Annual Congress SSAI-SGAI

Advances in immunology and allergology: from research to diagnosis and therapy

March 17–18, 2011, Lugano, Ticino

www.ctlag-congress.ch

Preliminary Program

Mehr LEBENSQUALITÄT bei allergischemAsthma dank Anti-IgE-Therapie!1

Kassenzulässig*

Referenzen:1. Humbert M, Beasley R, Ayres J, et al.: Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy, 2005Mar;60(3):309-16. *Kassenzulässig mit folgender Limitierung: "Schweres, gegenüber anderen Therapien resistentes, allergisches Asthma unter der Voraussetzung, dass die Behandlung durch einen Spezialarzt (Pneumologen, Allergologen) erfolgt.Die Weiterbehandlung des Patienten durch einen Grundversorger bedarf der Bewilligung des Vertrauensarztes der Krankenkasse." (gemäss Verfügung BAG vom 16.11.2006).

KurzfachinformationXOLAIR® (Omalizumab). Z: Omalizumab; Stechampulle mit Pulver 150mgOmalizumab und Lösungsmittel zur Herstellung einer Injektionslösung. I: In Kombinationmit anderen Asthmatherapien zur verbesserten Asthmakontrolle bei Erwachsenenund Jugendlichen (ab 12 Jahren) mit schwerem persistierendem allergischem Asthma (positiver Hauttest oder in vitro-Reaktivität gegen ein ganzjährig auftretendes Aeroallergen), falls diese trotz täglicher Therapie mit hoch dosierten inhalativenKortikosteroiden und einem langwirksamen Beta2-Agonisten eine reduzierte Lungenfunktion (FEV1 < 80 %) haben als auch unter häufigen Symptomen während des Tages oder nächtlichem Erwachen leiden und Asthma-Exazerbationen hatten. D:Erwachsene und Kinder ab 12 Jahren: 75 - 375 mg XOLAIR® 1 - 2 x/Monat basierend auf dem IgE-Basis-Wert (I.E./ml) im Serum und des Körpergewichts des Patienten. Einzelheiten s. Arzneimittel-Kompendium der Schweiz®. KI: Überempfindlichkeitgegenüber demWirkstoff oder einem der Inhaltsstoffe. VM: Nicht indiziert zur Behandlung von akuten Asthma-Exazerbationen, akuten Bronchospasmen und Status asthmaticus. Nicht untersucht bei Hyper-Immunglobulin-E-Syndrom, allergischerbronchopulmonaler Aspergillose, Prävention allergischer Reaktionen, atopischer Dermatitis, allergischer Rhinitis, Lebensmittelallergien, Autoimmunerkrankungen, Immunkomplex-vermittelten Zuständen, bestehender Nieren- oderLeberfunktionsstörung. Reduktion von Kortikosteroiden unter ärztlicher Aufsicht. Enthält Saccharose: Patienten mit Diabetes mellitus, Glukose-Galaktose-Malabsorption, Fruktose-Intoleranz, Saccharose-Isomaltase-Mangel müssen darauf hingewiesen werden. Allergische Reaktionen oder lebensbedrohlicheAnaphylaxie und anaphylaktischer Schock können auftreten; Probleme im Zusammenhang mit Immunogenität, parasitären (Wurm-) Infektionen oderMalignitäten können auftreten. Einzelheiten s. Arzneimittel-Kompendium der Schweiz®. IA: Es gibt keine Hinweise auf veränderte Sicherheit durch ande-re i.a. eingesetzten Asthmamedikamente. Die Wirksamkeit der Behandlung in Kombination mit spezifischer Immuntherapie wurde nicht nachgewiesen.UW: Häufig: Kopfschmerzen, Reaktionen an der Injektionsstelle wie Schmerzen, Erythem, Pruritus, Schwellung. Gelegentlich: Schwindel,Schläfrigkeit, Parästhesie, Synkope, orthostatische Hypotonie, Flush, Pharyngitis, Husten, allergische Bronchospasmen, Nausea, Diarrhoe,Dyspepsie, Urtikaria, Rash, Pruritus, Photosensibilität, Gewichtszunahme, Müdigkeit, Anschwellen der Arme, grippeähnliche Symptome. Seltenund sehr selten s. Arzneimittel-Kompendium der Schweiz®. Postmarketing: Anaphylaxie und anaphylaktoide Reaktionen, Alopezie, idiopathischeschwere Thrombozytopenie, allergische granulomatöse Angiitis (d.h. Churg-Strauss-Syndrom), Arthralgie, Myalgie, Gelenkschwellung.Malignitäten, Thrombozyten, Labordaten, Parasitäre Infektionen: s. Arzneimittel-Kompendium der Schweiz®. P: 1 Stechampulle zu 150 mg mit1 Lösungsmittelampulle zu 2 ml: je 1*. Verkaufskategorie: (B). *kassenzulässig. Verkaufskategorie: B. Weitere Informationen entnehmen Siebitte dem Arzneimittel-Kompendium der Schweiz®. ZUL: Novartis Pharma Schweiz AG, Postfach, 3001 Bern. www.novartispharma.ch V2

