Animal Breeding & Genomics Centre

Animal Breeding & Genomics Centre

Environmental and genetic regulation

of prenatal events and its importance for

postnatal growth performance and meat quality

te Pas et al.

Animal Breeding & Genomics Centre

Myogenesis – as we all know it….

myoblasts proliferation

myoblast differentiation (fusion)

maintenance of multinucleatedmuscle fibres

Animal Breeding & Genomics Centre

Myogenesis – as influenced by….Environment

• Nutrition

• Management

• Temperature

• Mother interaction

• Influence modulated by the Genotype

• …

secondary musclefibre formation

hypertrophic

muscle fibre growth

birth

primary musclefibre formation

maintenance

Genetics

• MRF genes

• Muscle-specific genes

• Cell division genes

• Energy-related genes

• Affected by Environment

• …

Species-

specific

Animal Breeding & Genomics Centre

A review? Environmental factors

Birth weight (Charlotte) Nutrition (Charlotte)

Muscle fibre numbers (Charlotte) Carcass composition Meat quality In vitro experiments..

Genetic factors IGF-II (Karijn)

• Epigenetic expression• Satellite cell activity

RYR1 (Karijn)• Interaction with IGF-II (growth)

Selection (Charlotte)• Mice: 70 generations• Selected – wt pigs

Myostatin (Charlotte)• hyperplasia

Prenatal expression patterns (Marinus)

…

Animal Breeding & Genomics Centre

A review? (2)

Why a review? To mark the results of our COST action To reference our publications in connection to each

other More references

Papers from Antalya Scan papers from other meetings General literature

Animal Breeding & Genomics Centre

Actions

Do we continue? Who would like to participate? Journal? Missing things?