ADVANCES IN MUCOSALIMMUNOLOGYPart B

Jiri Mestecky

Helena Tlaskalovä-Hogenovä

PART B

CLINICAL IMMUNOLOGY, IMMUNOPATHOLOGY, IMMUNO-DEFICIENCY, AND ALLERGOLOG Y

EVIDENCE FOR A GENERALIZED SIGNALING ABNORMALITY I NB CELLS FROM PATIENTS WITH COMMON VARIABLE IMMUNO-DEFICIENCY 69 9

E.M . Eisenstein and W. Strober

DEFECTS OF THE INTESTINAL HUMORAL IMMUNE SYSTEM INCOMMON VARIABLE IMMUNODEFICIENCY SYNDROME 705

E.W. Herbst, M . Armbruster, J .-A . Rump, H.-P . Buscher,and H.-H. Pete r

INCIDENCE OF PRIMARY IMMUNODEFICIENCIES IN A POPULA-TION OF SOUTH MORAVIA, CZECHOSLOVAKIA 709

J . Lokaj, J . Litzman, and P. Kukline k

ABERRATIONS IN TITER AND AVIDITY OF SERUM IgM AN DIgG ANTIBODIES TO MICROBIAL AND FOOD ANTIGENS INIgA DEFICIENCY 71 3

F. Cardinale, V . Friman, B . Carlsson, J . Björkander, L . Armenio ,and L .A. Hanson

IMMUNOLOGICAL STUDY OF CHILDREN WITH IgADEFICIENCY 717

M. Spicakova, J . Novakova, J . Bartova, R . Barot-Ciorbaru ,and H . Tlaskalova

DEVELOPMENT, FUNCTION, AND TRAFFICKING OF MUCOSA LLEUKOCYTES IN IMMUNODEFICIENT MICE 71 9

C.F. Cuff, D.H. Rubin, and J .J . Cebra

REARRANGEMENT OF RAG-1 RECOMBINASE GENE IN DNA-REPAIR DEFICIENT/IMMUNODEFICIENT "WASTED" MICE 72 5

G.E. Woloschak, C .R . Libertin, P . Weaver, M . Churchill ,and C .-M. Chang-Liu

T LYMPHOCYTES SUBPOPULATIONS IN THE INTESTINAL VILL IOF IMMUNE DEFICIENT RAT 729

S.G. Ariki and M.E. Roux

COMPARISON OF THE LOCAL IMMUNE RESPONSE TO NON-TYPABLE HAEMOPHILUS INFLUENZAE (nHI) AND MORAXELLACATARRHALIS (MC) DURING OTITIS MEDIA 733

H . Faden

IMMUNOLOGICAL EFFECTS OF TONSILLECTOMY/ADENECTOM YIN CHILDREN 73 7

B.E.D. Rio-Navarro, S . Torres, L. Barragan-Tame, C .D. la Torre ,A. Berber, G . Acosta, and J .J .L. Sienra-Mong e

TONSILLAR LYMPHOCYTE SUBSETS IN TONSILLITIS ANDHYPERPLASIA 74 1

A.V. Chernyshov and O.F . Melnikov

A STUDY OF LYMPHOCYTE ADHERENCE TO MIDDLE EA RMUCOSAL TISSUE 74 5

D.A. Spilman, N .L . O'Sullivan, and P.C . Montgomer y

AN ANIMAL MODEL TO STUDY THE MECHANISMS OF IMMUNIT YINDUCED IN THE RESPIRATORY TRACT BY INTESTINAL IMMU-NIZATION 74 9

A.W. Cripps, M.L . Dunkley, R .L . Clancy, F . Wallace, A . Buret ,and D.C. Taylor

IMMUNITY TO RESPIRATORY PSEUDOMONAS AERUGINOSAINFECTION: THE ROLE OF GUT-DERIVED T HELPER CELLS AN DIMMUNE SERUM 75 5

M.L. Dunkley, A .W . Cripps, P .W. Reinbott, and R.L . Clanc y

IMMUNITY TO PSEUDOMONASAERUGINOSA INDUCED BY OprFFOLLOWING INTESTINAL IMMUNIZATION 76 1

A.W. Cripps, M.L . Dunkley, D .C. Taylor, S . Cousins ,and R .L . Clanc y

THE PROTECTIVE ROLE OF PULMONARY NEUTROPHILS INRATS INTESTINALLY IMMUNIZED WITH PSEUDOMONASAERUGINOSA 76 5

A. Buret, M. Dunkley, R .L . Clancy, and A .W. Cripp s

IMMUNITY TO RESPIRATORY PSEUDOMONASAERUGINOSAINFECTION : P. AERUGINOSA-SPECIFIC T CELLS ARISING AFTE RINTESTINAL IMMUNIZATION 77 1

M.L. Dunkley, A .W. Cripps, and R .L . Clanc y

SECRETORY IgA AGAINST PERTUSSIS TOXIN AND SURFACESTRUCTURES OF BORDETELLA PERTUSSIS IN SALIVA OFCHILDREN WITH CULTURE PROVEN PERTUSSIS 77 7

M. Frühwirth, H. Wolf, H . Heininger, J .P . Guggenbichler ,

and E . Stehr

ALTERATION OF CYTOKINE SECRETION AND CYTOTOXICITY OFMURINE ALVEOLAR MACROPHAGES AFTER IN VITRO INFECTIO NWITH RESPIRATORY SYNCYTIAL VIRUS (RSV) 78 5

G. Franke, J . Freihorst, C. Pfirtner, H .v .d . Hardt, andM.-L. Lohmann-Matthe s

LOCAL SPECIFIC IMMUNIZATION AND NON-SPECIFIC STIMULA-TION OF THE DEFENSE MECHANISMS OF THE RESPIRATORYTRACT OF SWINE 79 1

G . Müller and H . Köhler

ASSESSMENT OF THE CLINICAL VALUE OF USING AN IMMUNO-MODULATOR IN RECURRENT RESPIRATORY INFECTIONS 79 5

K.-C. Bergmann

REDUCTION OF THE NUMBER AND SEVERITY OF RESPIRA-TORY TRACT INFECTIONS IN CHILDREN BY ORAL IMMUNO-STIMULATION 799

R.J . Riedl-Seifert, A . van Aubel, A . Kämmereit, and U. Elsasser

ORAL IMMUNIZATION WITH LUNG-PATHOGENIC BACTERI AIS PROTECTIVE AGAINST DEFINED CHALLENGE IN A PI GAEROSOL INFECTION MODEL 80 3

A. Hensel, S . Delventhal, H . Windt, N . Stockhofe-Zurwieden ,R. Pabst, and K. Petzoldt

INDUCTION OF IMMUNE RESPONSES IN NASOPHARYNGEA LSECRETIONS AFTER ORAL IMMUNIZATION WITH BACTERIA LLYSATES 807

A. Berber, R . Priego, L. Igelsias, S . Torres, and C . Camacho

USE OF GUT LAVAGE FLUID TO MEASURE INTESTINAL HUMORALIMMUNITY, GI BLEEDING AND PROTEIN LOSSES IN SIERR ALEONEAN CHILDREN 81 3