I520

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09 Novartis Pharma Schweiz AG, Postfach, 3001 Bern. www.novartispharma.ch

Add life, add XOLAIR®

Inserat Xolair A5 (d) 01:Inserat Xolair A4 (d) 05 8.9.2010 15:08 Uhr Seite 1

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Dear friends and colleagues

It is with a great pleasure that we invite you to the Annual Congress of the Swiss Society for Allergology and Immunology (SGAI-SSAI), which will be held, after 1986 and 2002, for the third time in Lugano, on the 17th and 18th of March 2011. The Congress is organized by the Institute for Research in Biomedicine (IRB) together with the Society of Allergologists and Immunolo-gists of Ticino (STAI) and will feature joint Symposia with the European Academy of Dermatology and Venereology (EADV) and the Swiss Multiple Sclerosis (MS) Society.

The Congress Opening Lecture will be given by John O’Shea who will discuss the «Transcriptional and epigenetic control of T cell differentiation». Thomas Schwartz will give the SGAI-EADV Joint Lecture with the title «Dermatoimmunology: dogmas going through a radical change», and David Hafler will give the SGAI-MS Society Joint Lecture «The genetics of multiple sclerosis». The program will feature 12 Symposia, 6 Sessions for short talks, the SGAI Practitioner Political Forum and Corporate Lunch Sympo-sium. The SGAI-SSAI General assembly will be held on Thursday at 17.30. All members of the society are welcome to attend and contribute to the as-sembly.

It is our goal to bring together established basic scientists and clinicians along with young researchers and residents, postdocs and students who will have ample space to present their work at symposia, workshops and poster sessions. It is our policy, and the policy of SGAI, to support the new genera-tions of immunologists and allergologists and to promote an interactive envi-ronment that enriches both senior and junior investigators.

We strongly encourage corporate organizations to sponsor and exhibit at the Congress and to take advantage of the opportunity to interact face-to-face with professionals from all over Switzerland to build visibility, to introduce new products and services and give product demonstrations. We count on their presence and support to make this meeting a great event.

Lugano is a beautiful town in the southernmost tip of Switzerland offering spectacular natural surroundings at the foot of the Alps and in the midst of the Lake district. All participants will be invited to the reception on Thursday,

Welcome to Lugano

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which is kindly offered by the City of Lugano, and to register for the Gala dinner at the «La Perla Wine and Dine» Restaurant on Casinò di Lugano’s top floor, which boasts an incomparable view of the lake and the gulf of Lugano.

Together with the members of the Local Organizing Committee we are looking forward to welcoming you to Lugano and to an exciting congress!

Federica Sallusto Brunello Wüthrich

Presidents of the Organizing Committee

Opera on the cover: «Ticino», by Daniele Buzzi, 1946taken from: Roberto Cavalli, «100 years of Ticino posters (1890–1990)», part 1, Germignana (VA), Art Editions Jansonius, 2008, page 46

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Program Overview

Thursday, March 17, 2011

10.00–11.20 Registration Welcome Coffee, Poster Exhibition, Industry Exhibition

11.20–12.10 Symposium 1: Basic Immunology Chair:FabioGrassi(Bellinzona,CH),AntoniusG.Rolink(Basel,CH) Ed Palmer (Basel, CH) Thymic selection and T cell tolerance Margot Thome-Miazza (Lausanne, CH) Signaling pathways for lymphocyte activation and survival

