HSCT2 20215th International Workshop on Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation and Cellular Therapy

October 7-9, 2021 Grand Hyatt New York New York City, NY

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Michael BishopThe University of Chicago Medicine/USA

Nicolaus Kröger University Hospital Hamburg/DE

Sergio GiraltMemorial Sloan Kettering Cancer Center/USA

Alan Wayne Children‘s Hospital Los Angeles/ USC Norris Comprehensive Cancer Center/USA

Relapse and disease progression are the leading causes of treatment failure for most hematologic malignancies treated with both allogeneic and autologous hematopoietic stem cell transplantation (HSCT) and also CAR T cell therapy. Since the first symposium, now more than 10 years ago, we have witnessed tremendous progress in our understanding and treatment of relapse including the development of therapies specifically licensed to treat or prevent relapse post HSCT. The planned objectives of the 5th Workshop are designed to present the latest scientific and clinical advances related to relapse after HSCT and to provide a forum for the presentation of ongoing laboratory, translational, and clinical research specifically related to this field. The educational content of this conference is relevant for medical and pediatric hematologists-oncologists, translational and basic scientists, hematopathologists, physicians-in-training (Fellows/Residents/Post Docs), advance practice providers, pharmacists, oncology nurses and other associated allied health professionals. The Workshop will feature internationally recognized speakers from a multidisciplinary, diverse group comprised of basic and translational scientists and clinical investigators.

The workshop will include formal didactic presentations and informal discussion panels. It will also offer investigators interested in the field the opportunity to present their work in dedicated oral and poster sessions. As in previous years, the four best abstracts will be selected for oral presentation in the meeting.

The Organizing Committee has been working hard to make the 5th International Workshop on the Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation and Cellular Therapies (HSCT2) a truly valuable experience for all participants. We shall be delighted to welcome you to fabulous New York City.

5TH INTERNATIONAL WORKSHOP ON BIOLOGY, PREVENTION AND TREATMENT OF RELAPSE AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION AND CELLULAR THERAPY

HSCT2 2021

OVERV I EW

AIMS OF THE WORKSHOP

Primary Aim: To review the state of the science and basic, translational and clinical research related to relapse after allogeneic and autologous HSCT, along with cellular therapies.

• Update the current state of the science relative to biology and clinical study of relapse related to autologous and allogeneic HSCT, along with cellular therapies.

• Provide a forum for the presentation of ongoing laboratory and translational research specifically related to relapse following HSCT or cellular therapy.

• Provide a forum to present ongoing clinical trials that are specific to the study of and treatment of relapse following HSCT or cellular therapy.

• Provide an overview of the potential role of CAR T cells and other cellular therapies in the prevention and treatment of relapse following HSCT.

MAIN TOPICSEpidemiology of relapse Biology of relapse

• Microenvironment• Checkpoint blockade• HLA-loss• T cell impairment• NK/CIK cells• Intrinsic tumor resistance

Methods to prevent and treat relapse• Tumor-specific T cells• Checkpoint inhibitors• Genetically modified T cells• CAR T cells• NK/CIK cells• Vaccination• Antibodies (e.g., bispecific and polyclonal)• Hypomethylating agents• HDAC inhibitors• Immunmodulating drugs (ImiDs)• Small molecular and TKIs

Role of minimal residual disease• FACS• Next Generation Sequencing• Digital PCR

Clinical results and trials• Lymphoid Malignancies• Acute Leukemias• Multiple Myeloma• MDS and MPN

Workshops (Meet the Experts)• Basic Immunology for Transplant• Trial Design/Biostatistics• CRS• Regulatory• Junior Faculty/Fellows• MRD Methods and Monitoring

Poster Session

Exhibits

HSCT2 2021

HSCT2 2021ACCREDITATION

AMA PRA CATEGORY 1 CREDIT™ This activity has been planned and implemented in accordance with the accreditationrequirements and policies of the Accreditation Council for Continuing MedicalEducation (ACCME) through the joint providership of the University of ChicagoPritzker School of Medicine and the Organizing Committee. The University ofChicago Pritzker School of Medicine is accredited by the ACCME to providecontinuing medical education for physicians.

