Activespheres Vit C PMgViscoelastic microspheres of magnesium ascorbyl phosphate (Vit C PMg) which provide 25% more skin permeation and prolonged release of the active, in addition to promoting greater stability against degradation reactions.

Vitamin CAscorbic acid is the most demanded ingredient for the treatment and maintenance of skin health due to its known benefits:

One of the vitamin C derivatives, magnesium ascorbyl phosphate stands out for high stability, but it has low skin permeability compared to its acid form.Activespheres Vit C PMg is an encapsulation system that combines the high stability of magnesium ascorbyl phosphate and the advanced permeation system for an intelligent release of the active on the skin.

Instability in contact with oxygen, light and water

Antioxidant Anti-inflammatoryAnti wrinkleSkin lightening

Disadvantage that compromises the effectiveness of vitamin C

Before permeation

Proteases action:free vitamin C PMg

Phosphatases action:free ascorbic acid

Deformation of the capsuleThe capsule returns to its initial format

Activespheres Vit C PMg Permeation MechanismViscoelastic Property of the Microcapsules

Note*1ml of Activespheres Vit C PMg dispersion in saline solution (NaCl 0.9%)

AfterBefore

Efficacy

Permeation Test in Polycarbonate Membrane

Optical microscopy analysis before and after permeation of Activespheres Vit C PMg microcapsules.

Note**average of 2.35% of Vit C PMg in Activespheres Vit C PMg

Efficacy

Permeation Testing

In Vivo

Confocal Raman Spectroscopy analysis after 4 hours of application.

3 volunteers 30 to 50 years old

Application of 32 mg/each product in the forearm

• Free Vit C PMg 1% • Activespheres Vit C PMg** 1%

Activespheres Vit C PMgFree Vit C PMg

Vit C

PM

g (u

.a.)

5000

1000150020002500

1800

25% 2250

2 Polycarbonate membranes(Pore diameter: 30 nm)

Adding sample*

Pressure 2.5 atm(36.7 Psi)

T = 37°C (98.6°F)

chemyunion.com

• Creams• Lotions• Cream-gels• Serums

1-10%

Water (and) Butylene glycol (and) Magnesium ascorbyl phosphate (and) Atelocollagen (and) Sodium chondroitin sulfate (and) Xanthan gum (and) Polysorbate 20.

• 25% more active permeation• Extended-release of Vit C PMg • 90% more collagen production compared to control – greater firmness and elasticity • 12% reduction in melanin production compared to control – skin whitening effect

Benefits

INCI

Application

Concentration of Use