Symposium 2: Clinical Immunology Chair:ChristianMünz(Zürich,CH),FrançoisSpertini(Lausanne,CH) George Hollander (Basel, CH) The role of the thymus in allogeneic hematopoietic stem cell

trans plantation Onur Boyman (Zürich, CH) Cytokines in immunotherapy

Symposium 3: Influence of Climate and Environmental Changes in Allergic Sensitization Chair: BrunelloWüthrich(Zürich,CH),MassimilianoFontana(Mendrisio,CH) Bernard Clot (Payerne, CH) Interregional variations of pollen, climate change and future trends in

Switzerland Claudio Ortolani (Milano, I) Influence of environmental changes on food allergy

12.15–13.00 Opening lecture 1 Chair:FedericaSallusto(Bellinzona,CH),AndreasBircher(Basel,CH) John O’Shea (Bethesda, USA) Transcriptional and epigenetic control of helper T cell differentiation

13.00–14.30 Lunch break in Exhibit Hall and Poster viewing

13.15–14.15 SSAI-SGAI Practitioners Political Forum Chair:FabienneGay-CrosierChabry(Carouge,CH)

13.15–14.15 Lunch Symposium 1 B Cell Therapies in Auto Immune Diseases (Organized by Merck Serono SA)

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14.30–16.00 Symposium 4: Basic Immunology Chair:AnnetteOxenius(Zürich,CH),HansAcha-Orbea(Lausanne,CH) Marco Colonna (St. Louis, USA) NK cells in innate and adaptive immunity Oliver Lantz (Paris, F) Development and function of mucosal-associated invariant T cells Gennaro De Libero (Basel, CH) The cellular and biochemical rules of lipid antigen presentation Short presentation

Symposium 5: Laboratory Diagnostics (supported by Sodiag SA) Chair:FrancoKeller(Bellinzona,CH),StephanRegenass(Zürich,CH) Arthur R. Bradwell (Birmingham, UK) Serum free light chain analysis Angela Vincent (Oxford, UK) Autoantibodies in neurological syndromes Steven Stapel (Amsterdam, NL) Monoclonal therapeuticals

Symposium 6: Joint SGAI / EADV Allergo-Immuno-Dermatology New Aspects of Contact Allergy and of Autoinflammatory Skin Disease Chair:AlbertoGiannetti(Modena,I),StefanoGilardi(Locarno,CH) Werner Aberer (Graz, A) Fragrance allergy: new aspects Andreas Bircher (Basel, CH) Sensitization to alloy metals used in orthopedic surgery and dentistry Lars French (Zürich, CH) Autoinflammatory skin diseases

16.00–16.30 Coffee break in Exhibit Hall

16.30–17.30 Short Communications: Basic Immunology

Short Communications: Laboratory Diagnostics

Short Communications: Allergy and Clinical Immunology

17.30–19.00 General Assembly SSAI-SGAI

19.00–20.00 Reception at the Convention Center offered by the Municipio della Città di Lugano

20.00–22.30 Gala Dinner at the Ristorante La Perla, Casinò di Lugano

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Friday, March 18, 2011

8.30–9.15 Plenary lecture 2 (Joint SGAI and EADV Society) Chair:NikihlYawalkar(Bern,CH) Thomas Schwartz (Kiel, D) Dermatoimmunology: dogmas going through a radical change

9.15–10.45 Symposium 7: Basic Immunology Chair:SilviaMonticelli(Bellinzona,CH),EdPalmer(Basel,CH) Doreen Cantrell (Dundee, UK) Facts, controversies, and unresolved issues about serine/threonine

kinases in T lymphocyte biology Jean Pieters (Basel, CH) Coronin 1 and the regulation of leukocyte-specific signaling events Vigo Heissmeyer (Munich, D) Regulation of microRNA pathway and control of immune functions Sergio Abrigani (Milano, I) Human lymphocyte microRNA signatures and their target genes that

regulate T cell differentiation

Symposium 8: Chronic infections and inflammation Chair:WernerPichler(Bern,CH),MariagraziaUguccioni(Bellinzona,CH) Cem Gabay (Geneva, CH) Mechanisms of articular inflammation and joint damage in arthritis Hiroshi Takayanagi (Tokyo, J) Osteoimmunology and the effects of the immune system on bone Vincenzo Barnaba (Rome, I) Infections and autoimmunity Short presentation