The University of Chicago Pritzker School of Medicine designates this live activity for a maximum of 14 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses and other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of Certificates of Participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.

European Union of Medical Specialties: The American Medical Association (AMA) has an agreement of mutual recognition of continuing medical education (CME) credit with the European Union of Medical Specialties (UEMS).

International physicians interested in converting AMA PRA Category 1 Credit™ to EACCME credit should contact the UEMS.

Executive Platinum – $100,000• 400-sq.-ft., 20' x 20' prime location exhibition space• 6 exhibitor registrations (additional registrations available at reduced rates)• One full-page, back cover, color advertisement in the program booklet• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Post-workshop mobile app push notification• Brochure in the participants’ bags• Banner at registration table on site• 2 invitations to Faculty Dinner

Platinum – $75,000• 320-sq.-ft., 16' x 20' exhibition space• 4 exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside back cover, color advertisement in the program booklet• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Post-workshop mobile app push notification• Brochure in the participants’ bags• 2 invitations to Faculty Dinner

Gold – $50,000• 160-sq.-ft., 8' x 20' exhibition space• 4 exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside front cover, color advertisement in the program booklet• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants‘ bags• 1 invitation to Faculty Dinner

Silver – $35,000• 80-sq.-ft., 8' x 10' exhibition space• 4 exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants‘ bags

Classic – $20,000• 80-sq.-ft., 8' x 10' exhibition space• 2 exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants‘ bags

HSCT2 2021

HSCT2 2021

SUPPORT

LEVELS OF SPONSORSHIP

LEVELS OF SPONSORSHIP

Break/Snack (Sole Support) (3 available) – $22,000• 2 exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants’ bags• Cocktail napkins and signage at event with logo

Coffee Breaks (Sole Support) (3 available) – $15,000• Includes a table in break area for brochures (table in exhibits is not included)• 1 exhibitor registration (additional registrations available at reduced rates)• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants’ bags• Signage at event with logo

Lunch, Strolling Exhibits (2 available) – $46,000Opportunity to support a lunch in the exhibit area for all participants of the workshop

• 160-sq.-ft., 8’ x 20’ exhibition space• 2 exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside back cover, color advertisement in the program booklet• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants’ bags• Cocktail napkins and signage at event with logo

Welcome Reception (Sole Support) – $55,000Opportunity to support the welcome reception for all participants of the workshop

• Company logo on the official invitation to the welcome reception• 160-sq.-ft., 8’ x 20’ exhibition space• 4 exhibitor registrations (additional registrations available at reduced rates)• One half-page, inside front cover, color advertisement in the program booklet• Acknowledgement: workshop website, program booklet, onsite signage, mobile app• Brochure in the participants’ bags• Cocktail napkins and signage at event with logo

Faculty Dinner (Sole Support) – $25,000Opportunity to support the dinner for faculty and speakers attending the workshop

• Company logo on the official invitation to the faculty dinner• 2 exhibitor registrations (additional registrations available at reduced rates)• Acknowledgement: at dinner, workshop website, program booklet, onsite signage, mobile app• Brochure in the participants’ bags• Signage at event with logo HSCT2 2021

Workshop Lanyards (SOLD!) – $10,000This opportunity is initially available to Executive Platinum, Platinum and Gold supporters; otherwise available on a first-come, first-served basis

• Branding of lanyards with sponsor’s logo (lanyards are provided by the organizer)• Brochure in the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

Tote Bags (SOLD!) – $12,000 Opportunity to brand the tote bags for all participants of the workshop (tote bags are provided by the organizer)

• One exhibitor registration (additional registrations available at reduced rates)• Brochure in the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

Brochure Insert – $5,000• Company brochure to be inserted into the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

Mobile App (Sole Support) – $15,000 Opportunity to support the mobile app for all participants of the workshop

• One exhibitor registration (additional registrations available at reduced rates)• Brochure in the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

Note Pads and Pens (Sole Support) – $8,000 Opportunity to sponsor note pads and pens for all participants of the workshop (note pads and pens are provided by the organizer)