M. Hodges, K. Kingstone, W .G. Brydon, J . Sallam, and A. Ferguson

SMALL INTESTINAL BIOPSIES CHARACTERIZED BY LECTIN AN DACTIN LABELLING AND CONFOCAL MICROSCOPY 81 7

K. Fälth-Magnusson, K .H. Peterson, H . Edenholm,L. Stenhammar, and K.-E . Magnusso n

TNFa SECRETING CELLS IN NORMAL AND DISEASED HUMA NINTESTINE 82 1

E. Breese and T .T . MacDonald

LYMPHOCYTE SUBPOPULATIONS IN GUT-ASSOCIATED LYMPHOIDTISSUE OF CATTLE WITH EXPERIMENTAL MUCOSAL DISEASE 82 5

E.M . Liebler, J .F. Pohlenz, and V . Moennig

CLONAL ANTIBODY DOMINANCE AFTER INFLUENZA VACCINA -TION IN IgA NEPHROPATHY PATIENTS AND CONTROLS 82 9

J . Radl, C .M. Hoogeveen, A .W.L. van den Wall Bake, and J . Mestecky

STUDY OF SALIVARY AND SERUM SECRETORY IgA IN Ig AMESANGIAL NEPHRITIS AND PRIMARY GLOMERULO -NEPHRITIS 83 5

G. Rostoker, H. Terzidis, M. Petit-Phar, P . Lang, and B . Weil

STUDY OF INTESTINAL PERMEABILITY IN IgA MESANGIA LNEPHRITIS AND PRIMARY GLOMERULONEPHRITIS 83 9

G. Rostoker, V. Wirquin, H. Terzidis, M .-T. Chaumette ,P . Lang, and B . Wei l

IgE HETEROGENEITY AND BIOLOGICAL ACTIVITY

843

V. Zaväzal, V . Krauz, H.D. Kratzin, and N . Hilschmann

IMMEDIATE NASAL RESPONSE TO ALLERGEN CHALLENG ECYTOLOGIC CHANGES IN THE NASAL SECRETIONS AN DHISTOLOGIC CHANGES IN THE NASAL MUCOSA 84 7

Z. Pelikan and M. Pelikan-Filipek

LATE NASAL RESPONSE TO ALLERGEN CHALLENGE CYTOLOGICCHANGES IN THE NASAL SECRETIONS AND HISTOLOGICCHANGES IN THE NASAL MUCOSA 85 5

Z. Pelikan and M. Pelikan-Filipek

THE SIGNIFICANCE OF TRANSIENT MUCOSAL IgA DEFICIENC YON THE DEVELOPMENT OF ASTHMA AND ATOPY IN CHILDREN 86 1

M. Gleeson, A.W. Cripps, R.L. Clancy, M .J. Hensley ,R .J . Henry, and J .H. Wlodarczyk .

HYPERSENSITIVITY TO SOYBEAN PROTEINS IN EARLY WEANE DPIGLETS : HUMORAL AND CELLULAR COMPONENTS 865

D. Dreau, J .P . Lalles, C . LeJan, R. Toullec, and H . Salmo n

CD23/FCeRII IS CONSTITUTIVELY EXPRESSED ON HUMA NINTESTINAL EPITHELIUM, AND UPREGULATED IN COW' SMILK PROTEIN INTOLERANCE 87 1

D. Kaiserlian, A. Lachaux, I . Grosjean, P. Graber, and J.-Y. Bonnefoy

TWO-DIMENSIONAL ANALYSIS OF COW'S MILK ALLERGENSWITH THE IPG-DALT TECHNIQUE 875

V. Brodard, H . Bernard, J .M . Wal, B. David, and G. Peltre

COW'S MILK ALLERGY : THE HUMORAL IMMUNE RESPONSE T OEIGHT PURIFIED ALLERGENS 87 9

J .M . Wal, H. Bernard, C . Creminon, C . Hamberger, B . David ,and G. Peltre

REGIONAL SMALL INTESTINAL PASSAGE IN THE RAT TO SOMECOMMONLY USED PERMEABILITY PROBES 88 3

N. Pantzar, S . Lundin, L . Lindberg, and B .R. Weström

INTESTINAL PASSAGE OF 51 CR-EDTA AND OVALBUMIN IN THERAT WITH INTRA-ABDOMINAL SEPSIS 887

B.R. Weström, Q. Wang, N. Pantzar, B . Jeppsson ,and B . Karlsson

CHEMOSENSITIVE AFFERENT NERVES IN THE REGULATIO NOF GASTRIC BLOOD FLOW AND PROTECTION 89 1

P . Holzer

IMMUNOPHENOTYPING OF HEMATOLOGICAL NEOPLASMS . I .EXPRESSION OF PROGENITOR CELL SURFACE ANTIGEN (CD34) 89 7

K. Koubek, J . Marinov, and J . Starl

THE GENE FOR FAMILIAL MEDITERRANEAN FEVER IS MAPPE DTO 16p 13.3- p13 .1 WITH EVIDENCE FOR HOMOGENEITY 90 1

M. Shohat, N . Fischel-Ghodsian, J .I. Rotter, and Y.L. Danon

COMPARISON OF THE EFFECTS OF SULPHASALAZINE, 5-AMINO-SALICYLIC ACID AND SULPHAPYRIDINE ON THE HUMORALRESPONSE TO ANTIGEN IN VIVO 905