Symposium 9: Food Allergy (supported by Unilabs) Chair:ArthurHelbling(Bern,CH),GianlucaVanini(Lugano,CH) Philippe Eigenmann (Geneva, CH) IgE-mediated food allergy in children: new diagnostic aspects Elide Pastorello (Milano, I) Mediterranean diet: healthy for allergic people? Stephan Scheurer (Langen, D) Relevance of immune responses to carbohydrate eptitopes and Maillard reaction products for the pathogenesis of type I allergy

10.45–11.15 Coffee break in Exhibit Hall

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11.15–12.00 Plenary lecture 3 (Joint SGAI and MS Society) Chair:LudwigKappos(Basel,CH),BrittaEngelhardt(Bern,CH) David Hafler (New Haven, USA) The genetics of multiple sclerosis

12.15–13.30 Lunch break in Exhibit Hall and Poster viewing

12.15–13.30 Lunch Symposium 2 Management of type I and type IV allergies – new perspectives and treatment options (Organized by ALK-ABELLO AG / Basilea Pharmaceutica International AG)

12.15–13.30 Lunch Symposium 3 Intolerance to biogenic amines: an update (Organized by Xanapharm AG and NutriDis)

13.00–14.15 MS Society Workshop

13.45–14.30 Plenary lecture 4 Chair:AntonioLanzavecchia(Bellinzona,CH) Jean-Claude Weill (Paris, F) Multiple layers of B cell memory

14.30–16.00 Symposium 10: Basic Immunology Chair:ChristophMüller(Bern,CH),ManfredKopf(Zürich,CH) Carola Vinuesa (Canberra, AUS) Heterogeneity of T follicular helper cells Facundo Batista (London, UK) Early events in B cell activation and initiation of immune response Andrew McPherson (Bern, CH) Commensal intestinal microbes and immune response Short Presentation

Symposium 11: Joint SGAI / MS Society Chair:MyriamSchluep(Lausanne,CH) Angela Vincent (Oxford, UK) Antibody-mediated encephalitides Short presentations

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Symposium 12: Novel treatment (supported by Shire HGT) Chair: PeterSchmid-Grendelmeier(Zürich,CH),SilvyBach-Bizzozzero

(Bellinzona,CH) Marcus Maurer (Berlin, D) Hereditary angioedema: pathophysiology and new treatments François Spertini (Lausanne, CH) A review of the off-label use of biological in systemic autoimmune

diseases Thomas Kündig (Zürich, CH) The present and the future of allergen specific immunotherapy

16.00–16.30 Coffee break in Exhibit Hall

16.30–17.30 Short Communications: Basic and Clinical Immunology

Short Communications: Joint SGAI / MS Society Short Communications: Allergy and Dermatology

17.30–18.00 Awards and Closing Ceremony

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DateMarch, 17–18, 2011

Congress VenuePalazzo dei congressi, Piazza Indipendenza 4, CH-6900 Lugano

Presidents of the organizing committeeFederica Sallusto, IRB Bellinzona (mail: federica.sallusto@irb.unisi.ch)Brunello Wüthrich, STAI Zollikerberg (mail: bs.wuethrich@bluewin.ch)

President of the Swiss Society for Allergology and ImmunologyProfessor Andreas Bircher, MD, Department of Dermatology, University Hospital Basel

Members of the local Organizing and Scientific CommitteeSilvy Bach-Bizzozero, STAI, BellinzonaMassimiliano Fontana, STAI, MendrisioStefano Gilardi, EADV, LocarnoFabio Grassi, IRB, BellinzonaFranco Keller, STAI, BellinzonaJean Pierre Lantin, STAI, Lugano-PregassonaAntonio Lanzavecchia, IRB, BellinzonaSilvia Monticelli, IRB, BellinzonaMyriam Schluep, Swiss MS SocietyRocco Torricelli, STAI, Lugano-ParadisoMariagrazia Uguccioni, IRB, BellinzonaGianluca Vanini, STAI, Lugano

Administrativ Congress OrganizationConvention Team Lucerne AG, Oberseeburg 10, 6006 LuzernTel. +41 41 371 18 60 Fax +41 41 371 18 61 E-mail ctlag@bluewin.ch

Important deadlineAbstract: December 5, 2010, at the latestHotel reservation until February 1, 2011Early registration: until February 1, 2011

Congress LanguageEnglish (no simultaneous translation)