• Brochure in the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

Water Bottles (SOLD!) – $8,000• Brochure in the participants’ bags• Acknowledgment: workshop website, program booklet, onsite signage, mobile app

LEVELS OF SPONSORSHIP

HSCT2 2021

DRAFT

2021 TENTATIVE AGENDAHSCT2 2021

SCHEDULE

Friday, October 8, 2021 Subject to modifications

7:00 – 8:00amSponsored Breakfast Symposium (tentative)

8:00 – 8:05am Welcome and Introduction Dr. S. Giralt

8:05 – 8:40am Session I: Keynote Lecture – Relapse Post Transplant, Where Are We Now? Dr. Robert Soiffer

8:40 – 11:00am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape Session IIa: Radio-Chemo Resistance (Moderators: Dr. Ritchie & Dr. Gyurkocza) Session IIb: Immune Escape (Moderators: Dr. Hsu & Dr. Vago)

11:00 – 11:15amBreak

11:15am – 12:20pmSession III: Measurable Residual Disease / Pre-emptive Therapy (Moderators: Dr. Pulsipher & Dr. Peggs)

12:20 – 1:00pmStrolling Lunch - Vendor Exhibits, Abstract Posters

1:00 – 1:35pmSession IV: Optimal Cells for Immunotherapy Dr. Joseph Fraietta

1:35 – 2:50pmSession V: T Cell Exhaustion and Checkpoint Blockade (Moderators: Dr. Komanduri & Dr. Shah)

2:50 – 3:15 pmBreak

3:15 – 4:45pm Session VI: Relapse Prevention - Drugs and Cells(Moderators: Dr. Craddock & Dr. DiPersio)

4:45 – 5:00pm Break

5:00 – 6:00pmSession VII: Best Abstracts

6:00 – 7:30pmWelcome Reception, Vendor Exhibits, and Poster Viewing

DRAFT

HSCT2 2021

2021 TENTATIVE AGENDA

SATURday, October 9, 2021 Subject to modifications

7:00 – 8:00am Sponsored Breakfast Symposium (tentative)

8:00 – 8:35am Session VIII Keynote Lecture – CAR T Cells What is next? Dr. Michael Sadelain

8:35 – 9:50am Session IX: Mechanisms of Relapse Microbiota -T Cell Trafficking - Immune Reconstitution (Moderators: Dr. Teshima & Dr. Bachanova)

9:50 – 10:00amBreak

10:00 – 11:45amSession X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond (Moderators: Dr. Bollard & Dr. Smith)

11:45am – 12:45pm Strolling Lunch - Vendor Exhibits, Abstract PostersLunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate

12:15 – 12:45pm Defending Yes TBD / Defending No TBD

12:45 – 2:15pmSession XI: Treatment of Relapse (Moderators: Dr. Porter & Dr. Dreger)

2:15 – 3:30pm Session XII: Relapse Post Auto and CAR T Cells - It’s Not All About Allo(Moderators: Dr. Giralt & Dr. Horowitz)

3:30 – 4:00pmSession XIII: Summary and Future Directions Dr. A. Wayne

4:00pmAdjourn

SCHEDULE

VENUEGrand Hyatt New York, 109 East 42nd Street, New York, NY 10017

To sign up for updates and additional information please visit www.relapse-after-hsct.com.

WORKSHOP SUPPORT/REGISTRATION/EXHIBITIONOur conference planning partner is MOC&CO, www.mocandco.com. Phone: 630.338.8517 Email: HSCTconference@mocandco.com

Please whitelist this email address as future communications about the workshop will come from this source.

Our exhibit partner will be announced in January 2021.

LIABILITY AND INSURANCEThe workshop organizer cannot accept liability for personal accidents, loss or damage to private property of participants, either during or indirectly arising from the Relapse Workshop. Participants are advised to secure their own personal travel and health insurance for their trip.

All exhibitors and sponsors are required to provide a certificate of insurance. Details will be provided inyour sponsor and exhibitor kit.

