W W W . I M E D E X . C O M

Chairs

Ruth M. O’Regan, MDWinship Cancer Institute

Emory UniversityAtlanta, Georgia

Christy A. Russell, MDUniversity of Southern California

Los Angeles, California

Organized forExamining and Debating Current Clinical Challenges

August 13, 2011New York, New York

The Helmsley Hotel

First Announcement

August 13, 2011 • New York, New York

Continuing Medical EducationPhysicians

Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide

continuing medical education for physicians.

Imedex, LLC designates this live educational activity for a maximum of 7.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Who Should AttendThis educational activity is designed for medical oncologists, radiation oncologists, surgical oncologists, and other healthcare providers involved and/or interested in the diagnosis, treatment, and management of patients with breast cancer.

ObjectivesUpon completion of this activity, participants should be able to:

Demonstrate increased knowledge regarding:

o Results of recent clinical trials of novel agents in early and advanced disease

o Key issues in breast cancer management

Feel more confi dent in their ability to:

o Comment on the optimal timing of sentinel lymph node biopsy

o Discuss the use bisphosphonates or monoclonal antibodies to prevent bone metastases

o Describe the clinical relevance of PARP inhibitors in breast cancer

Increase the frequency (compared to baseline)

with which they plan to:

o Use mutation status and genomic classifi ers to predict outcomes and select optimal treatments for each patient

Examining and Debating Current Clinical Challenges

FacultyMary Cianfrocca, DOBanner MD Anderson Cancer CenterGilbert, Arizona

Scott Christensen, MDUniversity of California Davis Cancer CenterSacramento, California

Stefan Glück , MD, PhD, FRCPC University of Miami Miami, Florida

Mohammed Jahanzeb, MD, FACPSylvester Comprehensive Cancer CenterDeerfi eld Beach, Florida

Monica Morrow, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

Ruth M. O’Regan, MDWinship Cancer Institute Emory UniversityAtlanta, Georgia

Christy A. Russell, MDUniversity of Southern California Los Angeles, California

Stephen F. Sener, MDUniversity of Southern California Los Angeles, California

Conference Organizer

11675 Rainwater DriveSuite 600Alpharetta, Georgia 30009 USATel.: +1 (770) 751 7332Fax: +1 (770) 751 7334Email: meetings@imedex.comwww.imedex.com

Scientifi c AgendaSaturday, August 13, 20117:30 am Breakfast and registration

8:00 am Welcome and introduction

8:05 am Demographic survey

Session I: Updates and Previews 8:10 am Pre-session audience survey

8:15 am News surrounding optimal neoadjuvant therapy for HER2-positive disease: Emerging data from NeoALTTO and similar investigations

8:30 am Potential of novel strategies in metastatic breast cancer

8:45 am Adjuvant bisphosphonates and other bone-directed agents: What we know about timing, duration, and choice of therapy

9:00 am Importance of pathologic and complete response in breast cancer subtypes

9:15 am Panel discussion: Top 5 potentially practice-changing strategies to come

9:35 am Post-session audience survey

9:40 am Coffee break

Session II: Great Debates on Breast Cancer Controversies10:00 am When is the optimal timing of SLN biopsy in clinically node

negative patients? Before preop chemo vs. After preop chemo

10:30 am Should we move away from the current use of PARP inhibitors in breast cancer for now? Yes vs. No

11:00 am Will chemotherapy be obsolete for HER2+ breast cancer in the near future? Yes vs. No

11:30 am Lunch with the Professors

12:30 pm Should gene array assays be routinely used in node positive disease? Yes vs. No

1:00 pm Should bisphosphonates be routinely used to prevent disease recurrence in early stage disease? Yes vs. No

1:30 pm Is there a role for trastuzumab-based therapy for HER2-positive T1 a/b tumors? Yes vs. No

2:00 pm Should nodal status always dictate adjuvant therapy? Yes vs. No

2:30 pm Coffee break

Session III: Teaching Lectures on Special Topics2:50 pm Pre-session survey

How I Manage…

2:55 pm Very young breast cancer patients

3:05 pm Infl ammatory breast cancer

3:15 pm Patients with brain metastasis

3:30 pm The need (or lack of need) of an axillary dissection for patients with positive sentinel node biopsy

3:45 pm Role of new genomic classifi ers in the loco-regional management of early-stage breast cancer

4:00 pm Post-session survey

Session IV: Challenging Cases*Attendees will be able to bring cases for the panel and submit them at the registration desk to be incorporated in this session. The Faculty panel will include perspectives from medical oncology and surgical oncology.