P. Sheldon and P . Pell

ADULT T CELL LEUKEMIA-DERIVED FACTOR AS ANENDOGENOUS RADICAL SCAVENGER 909

H. Nakamura, K . Furuke, M. Matsuda, T. Inamoto, and J . Yodoi

MICROBIAL, PARASITE, AND HIV MUCOSAL INFECTION S

IMMUNE REACTION OF PIGS FOLLOWING INTRA-GASTRIC ORILEAL INOCULATION OF ATTENUATED SALMONELLA TYPHI 91 3

M.K. Loftager, J . Elmerdahl-Olsen, and L . Eriksen

MUCOSAL IMMUNE RESPONSE IN PATIENTS WITH DYSENTERY 91 9

I . Ciznar, F . Qadri, S . Hoque, A .A. Bin, C . Schultsz ,and G. Bartkova

A MONOCLONAL ANTIBODY TO SHIGELLA DYSENTERIAE SERO -TYPE 13 CROSS-REACTING WITH SHIGA TOXIN 92 3

F. Qadri, T . Azim, A. Hossain, D . Islam, G . Mondal ,S .M. Faruque, and M .J . Albert

STOMACH LYMPHOCYTES IN EXPERIMENTAL HELICOBACTE RINFECTION 927

C. Williams, K . MacDonald, and A .M. Mowat

SELECTIVE INCREASE OF CD4 + AND CD25+ T CELLS BUT NOTOF 73 T CELLS IN H. PYLORI -ASSOCIATED GASTRITIS 93 1

C. Seifarth, A . Funk, K . Reich, I . Dähne, M. Classen ,and K . Deusch

MUCOSAL AND SERUM IgA ANTIBODIES IN PIGS FOLLOWIN GINFECTION WITH ACTINOBACILLUS PLEUROPNEUMONIAE 93 5

M.K. Loftager, L. Eriksen, and R. Nielsen

RECOGNITION OF ACIDIC PROTEINS OF GIARDIA MURISBY ANTI-TROPHOZOITE ANTIBODIES 939

M.F. Heyworth and J.A. Vergara

ELECTROPHYSIOLOGIC AND MORPHOLOGIC EFFECTS OFENTAMOEBA HISTOLYTICA LYSATES ON RABBIT COLON 945

F. Navarro-Garcia, R . Lopez-Revilla, and V . Tsutsumi

SPECIFIC ANTIAMEBIC SERUM ANTIBODIES IN MEXICANPUERPERAE AND THEIR NEWBORNS 949

L. Aguirre-Cruz, R . Lopez-Revilla, E . Zacapa, C . Martinez ,and O . Munoz

THE ROLE OF INTRA-EPITHELIAL AND LAMINA PROPRIALEUCOCYTES DURING INFECTION WITH EIMERIA TENELLA 95 3

L. Vervelde and S .H.M. Jeurissen

PATTERNS OF CYTOKINE mRNA IN TRICHINELLA SPIRALIS

INFECTED RATS 95 9

A.W. Stadnyk

SPECIFIC ANTI-E. HISTOLYTICA IgA MONOCLONAL ANTIBODIES 96 3

C. Ximenez, P . Moran, P . Ramos, O. Leyva, and E .I . Melendr o

IMMUNOPATHOLOGICAL RESPONSES OF DBA/2 MICE T O

PRIMARY INFECTIONS OF THE BILE DUCT TAPEWORM ,

HYMENOLEPIS MICROSTOMA AND THE EFFECT O F

ANTHELMINTIC TREATMENT 96 7

J . Andreassen and S . Holm

CYTOKINE REGULATION OF INTESTINAL MASTOCYTOSIS I NNIPPOSTRONGYLUS BRASILIENSIS INFECTION 97 1

I .M. Katona, J .F . Urban, Jr ., F .D. Finkelman, W .C . Gause ,and K.B . Madden

GLYCOCONJUGATES IN RAT SMALL INTESTINAL MUCOS ADURING INFECTION WITH THE INTESTINAL NEMATOD ENIP P OSTR ONG YL US BRASILIENSIS 97 5

T. Oinuma, T. Abe, Y. Nawa, J . Kawano, and T . Suganuma

CYTOKINE RESPONSE IN THE INTESTINAL LAMINA PROPRIA OFMICE AFTER INFECTION WITH FASCIOLA HEPATICA 97 9

P.J. van der Heijden, J .B .W.J . Cornelissen, E .G. Breedland ,H.F .J . Savelkoul, and A .T .J . Bianchi

EGG-NEGATIVE RESIDENTS OF AN OPISTHORCHIASIS-ENDEMI CAREA POSSESS HIGH LEVELS OF ANTI-OPISTHORCHIS ANTI-BODIES 98 3

P .S . Akai, S . Pungpak, V . Kitikoon, D . Bunnag, and D . Befu s

THE EFFECT OF T-CELL MITOGENS AND CYTOKINES ON TH EINFECTIVITY OF HUMAN FALLOPIAN TUBE MUCOSA B YCHLAMYDIA TRACHOMATIS 987

A. Khamesipour, E.J . Moticka, and M.D. Cooper

ANTIBODY SECRETING CELLS IN UPPER URINARY TRACTINFECTION : COMPARISON OF THE RESPONSE IN CHILDRE NAND ADULTS 99 1

A . Kantele, J . Kantele, O. Honkinen, J . Mertsola, and H. Arvilommi

DETECTION OF HEPATITIS C VIRUS (HCV)-RNA IN SALIV AAND GASTRIC JUICE 99 5

K. Komiyama, F. Kawamura, Y. Arakawa, H. Mastuo, N. Hayashi ,T . Shikata, and I . Moro

HERPES- AND CORONA-VIRUS INFECTION OF RAT LACRIMA LACINAR CELLS 999

L.A. Wickham, Z. Huang, R .W. Lambert, and D .A. Sullivan

INFECTIVITY BY HIV-1 OF HUMAN UTERINE ENDOMETRIALCARCINOMA CELLS 1003

E .J . Gosselin, A .L. Howell, L . Schwarz, R. Prabhala, R . Rossoll ,and C .R. Wira

IgA SUBCLASSES AND MOLECULAR SIZE IN CHILDREN WITHVERTICALLY TRANSMITTED HIV INFECTION 1007

F. Mascart-Lemone, J . Levy, S . Depelchin, J .-P . Dehennin ,R. Cooman, Y . Sibille, and J .-P. Vaerman

INTESTINAL IMMUNE RESPONSIVENESS IN HIV-INFECTEDINDIVIDUALS 101 1

K. Eriksson, A . Kilander, L. Hagberg, G . Norkrans, J . Holmgren ,and C . Czerkinsk y

LOSS OF CD4 POSITIVE T CELLS AND EVIDENCE FOR IMPAIREDDIFFERENTIATION OF BOTH CD4 AND CD8 POSITIVE T CELLS I NTHE LARGE INTESTINE OF PATIENTS INFECTED WITH HUMA NIMMUNODEFICIENCY VIRUS (HIV) 101 5

R. Ullrich, T. Schneider, C . Bergs, W. Schmidt, H .-U. Jahn ,A. Dormann, M. Zeitz, and the Berlin Diarrhea/Wasting SyndromeStudy Group

LOSS OF ACTIVATED CD4-POSITIVE T CELLS AND INCREASE I NACTIVATED CYTOTOXIC CD8-POSITIVE T CELLS IN THE DUO -DENUM OF PATIENTS INFECTED WITH HUMAN IMMUNO-DEFICIENCY VIRUS 101 9

T. Schneider, R . Ullrich, H.-U . Jahn, C. Bergs, W . Schmidt ,A. Dormann, M . Zeitz, and the Berlin Diarrhea/Wasting SyndromeStudy Group

BIASED T CELL RECEPTOR Vß REPERTOIRE OF INTESTINAL CD8 +T CELLS IN HIV DISEASE 102 3

K. Reich, I . Dähne, N . Endres, M. Classen, and K . Deusch

NEUTRALIZATION OF HIV INFECTION BY SERUM Ig AANTIBODIES 102 7

P. Kozlowski, R.W. Buckheit, Jr., and S . Jackso n

WHOLE AND PAROTID SALIVA IgA AND IgA-SUBCLAS SRESPONSES TO CANDIDA ALBICANS IN HIV INFECTION 103 1

S .P . Sweet, S .J . Challacombe, and J R . Naglik

DECREASED IgA-PRODUCING CELLS IN THE GUT OF SIV-INFECTE DRHESUS MONKEYS 103 5

S. Jackson, Z. Moldoveanu, J . Mestecky, A .M. Pitts, J .H . Eldridge ,

J .R. McGhee, C .J . Miller, and P.A. Mar x

FUNCTIONAL AND PHENOTYPIC LYMPHOCYTE POPULATIO NCHANGES IN THE MESENTERIC LYMPH NODES OF MURINE -AIDS INFECTED MICE 1039

M.C. Lopez, D.S . Huang, D .L. Way, and R .R. Watson

IMMUNOLOGY OF THE LIVER

TRANSPORT INTO RAT BILE OF RADIOLABELLED INTRAVENOU SHUMAN POLYMERIC IgAl AND IgA2, TREATED OR NOT WIT HNEURAMINIDASE 104 3

