14

Amiodarone advantageous in angina An increase in the ischaemic threshold occurred

when low-dose amiodarone was added to conventional antianginal medication, in a study of 63 patients with limiting angina pectoris. These patients had a history of persistent angina, despite double or triple combination antianginal medication, consisting of ~-blockers, calcium antagonists and long-acting nitrates.

The addition of amiodarone to these antianginal agents also resulted in a reduction in the rate-pressure product and ST segment depression, plus a significant increase in exercise tolerance, when compared with placebo. In addition, patients noted a mild reduction of anginal symptoms.

Amiodarone was well tolerated during this short-term study, although researchers recommended that careful follow-up should be made if this agent is given.

Meyer 81, Amann FW. Additional antianginal efficacy of amiodarone in patients with limiting angina pectoris. American Heart loumall25: 996-1001, Apr 1993 800',.,"

15 May 1993 INPHARMAe

THERAPY

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