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Thanks to the patented Gentlewing impeller,wall caking and incomplete emptying arethings of the past. The impeller shape matches the contour of the mixing container and its angled impeller plate ensures a forced mixing of the product. The precise manufacturing of the Hüttlin high-shear mixer granulator ensures a defined granulation gap along the entire length of the impeller plate, so that a considerably larger surface is used for granulation.
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Packaging Technology
High-shear mixer granulator systemsMixing, Granulating, Drying
2 | High-shear mixer granulator systems
Shortening the time between product development
and market launch and raising efficiency in production
while maintaining maximum quality are decisive
factors for our customers. The development of the
Hüttlin high shear mixer granulator responds to
precisely these demands. Gentlewing, SmartFlow and
UltraClean have become synonyms for innovative
technology for the benefit of customers. Gentlewing is
at the core of all Hüttlin units – available in an identical
design with bottom-drive or top-drive technology.
SmartFlowZ-shape of Gentlewing
Bottom Drive Top Drive
Superior mixing and granulation
Thanks to the patented Gentlewing impeller,
wall caking and incomplete emptying are
things of the past. The impeller shape matches
the contour of the mixing container and its
angled impeller plate ensures a forced mixing
Use the technological lead
High-shear mixer granulator
technology
of the product. The precise manufacturing
of the Hüttlin high-shear mixer granulator
ensures a defined granulation gap along the
entire length of the impeller plate, so
that a considerably larger surface is used
for granulation.
High-shear mixer granulator systems | 3
Form follows function
With the HTG (Hüttlin Top-Drive Granulator)
and HBG (Hüttlin Bottom-Drive Granulator),
Hüttlin has a high-shear mixer granulator
to meet every requirement. Gentlewing with
all of its benefits is available for use in
either version. The Hüttlin high-shear mixer
granulator with bottom drive is the best
Principle of the Gentlewing impeller
Granulation gap
choice for simple granulation applications in
combination with a fluid bed dryer. The top-
drive version satisfies the highest of demands.
A SinglePot application using UltraClean,
SmartFlow, vaccuum drying with solvent
recovery system can be extended with a high
containment design module.
4 | High-shear mixer granulator systems
HBG 600▶ Bottom Drive ▶ Inline operation▶ UltraClean – optional
HBG Hüttlin bottom drive high-shear mixer granulator
The innovative classic
Hüttlin has set another milestone with
its shaft seal design. Thanks to the
intelligent design and continuous flushed
seal, it is no longer necessary to lift or
remove the impeller for cleaning.
The combination of double lip seal and
wiper, flush seal, is designed as a
cartridge and has the same mounting
dimensions as the optional mechanical
seal. Consequently it can be easily
replaced. All of the GMP requirements
and pharmaceutical environment
standards are met. For easy cleaning all
utility connections are located in the
base frame of the machine. The lifting
mechanism of the container lid was
also developed with this in mind. The
lid is raised vertically to improve house
keeping in the process area.
Lifting mechanism
High-shear mixer Fluid bed
High-shear mixer granulator systems | 5
HTG 600 opened ▶ Top Drive ▶ SinglePot▶ Inline operation▶ UltraClean
HTG 600 with wet mill
HTG Hüttlin top drive high-shear mixer granulator
Innovation and GMP requirements
combined
The flexibility of a stand-alone unit as
a SinglePot or in combination with the
proven fluid-bed technology ensures
granulation and drying processes with
maximum efficiency.
The HTG high-shear mixer granulators
with top-drive technology differ from
those with bottom-drive technology
in that the seals of the Gentlewing and
chopper do not come into contact with
the product. This significantly reduces
wear and tear on the seal and the danger
of contaminating the product. HTG is
characterized by features such as lifting
columns for the product container,
the extreme ease with which cleanliness
can be checked, ultra-fast emptying times
and minimum effort in changing products.
Mixing, Granulating, Drying
SinglePot
High-shear mixer Fluid bed
6 | High-shear mixer granulator systems
Heated product container
Heated impeller shaft Heated lid SmartFlow,
360° strip gas feeding Discharge valve Gentlewing Chopper Temperature
measurement Cleaning nozzles Filter Vacuum pump Condensation unit Video camera
SinglePot: Consistent implementation of the benefits of top-drive technology
The Gentlewing along with the SmartFlow
continuous strip gas feeding system
replaces expensive, high-maintenance
accessories such as tilting options or
microwave technology with comparable
drying times. The wall installation enables
true separation of the GMP and technical
areas. All drives and supply lines can
be accessed via the technical area.
The logical consequence is to upgrade
this unit with the UltraClean (pat. pend.)
concept, split valves and additional
options from the Hüttlin product range
to create a genuine high-end
containment unit.
The SinglePot version of the Hüttlin high-shear mixer granulator combines
all of the benefits of the top-drive concept with the specific features
SmartFlow, heating jacket, product temperature regulation and vacuum
drying with solvent recovery. This concept meets the highest requirements
with regard to process times, product quality and handling.
