NeuroImage 13, Number 6, 2001, Part 2 of 2 Parts 10 E b[@ PSYCHIATRY A LONGITUDINAL MRI STUDY OF POSTERIOR INFERIOR VERMIS VOLUME IN CHILDHOOD ONSET SCHIZOPHRENIA (COS) Audrey Keller, A. Catherine Vaituzis, Lan Tran, Neal 0. Jeffries, Jonathan Blumenthal, Jay N. Giedd, Judith L. Rapoport, F. Xavier Castellanos Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892; Phone: 301-594-2499; Fax: 301-402-0296; Email address: [email protected] Objective: Childhood Onset Schizophrenia (COS) has been under study at the NIMH since 1990. Previous prospective brain MRI studies have found progressive cortical gray matter volume decrement in the frontal and temporal regions of adolescent COS patients, and progressive ventricular enlargement. Since a previous cross-sectional study of 24 patients showed that the volume of the posterior inferior lobules of the vermis was smaller in COS (L.K. Jacobsen et al, 1997), we hypothesized that the posterior inferior vermis volume would continue to decrease over time. Method: The volume of the posterior inferior lobules of the vermis was measured on 66 brain MRI scans from 42 COS (16 females) and on 59 scans from 42 controls (14 females). Scans were obtained approximately two years apart, at ages ranging from 9 to 22. Three raters obtained interrater reliabilities of 0.95, 0.94 and 0.99; intrarater reliabilities were 0.97, 0.92 and 0.90. A mixed model regression (to combine cross-sectional and longitudinal data) was used to detect linearand non-linear relationships with age for each diagnostic group (Wald test). Results: Initial results for the current sample showed an age related increase in healthy subjects that was absent in COS for posterior inferior vermis volume during adolescence (p= 0.05 two-tailed). This parallels the differential loss of total cerebral volume seen in COS. Conclusion: Results to be presented will reflect a doubling of the present sample size and analysis of the midsagittal areas of the 3 vet-ma1 lobes. Based on our preliminary data, we tentatively conclude that COS patients exhibit progressive loss of volume in the posterior inferior cerebellar vermis, in contrast to findings in cerebellar hemispheres which do not decrease differentially for COS. Reference: L.K. Jacobsen, J.N.Giedd, P.C.Berquin, A.L. Krain, S.D.Hamburger, S.Kumra, and J.L.Rapoport. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am.J.Psychiatry 154 (12): 1663-1669, 1997. S1065

A longitudinal MRI study of posterior inferior vermis volume in childhood onset schizophrenia (COS)

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Page 1: A longitudinal MRI study of posterior inferior vermis volume in childhood onset schizophrenia (COS)

NeuroImage 13, Number 6, 2001, Part 2 of 2 Parts 10 E b[@

PSYCHIATRY

A LONGITUDINAL MRI STUDY OF POSTERIOR INFERIOR VERMIS VOLUME IN CHILDHOOD ONSET SCHIZOPHRENIA (COS)

Audrey Keller, A. Catherine Vaituzis, Lan Tran, Neal 0. Jeffries, Jonathan Blumenthal, Jay N. Giedd, Judith L. Rapoport, F. Xavier Castellanos

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892; Phone: 301-594-2499; Fax: 301-402-0296; Email address: [email protected]

Objective: Childhood Onset Schizophrenia (COS) has been under study at the NIMH since 1990. Previous prospective brain MRI studies have found progressive cortical gray matter volume decrement in the frontal and temporal regions of adolescent COS patients, and progressive ventricular enlargement. Since a previous cross-sectional study of 24 patients showed that the volume of the posterior inferior lobules of the vermis was smaller in COS (L.K. Jacobsen et al, 1997), we hypothesized that the posterior inferior vermis volume would continue to decrease over time.

Method: The volume of the posterior inferior lobules of the vermis was measured on 66 brain MRI scans from 42 COS (16 females) and on 59 scans from 42 controls (14 females). Scans were obtained approximately two years apart, at ages ranging from 9 to 22. Three raters obtained interrater reliabilities of 0.95, 0.94 and 0.99; intrarater reliabilities were 0.97, 0.92 and 0.90. A mixed model regression (to combine cross-sectional and longitudinal data) was used to detect linearand non-linear relationships with age for each diagnostic group (Wald test).

Results: Initial results for the current sample showed an age related increase in healthy subjects that was absent in COS for posterior inferior vermis volume during adolescence (p= 0.05 two-tailed). This parallels the differential loss of total cerebral volume seen in COS.

Conclusion: Results to be presented will reflect a doubling of the present sample size and analysis of the midsagittal areas of the 3 vet-ma1 lobes. Based on our preliminary data, we tentatively conclude that COS patients exhibit progressive loss of volume in the posterior inferior cerebellar vermis, in contrast to findings in cerebellar hemispheres which do not decrease differentially for COS.

Reference: L.K. Jacobsen, J.N.Giedd, P.C.Berquin, A.L. Krain, S.D.Hamburger, S.Kumra, and J.L.Rapoport. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am.J.Psychiatry 154 (12): 1663-1669, 1997.

S 1065