J .-P . Vaerman, A. Langendries, C .V. Maelen ,and M .F . Van DenHove

HEPATIC ELIMINATION OF CIRCULATING IgA IMMUNE COM-PLEXES : A COMPARISON BETWEEN RATS AND GUINE APIGS 1049

A. Johansson and T. Skog h

THE INVOLVEMENT OF KUPFFER CELLS AND LIVER ENDO-THELIAL CELLS IN THE CLEARANCE OF LARGE SIZEDSOLUBLE IgA AGGREGATES IN RATS 105 3

R.K. Stad, W.M.J .M. Bogers, L .A. van Es, and M.R. Daha

ISOLATION AND PRELIMINARY CHARACTERIZATION OF HUMA NMONONUCLEAR LIVER CELLS 1057

H.U. Jahn, R . Ullrich, T. Schneider, H .L . Schieferdecker ,D.C. Schmidt, P . Neuhaus, U . Hopf, E.O. Riecken, and M . Zeitz

IgA PRODUCTION AND TRANSPORT IN THE MURINE LIVE RAFTER MUCOSAL IMMUNIZATION 106 1

H .-Y. Wu, P .L . White, K .W. Beagley, G .D.F . Jackson ,J. Mestecky, and M .W. Russel l

DETECTION OF IgA AND ITS RECEPTOR IN THE EXOCRINEPANCREAS AND THE EXTRAHEPATIC BILE DUCT OF THE RAT 106 7

X .B . Havaux, J .-P . Vaerman, P. Maldague, and P .J . Courtoy

MULTIPLE INTRAPERITONEAL INJECTIONS OF TURKEY SERU MCAUSE A MAJOR ENLARGEMENT OF THE BILIARY TREE INB ALB/c MICE 107 1

K. Goto, X .B. Havaux, P . Maldague, P .J . Courtoy, P.G. Pierre ,A. Langendries, and J .P. Vaerma n

ANTIBODY BINDING TO LIVER CELLS AND CELL DIFFEREN -TIATION STATE 107 5

T. Morizane, T . Watanabe, T . Kagawa, R . Tsunematsu ,S . Tada, S . Miyaguchi, H . Saito, and M. Tsuchiy a

EXPRESSION OF INTERFERON-y GENE IN THE LIVER FROMPATIENTS WITH LIVER AND GASTROINTESTINAL TRAC TDISEASES 107 9

H. Fukuma, S .A. Morshed, S . Watanabe, and M . Nishioka

TUMOR NECROSIS FACTOR a - A CONSTITUTIVE PROTEINOF BILE 108 3

G.D.F. Jackson, Y . Dai, C . Fung, and P .G .C . Hansen

ANTI-PARIETAL CELL ANTIBODY IN AUTOIMMUNE LIVERDISEASES IS ASSOCIATED WITH GASTRIC MUCOSAL ATROPHYAND INTESTINAL METAPLASIA 108 7

H. Oya , Y . Uchida, S .A. Morshed, and M . Nishioka

CYTOKINE GENE EXPRESSION IN THE LIVER

109 1

S .A. Morshed, H. Fukuma, and M . Nishioka

ORAL IMMUNOLOGY AND IMMUNOPATHOLOG Y

INTRAEPITHELIAL LYMPHOCYTES EXPRESSING TCRyS I NHUMAN GINGIVAL TISSUES 1097

C. Lundqvist, S . Hammarström, and M .-L. Hammarströ m

CHARACTERIZATION OF CYTOKINE PRODUCING T CELLS, TC REXPRESSION, AND IgA PLASMA CELLS IN SALIVARY GLAND-ASSOCIATED TISSUES 1103

J . Mega, J .R. McGhee, and H . Kiyon o

LOCAL ANTIBODIES AND CYTOKINE RESPONSES IN CREVICULA RFLUID OF PATIENTS WITH JUVENILE PERIODONTITIS 1109

J . Bärtovä, O. Krejsa, M . Sirovä, H . Tlaskalovä, J . Prochäzkovä ,and J . Duskov ä

GENERATION AND DISTRIBUTION OF ANTIBODY SECRETINGCELLS IN SALIVARY GLANDS OF MICE IMMUNIZED WIT HPORPHYROMONAS GINGIVALIS FIMBRIAE 111 3

S . Hamada, T . Ogawa, and Y. Kusumot o

EXPRESSION AND IMMUNOGENICITY OF A CLONEDPORPHYROMONAS GINGIVALIS HEMAGGLUTININ I NSALMONELLA TYPHIMURI UM 111 9

D.M. Dusek, A . Progulske-Fox, and T.A . Brown

T-SUBSETS AND DISTURBED IMMUNOREGULATION INPATIENTS WITH PERIODONTAL DISEASE 112 3

E. Heumader, B . Albini, I . Moschen, G. Wick, and H . Wolf

CHANGES IN NEUTROPHIL FUNCTION IN PATIENTS WIT HEARLY ONSET PERIODONTITIS ACCORDING TO FAMIL YOCCURRENCE OF THE DISEASE 112 7

J . Prochäzkovä, J . Bärtovä, O . Krejsa, R . Smausovä,J. Duskovä, and L . Mrklas

VLA-4/VCAM-1 PATHWAY IN HUMAN PERIODONTAL DISEASE 113 1

T. Tsurumachi, K . Nishi, M . Hayashi, T . Saito, I . Saito,and I . Moro

y/S T LYMPHOCYTES IN MARGINAL PERIODONTITIS INPATIENTS WITH DOWN'S SYNDROME 113 5

P.D.C. SOhoel, R . Jonsson, A .C. Johannessen, and R . Nilse n

PEPTIDE MAPPING AND AMINO ACID SEQUENCE ANALYSIS O FTHE 40 KDA OUTER MEMBRANE PROTEIN OF FUSOBACTERIUMNUCLEATUM 1137

H.C . SOhoel and E .N. Vasstran d

DEVELOPMENT OF SALIVARY IgA ANTIBODY TO ORAL STREP -TOCOCCAL ANTIGENS ASSOCIATED WITH VIRULENCE 114 1

D.J . Smith and M .A. Taubman

DENTAL CARIES AND SALIVARY ANTI-STREPTOCOCCUSMUTANS ANTIBODIES IN IgA DEFICIENT CHILDREN 114 5

F.R.C. Fernandes, A . T. Nagao, F. Zelante, andM.M.S. Carneiro-Sampaio

DIFFERENCES IN SECRETORY IgA AND SERUM ANTIBODIE STO STREPTOCOCCUS MUTANS ISOLATES FROM CARIES -RESISTANT AND CARIES-SUSCEPTIBLE SUBJECTS 1149

R.L. Gregory, L.E. Gfell, and H .S . Malmstrom

INDUCTION OF SALIVARY IgA RESPONSES TO STREPTOCOCCUSMUTANS ANTIGEN I/Il AFTER INTRANASAL IMMUNIZATION 115 3

J . Katz, M.W. Russell, C .C. Harmon, G.P. Buckner, P .L . White ,G.J . Richardson, and S .M. Michalek

