Alzheimer’s Disease Pathology

Senile Plaques and CAA Neurofibrillary Tangles

•Vascular factors (high cholesterol level, hypertension) increase the risk of developing AD

•A forms some deposits around blood vessels in AD brains

•What is the effect of A on blood vessels?

Control

A treatmentA treatment

Control

Vascularization

A treatment

Placebo

Blood vessels staining in tumor sections

Placebo

A treatment

Tumor

Tumor

Tumor

Tumor

A1-40

Placebo(Brain tumors)

0

10

20

30

40

50

60

70

80

Control (n=8) Aß1-40 (n=8)

Mic

rov

es

se

l co

un

t

Control

A treatment

Blood vessel staining