
Actinobacteria
Proteobacteria
Cyanobacteria
4
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▪ Skin microbiome
▪ Influences health and disease processes
▪ Manipulable
▪ Easily accessible
▪ Diagnostic test
▪ Therapeutic intervention
▪ Studies point to the modulation of the skin microbiome
after immersion in thermal water
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• Thermal water used in different treatments is
a non-sterile water that has its own bacterial
profile
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France
Cura termal
• eczema
• psoríasis
• burns
La RochePosay
Bicarbonatada
cálcio
sílica
selénio
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France
▪ Topical administration of a Vitreoscilla filiformis
lysate has been shown to benefit local skin
immunity, possibly by activating skin regulators
T cells 5
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Italy
▪ Comano's spring water has been shown to improve skin
regeneration:
▪ Increases keratinocyte proliferation and migration
▪ Modulates regenerated collagen and elastic fibers in the dermis
▪ However, these biological properties may not be fully explained
solely by their mineral composition6
Comano
• hypotonic
• bicarbonatada
• Ca2+
• Mg2+
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Morocco
▪ Aeromonas hydrophila represents a constant microbiota component in fresh
reservoirs, where it acts as a biofilter and promotes water self-purification
▪ Isolated on moroccan atlantic ocean water samples7 and demonstrated activity :
▪ antifungal
▪ antibacterial
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France
▪ From the culture of Aquaphilus dolomiae, an isolated
bacterium in Avène Thermal Water was obtained the organic
substance I-modulia, able to regulate inflammatory and
lymphocyte immune responses of keratinocytes 8
Skin barrier
Itching
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Endnotes
mineral composition
bacteria therapeuticeffect
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Endnotes
• Further research is needed to identify:
• probiotic strains
• prebiotic substrates
• immunoregulatory substances derived from microbes
Health
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Bibliography
▪ 1. Grice EA, The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease; Semin Cutan Med Surg. 2014 Jun;33(2):98-
103.
▪ 2. Hannigan GD, Grice EA. Microbial ecology of the skin in the era of metagenomics and molecular microbiology. Cold Spring Harb Perspect Med. 2013;
3(12):a015362
▪ 3. The human skin microbiome; in International journal of dermatology · July 2014
▪ 4. Restoring the balance: skin microbiome in atopic dermatitis; dermatologytimeas, September 1, 2016
▪ 5. Nakatsuji T and Gallo RL: Dermatological therapy by topical application of non-pathogenic bacteria. J Invest Dermatol 134: 11-14, 2014
▪ 6. Nicolettiet al: Non‐pathogenic microflora of a spring water with regenerative properties; Biomedical Reports 3: 758-762, 2015
▪ 7. El Amraoui B, El Amraoui M, Cohen N and Fassouane A: Antifungal and antibacterial activity of marine microorganisms. Ann Pharm Fr 72: 107-111, 2014
▪ 8. Nocera T, Fabre P, Rossi AB and Mengeaud V: Clinical devel- opment program of a new dermocosmetic range of products containing I-modulia (Aquaphilus
dolomiae extract) in atopic dermatitis. J Am Acad Dermatol 70 (suppl 1): AB6, 2014
Thank [email protected]