POTENTIAL FOR GLUCOSYLTRANSFERASE-BASED SYNTHETI CPEPTIDES IN A DENTAL CARIES VACCINE 115 7

D.J . Smith and M .A. Taubman

LACK OF CROSS-REACTION OF ANTIBODIES AGAINST CELL -ASSOCIATED GLUCOSYLTRANSFERASE FROM STREPTOCOCCUSMUTANS WITH HUMAN HEART TISSUE 116 1

T. Iwase, J . Hiraoka, T . Horikoshi, S. Hamada, and I. Moro

THE CONCENTRATIONS OF SECRETORY IMMUNOGLOBULIN AAND SPECIFIC S-IgA ANTIBODIES IN THE SALIVA OF SCHOO L

CHILDREN 1167

T .G. Nuesslein, C . Goebel, F . Riedel, H. Prinz ,and C.H.L. Rieger

IMMUNIZATION AGAINST THE ORAL INDIGENOUS BACTERI AOF THE BALB/c MOUSE 117 3

H. Marcotte, L . Rodrigue, M . Gamache, and M .C. Lavoi e

OLIGOSACCHARIDES IN MUCOSAL HOST DEFENSE :MODEL, METHOD AND FIRST DATA 117 7

A. Kage, S . Fimme, J .-P . Bernimoulin, S . Hägewald ,I. Nitschke, R . Kage, and E . Köttge n

POSSIBLE ROLE OF EBV IN ORAL SQUAMOUS CELL CARCINOMA -EBV INHIBITS PROGRAMMED CELL DEATH OF SQUAMOU SCELLS 118 3

T. Tanka, I . Kudo, and I. Moro

EXPRESSION OF ras-P21 IN SALIVARY GLAND TUMORS

118 7

K. Kusama, L . Chu, T . Suzuki, S . Okutsu, I . Kudo, and I . Moro

AUTOIMMUNITY, ORAL TOLERANCE, AND AGING

AUTOIMMUNE REACTIONS INDUCED BY GLIADIN 119 1

H. Tlaskalovä-Hogenovä, R . Stepänkova, L . Tuckovä, M .A .Farre, V. Vetvicka, J . Trävnicek, J . Kolilnskä, P . Kocna, P . Fric ,M. Holub, M . Zoric, L . Nilsson, H. Ascher, and L . Hanson

INFLUENCE OF ANDROGEN THERAPY ON LACRIMAL AUTO -IMMUNE DISEASE IN A MOUSE MODEL OF SJÖGREN'S SYN -DROME 1199

D.A. Sullivan, F .J . Rocha, and E .H . Sato

T-CELL RECEPTOR V-GENE USAGE IN SJÖGREN'S SYNDROME 1203

C. Fredriksen, A.C. Johannessen, and R . Jonsson

PREFERENTIAL USE OF THE VHID IMMUNOGLOBULIN GENEFAMILY FOR THE SYNTHESIS OF RHEUMATOID FACTORS 1207

M. Abderrazik, M . Moynier, and J . Brochie r

GENE HYPOTHESIS OF AUTOIMMUNITY, AND AUTOIMMUN EDISEASE 121 3

W.B . Storch

TREATMENT OF AUTOIMMUNE DISEASES BY ORAL TOLERANC E

TO AUTOANTIGENS 121 7

H.L. Weiner, A . Miller, S .J . Khoury, Z .J . Zhang, A . Al-Sabbagh ,

S .A . Brod, O. Lider , P . Higgins, R. Sobel, M. Matsui, M .

Sayegh, C. Carpenter, G. Eisenbarth, R .B . Nussenblatt, and D .A .

Haller

ORAL TOLERANCE IN HUMANS : T CELL BUT NOT B CELLTOLERANCE TO A SOLUBLE PROTEIN ANTIGEN 122 .

S . Husby, J . Mestecky, Z . Moldoveanu, and C.O. Elson

ORAL TOLERANCE TO OVALBUMIN IN MICE : EFFECT OF SOMEPARAMETERS ON THE INDUCTION AND PERSISTENCE OF THESUPPRESSION OF SYSTEMIC IgE AND IgG ANTIBOD YRESPONSES 122'.

M.C. Moreau, M. Coste,V. Gaboriau, and C . Dubuquo y

EVIDENCE OF A DIRECT ROLE FOR MUCOSAL IMMUNE CELLS I NTHE INDUCTION OF ORAL TOLERANCE 123_̀

E. Furrie, M. Turner, and S . Strobel

THE ABSENCE OF GUT FLORA HAS NO EFFECT ON THEINDUCTION OF ORAL TOLERANCE TO OVALBUMIN 1239

E. Furrie, M. Turner, and S . Strobel

SPECIFIC IMMUNOLOGICAL NON-RESPONSIVENESS INDUCEDBY ANTIGENS VIA MUCOSAL SURFACES 124 3

B . Metzler and D.C. Wraith

THE INFLUENCE OF ANTIGEN DIGESTION IN ORALLY INDUCEDIMMUNITY AND TOLERANCE 1245

S.L . Jain and J.G. Michael

MUCOSAL SUPPRESSION BY ORAL PRE-TREATMENT WIT HOVALBUMIN AND ITS CONVERSION INTO STIMULATION WHE NOVALBUMIN WAS CONJUGATED TO CHOLERA TOXIN OR ITS BSUBUNIT 125 1

P .J . van der Heijden, W. Stok, and A .T .J . Bianch i

CHRONIC INFLAMMATION, INFLAMMATORY BOWEL DISEASESAND CELIAC DISEAS E

EXPLOITATION OF THE WHOLE GUT LAVAGE TECHNIQUE FO RIN VIVO ASSESSMENT OF INTESTINAL IMMUNITY AND INFLAM-MATORY BOWEL DISEASE 125 7

A. Ferguson, C.P . Choudari, O . Mwantembe, and L. Handy

THE INCIDENCE OF COLONIC NATURAL KILLER CELLS, LARG EGRANULAR LYMPHOCYTES AND MAST CELLS IN INFLAMMA -TORY BOWEL DISEASE 126 1

L.R. Emmons, U . Schaub, and F . Hadziselimovic

EVIDENCE FOR A REGULATORY "DEFECT" FOR CD4 POSITIV EINTESTINAL T CELLS IN VITRO IN PATIENTS WITH IB DCOMPARED TO NORMALS 126 7

M. Niessner, W . Gerok, and B .A. Volk

EPITHELIAL DEPOSITS OF IMMUNOGLOBULIN GI AND ACTI-VATED COMPLEMENT CO-LOCALIZE WITH THE "Mr 40kD "PUTATIVE AUTO ANTIGEN IN ULCERATIVE COLITIS 127 3

T.S . Halstensen, K .M . Das, and P . Brandtzae g

IMMUNOGLOBULIN SUBCLASS DISTRIBUTION OF ANTI-LP SANTIBODY-SECRETING CELLS OF COLONIC MUCOSA FROMPATIENTS WITH INFLAMMATORY BOWEL DISEASE 127 7

M. Arashi, K . Konno, and A . Yach i

CELL ACTIVATION AND PROLIFERATION IN THE LARG EINTESTINE OF PATIENTS WITH CROHN'S DISEASE O RULCERATIVE COLITIS AND CONTROLS 128 1