High-shear mixer granulator systems | 7
From left to right: SmartFlow, metal filter, discharge valve
GMP-compliant design
There are things that do not compromise.
The Hüttlin high-shear mixer combines
a modular structure with implementation
of GMP requirements. The modular
structure offers maximum flexibility in
terms of adapting the unit to the specific
customer requirements. Consequent
implementation of the highest hygienic
requirements translates into a significant
increase in validation, cleaning and
production efficiency. When compared
with conventional high-shear mixer
granulators these are key benefits.
Gentlewing
▶ Maximum mixing quality with minimum mechanical stress on the product
▶ Minimum wall caking due to very close clearances between the product vessel and Gentlewing
▶ Excellent discharge due to Z-design of the Gentlewing impeller
▶ Effective drying without tilting or microwave technology
SmartFlow
▶ Highly efficient gas distribution over 360° for considerably higher drying homogeneity
▶ Shorter drying times due to continuous, effective strip gas feeding
Discharge valve
▶ The discharge valve design enables uninterrupted discharge, as the discharge velocity is not controlled by means of the valve opening, but by extremely low impeller speed
UltraClean
▶ The first CIP concept, which significantly reduces cleaning times and ensures highest cleaning quality
8 | High-shear mixer granulator systems
The variety in requirements on modern control systems means that it
must be possible to adjust them flexibly. Hüttlin’s control systems
were developed based on this premise. Their modular structure can be
adapted very easily, from control of an individual machine to entire
production lines and integration into ME-systems.
Based on a Siemens or Allan Bradley PLC,
the control system was consistently
developed according to GAMP guidelines
and is extended to include a PC above
a certain scope. Provicon fulfills all
requirements of the FDA 21 CFR part 11.
PAT Integration
Process monitoring is one of the most
important measures for meeting and
reproducing the required quality.
Device control and process monitoring
In addition to monitoring conventional
indicators such as temperature, torque,
pressure and flow rate for liquid binder
and strip gas, Hüttlin provides monitoring
of product humidity and particle size
distribution. A NIR (Near Infrared) sensor
can be integrated for inline monitoring
of the product quality, residual
humidity, mixing quality and particle
size distribution.
High-shear mixer granulator systems | 9
The cleaning requirements for high-shear mixer granulators from Hüttlin
can adapt to the customer’s process requirements. From WIP (Washing
in Place) to the CIP (Cleaning in Place) solution, the common denominator
for all of the cleaning concepts is efficiency.
Cleaning concept
Cleaning – WIP and CIP
Cleaning nozzle
M
Filter
Vacuum pump
High-shear mixer
Pneumatic filling
A 1
A 2E
B
C
DM
MA 1-2B CD EF
Cold water
Hot waterDI water
F
Detergent
To fluid bed
10 | High-shear mixer granulator systems
L
H
W
H
L
W
HTGHBG
Technical data subject to alterations *Depending on discharge container respectively discharge unit
Technical Data (Standard unit)
300 400 600 800 1 200 1 800
HBG
Total volume (litres) 300 400 600 800 1 200 1 800
Power (kW) 27 31 39 49 68 88
Length L (up to wall; mm) 1 800 1 845 1 925 2 120 2 600 2 650
Width W (mm) 1 400 1 460 1 560 1 560 2 160 2 200
Height H (mm)* 3 400 3 800 4 400 4 400 5 500 5 600
300 400 600 800 1 200 1 800
HTG
Total volume (litres) 300 400 600 800 1 200 1 800
Power (kW) 27 31 39 46 68 88
Length L (mm) 2 100 2 120 2 250 2 600 3 500 3 700
Width W (mm) 1 120 1 150 1 270 1 270 1 480 1 800
Height H (mm)* 3 100 3 200 3 500 3 600 4 050 4 200
High-shear mixer granulator systems | 11
Discharge valve HBG 600
Product overview / dimensions High-shear mixer granulator/dryer
HBG – Bottom Drive HTG – Top Drive
Standard systems HTG 300
HBG 400 HTG 400
HBG 600 HTG 600
HBG 800 HTG 800
HBG 1 200 HTG 1 200
HBG 1 800 HTG 1 800
UltraClean HTG 300UltraClean
HTG 400UltraClean
HTG 600UltraClean
HTG 800UltraClean
HTG 1 200UltraClean
HTG 1 800UltraClean
SinglePot HBG 300UltraClean SinglePot 300 SinglePot 300UltraClean
HBG 400UltraClean SinglePot 400 SinglePot 400UltraClean
HBG 600UltraClean SinglePot 600 SinglePot 600UltraClean
HBG 800UltraClean SinglePot 800 SinglePot 800UltraClean
HBG 1 200UltraClean SinglePot 1 200 SinglePot 1 200UltraClean
HBG 1 800UltraClean SinglePot 1 800 SinglePot 1 800UltraClean
Hüttlin GmbHA Bosch Packaging Technology Company
Hohe-Flum-Straße 42 79650 Schopfheim GermanyPhone +49 7622 6884-0Fax +49 7622 6884-111www.boschpackaging.com [email protected]
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