8/17/2019 AMPK in Energy Homeostasis

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ATP

ADP

AMP

Exercise

Hypoxia

AMPK in energy homeostasis

P172

AMPK

γ

      C      B      S

CBS

      C      B      SCBSAMPK

 

G!T"#G$%cose transporter "&

P'K#Phospho(r%cto)inase*

+,S1#+ns%$in ,eceptor

s%-strate 1&

e./S#.itric oxi0e synthase&

C'T,

mT/,

ACC2#Acety$CoA

car-oxy$ase&

GPAT#G$icerophosphate

acy$trans(erase&

PPA,γeptinA0iponectin

MCD#Ma$ony$CoA

car-oxy$ase&

Trig$iceri0es an0

Ma$ony$CoAG$%cose %pta)e

an0 meta-o$ism

GS#G$ycogen synthase&

Protein synthesis

an0 gro3th

/ther stim%$i4

PKCζ

CaMKK 

TSC152

PGC1 #PPA,γ coacti6ator&

Gene

expression

,he-

AMPKK#KB1&