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Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN MULTICELLULAR ORGANISMS Elizabeth Matley & TM Wang

Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

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Page 1: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

ApoptosisTHE PROCESS OF PROGRAMMED CELL DEATH IN MULTICELLULAR ORGANISMS

Elizabeth Matley & TM Wang

Page 2: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

Apoptosis

u Growth and Developmentu Immune system

Page 3: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

2 Pathways of cell death

u Extrinsic Signalu Intrinsic Signal

Page 4: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

Extrinsic Signal

Page 5: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

Intrinsic Signal

Page 6: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN
Page 7: Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

Regulation of Apoptosis

u Bcl-2 gene family u crmA

u IAP Inhibitors