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Combined approved technologies
Continuous Manufacturing
Prospekt Nr. 655
swiss made
Continuous Mixing and Granulation
The two Swiss companies Gerteis® and Gericke present the world’s
first solution for continuous tablet manufacturing. Therefore the
Gerteis® compacting and granulating technology is combined with
feeding and mixing solutions from Gericke. Both systems are fully
developed and have been proven in the market.
Approved systems for a reliable production
The most important challenge for the pharmaceutical industry is to
take the QbD concept and look at its manufacturing processes in
‘lean’ terms to start to adapt for a more efficient future. Gerteis® dry
granulation and Gericke continuous mixing process technologies are
ideally suited to the new era of efficient solid dose pharmaceutical
manufacturing.
Combining the continuous Gericke feeding and continuous mixing
and Gerteis® advanced dry granulation will enable consistent, cont-
rolled and stable granulated products to be manufactured. Using the
latest PAT techniques constant density can be achieved, leading to
consistent granule properties ideal for tableting and capsule filling
technologies.
ulation
Continuous Feeding and Mixing Technology
by Gericke
Process Control
Continuous metering and control of flow rates of API and Exciptients
Continuous metering of mixer content and mean mixing time
Chemical composition e.g. by on line NIR spectroscopy
Gericke continuous mixing systems have a capacity from 5kg/h to
500 kg/h and are used in the pharma industry for:
Precise and compact continuous feeding and mixing of API and
excipients
Minimising risk of segregation
Addition of lubricants
Wetting of mixtures upstream wet granulation or fluid bed granu-
lation
Mixing upstream roller compaction
Easy to Clean
Gericke feeders and mixers are designed for quick and easy cleaning.
All parts with product contact can be removed in short time for
cleaning.
y
Gericke continuo
500 kg/h and are
Precise and
excipients
Minimising r
Addition of
Continuous Roller Compaction & Dry Granulation
by Gerteis®
Gerteis® dry granulation technology is already a continuous technology
extensively proven. With the low energy compaction capability it minimises
high energy losses likely to generate control and process variability for
example caused by temperature variation.
Best suited for continuous manufacturing
Gerteis® advanced roller compaction technology has a number of control
parameters that are process critical and that are tightly controlled, defined
and stable. By calibrating this control functionality, a long-term stable,
consistent and a repeatable process can be achieved. There is also a signi-
ficant benefit to this tight repeatable control in terms of scale up and rapid
process stabilisation essential aspects of continuous manufacturing. This
also provides a much greater design space for process developers allowing
much improved capability with input raw material variability also providing
a wider compression window improving tableting speed, and tablet solubi-
lity for example by compressing at lower compression forces.
extensivel
high energ
example ca
Best suite
Gerteis® a
paramete
and stable
consistent
Product capacity
Mini-Pactor® for development, pilot plant, clinical and small scale production:
10 Grams up to 100 kg/h
Macro-Pactor® for development, pilot plant, clinical and full scale production:
100 Grams up to 400 kg/h
Area of applicationThe versatility of the machines from Gerteis
® and Gericke allows to
process virtually all kinds of powder, even the most difficult ones.
And with our ingenious machine design, the cleaning cycles are fast
and thorough, enabling you to switch between batches swiftly.
A wide range of applications are suitable for this advanced and effici-
ent technology combination. The overall efficiency gains in process
and true cost of ownership compared to other technologies offer an
interesting opportunity to reduce the cost per tablet, improve tablet
quality and substantially improve the pharmaceutical manufacturing
efficiency.
Pharmaceutics
Chemicals
Foods
Antibiotics
Lactose
Natrium bicarbonate
Ibuprofen
Paracetamol
Speciality Chemicals
Plastics
Colouring
Detergent powder
Vitamins
Aromas / Flavours
Minerals
Animal feeding
Spice extract
Instant blends
Gericke Feeding and Mixing Technologies
When space is at a premium, Gericke continuous mixing systems
offer the ideal solution. Gericke also provide full recipe management
programmes incorporating feeding and flow control for maximum
mixing consistency. When the process involves multiple components
and frequent product changes, Gericke batch mixing stations are
used.
About Gericke
Gericke supplies conveying, sifting, high-precision feeding and
mixing solutions that handle a broad range of ingredients such as
pellets, powders, floodable powders and fibreglass for food, chemi-
cal, industrial, and pharmaceutical industries.
Gericke was founded in 1894 and is managed by Markus Gericke in
the 4th generation.
Gerteis® your Dry Granulation Experts
Gerteis® is a Swiss manufacturer of advanced high quality roller com-
pactor dry granulators who have set the standard with their unique
dry granulation technology. Their understanding of the dry granulation
process combined with patented roller compaction systems make Ger-
teis® the unrivalled technology leader in the field of dry granulation.
About Gerteis®
With more than 25 years in business, Gerteis® Maschinen + Process-
engineering AG is dedicated to providing world leading technology
for dry powder granulation for the pharmaceutical and healthcare
industries. The company is privately owned and managed by Paul
Gerteis.
Gericke AG
Althardstrasse 120
8105 Regensdorf (Switzerland)
T +41 44 871 3636
F +41 44 871 36 00
www.gericke.net
Gerteis Maschinen + Processengineering AG
Stampfstrasse 74
Postfach 2247
8645 Jona SG (Switzerland)
T +41 55 222 55 22
F +41 55 222 55 23
www.gerteis.com