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Catalog no. 90364, June 2011, 831 pp.ISBN: 978-1-4200-9036-9

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Biomedical optics holds tremendous promise to deliver effec-tive, safe, non- or minimally invasive diagnostics and target-ed, customizable therapeutics. Handbook of BiomedicalOptics provides an in-depth treatment of the field, includingcoverage of applications for biomedical research, diagnosis,and therapy. It introduces the theory and fundamentals ofeach subject, ensuring accessibility to a wide multidisciplinaryreadership. It also offers a view of the state of the art and dis-cusses advantages and disadvantages of various techniques.

Organized into six sections, this handbook: • Contains introductory material on optics and the optical properties

of tissue • Describes the various forms of spectroscopy and its applications in

medicine and biology, including methods that exploit intrinsic absorption and scattering contrast; dynamic contrast; and fluorescence and Raman contrast mechanisms

• Provides extensive coverage of tomography from the microscopic (optical coherence tomography) to the macroscopic (diffuse opticaltomography) to photoacoustic tomography

• Discusses cutting-edge translations to biomedical applications in both basic sciences and clinical studies

• Details molecular imaging and molecular probe development• Highlights the use of light in disease and injury treatment

The breadth and depth of multidisciplinary knowledge inbiomedical optics has been expanding continuously and

exponentially, thus underscoring the lack of a singlesource to serve as a reference and teaching tool for

scientists in related fields. Handbook ofBiomedical Optics addresses this need, offering

the most complete up-to-date overview ofthe field for researchers and students alike.

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FEATURES • An in-depth introduction to the field,

including applications for biomedicalresearch, diagnosis, and therapy

• Includes the theory and fundamentalsof each subject with the aim of accessibility to a wide multidisciplinaryreadership

• Discusses advantages and disadvantagesof various state-of-the-art techniques

• Introduces the principles of optics,lights sources, and irradiation; as wellas basic concepts in tissue optics

• Covers spectroscopic methods, including tomographic imaging, microscopic imaging methods, molecular probe development, andphototherapy

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CONTENTS

Preface, David A. Boas, Constantinos Pitris, and Nimmi Ramanujam

I. BackgroundGeometrical Optics, Ting-Chung PoonDiffraction Optics, Colin SheppardOptics: Basic Physics,

Raghuveer ParthasarathyLight Sources, Detectors, and Irradiation

Guidelines, Carlo Amadeo Alonzo,Malte C. Gather, Jeon Woong Kang,Giuliano Scarcelli, and Seok-Hyun Yun

Tissue Optical Properties, Alexey N. Bashkatov, Elina A. Genina,and Valery V. Tuchin

II. Spectroscopy and SpectralImaging

Reflectance Spectroscopy, Sasha McGee,Jelena Mirkovic, and Michael Feld

Multi/Hyper-Spectral Imaging, Costas Balas, Christos Pappas, and George Epitropou

Light Scattering Spectroscopy, Le Qiu,Irving Itzkan, and Lev T. Perelman

Broadband Diffuse OpticalSpectroscopic Imaging, Bruce J. Tromberg, Albert E. Cerussi, So-Hyun Chung, Wendy Tanamai, andAmanda Durkin

Near Infrared Diffuse CorrelationSpectroscopy for Assessment ofTissue Blood Flow, Guoqiang Yu,Turgut Durduran, Chao Zhou, Ran Cheng, and Arjun G. Yodh

Fluorescence Spectroscopy, Darren Roblyer, Richard A. Schwarz,and Rebecca Richards-Kortum

Raman, SERS and FTIR Spectroscopy,Andrew J. Berger

III. Tomographic ImagingOptical Coherence Tomography:

Introduction and Theory, Yu Chen,Evgenia Bousie, Constantinos Pitris,and James G. Fujimoto

Functional Optical CoherenceTomography in Preclinical Models,Melissa C. Skala, Yuankai K. Tao, Anjul M. Davis, and Joseph A. Izatt

Optical Coherence Tomography:Clinical Applications, Brian D. Goldberg,Melissa J. Suter, Guillermo J. Tearney,and Brett E. Bouma

Forward Models of Light Transport inBiological Tissue, Andreas H. Hielscher,Hyun Keol Kim, and Alexander K. Klose

Inverse Models of Light Transport,Simon Arridge, Martin Schweiger, and John C. Schotland

Laminar Optical Tomography, Sean A. Burgess and Elizabeth M. C. Hillman

Diffuse Optical Tomography usingContinuous Wave and FrequencyDomain Imaging Systems, Subhadra Srinivasan, Scott C. Davis,and Colin M. Carpenter

Diffuse Optical Tomography: TimeDomain, Juliette Selb, and Adam Gibson

Photoacoustic Tomography andUltrasound-Modulated OpticalTomography, Changhui Li, Chulhong Kim, and Lihong V. Wang

Optical and Photoacoustic MolecularTomography of Small Animals, Vasilis Ntziachristos

IV. Microscopic ImagingAssesing Microscopic Structural

Features Using Fourier-Domain LowCoherence Interferometry, Robert N. Graf, Francisco E. Robles,and Adam Wax

Phase Imaging Microscopy: BeyondDarkfield, Phase and DifferentialInterference Contrast Microscopy,Chrysanthe Preza, Sharon V. King,Nicoleta M. Dragomir, and Carol J. Cogswell

Confocal Microscopy, William C. Warger II,Charles A. DiMarzio, andMilind Rajadhyaksha

Fluorescence Microscopy withStructured Excitation Illumination,Alexander Brunner, Gerrit Best, Roman Amberger, Paul Lemmer,Thomas Ach, Stefan Dithmar, Rainer Heintzmann, and Christoph Cremer

Nonlinear Optical Microscopy forBiology and Medicine, Daekeun Kim,Heejin Choi, Jae Won Cha, and Peter T. C. So

Fluorescence Lifetime Imaging Micro-scopy, Endoscopy and Tomography,James McGinty, Clifford Talbot, Dylan Owen, David Grant, Sunil Kumar,Neil Galletly, Bebhinn Treanor, Gordon Kennedy, Peter M. P. Lanigan,Ian Munro, Daniel S. Elson, Anthony Magee, Dan Davis, Gordon Stamp, Mark Neil, Christopher Dunsby, and Paul W. M. French

Application of Digital HolographicMicroscopy in Biomedicine, Christian Depeursinge, Pierre Marquet,and Nicolas Pavillon

Polarized Light Imaging of BiologicalTissues, Steven L. Jacques

V. Molecular Probe DevelopmentMolecular Reporter Systems for Optical

Imaging, Walter J. Akers, andSamuel Achilefu

Nanoparticles for Targeted Therapeuticsand Diagnostics, Timothy Larson, Kort Travis, Pratixa Joshi, and Konstantin Sokolov

Plasmonic Nanoprobes for BiomolecularDiagnostics of DNA Targets, Tuan Vo-Dinh, and Hsin-Neng Wang

VI. PhototherapyPhotodynamic Therapy, Jarod C. Finlay,

Keith Cengel, Theresa M. Busch, andTimothy C. Zhu

Low Level Laser and Light Therapy,Ying-Ying Huang, Aaron C-H Chen,and Michael R. Hamblin

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Handbook of Biomedical Optics

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