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高附加值抗癌抗肿瘤天然产物

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高附加值抗癌抗肿瘤天然产物. 常盼盼 2013.5.29. 目录. 1 番茄红素 1.1 番茄红素简介 1.2 研究论文 2 其他天然产物. 1.1 简介. 番茄红素( lycopene )是成熟 番茄 的主要 色素 ,属于 异戊二烯 类化合物,是一种不含氧的 类胡萝卜素 。。. 番茄红素具有优越的生理功能,它不仅具有 抗癌 抑癌的功效,而且对于预防心血管疾病、 动脉硬化 等各种成人病、增强 人体免疫系统 以及 延缓衰老 等都具有重要意义,是一种很有发展前途的新型功能性天然色素。. - PowerPoint PPT Presentation

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2013.5.291 1.1 1.2 2

lycopene1.1

155305100g 0.220100g5.235.50100g

/2009/Food Chemistry[1]Chun YiJohn ShiCanadaChina(7% )31.25 g/g100 C,40 MPa 1.5 mL/min70 70 1.7-1.32TP2010/The Journal of Supercritical Fluids[2]Juliana A. EgydioBrazil7.7% -76.7%80 C 35MPa40 C 35MPaTP2009/The Journal of Supercritical Fluids[3]

Loredana CiurliaItaly6%10%72.5%80%60 C, 40MPa,10 kgCO2/h1.2 /2009/Food Chemistry[4]

Beatriz P. NobrePortugalBrazil93%60 C , 30MPa0.59 g/min0.36 mm4.6%P40-6060-801.2. 2009/Journal of Food Engineering[5]John ShiCanadaChina7535MPa15% 4510% 7510%10%/2008/Bioresource Technology[6]

L.S.Vaughn KatherineUnited States38g/g7020.7MPa15%2006/[7]

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93.81%6035 MPa1.5~2 h

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2013/The Journal of Supercritical Fluids[8]Salima VaronaSpainGermanyCO2EA[1]

Chromatograph of SC-CO2 fluid extract obtained at 50 C (A) and 90 C (B) at constant pressure (30 MPa) and flow rate (1.5 mL/min)15.876.88.916.11.182.131.03

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ABC45

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2010/[9] 2% 2:10.6g/100g35pH5.05h2% 20min4000r/min 10min/2006/[10]

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0. 6~0. 8 mm,34MPa,40,,

2010/[11]

7.83mg/50g

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2011/[12]

CO2,(MTT)

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2007/[13]

2.49% 0.08% 20MPa452.5h

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1. Yi, C., Shi, J., Xue, S.J., Jiang, Y., Li, D., 2009. Effects of supercritical fluid extraction parameters on lycopene yield and antioxidant activity. Food Chem. 113, 10881094. 2. Egydio, J.A., Moraes, A.M., Rosa, P.T.V., 2010. Supercritical fluid extraction of lycopene from tomato juice and characterization of its antioxidant activity. J. Supercrit. Fluids 54, 159164.3. Ciurlia, L., Bleve, M., Rescio, L., 2009. Supercritical carbon dioxide co-extraction of tomatoes (Lycopersicum esculentum L.) and hazelnuts (Corylus avellana L.): A new procedure in obtaining a source of natural lycopene. J. Supercrit. Fluids 49, 338344.4. Nobre, B.P., Palavra, A.F., Pessoa, F.L.P., Mendes, R.L., 2009. Supercritical CO2 extraction of trans-lycopene from Portuguese tomato industrial waste. Food Chem. 116, 680685.5. Shi, J., Yi, C., Xue, S.J., Jiang, Y., Ma, Y., Li, D., 2009b. Effects of modifiers on the profile of lycopene extracted from tomato skins by supercritical CO2. J. Food Eng. 93, 431436.6. Vaughn, K.L.S., Clausen, E.C., King, J.W., Howard, L.R., Carrier, D.J., 2008. Extraction conditions affecting supercritical fluid extraction (SFE) of lycopene from watermelon. Bioresour. Technol. 99, 78357841.7. ,,,,. [J]. ,2006,05:159-162.8. Salima Varona, Andreas Braeuer, Alfred Leipertz. 2013. Lycopene solubility in mixtures of carbon dioxide and ethyl acetate. J. Supercrit. Fluids 75, 610.9. ,. [J]. ,2010,13:100-104.10. ,,,,. CO_2[J]. ,2006,04:480-482.11. ,. CO_2[J]. ,2010,10:772-773.12. ,,,,,. GC-MS[J]. ,2011,01:113-116.13. ,,,. -[J]. ,2007,08:1821-1823.

A ,6/kg

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89.14%35MPa,80195%;3 h,

9070~80

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2011/

; 0.099 6% 35 MPa 60 2 h 100 g 15 mL

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20 mg/kg,80,45 MPa,2.5 h,CO220 kg/h,

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1999/

95%20MPa,602 h0.2-2mm

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2000/

18 MPa,I14 MPa,6 MPa40,I60,505h,CO210-20 kg/h

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2006/

0.48% 92% 20 MPa 50 CO2 1kg/hkg() 2 h

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2006/

95%,15%20 MPa,50,CO21 kg/h,60,14 MPa.4 h

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