C H A I R S :

John M. Kirkwood, MD University of Pittsburgh Medical Center University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States

Alexander M.M. Eggermont, MD, PhD Erasmus University Medical Center Daniel Den Hoed Cancer Center Rotterdam, The Netherlands

C O - C H A I R S :

Keith T. F laherty, MD University of Pennsylvania Philadelphia, Pennsylvania

Craig L. Slingluff, Jr., MD University of Virginia Charlottesville, Virginia

Susan M. Swetter, MD Stanford University Medical Center Stanford, California

October 8-10, 2009 Baltimore, MarylandRenaissance Harborplace Hotel

W W W . I M E D E X . C O M

4-6 November 2009Baltimore, Maryland

Renaissance Harborplace Hotel

4-6 November 2009Baltimore, Maryland

Renaissance Harborplace Hotel

MELANOMA XIIIP E R S P E C T I V E S I N

MELANOMA XIIIP E R S P E C T I V E S I N

4-6 November 2009Baltimore, Maryland

Renaissance Harborplace HotelMELANOMA XIIIP E R S P E C T I V E S I N

First Announcement and Call for Abstracts

Dear Colleague,

It is with great pleasure that we invite you to join us for Perspectives in Melanoma XIII. This fall’s conference, October 8-10, 2009 in Baltimore, Maryland, promises to be an outstanding educational conference!

Perspectives in Melanoma XIII has become a premier forum for discussion on the latest advances in melanoma research and emerging therapies. With an interactive and exciting scientific agenda planned, this conference provides an overview of the most current and controversial topics in the field of melanoma.

With 12 years of exceptional educational content, this conference remains a forum to update your knowledge in the field, confirm your current practices and receive essential take-home information on exciting new screening and staging modalities, management approaches, emerging treatment options and clinical trial updates. Providing an overview of recent advances, Perspectives in Melanoma XIII is led by renowned thought leaders and current investigators in melanoma; this conference will expand several of the most promising new leads from the bench to the clinic.

Over 200 physicians, researchers, nurses other healthcare professionals attended Perspectives in Melanoma XI in 2007 in California and nearly 400 attended last year in The Netherlands. Attendees of both appreciated the scope and depth of the information on disease biology, management, and research presented.

Additionally, the valuable opportunity to interact with colleagues and learn from key thought leaders in melanoma, as well as network with the diverse mix of oncologists, surgeons, dermatologists and researchers who attend, is immeasurable.

We look forward to seeing you for what is sure to be a rewarding and dynamic experience; your diverse perspectives and contributions add immeasurable value to this educational and interactive conference! Sincerely,

John M. Kirkwood, MD, Chair Alexander M.M. Eggermont, MD, PhD, Chair

Keith T. Flaherty, MD, Co-Chair Craig L. Slinghuff, Jr., MD, Co-Chair Susan M. Swetter, MD, Co-Chair

L e t t e r f r o m

t h e C h a i r s

October 8-10, 2009 - Baltimore, Maryland

Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to

provide continuing medical education for physicians.

This activity has been approved for AMA PRA Category 1 Credit TM.

W h o S h o u l d At t e n d

This educational activity is specifically designed for medical and surgical oncologists, dermatologists, and other physicians, physicians-in-training, and researchers interested and/or involved in the treatment of patients with melanoma and associated complications.

E d u c a t i o n a l O b j e c t i v e s

Upon completion of this educational activity, attendees should be able to:

• Discuss important aspects of the biology, pathogenesis and epidemiology of melanoma

• Evaluate emerging technologies for biomarker identification and the potential impact of biomarkers on treatment and management of melanoma

• Integrate important advances in diagnostic and imaging methodologies into clinical practice

• Describe emerging concepts and progress in the role of surgery and staging of melanoma

• Explain the role of the immune system in melanoma pathogenesis and identify immunological targets for therapy

• Evaluate the therapeutic benefit from immunotherapeutic strategies such as anti–CTLA-4 monoclonal antibodies and Toll-like receptor agonists based on their effect on the signaling pathways involved in T-cell regulation and activation

• Analyze recent progress in melanoma vaccine development

• Discuss the molecular biology and therapeutic potential of targeting signal transduction pathways involved in the pathogenesis of melanoma, such as the MAPK and PI3K pathways, as well as mediators of angiogenesis