R . Ullrich, T. Schneider, H .L . Schieferdecker, H .-U . Jahn ,E .O. Riecken, and M . Zeitz

ALTERED EXPRESSION OF T CELL DIFFERENTIATION ANTIGEN SIN T CELLS ISOLATED FROM THE LARGE INTESTINE O FPATIENTS WITH CROHN'S DISEASE OR ULCERATIVE COLITIS 128 3

R . Ullrich, T. Schneider, H .-U . Jahn, H.L . Schieferdecker,S .R. Wicz, E .O. Riecken, and M . Zeit z

ACTIVATION OF LAMINA PROPRIA T LYMPHOCYTES INCROHN'S DISEASE 128 7

L. Qiao, G . Schürmann, S .C . Meuer, and F . Autschbac h

ALTERATIONS IN THE CYTOTOXIC ACTIVITY OF CROHN'S DIS -EASE PERIPHERAL BLOOD T CELLS EXPRESSING DIFFEREN TT CELL RECEPTOR VARIABLE GENE PRODUCTS 129 3

M.E. Baca-Estrada and K . Croitoru

IN SITU DETECTION OF INTERLEUKIN-18 AND INTERLEUKIN 8IN BIOPSY SPECIMENS FROM PATIENTS WITH ULCERATIV ECOLITIS 129 7

S.A. Radema, G .N .J . Tytgat, and S .J .H. van Deventer

EFFECTS OF MESALAZINE ON THE FORMATION O FLIPOXYGENASE AND CYCLOOXYGENASE PRODUCTS 130 1

K. Lauritsen, L .S . Laursen, J. Kjeldsen, K . Bukhave ,T.K. Hansen, and J . RaskMadsen

LEUKOCYTE-ENDOTHELIAL CELL INTERACTIONS : POTENTIALTARGETS FOR MESALAZINE IN CROHN'S DISEASE 1307

A .J . Wakefield, M. Hudson, and R .E . Pounder

P-ANCA AS A DIFFERENTIAL DIAGNOSTIC MARKER I NINFLAMMATORY BOWEL DISEASE 131 3

K. Oberstadt, W. Schaedel, M . Weber, M . Classen, and K. Deusc h

ANTIOXIDANT PROPERTIES OF 5-AMINOSALICYLIC ACID :POTENTIAL MECHANISM FOR ITS PROTECTIVE EFFECT INULCERATIVE COLITIS 131 7

A.M. Miles and M.B . Grisham

INTERFERON ALFA-2A (ROFERON) AS A TREATMENT O FINFLAMMATORY BOWEL DISEASE IN CHILDREN AN DADOLESCENTS 132 3

F. Hadziselimovic, U . Schaub, and L .R. Emmon s

DISTRIBUTION AND DENSITY OF TNF IMMUNOREACTIVITY INCHRONIC INFLAMMATORY BOWEL DISEASE 1327

S.H . Murch, C.P . Braegger, J .A . Walker-Smithand T .T . MacDonal d

4D5.4, A MONOCLONAL ANTIBODY WHICH RECOGNIZES CELL SIN INFLAMED HUMAN INTESTINE 133 1

J . Taylor, T .T . MacDonald, and J . Spence r

TCRy/S+ AND CD8+TCRcx/ INTRAEPITHELIAL LYMPHOCYTES(IEL) EXPRESS PROLIFERATION MARKER (Ki-67) IN THE

COELIAC LESION 1333

T.S . Halstensen and P . Brandtzae g

ANALYSIS OF MARKER GENES CONTRIBUTING TO COELIA CDISEASE SUSCEPTIBILITY 133 9

E. Roschmann, T .F . Wienker, W. Gerok, and B .A. Volk

JEJUNAL FLUID ANTIBODIES AND MUCOSAL GAMMA/DELTA IE LIN LATENT AND POTENTIAL COELIAC DISEASE 134 5

E. Arranz and A. Ferguson

IgA SUBCLASS DISTRIBUTION OF IgA ANTI-GLIADIN ANTIBODIE SIN FECES OF PATIENTS WITH COELIAC DISEASE 1349

L. Haas, M. Petit-Phar, H. Terzidis, N . Kapel, D. Meillet,J .-G . Gobert, and G. Rostoker

SOLUBLE CD4 ANTIGEN IS INCREASED IN ACTIVE COELIA CDISEASE 135 5

A. Blanco, J .A. Garrote, M. Alonso, E . Arranz, and C. Calvo

THE INTERACTION OF GLIADIN WITH EFFECTOR AND TARGETCELLS IN NK CELL ACTIVITY OF PATIENTS WITH CELIACDISEASE 135 9

H.H. Nguyen, M.A. Farre, H. Tlaskalovä, M. Pospisil ,and P . Fric

CRYPT EPITHELIAL CELLS EXPRESS THE 4F2 ANTIGEN I NUNTREATED COELIAC MUCOSA 136 3

L. Maiuri, R. Troncone, S . Fais, S . Coletta, A . Picarelli ,and F . Pallone

SHORT-TERM CULTIVATION OF DUODENAL BIOPSIES IN PATIENTSWITH COELIAC DISEASE . EFFECT OF THE GLUTEN CHALLENGEAND GLIADIN PEPTIDES 1367

P. Kocna, P . Fric, H . Tlaskalovä, V. Krchnäk, E . Kasafirek ,M. Siovä, and C. Czerkinsky

INTERACTION OF NATURAL AND SYNTHETIC PEPTIDES DERIVE DFROM GLIADIN WITH DIFFERENT CELL LINES 137 1

M .A . Farre, H. Tlaskalovä, H .H. Nguyen, P. Kocna, L .Tuckovd, V . Krchnäk, V . Vetvicka, M . Baudisovä, M. Pospisil ,and P . Fri c

DOSE- AND TIME-DEPENDENT ULTRASTRUCTURAL AN DFUNCTIONAL LESIONS OF THE COLONIC MUCOSA B YENTAMOEBA HISTOLYTICA LYSATES 137 5

