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AIIN IMAGING
DanielL.Rubin,MD,MSAssociate Professor of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics)
Matthew Lungren MD MPHAssistantProfessorofRadiology
@mattlungrenMD
Department of RadiologyStanford University
AIinMedicalImagingOpportunities� Efficientimagecreation� Imagequalitycontrol� Imagingtriage� Computer-aideddetection� Computer-aidedclassification� Automaticreportdrafting
http://aimi.stanford.edu
DiseaseDetection:Retinalhemorrhages
224x224inputCNNslidingwindow:DetectinganyabnormalfeatureRed=P~.99 Green=P~0.5 Blue=~0.01
Predicted Physician
Carson Lam, et al, in preparationCopyright © Daniel Rubin 2017
Diagnosis:Real-timediagnosisofcancerusingdeeplearningComputerized interpretation during confocal endomicroscopyexamination of the bladder permits localization of tumors in heterogeneous bladder lesions
Copyright © Daniel Rubin 2017
Cancer region Normal region
Darvin Yi, et al, in preparation
CheXNet:121-layerCNN
Matt Lungren, MD, MPH and Andrew Ng, PhD. https://arxiv.org/abs/1711.05225
http://aimi.stanford.edu
AffiliatedFacultyFrom8DepartmentsAcross3SchoolsRadiology
� CurtisLanglotz,MD,PhDProfessorofRadiologyandMedicine(BiomedicalInformaticsResearch)
� SandyNapel,PhDProfessorofRadiology,and,bycourtesy,Medicine(MedicalInformatics)andElectricalEngineering
� MatthewLungren,MD,MPHAssistantProfessorofRadiology
� DavidLarson,MD,MBAAssociateProfessorofRadiology
� SafwanHalabi,MDClinicalAssistantProfessorofRadiology
� KristinYeom,MD,PhDAssociateProfessorofRadiology
� ChristopherBeaulieu,MD,PhDProfessorofRadiologyand,bycourtesy,OrthopedicSurgery
� LawrenceHofmann,MDProfessorofRadiology
� GregZaharchuk,MD,PhDAssociateProfessorofRadiology
� GuidoDavidzon,MDClinicalAssistantProfessorofRadiology
� ShreyasVasanawal,MD,PhDAssociateProfessorofRadiology
� BrianHargreaves,PhDAssociateProfessorofRadiologyand,bycourtesy,ElectricalEngineering
� GarryGold,MDProfessorofRadiologyand,bycourtesy,Bioengineering
Medicine(BiomedicalInformaticsResearch)andBiomedicalDataScience
� NigamShah,MBBS,PhDAssociateProfessorofMedicine(BiomedicalInformatics)
� OlivierGevaert,PhDAssistantProfessorofMedicine(BiomedicalInformaticsResearch)andBiomedicalDataScience
� ManishaDesai,PhDProfessorofMedicine(BiomedicalInformaticsResearch),BiomedicalDataScience,and,bycourtesy,ofHealthResearchandPolicy
� DanielRubin,MD,MSAssociateProfessorofBiomedicalDataScience,Radiology,Medicine(BiomedicalInformaticsResearch),and,bycourtesy,Ophthalmology
ComputerScience
� Fei Fei Li,PhDAssociateProfessorofComputerScience
� AndrewNg,PhDAdjunctProfessorofComputerScience
� ChristopherRe’,PhDAssociateProfessorofComputerScience
� RussellPoldrack,PhDAlbertRayLangProfessorofPsychologyandProfessor,bycourtesy,ofComputerScience
Pathology
� RobertWest,MDProfessorofPathology
� SaurabhGombar,MD,PhDClinicalInstructorinPathology
� JeanneShen,MDAssistantProfessorofPathology
� RobertoNovoa,MDClinicalAssistantProfessorofPathologyandDermatology
Ophthalmology
� DavidMyung,MD,PhDAssistantProfessorofOphthalmology
� JoyceLiao,MD,PhDAssociateProfessorofOphthalmologyandNeurology
� RobertChang,MDAssistantProfessorofOphthalmology
Dermatology
� JustinKo,MD,MBAClinicalAssociateProfessorofDermatology
Anesthesia
� SeanMackey,MD,PhDRedlichProfessorofAnesthesiology,PerioperativeandPainMedicine,Neurosciences,andNeurology
Computer Science• Fei Fei Li, PhD
Associate Professor of Computer Science
• Andrew Ng, PhDAdjunct Professor of Computer Science
• Christopher Re’, PhDAssociate Professor of Computer Science
Supporting Departments:• Radiology• Pathology• Medicine• Ophthalmology• Dermatology• Computer Science• Biomedical Data Science• Anesthesia
AcknowledgementsStudents,Post-docs,Residents,Staff,andCollaborators
– BaoDo
– Assaf Hoogi
– Selen Bozkurt
– Emel Alkim
– Sheryl John
Funding Support– NCI QIN grants
U01CA142555,1U01CA190214, 1U01CA187947
– ECOG-ACRIN– Stanford-AstraZeneca Collaboration Grant– NVIDIA Academic Hardware Grant Program
– Alfiia Galimzianova
– ImonBanerjee – Niranjan Balachandar
– SandyNapel
– CurtLanglotz
– ChristopherRe
– ChrisBeaulieu
– CarsonLam
– DarvinYi
– Xuerong Xiao
– BlaineRister
– HershSagreiya
– MatthewLungren
– AnnLeung
– Jocelyn Barker
Issuesfordiscussion1. Howdoyougetlabelsinpractice?Whatdothey
mean?2. Issuesaboutlabelquality
a) Animageannotationisnotgroundtruthb) Impactofqualityofimagelabelsonmodelsc) Uncertaintyinthelabels;inter-annotatordisagreement
3. Confoundingvariables4. Integratingdomainexpertiseintomodels5. Leveragingun-annotatedimages,weaksupervision6. Deploymentandevaluationofmodels(“post-
marketingsurveillance”)7. Structuresforsharinglabelsandannotations