• Recommend appropriate strategies for therapeutic intervention in patients with metastatic melanoma

October 8-10, 2009 - Baltimore, Maryland

c o n t i n u i n g m e d i c a l e d u c a t i o n

s c i e n t i f i c To p i c s

• Epidemiology, genetics, and prevention

- Increasing burden of melanoma in young women - Differential effects of UVA and UVB radiation

• Detection and prognosis

- Automated detection and diagnosis - Molecular diagnostic assays - Prognostic significance of lymphatic invasion

• Surgery and Staging

• Immunomodulation

- Molecular insight on the impact of toll-like receptor agonists - Tumor localization of T-cells - Myeloid-derived suppressive cells - Melanoma vaccines

• Emerging molecular targets in melanoma

• Adjuvant therapy

• Chemotherapy

• Drug resistance

• Management of brain metastases

• Clinical trial updates

• Special address to the melanoma community by Valerie Guild of the Charlie Guild Melanoma Foundation

*Please visit www.imedex.com for the most up-to-date program and to register.

C o r p o r a t e S u p p o r t

Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) 751 7332 or by email at cme@imedex.com.

E n d o r s i n g S o c i e t i e s

Renaissance Harborplace Baltimore Hotel 202 East Pratt Street Baltimore, Maryland 21202 Tel.: +1 (410) 547 1200 Fax: +1 (410) 539 5780 Renaissancehotels.com/bwish

The Renaissance Harborplace Baltimore Hotel is delighted to showcase a new distinctive design featuring modern urban sophistication. The hotel is situated just steps from the area's most unique sights and attractions. Enjoy premier access to the world-famous Inner Harbor - home to the Baltimore Aquarium, the Maryland Science Center. The Renaissance Baltimore hotel's WATERTABLE restaurant/lounge and Ground Floor Café have become local favorites, boasting award-winning culinary talent and offering an all-natural menu bringing stylish twists to each season's finest ingredients. Refresh in comfortable yet refined environs at the Renaissance hotel in Baltimore Inner Harbor. Experience the rich culture of Charm City, in a vibrant location sure to delight you, at this Baltimore Inner Harbor hotel.

For the convenience of attendees, a limited number of rooms have been reserved until September 16, 2009 at a discounted rate of $199.00 for single or double occupancy, plus tax, currently at 13.5%. This rate is not guaranteed outside the conference dates or after September 16, 2009.

To reserve your room please contact the Renaissance Harborplace Baltimore Hotel reservations department at +1 800 Hotels-1 (+1 (800) 468-3571. To receive the group rate, callers must identify themselves as being with the Imedex USA block or use the market code DEXC. You may also visit the hotel’s website at www.renaissanceharborplace.com. Internet users must enter the meeting promotional code: DEXDEXA. Reservation requests received after September 16, 2009 may not be guaranteed the group rate.

h o t e l a c c o m m o d a t i o n sImedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda’s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES’ RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED.

In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society.

Copyright © 2009 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.

October 8-10, 2009 - Baltimore, Maryland

C a l l f o r a b s t r a c t sParticipants interested in presenting data should submit abstracts online at www.imedex.com by August 17, 2009. Abstracts are subject to acceptance by the Scientific Committee. Once accepted, abstracts will be published in the final course book and scheduled for oral or poster presentation.

Acceptance notifications and guidelines for poster presentation will be sent on September 7, 2009. Authors of accepted abstracts who have not registered will have until September 24, 2009 to do so at the rate of $299.00. After this date, abstracts without registered presenters will be disregarded.

Submit your abstract online by going to www.imedex.com, selecting this Congress and following the instructions in the “Abstracts” section.

• Follow the online instructions

• Abstracts must be written in English

• Accepted format: Word document format, 9 point Arial font, 500 word count limit

• Use a concise title

• List affiliations of author(s) as briefly as possible, with city, state and country

• Place an asterisk (*) before the name of the presenting author

• Use standard and well-accepted abbreviations

• When using references, use standard and well-accepted formats

• Abstract content should be single- spaced, typed in lower case and contain: - Purpose of the study - Summarized description of the project - Results and conclusions

Ab s t r a c t G u i d e l i n e s

S u b m i s s i o n D e a d l i n e : August 17, 2009

S u b m i s s i o n I n s r u c t i o n sGo to www.imedex.com, select this Congress and follow instructions in the “Abstracts” section.