F. Navarro-Garcia, R . Lopez-Revilla, and V . Tsutsumi

IMMUNOPATHOGENETIC MECHANISMS IN SPONDYLARTHRO -PATHY AND GUT INFLAMMATION 137 9

C.A. Cuvelier, H . Mielants, J . Ouatacker, M . De Vos, E . Veys ,and H. Roel s

RECURRING VIRAL PATHOLOGY AND IMMUNOLOGICA LIMPLICATIONS 138 1

P . Grima, A. De Maria, M. Massa, A. Romano, and P . Tundo

IMMUNOLOGICAL STUDIES OF THE MUCOSA IN COLITISINDUCED BY SODIUM DEXTRAN SULFATE IN RATS 138 3

H. Takizawa, H . Asakura, T . Sasakawa, H . Bannai,and M. Nomoto

NON-LYMPHOID CELLS IN EXPERIMENTAL INFLAMMATOR YBOWEL DISEASE 1389

E.P. van Rees, M. Soesatyo, M . van der Ende, A.S . Pena ,and T. Sminia

IMMUNOHISTOCHEMICAL STUDY OF RAT PEYER'S PATCHE SIN PEPTIDOGLYCAN-POLYSACCHARIDE COMPLEX-INDUCE DCHRONIC ENTERITIS 1395

S. Tanaka, S . Miura, H. Suzuki, N . Ohkubo, H. Imaeda ,H. Shiozaki, H . Tashiro, H. Serizawa, and M. Tsuchiya

ORAL MERCURIC CHLORIDE LEADS TO INTESTINAL BASEMENTMEMBRANE (IBM) IMMUNE COMPLEX DEPOSITION AND FECA LPROTEIN LOSS 1399

P. Knoflach, B . Albini, and M.M. Weise r

THE ROLE OF NITRIC OXIDE IN ENTEROPATHY

140 3

P. Garside, A. Severn, F.Y. Liew, and A . McI . Mowat

INDUCTION OF MUCOSAL IMMUNE RESPONSES AND VACCIN EDELIVERY SYSTEM S

INDUCTION OF SPECIFIC IMMUNITY AT MUCOSAL SURFACES :PROSPECTS FOR VACCINE DEVELOPMENT 140 9

C. Czerkinsky, M . Quiding, K. Eriksson, I . Nordström, M . Lakew ,C. Weneräs, A . Kilander, S . Björck, A.-M. Svennerholm, E .Butcher, and J . Holmgren

MUCOSAL RESPONSIVENESS AS A DETERMINANT OF PRO-TECTION MECHANISMS INDUCED BY ORAL IMMUNIZATION 1417

R. Clancy, G . Pang, and A . Cripps

ORAL IMMUNIZATION STUDIES WITH STREPTOCOCCUSMUTANS AND INFLUENZA VACCINES IN RHESUS MACAQU EMONKEYS 142 3

S.M. Michalek, A.A. Lackner, J . Katz, M.W. Russell, J .H .Eldridge, J . Mestecky, R . Lallone, and Z. Moldovean u

THE ANTIBODY RESPONSE IN INFANTS AFTER ORALADMINISTRATION OF INACTIVATED AND LIVING E. COLIVACCINES AND THEIR PROTECTIVE EFFECT AGAINS TNOSOCOMIAL INFECTIONS 143 1

R. Lodinovd-Zädnikovä, H . Tlaskalovä, B. Korych ,and Z . Bartdkov ä

DO CD5 B CELLS RESPOND TO ORAL ANTIGENS? 1439

K.W. Beagley, C .A. Black, S . DiFabio, J .R . McGhee ,J .F. Kearney, and J .H. Eldridg e

INDUCTION OF SPECIFIC ANTIBODY RESPONSES IN THEHUMAN NASOPHARYNGEAL MUCOSA 144 5

M. Quiding, M. Lakew, G . Granström, I . Nordstrom ,J . Holmgren, and C . Czerkinsky

PHENOTYPIC CHARACTERIZATION OF CIRCULATING ANTI-BODY-SECRETING CELLS AFTER MUCOSAL AND SYSTEMICIMMUNIZATIONS IN HUMANS 145 1

M. Lakew, I . Butcher, and C . Czerkinsky

INDUCTION OF CTL BY ORAL IMMUNIZATION

145 5

G.A. Enders

IMMUNIZATION BY THE ENTERAL AND RESPIRATORY ROUTEWITH VIABLE AND INACTIVATED BACTERIA RESULTS IN ADIFFERENTIAL INCREASE IN LYMPHOCYTE SUBSETS IN TH EBRONCHOALVEOLAR SPACE 145 9

R. Pabst, S . Delventhal, A . Hensel, and K . Petzold t

BIODEGRADABLE MICROPARTICLES AS ORAL VACCINES 146 3

D.T. O'Hagan, H. Jeffery, K.J . Maloy, A . MCI. Mowat ,D. Rahman, and S .J . Challacombe

INTRADUODENAL IMMUNIZATION WITH MICROENCAPSULATE DCFA/II INDUCES A DELAYED, ANTI-CFA/II, IgG ANTIBODY -SECRETING SPLEEN CELL RESPONSE 1469

K. Sau, R.H. Reid, C. McQueen, E .C. Boedeker,R. Nellore, P . Dalai, and H.R. Bhagat

XENOBIOTIC POLYMERS AS VACCINE VEHICLES 147 5

L.G. Payne, S .A. Jenkins, A . Andrianov, R . Langer,and B .E . Robert s

ORAL IMMUNIZATION WITH DEHYDRATED LIPOSOMES CONTAININ GSTREPTOCOCCUS MUTANS GLUCOSYLTRANSFERASE (GTF) INHUMANS 148 1

N.K. Childers, S .S . Zhang, and S .M. Michalek

FLUORESCENT LABELLING OF VIRUS, BACTERIA AND ISCOMS :IN VIVO SYSTEMIC AND MUCOSAL LOCALISATION PATTERNS 1485

I . Claassen, A . Osterhaus, W. Boersma, M. Schellekens ,and E. Claassen

BIOADHESIVE POLYMERS FOR ORAL DRUG DELIVERY

149 1

B. Rihovä, R.C . Rathi, P . Kopeckovä, and J . Kopecek

PRESENCE OF ANTIGEN-SPECIFIC LONG-TERM MEMOR YCELLS IN SYSTEMIC LYMPHOID TISSUES AS WELL A SLOCALLY IN THE GUT LAMINA PROPRIA FOLLOWIN GORAL IMMUNIZATION WITH CHOLERA TOXIN ADJUVANT 1495

M. Vajdy and N . Lycke

CHOLERA TOXIN ENHANCES ANTIGEN PRESENTATION

150 1

A.K. Bromander, M . Kjerrulf, J . Holmgren, and N . Lycke

CHOLERA TOXIN INCREASES T LYMPHOCYTE RESPONSES TOUNRELATED ANTIGENS 1507

E. Hornquist and N . Lycke

MOLECULAR ENGINEERING OF CHOLERA TOXIN

151 3

W.N. Burnette, H.R. Kaslow, and J . Mos s

EFFECT OF CHOLERA TOXIN AND ITS B SUBUNIT O NINTESTINAL PERMEABILITY FOR OVALBUMIN 151 9

P.G. Pierre, E .G.M. Mbella, and J .-P . Vaerma n

CHOLERA AND PERTUSSIS TOXINS, BUT NOT FORSKOLIN ORLT-B, ADJUVANT IgA ANTIBODY RESPONSES TO ORALL YADMINISTERED ANTIGEN 1523

A.D. Wilson, A . Robinson, L . Irons, C.R. Stokes,and P.W. Bland

THE KINETICS OF AN INTESTINAL IMMUNE RESPONSE

1527

P.J. van der Heijden, I .H. Muileman, and W . Stok

CHOLERA TOXIN MEDIATED CELLULAR IMMUNE RESPONSE SAGAINST OVALBUMIN ADMINISTERED ORALLY 153 1

J .C. Bowen, R .M. Reddy, and B .T . Rouse

INDUCTION OF TRANSMISSIBLE GASTROENTERITIS CORONA -VIRUS SPECIFIC IMMUNE RESPONSES USING VECTORS WITHENTERIC TROPISM 1535