TERMS AND CONDITIONS• Support items are allocated on a first-come, first-served basis.• All support and exhibition prices quoted are in U.S. Dollars.• All payments must be received before the beginning of the workshop. Should the company fail to make the payment prior to the commencement of the workshop, the organizer reserves the right to cancel the company‘s participation and benefits.• Time slot allocation will be based on level of support and approval of the organizing committee.• The exhibitor agrees to abide by ACCME Standards for Commercial Support as stated at www.accme.org: SCS 4.2: • Product-promotion material or product-specific advertisement of any type is prohibited in or during CME activities. The juxtaposition of editorial and advertising material on the same products or subjects must be avoided. Live (staffed exhibits, presentations) or enduring (printed or electronic advertisements) promotional activities must be kept separate from CME.

HSCT2 2021

I N FORMAT ION

GENERAL INFORMATION

TERMS AND CONDITIONS (continued) • Live, face-to-face CME, advertisements and promotional materials cannot be displayed or distributed in the educational space immediately before, during or after a CME activity. Providers cannot allow representatives of Commercial Interests to engage in sales or promotional activities while in the space or in the place of the CME activity.• The workshop organizer reserves the right to accept or decline offers of support and applications for exhibition space.• The workshop organizer reserves the right to amend the published floorplan, should it be deemed necessary, for the benefit of the exhibition as a whole.

EXHIBITIONThe exhibition will be held at the Grand Hyatt New York. The exhibition floor plan is designed to maximize exposure to the participants. Some meals and the welcome reception will be held in the exhibition area.

Exhibition space will be available on a first-come, first-served basis with priority given to Executive Platinum, Platinum and Gold supporters.

The standard booth size is 8’ x 10’.

Companies that have exhibits only will be acknowledged as exhibitors only.

Exhibition space rental is priced according to size and includes:

• 8’ High back wall• 3’ High side rail• One 6’ skirted table• Two padded chairs• One wastebasket• One 7” x 44” booth ID sign• One exhibitor registration per booth

– Additional exhibitor registrations available for $400 per person• General cleaning of public areas

Additional exhibition equipment and services are available. Information will be provided in January 2021.

HSCT2 2021GENERAL INFORMATION

HSCT2 2021

REG I STRAT I ON

SPONSOR/EXHIBITOR REGISTRATION FORM

_________________________________________________________________________________ Company

_________________________________________________________________________________ Contact _________________________________________________________________________________ Department_________________________________________________________________________________ Address _________________________________________________________________________________ City/State/Zip Code _________________________________________________________________________________ Phone Email_________________________________________________________________________________ Invoice Address (if different)

Order No./PO No./Tax No., if necessary _____________________________An invoice with payment instructions will be sent to the email address designated above.

Categories of Sponsorship¨ Executive Platinum $100,000¨ Platinum $75,000 ¨ Gold $50,000¨ Silver $35,000¨ Classic $20,000

Support Opportunities¨ Break/Snack (3 available), each $22,000¨ Coffee Breaks (3 available), each $15,000¨ Lunch, Strolling Exhibits (2 available), each $46,000¨ Welcome Reception $55,000¨ Faculty Dinner $25,000¨ Lanyards $10,000¨ Tote Bags $12,000¨ Brochure Insert $5,000¨ Mobile App $15,000¨ Note Pads and Pens $8,000¨ Water Bottles $8,000

Must be returned before June 30, 2021, to: MOC&CO-Conference Planning Company5th International Workshop on Biology, Prevention and Treatment of Relapse after Hematopoietic Stem Cell Transplantation and Cellular Therapy

Email: HSCTconference@mocandco.com

Phone/Fax:630.338.8517 / 630.443.7003

Address:220 W. River Drive, St. Charles, IL 60174

Date:October 7-9, 2021

Location:Grand Hyatt - New York City

Payments:Payments will be invoiced by and made to Mary O’Connor & Company our official conference planning company. Remit to Mary O’Connor & Company (MOC&CO), 220 West River Drive, St. Charles, IL 60174. FEIN: 36-4046221

EXHIBITION (STANDARD BOOTH SIZE OF 80 SQ. FT.)