General Information

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Credits for two days (March 17–18, 2011)Swiss Society for Allergology and Immunoloy 5 credits (17.3.) / 6 credits (18.3.)Swiss Society of Dermatology and Venereology 5 credits (17.3.) / 8 credits (18.3.)Swiss Society of Hematology 5 creditsSwiss Society of Infectious Diseases: recognized by other societiesSwiss Society of Neurology 3 creditsSwiss Federal Veterinary Office 1 day

Registration fees before 1.2.2011 after 1.2.2011Members SSAI, SSDV, MS Society (2 days) CHF 200.– CHF 250.–Members SSAI, SSDV, MS Society (1 day) CHF 110.– CHF 150.–Non-Members (2 days) CHF 260.– CHF 310.–Non-Members (1 day) CHF 130.– CHF 160.–Assistant Doctors/Students (2 days) CHF 150.– CHF 180.–Assistant Doctors/Students (1 day) CHF 80.– CHF 90.–Gala dinner CHF 100.–

Method of paymentPayments should be made by either

Banktransferto(freeofcharge)Bank: UBS AG, CH-6002 Lucerne (BC 248)Beneficiary: Convention Team Lucerne AGAccount: 0248-469471.06TRemark: SGAI 2011IBAN: CH830024824846947106TBIC: UBSWCHZH80A

Creditcards(VISA,MasterCard)

RegistrationPlease use the enclosed registration form and return it before February 1, 2011. After receipt of the registration fee, you will receive a written confirmation.

(Download form on www.ctlag-congress.ch or www.sgai.ch and online regis-tration possible on www.ctlag-congress.ch)

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AbstractsAbstracts for oral or poster presentations must be submitted on our website (www.ctlag-congress.ch). Abstracts sent by post, fax or e-mail will not be accepted. The decision of the Scientific Committee as well as further information will be communicated to the authors by December 31, 2010. The abstracts will be published in ALLERGOLOGIE (Dustri-Verlag Dr. Karl Feistle)Deadline for submission: December 5, 2010

CancellationCancellations until February 1, 2011: Refund of total amount paid minus CHF 50.– per person for administrative charges. No refund after this date. Cancellations must be written to the congess organization.

Hotel accommodationPlease use the hotel reservation form for accommodation as early as possi-ble. Reservations should be made by February 1, 2011 at the very latest (Download form from www. ctlag-congress.ch). After this date accommoda-tions will not be available in the vicinity of the congress venue.

PostersPosters will be exhibited in the poster area from Thursday to Friday(size of posters: 125 cm × 200 cm (width × hight).

Industry exhibitionThe exhibition is located in the main congress area at the Palazzo dei congressi and will be open from Thursday, 10.00 to Friday, 18.00.

Public transportFrom Lugano Airport to Palazzo dei Congressi approx. 15–20 min. by taxi or by regular shuttle bus service between the airport and the center of Lugano (Tel. Taxi Airport 091 605 25 10 / Shuttle Bus Airport – Lugano City Tel. 079 221 42 43).From the main station: bus No 2 in direction to «Cornaredo» until stop «Palazzo dei Congressi».

ParkingThere are limited parking spaces at the «Parking Piazzo Castello».

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Prizes

SGAI-Prize (sponsored by CSL Behring)The poster price award in the amount of CHF 1000.– will be given to the first author of the best poster in the category «Basic Immunology», «Clinical Immu-nology» and «Allergology» incl. «Allergy Laboratory Diagnostic».

Brunello Wüthrich Allergy Poster Prize (CHF 1000.–) will be awarded to an original and intersting allergy case description or casuistics.

The annual award of CHF 10 000.– of the Allergy Foundation Ulrich-Müller-Gierok will be given for an excellent peer reviewed Swiss publication in clinical Allergology.

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The Scientific and Organizing Committee wish to acknowledge the financial support of the following companies: (up-date until 25.9.2010)

Lunch Symposia ALK-ABELLO AG Basilea Pharmaceutica International Ltd Merck Serono SA NutriDis Xanapharm AG

Symposia SHIRE HGT Sodiag SA Unilabs

Gold Sponsor Novartis Pharma Schweiz AG

Silver Sponsor CSL Behring In addition supported by Città di Lugano CSL Behring DUSTRI Verlag Dr. Karl Feistle IBSA Phadia AG RUWAG Handels AG Siemens Health Care Diagnostics AG

Sponsors