4:05 pm Faculty panel: Challenging cases

4:45 pm Audience questions

5:00 pm Closing remarks and adjourn

Quotes from your colleagues“The debate format was a great source of additional info, especially since the presenters were from various institutions and areas of country.”

“An excellent meeting” { {Support

The following company provided an educational grant in support of this conference:

Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) 751 7332 or by email atcme@imedex.com.

Call for Exhibitors

Exhibit space is available to companies interested in participating in this conference through exhibition. For more information, please contact Imedex at +1 (678) 242 0719 or by email at exhibits@imedex.com.

Visit www.imedex.com for the most up-to-date agenda and to register.

x.com for the most up-to-date agenda and to registe

Four EASY ways to register

ONLINE. . .www.imedex.com

FAX US. . .+1 (678) 242 0920

C ALL US. . .The Registrar will take your registration over the phone.+1 (678) 242 0906

MAIL US. . .Imedex®11675 Rainwater Drive, Suite 600Alpharetta, Georgia 30009 USA

R E G I S T R AT I O N F E E SPHYSICIANSPayment received by August 8, 2011

$150

NURSES/RESIDENTS/STUDENTSProof of eligibility must accompany reg-istration; cannot be combined with any other discounts.

$75

To Register: You may register online by August 8, 2011 at www.imedex.com by calling Imedex at +1 (678) 242 0906 or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confi rmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specifi ed.

The Registration and Information Desk at the New York Helmsley Hotel will be staffed:

Saturday, August 13, 2011. . . . . . .7:30 am – 5:00 pm

Payment: To pre-register, registration and payment must be received no later than August 8, 2011. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the course is being held as scheduled and to confi rm that the meeting is not full.

Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received.

Registration Fee Inclusions: Registration fees include admittance to all scientifi c sessions, conference materials, processing of certifi cates of attendance or continuing medical education, and all event functions as specifi ed in the agenda.

Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than August 8, 2011. The amount of registration fees remitted, minus a $50 administrative charge, will be refunded after the conference. Substitutions are accepted with written notifi cation. No refunds will be made if notice is received after August 8, 2011.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.

Conference Location and Hotel Accommodations The New York Helmsley Hotel212 East 42nd Street New York, New York 10017 Tel.: +1 (212) 490-8900 Fax: +1 (212) 405-4299

For the convenience of attendees, a room block with a limited number of rooms has been reserved at the discounted group rate of $249.00 single/double occupancy, plus tax, currently at 14.75% and $3.50 per room per night occupancy charges. This limited number of discounted rooms will be available until 5:00 pm local New York City time on July 13, 2011. This discounted rate is not guaranteed outside the conference dates. Reservations received after 5:00 pm local New York City time on July 13, 2011 or after the room block has been fi lled (whichever comes fi rst) are subject to availability and prevailing hotel rates.

To book your room, please contact the The New York Helmsley Hotel reservations department at +1(212) 490-8900 or visit the hotel’s website at www.newyorkhelmsley.com.

Examining and Debating Current Clinical Challenges

Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda’s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES’ RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED.

In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society.

© 2011 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.

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Organized forExamining and Debating Current Clinical Challenges

R E G I S T R A T I O N F E E S A 2 7 1 . 0 1

PhysiciansPayment received by July 18, 2011 $150

Nurses/Residents/Students*Proof of eligibility must accompany registration; cannot be combined with any other discounts.

$75

R E G I S T R A N T I N F O R M A T I O N

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Check if you require special facilities or assistance and attach a note with specific details and requirements.

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Nurse (please specify credentials): ___________________________

Other: __________________________________________________

S P E C I A LT Y :

Medical Oncology Nursing Radiation Oncology

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__________________________________________________________EMAIL ADDRESS

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Check in the amount of $ _______________________________

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NOTE: After August 8, 2011 only credit card payments will be accept-ed for pre-registration.

To pre-register, registration and payment must be received no later than August 8, 2011. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure that the meeting is being held as scheduled and to confirm that the meeting is not full.

For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than August 8, 2011. The amount of registration fees remitted, minus a $25 adminis-trative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after August 8, 2011.

Imedex does not accept responsibility for covering travel, accom-modation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice.

Save time and register online at www.imedex.com

“The meeting was really valuable for me, and Imedex organization makes a big difference.”