L. Enjuanes, C . Smerdou, C .M. Sanchez, C . Sune, S . Kelly ,R. Curtiss III, and J .M. Torre s

EXPRESSION AND STABILITY OF HERPES SIMPLEX VIRU SANTIGENS IN SALMONELLA TYPHIMURIUM 154 3

J .C. Bowen, R .M . Reddy, H .O. Alpar, M.R.W. Brown,and B . Rouse

LACTOBACILLI : VEHICLES FOR ANTIGEN DELIVERY TO TH EFEMALE UROGENITAL TRACT 154 7

C.M. Rush., L .M . Hafner, and P. Timm s

NEW AND SAFE "ORAL" LIVE VACCINES BASED ON LACTO -BACILLUS 155 3

E. Claassen, R. Van Winsen, M . Posno, and W .J .A. Boersma

MUCOSAL AND SYSTEMIC RESPONSES FOLLOWING ENTERI CEXPOSURE TO LACTIC ACID BACTERIA 155 9

P.M. Norton, H .W.G. Brown, and R.W.F . Le Pag e

SPECIFIC ANTIBODY-PRODUCING CELLS IN HUMANS AFTE RORAL IMMUNIZATION WITH A RIBOSOMAL VACCINERIBOMUNYL TM 156 3

M.C. Bene, C . Zanin, P . Perrin, A .M. Perruchet, C .M . Mole ,and G.C . Faure

INDUCTION OF IgA AND IgG ANTIBODIES IN VAGINAL FLUID ,SERUM AND SALIVA FOLLOWING IMMUNIZATION OF GENITALAND GUT ASSOCIATED LYMPHOID TISSUE 156 7

L.A. Bergmeier, L . Tao, A .J .M. Gearing, S . Adams, and T . Lehner

T CELL RESPONSES IN MACAQUES AFTER VAGINAL IMMUNI -ZATION WITH PARTICULATE SIV P27 ANTIGEN 157 5

C. Panagiotidi, L .A. Bergmeier, A .J.M. Gearing, S .E . Adams ,and T. Lehner

MUCOSAL IMMUNIZATION WITH A RECOMBINANT ADENO-VIRUS VECTOR INDUCES LOCAL AND SYSTEMIC IMMUNIT YAND PROTECTION FROM HERPES SIMPLEX VIRUS 158 1

W.S . Gallichan, D .C. Johnson, F .L . Graham, and K.L. Rosentha l

Ig-SECRETING AND INTERFERON-y-PRODUCING CELLS INMICE MUCOSALLY IMMUNIZED WITH INFLUENZA VIRUS 158 7

M. Novak, M . Yamamoto, K . Fujihashi, Z . Moldoveanu ,H. Kiyono, J .R. McGhee, and J . Mestecky

CELL-MEDIATED IMMUNITY IN OWL MONKEYS FOLLOWINGINOCULATION WITH HEPATITIS A VIRUS 159 1

L.V.S . Asher, R.A. Vassell, L .N. Binn, and Y .E . Polotsk y

ORAL IMMUNIZATION AGAINST RESPIRATORY VIRUSES I NMICE 159 5

J . Nedrud, N . Sigmund, E . Brunschwig, and M . Lamm

ANTI-HSV-I HERPES VACCINATION BY LUPIDON H : PRELIMINARYRESULTS 1599

A. De Maria, P . Tundo, A . Romano, and P. Grima

NASOPHARYNGEAL AND SYSTEMIC HUMORAL RESPONSESINDUCED BY TRIVALENT A'1'lENUATED POLIOMYELITI SVACCINE IN NEWBORNS 160 1

J .C . Padilla-Ramos, J . Casasola, A. Berber, P .A. Valdivia -Gallardo, E .R. Leal, and G . Acosta-Altamirano

MUCOSAL AND SYSTEMIC IMMUNIZATION WITH PNEUMOCOC -CAL POLYSACCHARIDE TYPE 3, 4 AND 14 IN THE RAT 1605

G.P.J .M. van den Dobbelsteen, K . Brunekreef, T . Sminia ,and E .P . van Ree s

AEROSOL TREATMENT OF PIGS WITH A CTINOBA CILLUSPLEUROPNEUMONIAE SEROTYPE 2 : MUCOSAL IMMUNIT YAND RESISTANCE AGAINST CHALLENGE 161 1

M.K. Loftager, L. Eriksen, and R. Nielsen

IMMUNITY TO AEROSOLIZED STAPHYLOCOCCAL ENTEROTOXIN B 161 5

J . Tseng, J . Komisar, J .Y. Chen, R . Hunt, A.J . Johnson ,L . Pitt, and D. Rubl e

COMPARATIVE STUDY OF BRONCHOALVEOLAR LAVAGES INNORMAL SUBJECTS AND IN PATIENTS WITH CHRONICPULMONARY OBSTRUCTIVE DISEASE 162 1

A. Berber, L . Iglesias, and S. Torre s

ORAL VACCINES AGAINST CHOLERA AND ENTEROTOXIGENI CESCHERICHIA COLI DIARRHEA 162 3

A.-M. Svennerholm and J . Holmgren

IMPAIRED MUCOSAL IMMUNE REPONSE IN VITAMIN ADEFICIENT RATS IMMUNIZED WITH ORAL CHOLERA VACCINE 1629

U . Wiedermann, L.A. Hanson, J . Holmgren, and U .I . Dahlgren

WHY DO WE NOT YET HAVE A SUITABLE VACCINE AGAINS TCHOLERA? 163 3

R.A. Finkelstei n

VACCINE-SPECIFIC T CELLS IN HUMAN PERIPHERAL BLOO DAFTER ORAL IMMUNIZATION WITH AN INACTIVATED ENTERO -TOXIGENIC ESCHERICHIA COLI VACCINE 164 1

C. Wenneräs, C . Czerkinsky, and A .-M. Svennerholm

ORAL IMMUNIZATION INDUCES HUMORAL AND CELL-MEDIATED IMMUNITY AND PROTECTS GERM-FREE MICEAGAINST INFECTION FROM HELICOBACTER FELIS 1645

S.J . Czinn, A . Cai, S .P .B . Sellman, and J .G. Nedrud

IMPAIRMENT OF IMMUNOGENICITY OF SALMONELLA TYPHITy2l a DUE TO PRE-EXISTING CROSS-REACTING INTESTINALANTIBODIES 164 9

B .D. Forrest

ASSESSMENT OF ATTENUATED SALMONELLA TYPHIMURIUMSTRAINS DESIGNED AS POTENTIAL CARRIERS OF FOREIG NANTIGENS FOR MUCOSAL LOCALIZATION AND IMMUNO -GENICITY IN A RABBIT MODEL 165 3

E.C. Boedeker, H .-S .H . Houng, D . Hone, L .-Y. Tseng ,M. Wolf, and C . McQueen

HUMORAL IMMUNE RESPONSE AGAINST S. TYPHIMURIUMANTIGEN FRACTIONS AND PROTECTION 1659

G.M. Calderon, C . Perez, C . Ximenez, and E .I . Melendro

ORAL IMMUNIZATION AGAINST MUCOSAL CANDIDIASIS IN AMOUSE MODEL 166 3

D. Rahman and S .J . Challacombe

AUTHOR INDEX 1667

SUBJECT INDEX 1677