October 8-10, 2009 - Baltimore, Maryland

C o n f e r e n c e L o c a t i o n a n d R e g i s t r a t i o n

Renaissance Harborplace Baltimore Hotel 202 East Pratt Street Baltimore, Maryland 21202 Tel.: +1 (410) 547 1200 Fax: +1 (410) 539 5780 Renaissancehotels.com/bwish

The Registration and Information Desk will be staffed: Thursday, October 8, 2009 7:30 am – 4:20 pm Friday, October 9, 2009 8:00 am – 4:40 pm Saturday, October 10, 2009 8:00 am – 12:30 pm

I m p o r t a n t D a t e s

Visit www.imedex.com to learn more

ONLINE products are produced by Imedex in 6 user-friendly formats

LIVE meetings are produced by Imedex in 15 countries

PRINT materials are produced by Imedex for your reference needs

3 Wa y s t o L e a r n :

Discounted Registration Deadline August 6, 2009

Abstract Submission Deadline August 17, 2009

Abstract Notifications Mailed September 7, 2009

Abstract Presenter Registration Deadline September 24, 2009

Regular Registration Deadline October 1, 2009

Presentation Dates October 8-10, 2009

q Check if you require special facilities or assistance and attach a note with specific details and requirements.

_______________________________________________________________________________________ FAMILY NAME GIVEN NAME MI

DEGREE: qMD qPhD qPharmD q RN qOther Degree ________________________________________

SPECIALTY: qDermatology qMedical Oncology q Nursing qRadiation Oncology qResearch

qSurgery qOther _______________________________________________________________________ ________________________________________________________________________________________ EMAIL ADDRESS ____________________________________________________________________________________________________ TELEPHONE FAX ____________________________________________________________________________________________________ INSTITUTE DEPARTMENT ___________________________________________________________________________________________________ ADDRESS

___________________________________________________________________________________________________ CITY STATE / PROVINCE

___________________________________________________________________________________________________ ZIP / POSTAL CODE COUNTRY

A105.01C O N g r e s s r e g I s T r AT I O N

r e g I s T r AT I O N F e e s

q $299.00 Discounted If payment received by August 6, 2009

q $399.00 Regular If payment received by October 1, 2009

q $499.00 Full/Onsite If payment received after October 1, 2009

q -$50.00 Group discount (physicians only)* *cannot be combined with any other discounts

q $199 .00 Nurses/Students/Residents* *proof of eligibility must accompany registration

Credit card transactions will appear under the name Imedex, LLC on your next statement.

To pre-register, registration and payment must be received no later than October 1, 2009. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure that the program is being held as scheduled and to confirm that the meeting is not full.

For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than October 1, 2009. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after October 1, 2009.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this program should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice.

q American Express q MasterCard q Visa

q Check in the amount of $________________________________________________________________

Card No. _____________________________________________________ Exp. Date: __________/__________

ONLINE www.imedex.com

FAX +1 (678) 242 0920

CALL +1 (678) 242 0906

MAIL Imedex®,4325 Alexander Dr. Alpharetta, Georgia 30022-3740, USA

F o u r E A S Y w a y s t o r e g i s t e r :

PAY M e N T M e T H O D

October 8-10, 2009 - Baltimore, Maryland

To R e g i s t e r : You may register online by October 1, 2009 at www.imedex.com, by calling Imedex at +1 (678) 242 0906 or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified.

Pa y m e n t : To pre-register, registration and payment must be received no later than October 1, 2009. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received.

R e g i s t r a t i o n F e e I n c l u s i o n s : Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the program.

C a n c e l l a t i o n : For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than October 1, 2009. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after October 1, 2009.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this program should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.

r e g i s t r a t i o n p r o c e d u r e

r e g i s t r a t i o n f e e sDiscounted .................................. $299.00 If payment received by August 6, 2009

Regular ....................................... $399.00 If payment received by October 1, 2009

Full/Onsite .................................. $499.00 If payment received after October 1, 2009

Group discount (physicians only)* .... -$50.00 *cannot be combined with any other discounts

Nurses/Students/Residents * ........... $199 *proof of eligibility must accompany registration

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