Please note, space is limited; sponsors will have priority on securing space.

¨ 8’ x 10’ Booth - $7,500¨ 8’ x 20’ Booth - $15,000

Includes company profile in the program booklet, the booth area, 1 table, 2 chairs during the exhibition, 1 exhibitor registration (8’ x 10’) or 2 exhibitor registrations (8’ x 20’), set-up and tear-down time as well as a general cleaning.

Once you have registered for your sponsorship and/or exhibits, you will receive an exhibit booklet with further details from our exhibit partner. Please note, the Grand Hyatt cannot receive freight; all freight must go through the exhibit company.

Freight will move in the evening of October 7. Exhibitors will have access to set up their booths from 7am to 11am on October 8. Exhibits will be open October 8 for lunch and the Welcome Reception.

On October 9, the exhibits will be open for lunch, concluding at 1:30pm. Tear-out must be complete by 4pm on October 9. Due to time constraints, please keep this in mind when designing your exhibit.

There is no entitlement to a specific exhibition space. Booth space will be available on a first-come, first-served basis with priority given to Executive Platinum, Platinum and Gold sponsors.

Staff/ParticipantsRegistration pass for 1 (8’ x 10’) or 2 (8’ x 20’) is included in the exhibitor fee, which also entitles the participant(s) to attend the scientific program.

Additional staff ______ person(s) at $400 each

General SponsoringBecome a sponsor of the event and design your individual sponsorship. Please feel free to contact us so that we may provide you with a personal proposal according to your needs and wishes.

We will support the event with: $ __________

Booking (binding) Once we have received your registration form, the reservation will be confirmed with a contract. The amount for all booked items is payable by credit card or bank transfer and will be contained in a confirmation email with invoice.

My signature confirms my booking. Terms and conditions will be included in the sponsorship contract.

Signature _____________________________________________ Date ______________________

Fax or email completed two-page registration form to:email - HSCTconference@mocandco.comfax - 630.443.7003address - 220 W. River Drive St. Charles, IL 60174

HSCT2 2021

Dr. Veronika BachanovaUniversity of Minnesota

Dr. Catherine Bollard Children’s National

Dr. Charles CraddockUniversity of Birmingham

Dr. John DiPersio Washington University School of Medicine

Dr. Peter Dreger University of Heidelberg

Dr. Boglarka Gyurkocza Memorial Sloan Kettering Cancer Center

Dr. Mary Horowitz Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research

Dr. Katharine Hsu Memorial Sloan Kettering Cancer Center

Dr. Xiao-Jun Huang Peking UniversityPeople’s Hospital & Peking University Institute of Hematology

Dr. Krishna V. Komanduri University of Miami Health Systems

Dr. Karl Peggs University College London Hospitals

Dr. David Porter Perelman School of Medicine, University of Pennsylvania

Dr. Michael PulsipherChildren’s Hospital Los Angeles

Dr. David RitchieMacCallum Cancer Centre

Dr. Nirali Shah National Cancer Institute

Dr. Melody SmithMemorial Sloan Kettering Cancer Center

Dr. Takanori Teshima Hokkaido University

Dr. Luca Vago San Raffaele Scientific Institute

HSCT2 2021

2021

STEERING COMMITTEE

Organizers of the Scientific WorkshopSergio Giralt, MD, Workshop Co-chair and HostMemorial Sloan Kettering Cancer Center/USA

Michael Bishop, MD, Workshop Co-chairThe University of Chicago Medicine/USA

Nicolaus Kröger, MD, Workshop Co-chairUniversity Hospital Hamburg/DE

Alan Wayne, MD, Workshop Co-chairChildren‘s Hospital Los Angeles/USC Norris Comprehensive Cancer Center/USA

Registration and ContactOur conference planning partner

www.mocandco.comPhone: 630.338.8517Fax: 630.443.7003Email: HSCTconference@mocandco.comAddress: 220 W. River Drive, St. Charles, IL 60174

Exhibit PartnerTo be announced

LocationGrand Hyatt New York109 East 42nd Street, New York, NY 10017